Horm Metab Res 2019; 51: 568-574DOI: 10.1055/a-0897-8785The aim of this study was to investigate in a longitudinal approach whether levothyroxine (LT4) substitution has a different impact on quality of life (QoL) and thyroid related QoL in younger (<40 years) and older subjects (>60 years) with elevated thyroid-stimulating hormone (TSH) concentrations. The study included male and female patients with newly diagnosed, untreated subclinical hypothyroidism defined by TSH>8 mU/l. Patients were...
Tue Sep 10, 2019 02:00
Horm Metab Res 2019; 51: 559-567DOI: 10.1055/a-0994-0489Based on the American (Bethesda, 2017) or Italian (SIAPEC 2014) cytological categories of thyroid nodules, the risk of malignancy and management vary. This risk is 5–10% or<3% (benign or TIR2), 6–18% or<10% (AUS/FLUS or TIR3A), 10–40% or 15–30% (FN/SFN or TIR3B), 45–60% or 60–80% (suspicious or TIR4), 94–96% or 95% (malignant or TIR5). In 408 thyroid nodules evaluated cytologically, we computed the malignancy rate in each category considering...
Tue Sep 10, 2019 02:00
Horm Metab Res 2019; 51: 595-601DOI: 10.1055/a-0955-6563This aim of this study was to investigate the correlation between urine haptoglobin/creatinine ratio(UHCR) and tubular injury biomarkers or severity of albuminuria in type 2 diabetes. Recruited T2DM patients (n=120) were divided into three groups based on urine albumin/creatinine ratio (UACR): normal albuminuria (Normo group, UACR<30 mg/g, n=40), microalbuminuria (Micro group, 30 mg/g ≤UACR<300 mg/g, n=38), and macroalbuminuria (Macro...
Tue Sep 10, 2019 02:00
Those with even a rudimentary knowledge of biomedical progress understand how advances in delineating the components of the immune system have led to new means of manipulating it, including vaccines as well as drugs and biologic agents to ameliorate cancer and autoimmune conditions. The importance…
Tue Sep 10, 2019 03:00
Authors: Yuan, Shunzong / Qiao, Bing / Zheng, Naxin / Zheng, Wenwen / Jing, Huarong / Wen, Guanhui / Song, Shiping
Sat Aug 31, 2019 03:00
Authors: de Almeida, Sérgio Monteiro / Nogueira, Meri Bordignon / Nogueira, Keite
Sat Aug 31, 2019 03:00
Authors: Provencio, Mariano / Pérez-Barrios, Clara / Barquin, Miguel / Calvo, Virginia / Franco, Fabio / Sánchez, Estela / Sánchez, Ricardo / Marsden, Daniel / Cristóbal Sánchez, Juan / Martin Acosta, Paloma / Laza-Briviesca, Raquel / Cruz-Bermúdez, Alberto / Romero, Atocha
Fri Aug 30, 2019 03:00
Authors: Aloisio, Elena / Pasqualetti, Sara / Dolci, Alberto / Panteghini, Mauro
Thu Aug 29, 2019 03:00
Authors: Pantiya, Patcharapong / Chairatanapiwong, Saowanit / Dankai, Dararat / Nualkeaw, Sarayut / Jaiping, Kanokwan / Singboottra, Panthong / Pornprasert, Sakorn
Thu Aug 29, 2019 03:00
Authors: Galliera, Emanuela / Massaccesi, Luca / de Vecchi, Elena / Banfi, Giuseppe / Romanelli, Massimiliano M. Corsi
Sat Aug 17, 2019 03:00
Clear aligners (CA) are among the most chosen orthodontic therapies for patients who require an invisible treatment. Previous studies showed that the thermoforming process and the complexity of the intraoral e...
Mon Sep 09, 2019 03:00
Mon Sep 09, 2019 20:13
In the case of most mandibular fractures, the prescription of antimicrobials for more than 24 hours postoperatively confers no clinical benefit. To establish the prescribing patterns for mandibular fractures in UK OMFS units, and to compare them with those used 12 years ago, we did a telephone and email survey of OMFS units in the UK. Antimicrobials were prescribed for more than 24 hours postoperatively by 76 units (65%) (considerably fewer than the 82 (87%) in 2005). The most commonly prescribed...
Tue Sep 10, 2019 03:00
The NHS in England requires the reporting of defined “never events” that are directly related to patients’ safety. Analysis of data from 2012–2015 has been published previously in this journal. An examination of continuing data from 2015–2019 shows that “wrong tooth/teeth removed” has not reduced in frequency and it still remains a common “wrong-site surgery” event accounting for between 16% and 24% of wrong-site surgery never events and 7%–10% of all never events reported. Hospitals and community...
Tue Sep 10, 2019 03:00
Abstract Human epidermal growth factor receptors (EGFR) are an important target in drug discovery in terms of both protein–small-molecule interactions and protein–protein interactions. In this work, the isolation of a stable soluble protein of the tyrosine kinase domain of EGFR in Escherichia coli expression has been accomplished. This successful study presents the expression and purification conditions to obtain a stable soluble protein of the active tyrosine kinase domain of...
Tue Sep 10, 2019 03:00
Abstract Purpose Overexpression of CD44 has been detected in many types of tumor tissues. Moreover, CD44 is recognized as a cancer stem cell marker for many cancers. However, the prognostic value of CD44 for glioma patients has not yet been clarified. The authors tried to explore the impact of CD44 expression on grade II/III glioma patients. Methods To assess...
Tue Sep 10, 2019 03:00
Tue Sep 10, 2019 03:00
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01247H, PaperStephan Sass, Walter F.M. Stöcklein, Anja Klevesath, Jeanne Hurpin, Marcus Menger, Carsten HilleAnthracyclines like daunorubicin (DRN) and doxorubicin (DOX) play an undisputed key role in cancer treatment, but their chronic administration can cause severe side effects. For precise anthracycline analytical systems, aptamers...The content of this RSS Feed (c) The Royal Society of Chemistry
Tue Sep 10, 2019 02:00
Agreement between surgical and anesthesia teams regarding appropriate perioperative management strategies is vital to delivering safe and effective patient care. Perioperative guidelines serve as a valuable reference in optimizing patients for surgery. The article provides a broad set of guidelines related to cardiovascular evaluation, medication reconciliation, and preoperative fasting and includes a framework for the care of patients with comorbidities, such as coronary artery disease and obstructive...
Tue Sep 10, 2019 03:00
To provide fast and accurate dose calculation in voxelized geometries for proton radiation therapy by implementing an adaptive step size algorithm in the proton macro Monte Carlo (pMMC) method.
Mon Sep 09, 2019 03:00
Primary spontaneous pneumothorax is a common disorder occurring in young adults without underlying lung disease. Although tobacco smoking is a well-documented risk factor for spontaneous pneumothorax, an assoc...
Mon Sep 09, 2019 03:00
Enterococcus faecium is part of the human gastrointestinal flora but may act as opportunistic pathogen. Environmental persistence, high colonization capability and diverse intrinsic and acquired resistance mechan...
Mon Sep 09, 2019 03:00
Zusammenfassung Einleitung Schwindel ist ein häufiges Symptom in allen Altersklassen. Dennoch gibt es bisher kaum belastbare Daten zur Alters- und Geschlechtsverteilung peripher-vestibulärer Schwindelerkrankungen bei unter 15-Jährigen. Ziel der vorliegenden Studie ist es, die Prävalenz und Geschlechtsverteilung der 3 klassischen peripher-vestibulären Erkrankungen – benigner paroxysmaler Lagerungsschwindel (BPPV), Neuropathia vestibularis...
Tue Sep 10, 2019 03:00
Abstract Jazan region of Saudi Arabia has a high prevalence of oral cancer: 35% of cases. However, little is known about the view of dentists and dental students on possible factors that contribute to this high rate with scarce efforts regarding prevention. The study investigated possible factors related to oral cancer as perceived by dentists and dental students, using a qualitative approach. Six focus groups conducted in Jazan Dental School (JDS) and participants included dental...
Tue Sep 10, 2019 03:00
South American rivers are home to at least three different species of electric eels, including a newly identified species capable of generating a greater electrical discharge than any other known animal, according to a new analysis of 107 fish collected in Brazil, French Guiana, Guyana and Suriname in recent years.
Tue Sep 10, 2019 20:43
For the first time, researchers have measured how the production of algae and the Earth's oxygen level affect each other -- what you might call 'Earth's heartbeat'. Studies of 540 million-year-old limestone indicate that it is not just the oxygen level that affects animals, but that animals can indeed regulate the oxygen level.
Tue Sep 10, 2019 17:54
Here's a discovery well worth toasting: A research team has deciphered the genome of the Chardonnay grape. By doing so, they have uncovered something fascinating: grapes inherit different numbers of genes from their mothers and fathers.
Tue Sep 10, 2019 16:54
A new study advances existing knowledge about transcription and gene expression. This multi-institution team of researchers made interesting discoveries about the role of the Mediator protein complex in expressing genetic information as diverse cell proteins.
Tue Sep 10, 2019 16:54
Life uses 20 coded amino acids (CAAs) to construct proteins. This set was likely evolutionarily 'standardized' from smaller sets as organisms discovered how to make and encode them. Scientists modeled how the adaptive properties of the CAAs evolved over time. They found that sets containing even only a few CAAs were better than an enormous choice of alternatives, suggesting each time a modern CAA was discovered, it bootstrapped the set to include still more CAAs.
Tue Sep 10, 2019 15:00
Η τακτική σωματική δραστηριότητα είναι ένα σημαντικό κομμάτι ενός υγιεινού τρόπου ζωής. Ωστόσο, η πλειονότητα των αμερικανών ενήλικων τεμπελιάζουν σε έναν καναπέ, γεγονός που οδηγεί σε ποικίλα θέματα υγείας όπως η παχυσαρκία, οι καρδιαγγειακές παθήσεις και ο καρκίνος. Σύμφωνα με τα στοιχεία της αμερικανικής κυβέρνησης, το κόστος που συνδέεται με σωματική αδράνεια ανέρχεται σε 138 δισεκατομμύρια δολάρια και αντιπροσωπεύει πάνω από το 11% των συνολικών δαπανών για την υγειονομική περίθαλψη. Εκτός...
Tue Sep 10, 2019 17:30
«Οἶνος εὐφραίνει καρδίαν ἀνθρώπου», σύμφωνα με την βιβλική ρήση και τώρα μια νέα μελέτη, η μεγαλύτερη στο είδος της, έρχεται να επιβεβαιώσει ότι το ίδιο ισχύει και για τη διατροφή και την ευεργετική επίδρασή της στην ψυχική μας υγεία. Σύμφωνα με την πρώτη στο είδος της μετα-σύνθεση (πρόκειται για επαναξιολόγηση στοιχείων από μετα-αναλύσεις) που δημοσιεύεται στο World Psychiatry, τεκμηριώνεται πλέον μια λίστα διατροφικών συστατικών που αποδεδειγμένα βοηθούν στη διαχείριση μιας ευρείας γκάμας ψυχικών...
Tue Sep 10, 2019 16:30
Πάνω από ένα εκατομμύριο (1.125.000) άντρες παγκοσμίως πάσχουν από αιμορροφιλία (ή αιμοφιλία) και μάλιστα σχεδόν οι μισοί από αυτούς (418.00) έχουν την πιο σοβαρή μορφή αυτής της κληρονομικής διαταραχής η οποία μένει συνήθως αδιάγνωστη, σύμφωνα με νέα μελέτη. Τα αποτελέσματα της συγκεκριμένης έρευνας, που δημοσιεύτηκαν στο Annals of Internal Medicine, αναδεικνύουν ότι τα νούμερα αυτά είναι τριπλάσια σε σχέση με όσα γνώριζε μέχρι σήμερα η παγκόσμια επιστημονική κοινότητα, η οποία υπολόγιζε ότι περίπου...
Tue Sep 10, 2019 14:31
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