BACKGROUND There is inadequate information on the association of pre-operative and postoperative peak level of lactate with mortality of surgical ICU patients. OBJECTIVE To investigate the association between peri-operative lactate level and 90-day mortality in patients admtted to the surgical ICU. DESIGN Retrospective cohort study. SETTING ICUs in single tertiary academic hospital. PATIENTS Adult patients postoperatively admitted to the ICU between January 2012 and December...
Wed Oct 16, 2019 03:00
Background: Few studies have directly compared the immunologic responses to specific subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT). Objective: We aimed to directly compare clinical efficacy and immunological responses between SLIT and SCIT in allergic rhinitis (AR) sensitized to house dust mites. Methods: Sixty-seven patients (age 5–55 years) with moderate-severe Dermatophagoides pteronyssinus (Der-p) and Dermatophagoides farinae AR with or without asthma were randomized (2:2:1)...
09:38
Publication date: Available online 12 November 2019Source: American Journal of OtolaryngologyAuthor(s): Nidal F. AL Deek
Tue Nov 12, 2019 17:53
Publication date: Available online 12 November 2019Source: American Journal of OtolaryngologyAuthor(s): Elizabeth O. Shay, Janki Shah, Blake Smith, Samantha AnneAbstractObjectivesRates of success with pediatric myringoplasty range from 35 to 95%. The objective of this study is to evaluate the impact of perforation size on successful closure of the tympanic membrane (TM) after gelfoam myringoplasty. We also aim to identify variables that affect perforation closure rates and define predictive factors...
Tue Nov 12, 2019 17:53
Publication date: Available online 11 November 2019Source: American Journal of OtolaryngologyAuthor(s): Michael J. EliasonAbstractPurposeEndoscopic sinus surgery (ESS) is the mainstay for chronic inflammatory and neoplastic sinonasal process and as a result many modalities have been studied to minimize blood loss and patient morbidity and to maximize intraoperative visualization. However, often conclusions of actual blood loss are based on surgeons' estimations without ever actually assessing the...
Tue Nov 12, 2019 17:53
Publication date: Available online 11 November 2019Source: American Journal of OtolaryngologyAuthor(s): Sarah L. Spaulding, Rebecca Ho, Sedef Everest, Raymond L. ChaiAbstractBackgroundMedullary thyroid carcinoma (MTC) is a somewhat rare, particularly aggressive form of thyroid cancer. The authors present what we believe to be the first case of MTC diagnosed solely on the basis of molecular testing, as well as a review of the literature concerning this topic and oncocytic variants of MTC.Case descriptionA...
Tue Nov 12, 2019 17:53
Publication date: November–December 2019Source: American Journal of Otolaryngology, Volume 40, Issue 6Author(s):
Tue Nov 12, 2019 17:53
Publication date: Available online 11 November 2019Source: Clinical TherapeuticsAuthor(s): Moo-Yong Rhee, Kyung-Jin Kim, Sang-Hyun Kim, Young Won Yoon, Seung-Woon Rha, Soon Jun Hong, Choong-Hwan Kwak, Weon Kim, Chang-Wook Nam, Tae-Ho Park, Taek-Jong Hong, Sungha Park, Youngkeun Ahn, Namho Lee, Hui-Kyung Jeon, Dong Woon Jeon, Kyoo-Rok Han, Keon-Woong Moon, In-Ho Chae, Hae-Young KimAbstractPurposeThe goal of this study was to compare the lipid-lowering efficacy of the combination of ezetimibe and low-...
Tue Nov 12, 2019 17:51
Abstract Background Transoral robotic and laser surgery is rising in popularity due to the increasing incidence of Human Papilloma Virus (HPV) related oropharyngeal cancer. However, adequate exposure of the tongue base remains a major hurdle in many cases. This study introduces a novel surgical technique called the Floor of Mouth Window, which can be used to improve tongue base exposure at the time of transoral surgery. ...
Tue Nov 12, 2019 02:00
Publication date: Available online 11 November 2019Source: Pathology - Research and PracticeAuthor(s): Fu-neng Jiang, Li-jun Dai, Sheng-bang Yang, Yong-ding Wu, Yu-xiang Liang, Xiao-li Yin, Cui-yun Zou, Wei-de ZhongAbstractBackgroundFK506 binding protein 9 (FKBP9) has been reported and identified for a long time, but its relationship with cancer is rarely studied. For example, the role of FK506 binding protein 9 in prostate cancer (PCa) is still unclear. Therefore, we decided to detect the expression...
Tue Nov 12, 2019 17:49
Publication date: Available online 11 November 2019Source: Pathology - Research and PracticeAuthor(s): Jianjun Gao, Wei Qin, Pengcheng Kang, Yi Xu, Kaiming Leng, Zhenglong Li, Lining Huang, Yunfu Cui, Xiangyu ZhongAbstractObjectiveLINC00261 plays a vital role in tumorigenesis and metastasis of digestive system cancer. However, an influence of LINC00261 on cholangiocarcinoma has a little research. There, we investigated clinical role and molecular mechanisms of LINC00261 in cholangiocarcinoma.MethodsThe...
Tue Nov 12, 2019 17:49
Publication date: Available online 11 November 2019Source: Pathology - Research and PracticeAuthor(s): Anne K. Braczynski, David Capper, David T.W. Jones, Jens Schittenhelm, Damian Stichel, Andreas von Deimling, Patrick N. Harter, Michel MittelbronnAbstractAimMGMT promoter methylation status is an important biomarker predicting survival and response to chemotherapy in patients suffering from glioblastoma. Since new diagnostic methods such as methylome-based classification of brain tumors are more...
Tue Nov 12, 2019 17:49
Publication date: Available online 11 November 2019Source: Pathology - Research and PracticeAuthor(s): Pablo Igor Ribeiro Francoa, Arthur Perillo Rodrigues, Liliana Borges de Menezes Leite, Marina Pacheco MiguelAbstractCancer is a disease that affects millions of individuals worldwide and has a great impact on public health. Therefore, the study of tumor biology and an understanding of how the components of the tumor microenvironment behave and interact is extremely important for cancer research....
Tue Nov 12, 2019 17:49
Publication date: Available online 11 November 2019Source: Pathology - Research and PracticeAuthor(s): Nenggang Zhang, Asis K. Sarkar, Debananda PatiAbstractSepin-1 is a small compound that inhibits enzymatic activity of Separase and growth of cancer cells. As part of the IND-enabling studies to develop Sepin-1 as a chemotherapeutic agent, herein we have profiled the toxicity of Sepin-1 in Sprague-Dawley rats in a good laboratory practice (GLP) setting. The maximum tolerated dose (MTD) of Sepin-1...
Tue Nov 12, 2019 17:49
Publication date: Available online 11 November 2019Source: Pathology - Research and PracticeAuthor(s): Jie Mei, Bujie Xu, Leiyu Hao, Zhuang Xiao, Yan Liu, Ting Yan, Yichao ZhuAbstractRecent studies have reported that dishevelled-associated activator of morphogenesis 1 (DAAM1) is remarkably essential for mediating cell migration and invasion in breast cancer (BrCa). Nonetheless, the definite expression profile of DAAM1 in BrCa patients and the impact on metastasis of BrCa in vivo have not been explored...
Tue Nov 12, 2019 17:49
Publication date: Available online 11 November 2019Source: Pathology - Research and PracticeAuthor(s): Can Yi, Chao Huang, Huan Wang, Chen Wang, Lijuan Dong, Xiuli Gu, Xianhong Feng, Bifeng ChenAbstractCYP24A1, an essential gene in regulation of vitamin D, has been reported to play an important role in enhancing immune activity and inhibiting tumorigenesis. Previous studies proposed that rs2585428, rs4809960, rs6022999 and rs6068816 in CYP24A1 gene might be greatly associated with cancer risk. To...
Tue Nov 12, 2019 17:49
Publication date: Available online 11 November 2019Source: Pathology - Research and PracticeAuthor(s): Weijie Dai, Jiajie Zhou, Han Wang, Menghui Zhang, Xiaozhong Yang, Wei SongAbstractBackgroundColorectal cancer (CRC) is one of the most common malignancies worldwide usually diagnosed at advanced stages which causes poor prognosis of patients. Therefore, novel diagnostic biomarkers and therapeutic targets are urgently needed.Materials and methodsmiR-424-5p was identified through integrated analysis...
Tue Nov 12, 2019 17:49
Publication date: Available online 11 November 2019Source: Pathology - Research and PracticeAuthor(s): Heejin Bang, Soomin Ahn, Eun Ji Kim, Seung Tae Kim, Ha Young Park, Jeeyun Lee, Kyoung-Mee KimABSTRACTRapamycin-insensitive companion of mTOR (RICTOR) is a key component of mammalian target of rapamycin (mTOR) complex 2 (mTORC2), and promotes cellular proliferation and survival through the activation of downstream AGC kinase family members. The amplification of RICTOR has been proposed as a therapeutically...
Tue Nov 12, 2019 17:49
Publication date: Available online 11 November 2019Source: Pathology - Research and PracticeAuthor(s): Bin Wang, Hao Li, Xuchao Wang, Xinguo ZhuAbstractColorectal carcinoma (CRC) is one of the most common malignancies worldwide, and except for surgery, treatments effects are limited. Recently, NLRP3 has been reported as an activator in the tumorigenesis of CRC. However, the function and mechanism of NLRP3 in CRC remains elusive. In this study, we revealed that NLRP3 was elevated in CRC tissues and...
Tue Nov 12, 2019 17:49
Publication date: Available online 11 November 2019Source: The Journal of Emergency MedicineAuthor(s): Nathan Teismann, Jersey Neilson, Jeremy KeenanAbstractBackgroundEmergency physicians (EPs) frequently evaluate patients at risk for sight-threatening conditions but may have difficulty performing direct ophthalmoscopy effectively. Digital fundus photography offers a potential alternative.ObjectiveWe sought to assess the performance of an automated digital retinal imaging platform in a real-world...
Tue Nov 12, 2019 17:42
Publication date: Available online 11 November 2019Source: The Journal of Emergency MedicineAuthor(s): Diana Macian, Joel M. Schofer, Cory Pitre, Dan S. Mosely, Robert G. Buckley, Carol L. Barsky, Mohamad Ali Cheaito, Shahram Lotfipour, Amin KazziAbstract“Uniformed medical students and residents” refers to medical school enrollees and physicians in training who are obligated to serve in the military after graduation or training completion. This is in exchange for 2 forms of financial support that...
Tue Nov 12, 2019 17:42
Publication date: Available online 11 November 2019Source: Ultrasound in Medicine & BiologyAuthor(s): Hexuan Wang, Bradley Mills, Reem Mislati, Rifat Ahmed, Scott A. Gerber, David Linehan, Marvin M. DoyleyAbstractNeither contrast-enhanced computed tomography nor magnetic resonance imaging can monitor changes in the pancreatic ductal adenocarcinoma microenvironment during therapy. We hypothesized that shear wave elastography could overcome this limitation. To test this hypothesis, we measured...
Tue Nov 12, 2019 17:42
Publication date: December 2019Source: Journal of Archaeological Science, Volume 112Author(s): Riczar Fuentes, Rintaro Ono, Naoki Nakajima, Hiroe Nishizawa, Joko Siswanto, Nasrullah Aziz, Sriwigati, Harry Octavianus Sofian, Tatiana Miranda, Alfred PawlikAbstractExpedient lithic technology has been described as unchanging and without or very limited presence of formal tool types. However, this premise seems to limit the discussion on technological and behavioural complexity when studying amorphous...
Tue Nov 12, 2019 17:39
Publication date: November 2019Source: Journal of Phonetics, Volume 77Author(s): Miran Oh, Dani ByrdAbstractIn producing linguistic prominence, certain linguistic elements are highlighted relative to others in a given domain; focus is an instance of prominence in which speakers highlight new or important information. This study investigates prominence modulation at the sub-syllable level using a corrective focus task, examining acoustic duration and pitch with particular attention to the gestural...
Tue Nov 12, 2019 17:38
Publication date: February 2020Source: Journal of Experimental Child Psychology, Volume 190Author(s): Niamh Oeri, Claudia M. RoebersAbstractCognitive performance can be affected adversely when exerting self-control beforehand; a phenomenon known as ego depletion. The aim of the current study was to examine whether regulation of disappointment impairs cognitive performance in kindergarten children (mean age = 5 years, 6 months). Disappointment was induced by means of a modified version of the disappointing...
Tue Nov 12, 2019 17:38
Publication date: February 2020Source: Journal of Experimental Child Psychology, Volume 190Author(s): Shuai Zhang, R. Malatesha JoshiAbstractThe current research tracked kindergarteners into Grade 4 to investigate the longitudinal relations between reading and verbal working memory (VWM). The samples for investigation included the overall weighted sample, English monolingual (EL1) learners, language minority learners with high English proficiency (HP-LM), and language minority learners with persistently...
Tue Nov 12, 2019 17:38
Publication date: February 2020Source: Journal of Experimental Child Psychology, Volume 190Author(s): Alba Castellano-Navarro, Federico Guillén-Salazar, Anna Albiach-SerranoAbstractOur capacity to attribute mental states to others, or theory of mind (ToM), affects the way in which we manage social interactions. Likewise, the social scenario in which we find ourselves probably influences our use of ToM. In this study, 6-year-old children and adult women participated in pairs in a task where participants...
Tue Nov 12, 2019 17:38
The role of context in “over-imitation”: Evidence of movement-based goal inference in young children
Publication date: February 2020Source: Journal of Experimental Child Psychology, Volume 190Author(s): Joshua March, Brier Rigby Dames, Christine Caldwell, Martin Doherty, Eva RafetsederAbstractChildren, as well as adults, often imitate causally unnecessary actions. Three experiments investigated whether such “over-imitation” occurs because these actions are interpreted as performed for the movement’s sake (i.e., having a “movement-based” goal). Experiment 1 (N = 30, 2–5-year-olds) replicated previous...
Tue Nov 12, 2019 17:38
Publication date: February 2020Source: World Neurosurgery, Volume 134Author(s): Wataru Yanagihara, Takaaki Beppu, Yasushi Ogasawara, Shigeki Ito, Yuichi Sato, Tamotsu Sugai, Kuniaki OgasawaraBackgroundMost plasmacytomas arise in the bone marrow (intramedullary), as part of multiple myeloma (MM). In contrast, extramedullary plasmacytoma without MM is rare, and plasmacytoma primarily occurring in the brain parenchyma is extremely rare. Clinical behaviors of primary plasmacytoma in the brain have remained...
Tue Nov 12, 2019 17:37
Publication date: Available online 11 November 2019Source: World NeurosurgeryAuthor(s): Jonathon Lebovitz, Christopher Storey, Ahmad Sweid, Stavropoula Tjoumakaris, M. Reid Gooch, Robert Rosenwasser, Pascal JabbourBackgroundSpinal arteriovenous fistulas (AVFs) are a rare entity that can have devastating neurologic outcomes. Currently, these lesions are treated via open microsurgical resection or transarterial embolization with good success. However, some patients cannot be treated with a minimally...
Tue Nov 12, 2019 17:37
Ruptured tentorial AV fistula: endoscopic-assisted microsurgical disconnection using ICG-VA guidance
Publication date: Available online 11 November 2019Source: World NeurosurgeryAuthor(s): Raffaella Messina, Maria Teresa Bozzi, Luigi Chiumarulo, Leonello Tacconi, Francesco Signorelli
Tue Nov 12, 2019 17:37
Publication date: Available online 11 November 2019Source: World NeurosurgeryAuthor(s): A.M. Alexandre, C. Ciardi
Tue Nov 12, 2019 17:37
Publication date: Available online 11 November 2019Source: World NeurosurgeryAuthor(s): Fernando Luiz Rolemberg Dantas, François Dantas, Antônio Carlos Vieira Caires, Gilberto de Almeida Fonseca Filho, Gustavo Agra Cariri, Ricardo Vieira BotelhoAbstractThe treatments described for spinal synovial cysts range from percutaneous puncture to arthrodesis. There is a fear of postoperative instability after surgical resection of cysts mainly when they are associated with degenerative spondylolisthesis....
Tue Nov 12, 2019 17:37
Publication date: Available online 11 November 2019Source: World NeurosurgeryAuthor(s): Zachary A. Smith, Kenneth A. Weber, Monica Paliwal, Benjamin S. Hopkins, Alexander J. Barry, Donald Cantrell, Aruna Ganju, Tyler R. Koski, Todd B. Parrish, Yasin DhaherBackgroundWhite matter volume loss may be an anatomic driver in the development of clinical symptoms in cervical spondylotic myelopathy (CSM). Considerably less attention has been devoted to gray matter (GM) injury. Newly developed atlas-based mapping...
Tue Nov 12, 2019 17:37
Publication date: Available online 11 November 2019Source: World NeurosurgeryAuthor(s): Satoshi Ogihara, Takashi Yamazaki, Michio Shiibashi, Toru Maruyama, Hirotaka Chikuda, Kota Miyoshi, Hirohiko Inanami, Yasushi Oshima, Seiichi Azuma, Naohiro Kawamura, Kiyofumi Yamakawa, Nobuhiro Hara, Jiro Morii, Rentaro Okazaki, Yujiro Takeshita, Kei Sato, Sakae Tanaka, Kazuo SaitaBackgroundSurgical site infection (SSI) is a dire complication in spinal surgeries, resulting in reoperation, prolonged hospitalization,...
Tue Nov 12, 2019 17:37
Publication date: Available online 11 November 2019Source: World NeurosurgeryAuthor(s): Florian Roser, Mohamed Samy Elhammady, Nader M. Hebela
Tue Nov 12, 2019 17:37
Publication date: Available online 11 November 2019Source: World NeurosurgeryAuthor(s): Sanne Emilie Detiger, Faiz Karim, Dominiek Monserez, Robert Verdijk, Martin van Hagen, Dion Paridaens, Jan van LaarBackgroundIgG4-related disease (IgG4-RD) is an immune-mediated, systemic, fibroinflammatory disease. IgG4-RD may manifest in almost every part of the human body. Here, we describe 3 patients with a skull base manifestation of IgG4-RD that mimicked malignancy.Case DescriptionPatient 1, a 73-year-old...
Tue Nov 12, 2019 17:37
Zusammenfassung Hintergrund Auf Basis rezenter historischer Forschungen kann gezeigt werden, dass der mentalitätsgeschichtliche Kontext für die Medizin- und Pathologiegeschichte im Nationalsozialismus eine entscheidende Rolle spielt. Fragestellung Welche Auswirkung hatte das „Zeitalter der Gewalt“, die Zeit zwischen 1914 und 1945, auf den Betrieb der Pathologie...
Tue Nov 12, 2019 02:00
Zusammenfassung Hintergrund Um Patienten die optimale Therapie anbieten zu können, sind heutzutage immer präzisere Diagnosen notwendig. Daher wird das oft nur in geringen Mengen vorliegende Probenmaterial mit immer aufwendigeren, insbesondere genomischen Methoden untersucht. Da die Genomik aber nur eine unvollständige Abbildung der Dynamik des menschlichen Organismus bietet, liegt eine Lösung in der Verwendung proteomischer Methoden, d. h....
Tue Nov 12, 2019 02:00
Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Chen Huang, Qianshun Chen, Xunyu Xu, Xu WuAbstractBackgroundMiR-195 plays an important role in metastasis and invasion of esophageal cancer (EC). However, the specific mechanism is not clear. The aim of this study was to explore the pathways how miR-195 controls EC cell proliferation.MethodQuantitative reverse transcription polymerase chain reaction (qRT-PCR) was applied to detect theexpression of miR-195...
Tue Nov 12, 2019 17:35
Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Zi-Cheng Zhang, Yi-Lin Yang, Bo Li, Xu-Ce Hu, Shuai Xu, Fei Wang, Ming Li, Xiao-Yi Zhou, Xian-Zhao WeiAbstractBackgroundSpinal fusion is considered the gold standard procedure for treating spinal degeneration, tumors, and trauma. An inflammatory response is an important part of bone repair. We investigated the polarization change of inflammatory macrophages (M1) and resident macrophages (M2) during low-intensity...
Tue Nov 12, 2019 17:35
Tue Nov 12, 2019 02:00
Publication date: Available online 11 November 2019Source: GeneAuthor(s): Antoon Zwiers, Roy L.J. van Wanrooij, Tessa Dieckman, Petula Nijeboer, Georg Kraal, Gerd BoumaAbstractGWAS studies have identified variant rs17810546 in a non-coding region on chromosome 3 as a risk factor for several auto-immune diseases, including Celiac Disease. In silico analysis reveals that this variant is located in a transcription regulatory site. By means of reporter constructs we show that this region can override...
Tue Nov 12, 2019 17:32
Publication date: Available online 11 November 2019Source: GeneAuthor(s): Serrote Caetano Miguel Lemos, Reiniger Lia Rejane Silveira, Silva Karol Buuron, Rabaiolli Silvia Machado dos Santos, Stefanel Charlene MoroAbstractThis review was carried out with the purpose of contributing to the discussion on the equations used in calculating the Polymorphism Information Content (PIC) of molecular markers. PIC measures the ability of a marker to detect polymorphisms, and therefore has enormous importance...
Tue Nov 12, 2019 17:32
Abstract Background Current soft endoscope intervention mainly depends on the skills of endoscopists, especially for the orientation of the endoscope within the human tortuous lumen. This dependence causes inefficient and time consuming surgery. Methods A human‐robot cooperation navigation strategy is proposed to perform the intervention of soft endoscope. The navigation strategy firstly detects the cavity center by processing the image of endoscope, then an auto‐orienting strategy is presented...
Tue Nov 12, 2019 14:45
Abstract Background Various techniques have been proposed in the literature for phase and tool recognition from laparoscopic videos. In comparison, research in multi‐label annotation of still frames is limited. Methods We describe a framework for multi‐label annotation of images extracted from laparoscopic cholecystectomy (LC) videos based on multi‐instance multiple‐label learning. The image is considered as a bag of features extracted from local regions after coarse segmentation. A method...
Mon Nov 11, 2019 20:49
Abstract Background Although many techniques are used to treat the Acromioclavicular (AC) joint dislocations, minimal invasive or arthroscopic coracoclavicular ligament reconstructions became popular recently. In this study authors compared the biomechanical results of double versus triple button reconstruction techniques. Methods Three‐dimensional solid modeling of the shoulder girdle was carried out using virtual finite element modeling. AC joint dislocation was applied to the reference...
Mon Nov 11, 2019 20:48
Publication date: Available online 12 November 2019Source: Journal of ProteomicsAuthor(s): Graphical abstract
Tue Nov 12, 2019 17:26
Publication date: Available online 11 November 2019Source: Brain Research BulletinAuthor(s): Moran Guo, Huifang Chen, Weisong Duan, Zhongyao Li, Yuanyuan Li, Yanqin Ma, Xiangyang Xu, Le Yi, Yue Bi, Yakun Liu, Jie Zhang, Chunyan LiAbstractFibroblast growth factor 9 (FGF9) is a member of the fibroblast growth factor family and is widely expressed in the central nervous system (CNS). However, it is not clear how the working mechanism of FGF9 is involved in cerebellar development. To address this question,...
Tue Nov 12, 2019 17:23
New Findings What is the central question of this study? Characterize the time courses of blood flow in the brachial artery and microvascular beds of the skin and skeletal muscle following transient ischemia. What is the main finding and its importance? Skeletal muscle blood flow was significantly slower than the transient increase in the cutaneous tissue, suggesting mechanistic differences between cutaneous and muscular blood flow distribution after transient ischemia. These results challenge...
Tue Nov 12, 2019 12:07
New Findings •What is the central question of this study? Quantitative values of shear rate‐specific blood viscosity and shear stress in the human macrovasculature in response to exercise hyperaemia are unknown. •What is the main finding and its importance? Using the handgrip exercise model, we show that an increase in brachial artery shear rate led to a decrease in blood viscosity, despite concomitant haemoconcentration. This shear‐thinning behaviour of blood, secondary to increased erythrocyte...
Mon Nov 11, 2019 20:03
Publication date: Available online 12 November 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): José Athayde Vasconcelos Morais, Mosar C. Rodrigues, Fernanda F. Ferreira, Kunal Ranjan, Ricardo Bentes Azevedo, Marcio J. Poças-Fonseca, Luis A. MuehlmannAbstractCryptococcosis is a disseminated infection caused mainly by C. neoformans and C. gattii. Limitations for the treatment involve the selection of isolates resistant to conventional antifungal drugs, prolonged treatment time and drugs...
Tue Nov 12, 2019 17:20
Publication date: Available online 12 November 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Mohamad S. AlSalhi, Sandhanasamy Devanesan, Muhammad Atif, M. Naveed Akhtar Saleem, Tahir N. Khan, Fatima AlQahtani, Vadivel MasilamaniAbstractHemophilia (HP), the deficiency of clotting factors such as VIII (FVIII) and IX, is an inherited blood disorder which is due to the lack of clotting protein. Conventional techniques for detecting hemophilia are based on clotting factor tests such as...
Tue Nov 12, 2019 17:20
Publication date: Available online 12 November 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Waseem Jerjes, Zaid Hamdoon, Colin Hopper
Tue Nov 12, 2019 17:20
Abstract The goal of this paper is to report a study that tested the moderation effect of materialism on the relationship between household income and satisfaction with standard of living (SOL) and subjective well-being. Through a study among 5240 employed members of a representative survey panel in Germany, we found that household income has a positive influence on satisfaction with SOL (as hypothesized), which in turn has a positive impact on subjective well-being (as hypothesized)....
Tue Nov 12, 2019 02:00
Είναι όλα θέμα μεθόδου και ψυχραιμίας φίλη μου
Tue Nov 12, 2019 16:30
Συμβουλές που κόβουν την ανάσα.
Tue Nov 12, 2019 12:20
Γνώριζα καλά όλα τα σύγχρονα dating trends που έπρεπε να προσέχω: Από το stashing στο…
Tue Nov 12, 2019 09:53
Publication date: Available online 11 November 2019Source: International ImmunopharmacologyAuthor(s): Hui Zhang, Xinyang Gong, Shimao Ni, Yu Wang, Lingbo Zhu, Ningning JiAbstractBackgroundsC1q tumor necrosis factor-related protein 9 (CTRP9) has been suggested to exert an atheroprotective effect by modulating the inflammation, foam cell formation, endothelia and smooth muscle cell function via Adenosine Monophosphate Activated Protein Kinase (AMPK) pathway. On the other hand, the NLR Family Pyrin...
Tue Nov 12, 2019 17:09
Publication date: Available online 11 November 2019Source: International ImmunopharmacologyAuthor(s): Sara Ghaffarpour, Abbas Foroutan, Nayere Askari, Fatemeh Mashhadi Abbas, Eisa Salehi, Maryam Nikoonejad, Mohammad Mehdi Naghizadeh, Maryam Eskandarian, Keivan Gohari Moghadam, Hassan Mohammad Hosseini Akbari, Mohammad Ebrahim Yarmohammadi, Tooba GhazanfariAbstractIntroductionLong-term pulmonary complications are one of the major long-term consequences of sulfur mustard (SM) exposure. Toll-like receptor...
Tue Nov 12, 2019 17:09
Abstract Time-consuming reconstruction of volumetric data by area-detector-computed tomography (ADCT) scanning and narrow coverage of small-row ADCT may hinder volumetric scanning in acute stroke stage. To design a practical protocol of volumetric scanning for thrombectomy using an 80-row ADCT. An imaging protocol that focuses on the middle cerebral arteries by tilting the gantry of an 80-row ADCT with 0.5-mm-thick detectors can shorten the reconstruction time by 1.0-mm thickness...
Tue Nov 12, 2019 02:00
Abstract Purpose To compare the association of different measures of intracranial thrombus permeability on non-contrast computerized tomography (NCCT) and computed tomography angiography (CTA) with recanalization with or without intravenous alteplase. Methods Patients with anterior circulation occlusion from the INTERRSeCT study were included. Thrombus permeability...
Tue Nov 12, 2019 02:00
Abstract Purpose Myxoma-related intracranial diseases were rarely documented in history. The main purpose of our study is to provide a more comprehensive and detailed understanding of the pathogenesis, imaging features, surgical procedures and pathology of such patients through long-term follow-up. Methods From March 2012 to July 2018, baseline information...
Tue Nov 12, 2019 02:00
Publication date: Available online 11 November 2019Source: Journal of Clinical VirologyAuthor(s): Corneliu Petru Popescu, Simin Aysel Florescu, Rodrigo Hasbun, Arjan Harxhi, Razi Evendar, Hasip Kahraman, Ami Neuberger, Daniel Codreanu, Mihaela Florentina Zaharia, Selma Tosun, Emanoil Ceausu, Simona Maria Ruta, Gorana Dragovac, Natalia Pshenichnaya, Galina Gopatsa, Olga Shmaylenko, Éva Nagy, Jelena Djekic Malbasa, Mirjana Strbac, Nenad PandakAbstractBackgroundWNV causes 1.4% of all central nervous...
Tue Nov 12, 2019 17:07
Publication date: Available online 12 November 2019Source: Cellular SignallingAuthor(s): Yue-Hong Huang, Ming-Hua Chen, Qi-Lan Guo, Zhi-Xin Chen, Qing-Duo Chen, Xiao-Zhong WangAbstractHepatic fibrosis is a wound healing process which results in deposition of excessive abnormal extracellular matrix (ECM) in response to various liver injuries. Activated hepatic stellate cells (HSCs) are the major sources of ECM and induction of senescence of activated HSCs is an attractive therapeutic strategy for...
Tue Nov 12, 2019 17:05
Publication date: Available online 12 November 2019Source: Cellular SignallingAuthor(s): Yini Dang, TingYu Liu, Jin Yan, Jan D. Reinhardt, Chengqiang Yin, Feng Ye, Guoxin ZhangAbstractGastric cancer is a malignancy of very poor prognosis and survival rates. Macrocalyxin C is a Chinese herb-derived diterpenoid compound that has been postulated to possess anti-cancer characteristics. Gastic cell viability and stage of cell cycle were assessed using CCK8 assay and flow cytometry, respectively. Cell...
Tue Nov 12, 2019 17:05
Publication date: 1 December 2019Source: International Journal of Biological Macromolecules, Volume 141Author(s): Chengying Zhang, Fengyan Tang, Jingjing Zhang, Jichao Cao, Huijuan Li, Chunhui LiuAbstractFor a more insightful investigation into the specificity of bacterial heparinase I, a series of structurally well-defined heparin oligosaccharides was synthesized using a highly efficient chemoenzymatic strategy. Apart from the primary cleavage site, five glycosidic linkages of oligosaccharides with...
Tue Nov 12, 2019 17:04
Publication date: Available online 12 November 2019Source: International Journal of Biological MacromoleculesAuthor(s): Lei Zhang, Jiali Mi, Guannan Hu, Chen Zhang, Haishan QiAbstractIn this study, we developed a smart microfluidic device to prepare biocatalyst HRP-pCBMA. HRP-pCBMA is composed of horseradish peroxidase (HRP) and zwitterionic polymers poly(carboxybetaine methacrylate) (pCBMA), and could be applied to biodegrade bisphenol A (BPA) efficiently. Compared to free HRP, HRP-pCBMA exhibited...
Tue Nov 12, 2019 17:04
Publication date: Available online 12 November 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Annina Lyly, Antti Kontturi, Eeva Salo, Tea Nieminen, Johanna Nokso-KoivistoAbstractObjectiveCervicofacial lymphadenitis caused by nontuberculous mycobacteria (NTM) is commonly treated with surgery or antimicrobial therapy. The aim of this study was to analyze the utility of our new blood-based diagnostic method and the treatment protocol, surgery or observation alone, in NTM...
Tue Nov 12, 2019 17:04
Publication date: Available online 12 November 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Nadia Vilela, Seisse Gabriela Gandolfi Sanches, Renata Mota Mamede CarvalloAbstractObjectiveThe aim of this study was to determine whether the auditory skills presented by five-year-old children can predict their performance in auditory processing (AP) tests at seven years old.DesignThirty-five children were evaluated for AP at two different times. At evaluation 1, the children...
Tue Nov 12, 2019 17:04
You have less than one second to make the right impression. Almost immediately after landing on your website users will make an uninformed, mostly subconscious judgment about what type of organization they’re interacting with. This initial judgment will largely be influenced by layout, design, and visual tone. It will not only influence the rest of their experience on the site, but also future visits and overall perception of your organization as a whole. This is a phenomenon called...
Mon Nov 11, 2019 16:10
Publication date: Available online 11 November 2019Source: Journal of Medical Imaging and Radiation SciencesAuthor(s): Snehal Khairnar, Namdev More, Choppadandi Mounika, Govinda KapusettiAbstractIntroductionMagnetic resonance imaging (MRI) is a well-established medical invention in modern medical technology diagnosis. It is a nondestructive, versatile, and sensitive technique with a high spatial resolution for medical diagnosis. However, MRI has some limitations in differentiating certain tissues,...
Tue Nov 12, 2019 17:03
Publication date: Available online 11 November 2019Source: Journal of Medical Imaging and Radiation SciencesAuthor(s): Suresh Rana, Jaafar BennounaAbstractObjectiveThe primary purpose of this study was to investigate the impact of an air gap (AG) on breast cancer plans that are generated using the intensity-modulated proton therapy technique.MethodsIn this retrospective study, we have included a total of ten female patients with left breast cancer. A total clinical target volume (CTV_Total) was generated...
Tue Nov 12, 2019 17:03
Publication date: Available online 11 November 2019Source: Archives of Oral BiologyAuthor(s): Masahiro Mizuhara, Kaori Kometani-Gunjigake, Kayoko Nakao-Kuroishi, Takashi Toyono, Suzuro Hitomi, Aoi Morii, Momotoshi Shiga, Yuji Seta, Kentaro Ono, Tatsuo KawamotoAbstractObjectivePain control is imperative in orthodontic treatment. Adenosine triphosphate (ATP) is a key mediator released from periodontal ligament cells that excites nociceptive nerve endings. Vesicular nucleotide transporter (VNUT), encoded...
Tue Nov 12, 2019 17:02
Publication date: Available online 12 November 2019Source: Journal of VoiceAuthor(s): Eugenia San Segundo, Radek SkarnitzlSummaryIn this study we propose a new tool for the perceptual assessment of voice quality. For its design, we have adapted the Simplified Vocal Profile Analysis so that the new tool features two main characteristics: (1) the ordinal scalar degrees of the original protocol are turned into a visual analog scale; and (2) the original paper-based version of the protocol is now a computer-based...
Tue Nov 12, 2019 17:01
Publication date: Available online 11 November 2019Source: Gait & PostureAuthor(s): Alessandro Picelli, Giorgio Sandrini, Carlo Cisari, Stefano Paolucci, Nicola Smania, Alessio Baricich
Tue Nov 12, 2019 17:01
Publication date: Available online 11 November 2019Source: Gait & PostureAuthor(s): Lindsey Brown, Jordan Wilson, Michael McNally, Jennifer Perry, Rebecca D Jackson, Timothy E Hewett, John Ryan, Michael V Knopp, Jason E Payne, Stephanie Di StasiAbstractBackgroundSuboptimal patient-reported function and movement impairments often persist after hip arthroscopy for femoroacetabular impingement syndrome(FAIS). Individuals with FAIS with preoperative cartilage pathology (ie. chondropathy) demonstrate...
Tue Nov 12, 2019 17:01
Abstract Dibenzothiophene 5,5‐dioxide (DBTOO) derivatives have recently been shown to processes utility as fluorescent cell dyes. In an effort to extend the functionality of DBTOO based dyes to include the visualization of cellular membranes, two lipophilic DBTOO were synthesized and their ability to incorporate into the plasma membrane of HeLa cells was examined by fluorescent microscopy. The photophysical properties of the two new DBTOO derivatives weredeterminedand both have good fluorescent...
Tue Nov 12, 2019 14:50
Cells, Vol. 8, Pages 1426: Autophagy and Nutrients Management in Plants Cells doi: 10.3390/cells8111426 Authors: Chen Shinozaki Luo Pottier Havé Marmagne Reisdorf-Cren Chardon Thomine Yoshimoto Masclaux-Daubresse Nutrient recycling and mobilization from organ to organ all along the plant lifespan is essential for plant survival under changing environments. Nutrient remobilization to the seeds is also essential for good seed production. In this...
Tue Nov 12, 2019 02:00
Cells, Vol. 8, Pages 1425: Identification of A Novel Class of Benzofuran Oxoacetic Acid-Derived Ligands that Selectively Activate Cellular EPAC1 Cells doi: 10.3390/cells8111425 Authors: Elizabeth M. Beck Euan Parnell Angela Cowley Alison Porter Jonathan Gillespie John Robinson Lindsay Robinson Andrew D. Pannifer Veronique Hamon Philip Jones Angus Morrison Stuart McElroy Martin Timmerman Helma Rutjes Pravin Mahajan Jolanta Wiejak Urszula Luchowska-Stańska...
Tue Nov 12, 2019 02:00
Cells, Vol. 8, Pages 1422: Combinatory Multifactor Treatment Effects on Primary Nanofiber Oligodendrocyte Cultures Cells doi: 10.3390/cells8111422 Authors: Lukas S. Enz Thomas Zeis Annalisa Hauck Christopher Linington Nicole Schaeren-Wiemers Multiple sclerosis (MS) is a chronic inflammatory demyelinating and neurodegenerative disease of the central nervous system. Neurological deficits are attributed to inflammatory demyelination, which compromises axonal function and survival....
Tue Nov 12, 2019 02:00
Cells, Vol. 8, Pages 1423: Metabolic Signature of Hepatic Fibrosis: From Individual Pathways to Systems Biology Cells doi: 10.3390/cells8111423 Authors: Ming-Ling Chang Sien-Sing Yang Hepatic fibrosis is a major cause of morbidity and mortality worldwide, as it ultimately leads to cirrhosis, which is estimated to affect up to 2% of the global population. Hepatic fibrosis is confirmed by liver biopsy, and the erroneous nature of this technique necessitates the search for noninvasive...
Tue Nov 12, 2019 02:00
Cells, Vol. 8, Pages 1424: Oligodendrocytes in Development, Myelin Generation and Beyond Cells doi: 10.3390/cells8111424 Authors: Sarah Kuhn Laura Gritti Daniel Crooks Yvonne Dombrowski Oligodendrocytes are the myelinating cells of the central nervous system (CNS) that are generated from oligodendrocyte progenitor cells (OPC). OPC are distributed throughout the CNS and represent a pool of migratory and proliferative adult progenitor cells that can differentiate into oligodendrocytes....
Tue Nov 12, 2019 02:00
Cells, Vol. 8, Pages 1421: Augmenter of Liver Regeneration Reduces Ischemia Reperfusion Injury by Less Chemokine Expression, Gr-1 Infiltration and Oxidative Stress Cells doi: 10.3390/cells8111421 Authors: Thomas S. Weiss Madeleine Lupke Rania Dayoub Edward K. Geissler Hans J. Schlitt Michael Melter Elke Eggenhofer Hepatic ischemia reperfusion injury (IRI) is a major complication in liver resection and transplantation. Here, we analyzed the impact of recombinant human...
Tue Nov 12, 2019 02:00
Publication date: Available online 12 November 2019Source: Dental MaterialsAuthor(s): Marina R. Kaizer, Nantawan Kolakarnprasert, Camila Rodrigues, Herzl Chai, Yu ZhangAbstractObjectivesThe rapidly increasing use of zirconia-based CAD/CAM multi-layer structures in dentistry calls for a thorough evaluation of their mechanical integrity. This work examines the effect of the multi-layering architecture as well as variations in composition and inclusion of pigments among the layers on the flexural strength...
Tue Nov 12, 2019 16:47
Publication date: Available online 12 November 2019Source: Dental MaterialsAuthor(s): Fei Zhang, Benedikt C. Spies, Jef Vleugels, Helen Reveron, Christian Wesemann, Wolf-Dieter Müller, Bart van Meerbeek, Jérôme ChevalierAbstractObjectivesTo evaluate two-body wear of three zirconia ceramics stabilized with 3, 4 and 5 mol% yttria and to compare their wear behavior with that of a lithium-disilicate glass-ceramic.MethodsSixteen rectangular-shaped specimens made from three grades of zirconia ceramics...
Tue Nov 12, 2019 16:47
Publication date: Available online 12 November 2019Source: Dental MaterialsAuthor(s): David LeesonAbstractObjectiveSignificant technological advances are occurring in the dental industry that are complementary to the introduction of monolithic restorative materials. Glidewell Laboratories has been at the forefront of innovation of these developments and these internal developments may be instructive of future trends in dentistry.MethodsThis paper examines internal Glidewell data from 2010 to 2019...
Tue Nov 12, 2019 16:47
Publication date: Available online 12 November 2019Source: Dental MaterialsAuthor(s): Toshiki Takamizawa, Arisa Imai, Eizo Hirokane, Akimasa Tsujimoto, Wayne W. Barkmeier, Robert L. Erickson, Mark A. Latta, Masashi MiyazakiAbstractObjectiveThe aim of this study was to observe the resin/dentin interfaces of universal adhesives by using scanning electron microscopy (SEM), and to compare their morphologies with conventional etch & rinse (ER) and self-etch (SE) adhesive systems.MethodsTwo three-step...
Tue Nov 12, 2019 16:47
Publication date: Available online 12 November 2019Source: Dental MaterialsAuthor(s): Andreas Kessler, Marcel Reymus, Reinhard Hickel, Karl-Hein KunzelmannAbstractObjectiveThe aim of this study was to investigate the three-body wear of different additively manufactured temporary materials, one temporary PMMA material for CAD/CAM milling and one resin-based composite for direct restorations as a control group by using an ACTA machine.MethodsSpecimens (n = 8) of the 3D printing materials 3Delta temp,...
Tue Nov 12, 2019 16:47
Το Medical Recruiting ( Best Med Career ) τμήμα της TELEOS Group αναζητεί 2 Ψυχίατρους για μόνιμη εργασία σε νοσοκομείο του Βελγίου (Περιφέρεια Λιέγης). Επίπεδο γλωσσομάθειας Β2 Γαλλικά Πληροφορίες Θέσεων: Πληροφορίες www.bestmedcareer.com Βest Med Career-TELEOS Group The post Ψυχίατροι για μόνιμη εργασία στο Βέλγιο – Best Med Career appeared first on Ιατρικός Σύλλογος Πάτρας.
Tue Nov 12, 2019 15:55
Οι συνεργάτες μου και εγώ σας προσκαλούμε στο πρώτο μάθημα που θα πραγματοποιηθεί τη Δευτέρα, 25/11/2019 και ώρα 19.00-21.00 στο αμφιθέατρο του Πανεπιστημιακού Νοσοκομείου, στα πλαίσια των ετήσιων Μετεκπαιδευτικών Μαθημάτων της Πανεπιστημιακής Χειρουργικής Κλινικής. Όπως κάθε χρόνο έτσι και αυτή τη χρονιά η επιλογή των θεμάτων έχει γίνει με στόχο την πληρέστερη κάλυψη των αναγκών που απαιτεί η σύγχρονη αντιμετώπιση των παθήσεων. Με εκτίμηση, Ιωάννης Χ. Μαρούλης Καθηγητής Χειρουργικής Διευθυντής...
Tue Nov 12, 2019 15:40
Optical coherence tomography can differentiate brain regions with intrinsic contrast and at a micron scale resolution. Such a device can be particularly useful as a realtime neurosurgical guidance tool. We present, to our knowledge, the first full‐field swept‐source optical coherence tomography system operating near a wavelength of 1310 nm. The proof‐of‐concept system was integrated with an endoscopic probe tip, that is compatible with deep brain stimulation keyhole neurosurgery. Neuroimaging experiments...
Mon Nov 11, 2019 20:49
Abstract In the current clinical care practice, Gleason grading system is one of the most powerful prognostic predictors for prostate cancer (PCa). The grading system is based on the architectural pattern of cancerous epithelium in histological images. However, the standard procedure of histological examination often involves complicated tissue fixation and staining, which are time‐consuming and may delay the diagnosis and surgery. In this study, label‐free multiphoton microscopy (MPM) was used...
Mon Nov 11, 2019 20:29
Abstract Incomplete surgical resection of head and neck squamous cell carcinoma (HNSCC) is the most common cause of local HNSCC recurrence. Currently, surgeons rely on pre‐operative imaging, direct visualization, palpation, and frozen section to determine the extent of tissue resection. It has been demonstrated that optical coherence tomography (OCT), a minimally invasive, non‐ionizing near infrared mesoscopic imaging modality can resolve subsurface differences between normal and abnormal head and...
Mon Nov 11, 2019 20:26
Abstract Understanding and quantifying the temporal acquisition of host cell molecules by intracellular pathogens is fundamentally important in biology. In this study, a recently developed holographic optical trapping (HOT)‐based Raman micro‐spectroscopy (RMS) instrument is applied to detect, characterize and monitor in real time the molecular trafficking of a specific molecular species (isotope‐labelled phenylalanine (L‐Phe(D8)) at the single cell level. This approach enables simultaneous measurement...
Mon Nov 11, 2019 20:25
Genes, Vol. 10, Pages 923: Proteomics Recapitulates Ovarian Proteins Relevant to Puberty and Fertility in Brahman Heifers (Bos indicus L.) Genes doi: 10.3390/genes10110923 Authors: Muhammad S. Tahir Loan T. Nguyen Benjamin L. Schulz Gry A. Boe-Hansen Milton G. Thomas Stephen S. Moore Li Yieng Lau Marina R. S. Fortes High fertility and early puberty in Bos indicus heifers are desirable and genetically correlated traits in beef production. The hypothalamus–pituitary–ovarian...
Tue Nov 12, 2019 02:00
Genes, Vol. 10, Pages 924: Global Vectors Representation of Protein Sequences and Its Application for Predicting Self-Interacting Proteins with Multi-Grained Cascade Forest Model Genes doi: 10.3390/genes10110924 Authors: Chen You Zhang Wang Cheng Alghazzawi Self-interacting proteins (SIPs) is of paramount importance in current molecular biology. There have been developed a number of traditional biological experiment methods for predicting SIPs in the past few years....
Tue Nov 12, 2019 02:00
Genes, Vol. 10, Pages 922: A Weighted Genomic Relationship Matrix Based on Fixation Index (FST) Prioritized SNPs for Genomic Selection Genes doi: 10.3390/genes10110922 Authors: Ling-Yun Chang Sajjad Toghiani El Hamidi Hay Samuel E. Aggrey Romdhane Rekaya A dramatic increase in the density of marker panels has been expected to increase the accuracy of genomic selection (GS), unfortunately, little to no improvement has been observed. By including all variants in the association...
Tue Nov 12, 2019 02:00
Abstract Dengue virus (DENV) requires clathrin-mediated endocytosis for its entry into the cells where the adaptor protein complex (AP) is vital for the clathrin-coated vesicle formation. The role of AP-2 was previously examined in the early stages of DENV infection; however, the role of AP-2 in the late stage of DENV infection was not determined. The µ1 subunit of AP-2 (AP2M1) is one of the most important cytoplasmic carrier domains in clathrin-mediated endocytosis and the phosphorylation...
Tue Nov 12, 2019 02:00
Virtual cast of a human carotid canal that passes the internal carotid artery. We used measurements at five locations in the canal to show that the size of the artery is fairly constant and close to the size of the outer opening. Abstract Some blood vessels enter bones through foramina, leaving the size of the foramen as a gauge for estimating the rate of blood flow and hence the metabolic rate of the supplied tissues. Foramen dimensions have been measured using varied methods in previous foramen...
Tue Nov 12, 2019 15:57
The size of the most studied skeletal traits was largely determined by body mass. Shapes of skull, sternum and pelvis covary by the standard PLS, but only covariation of skull and pelvis remained after correction for phylogeny. Covariation was mainly influenced by body mass and dietary preferences. Abstract Morphological integration of the bird skeleton is of great interest because it relates to issues of specialization, plasticity, and rate of evolutionary transformations of a skeleton as a whole...
Tue Nov 12, 2019 13:19
We described for the first time the development of the pectoral appendages of the living coelacanth Latimeria. The pectoral fin and girdle are form early in the development of the coelacanth. The pectoral fin shows a reorientation of its girdle and a proportional reduction of its proximal radial elements, rendering the external morphology of the fin more lobe-shaped. Abstract The monobasal pectoral fins of living coelacanths and lungfishes are homologous to the forelimbs of tetrapods...
Tue Nov 12, 2019 12:50
The surface areas of the skin of the foot in situ and of the foot's skeletal components are strongly correlated and thus should be predictable in terrestrial tetrapods. Skin surface area was approximately 1.67 times that of skeletal surface area (~ 2 times for manus, ~ 1.6 times for pes, if analysed separately). This trend was not affected by body mass and showed little evidence of being strongly affected by phylogeny. This predictability has potential in aiding with estimating the size and possible...
Tue Nov 12, 2019 12:40
This study showed that the amount of MCT2 was higher in cerebellum than cortex and hippocampus in wild‐type mice. Immunohistochemistry assay revealed the highest density of MCT2 in the CA3 of the hippocampus. The granular cell layer of the cerebellum contained more MCT2 than the molecular layer. The density of MCT2 on the end feet of astrocytes was low, but the postsynaptic densities (PSDs) of asymmetric synapses in the molecular layer of the cerebellum exhibited a high density using immunogold post‐embedding...
Mon Nov 11, 2019 20:38
Using animals for cosmetics and medical tests has contributed towards a debate based on conflicting interests. Despite the efforts in justifying the value of animals in conducting analyses, this study seeks to elaborate whether or not it is rational to use animals as test subjects in medical and cosmetics fields. The value of animal life is at the core of the emotional conflicts that arise when animals become experimental subjects in medical and cosmetics fields. The aim of this study is to determine...
Tue Nov 12, 2019 12:37
Journal of Investigative Medicine High Impact Case Reports, Volume 7, Issue , January-December 2019. Biliopancreatic diversion is a surgical procedure that causes weight loss via volume restriction and malabsorption. It is now rarely performed due to the risk of severe nutritional deficiencies including vitamin A. We report a case of severe vitamin A deficiency due to malabsorption from a biliopancreatic diversion procedure for weight loss. By the time the patient presented to our department, she...
Tue Nov 12, 2019 08:53
miR‐92b promotes gastric cancer growth by activating the DAB2IP‐mediated PI3K/AKT signalling pathway
Abstract Objectives miR‐92b has been reported to play critical roles in several carcinomas; however, our understanding of the mechanisms by which miR‐92b stimulates gastric cancer (GC) is incomplete. The aim of this study was to investigate the clinical significance and functional relevance of miR‐92b in GC. Materials and methods Expression of miR‐92b in GC and peritumoural tissues was determined using qRT‐PCR, in situ hybridization and bioinformatics. CCK‐8, colony formation and...
Tue Nov 12, 2019 13:21
Tue Nov 12, 2019 07:33
Abstract The term hygiene is deeply rooted with the concept of maintaining sound health and alertness towards cleanliness, while “hygiene hypothesis” depicts the protective role of microbial community exposure in development of early immunity and initial allergic and aesthetic reactions. The tug-of-war has now been pushed toward the literal term “hygiene” over the “hygiene hypothesis” and has continued with disinfection of all microbial loads from the related environments to avoid...
Tue Nov 12, 2019 02:00
Abstract Purpose of Narrative To enlighten the audience and suggest potential gaps and areas of future interest for further exploration and discussion related to wound care in developing regions of the world. Recent Findings Beyond limited case reports and a relative handful of typical epidemiological studies and clinical trials, there exist little significant...
Tue Nov 12, 2019 02:00
Abstract Purpose of Review Commercialization of an automated epidermal harvesting device (CelluTome™, Kinetic Concepts Inc., San Antonio, TX) in the last 6 years has led to numerous publications describing a growing number of clinical applications. The current article reviews this literature while summarizing outcomes. Recent Findings A total of 20 published...
Tue Nov 12, 2019 02:00
Are prescribers not aware of cardiovascular contraindications for diclofenac? A claims data analysis
Abstract Objectives To compare diclofenac use before and after implementation of European risk minimization measures in 2013, focusing on diclofenac initiators and prevalence of congestive heart failure (NYHA class II–IV), ischaemic heart disease, peripheral arterial disease and cerebrovascular disease (new contraindications) in these patients in Germany. Methods We included adults with health insurance coverage on 1 January 2011 (cohort 2011) or 1 January 2014 (cohort 2014) and...
Mon Nov 11, 2019 20:34
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