Nature Communications, Published online: 22 November 2019; doi:10.1038/s41467-019-13242-xSensing DNA bases by surface-enhanced Raman spectroscopy (SERS) in plasmonic nanopores has suffered from rapid flow through of molecules. Here, the authors attach DNA molecules to gold nanoparticles which, due to electro-plasmonic trapping, allow for controlled residence times and discrimination of single nucleotides.
Fri Nov 22, 2019 02:00
Nature Communications, Published online: 22 November 2019; doi:10.1038/s41467-019-13287-yThe role of Africa in the global spread of highly pathogenic avian influenza (HPAI) is not well understood. Here, using evolutionary analyses, the authors show that Africa mainly acts as ecological sink for HPAI H5, and reveal varying paths of HPAI incursions either through domestic or wild birds.
Fri Nov 22, 2019 02:00
Nature Communications, Published online: 22 November 2019; doi:10.1038/s41467-019-13331-xPDLIM2 is repressed epigenetically in lung cancers, which are frequently resistant to anti-PD-1/PD-L1 and chemotherapy. Here, the authors describe the mechanism through which epigenetic restoration of PDLIM2 synergises with anti-PD-1 and chemotherapy in lung cancers.
Fri Nov 22, 2019 02:00
Nature Communications, Published online: 22 November 2019; doi:10.1038/s41467-019-13180-8Histone deacetylase 3 (HDAC3) is a regulator of lipid homeostasis in several tissues, however, its role in intestinal lipid metabolism was not yet known. Here the authors study intestine specific HDAC3 knock out mice and report that these animals have increased fatty acid oxidation and undergo remodeling of the intestinal epithelial cell lipidome.
Fri Nov 22, 2019 02:00
Nature Communications, Published online: 22 November 2019; doi:10.1038/s41467-019-13223-0In Arabidopsis, PGR5 and PGRL1 heterodimers enable cyclic electron flow to safeguard photosystem I during high light intensity. Here, the authors provide evidence that cyanobacteria, while lacking an obvious PGRL1 homologue, use an analogous PGRL1-like protein to facilitate cyclic electron flow.
Fri Nov 22, 2019 02:00
Nature Communications, Published online: 22 November 2019; doi:10.1038/s41467-019-13327-7The endoplasmic reticulum (ER) is an intracellular network characterized by highly dynamic behavior whose control mechanisms are unclear. Here, the authors show that the ER-membrane protein Reticulon (Rtnl1) can constrict ER bilayers and lead to ER fission.
Fri Nov 22, 2019 02:00
Nature Communications, Published online: 22 November 2019; doi:10.1038/s41467-019-13235-wRNA-interacting proteome can be identified by RNA affinity purification followed by mass spectrometry. Here the authors developed a different RNA-centric technology that combines high-throughput immunoprecipitation of RNA binding proteins and luciferase-based detection of their interaction with the RNA.
Fri Nov 22, 2019 02:00
Nature Communications, Published online: 22 November 2019; doi:10.1038/s41467-019-13228-9The poly(A) tails on mRNA are vital for their function but it is difficult to map full-length sequences of mRNA isoforms with the entire poly(A) tails. Here the authors develop PAIso−seq which can measure isoform specific poly(A) tail length and base composition at single-cell sensitivity.
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