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10:04
Journal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.9b06034
Tue Nov 12, 2019 07:00
Journal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.9b05037
Tue Nov 12, 2019 07:00
Journal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.9b05147
Tue Nov 12, 2019 07:00
Journal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.9b04600
Tue Nov 12, 2019 07:00
Journal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.9b05665
Tue Nov 12, 2019 07:00
Journal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.9b04354
Tue Nov 12, 2019 07:00
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Tue Nov 12, 2019 23:11
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Tue Nov 12, 2019 23:11
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Tue Nov 12, 2019 23:11
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Tue Nov 12, 2019 23:11
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Tue Nov 12, 2019 23:11
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Tue Nov 12, 2019 23:11
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Tue Nov 12, 2019 23:11
Abstract The aim of this study was to investigate the frequency of consumption of snack products, as well as the association between snacking and restorative treatment need, and associated factors among a healthy Finnish male population. Approximately 8500 conscripts answered a computer-based questionnaire covering their snacking habits and other health behaviours. Restorative treatment need and history (DT, DMFT) were examined by trained and calibrated dentists. Cross-tabulations...
Tue Nov 12, 2019 02:00
Abstract Periodontitis is an inflammatory disease that causes bone resorption. This study used a ligature‐induced experimental periodontitis model to observe the kinetic process of microstructural changes in alveolar bone and introduced star volume analysis as a new methodology to assess microstructural changes. Thirty Wistar rats were used. To induce experimental periodontitis, ligatures were placed around the maxillary first molar. Rats were euthanized on days 0, 1, 3, 7, 14,...
Tue Nov 12, 2019 02:00
Abstract Intellectual disability (ID) is one of the most common developmental disorders characterized by a congenital limitation in intellectual functioning and adaptive behavior. More than 800 genes have been implicated so far in the pathogenesis of syndromic and non-syndromic ID conditions with the actual number is expected to be over two thousand. The advent of next-generation sequencing resulted in the identification of many novel ID genes with new genes are being reported...
Tue Nov 12, 2019 02:00
Abstract The neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD) share some common molecular deficits including disruption of protein homeostasis leading to disease-specific protein aggregation. While insoluble protein aggregates are the defining pathological confirmation of diagnosis, patient stratification based on early molecular etiologies may identify distinct subgroups within a clinical diagnosis that would respond differently in therapeutic...
Tue Nov 12, 2019 02:00
Scottish biomaterial developer, Biogelx, and Regemat 3D, a Spain manufacturer of bioprinting systems, have partnered to develop a new skin model as well as offering complete bioprinting solutions for research institutes worldwide. “We are excited to see future tissue models using Biogelx-INKs,” said Sandy Bulloch, Director of Strategic Alliances, Biogelx. “We believe that this strategic partnership will expand the […]
Tue Nov 12, 2019 20:54
BCN3D Technologies, the Barcelona-based desktop 3D printer manufacturer, has released a new dual-extruder FFF/FDM system, named the BCN3D Epsilon. Intended for more demanding settings compared to its range of Sigma desktop machines, the BCN3D Epsilon is designed to provide large-scale FFF 3D printed parts with high-performing materials. As such, BCN3D is currently in negotiation with […]
Tue Nov 12, 2019 20:28
3D printing is a growing business at Protolabs, as evidenced by its recent financial report for Q3 2019, published in October. Furthermore, throughout the year, the company has seen a number of new product additions to its 3D printing offering. In the second quarter, the company added a new DMLS metal 3D printing service to its portfolio. Following […]
Tue Nov 12, 2019 19:05
New York-based automated post-printing developer PostProcess Technologies has completed a $20M Series B funding round. The company has also revealed plans to expand its European presence, comprising a new benchmarking facility in France, and EU Channel Partner Network appointments. PostProcess’ Series B funding round was led by Grand Oaks Capital, a private investment firm headed […]
Tue Nov 12, 2019 18:10
This week’s edition of Sliced, the 3D Printing Industry news digest, features the latest developments of additive manufacturing in fashion, footwear, and art, as well as novel research in tissue engineering to combat cardiovascular disease. The latest news from Farsoon Technologies, Rize, Titomic, 3D Systems, Formlabs, Protolabs, Dassault Systèmes, and others can be found prior to Formnext, […]
Tue Nov 12, 2019 17:51
Formlabs has launched a new 3D printer and business unit for dental 3D printing. The Formlabs Form 3B 3D printer is a resin-based system marketed to dental labs and supported by an expanded range of materials. The new business unit will be called Formlabs Dental. Max Lobovsky, CEO and co-founder of Formlabs said, “Our new […]
Tue Nov 12, 2019 16:00
Standards help facilitate communication between geographical communities and within businesses. As a relatively new industry, there is an overwhelming need for standards development in 3D printing, not only to ensure the safety of process, but also to improve efficiency, strengthen interactions, more easily exchange equipment and broaden the technology’s capabilities. There are currently standards in […]
Tue Nov 12, 2019 13:54
Avi Reichental’s Jewish mother wanted him to be a rabbi. While he didn’t take that particular path, during a long career in tech – prayer has certainly come in handy. Now the leader of XponentialWorks, a combination of venture fund, advisory firm and product developer, the 3D printing industry veteran has seen it all, from […]
Tue Nov 12, 2019 13:53
Belgian software and 3D printing service provider Materialise has conducted a survey to determine the interest and attitudes of Chinese manufacturing companies towards 3D printing. From the results of the survey, it is suggested that China is doubtful about 3D printing’s readiness for manufacturing end products. Instead, the country is focused on utilizing the technology for prototyping […]
Tue Nov 12, 2019 13:43
Leading German specialty chemicals business Evonik has signed a long-term agreement with 3D printed scaffold developer BellaSeno GmbH. The agreement guarantees BellaSeno’s use of Evonik’s bioresorbable polymer RESOMER in the production of its proprietary 3D printed Senella product. BellaSeno achieved ISO 13485 certification for its Senella breast scaffolds in July this year, and successfully raised a further €1 million to […]
Tue Nov 12, 2019 13:38
Abstract Objective To analyze why numerous acute stroke treatments were successful in the laboratory but failed in large clinical trials. Methods We searched all phase III trials of medical treatments for acute ischemic stroke and corresponding early clinical and experimental studies. We compared the overall efficacy and assessed the impact of publication bias and study design on the efficacy. Furthermore, we estimated power and true report probability of experimental studies. Results...
Tue Nov 12, 2019 17:11
Abstract Objective To examine whether genetic variation affecting the expression or function of lipid‐lowering drug targets is associated with Alzheimer's disease (AD) risk, to evaluate the potential impact of long‐term exposure to corresponding therapeutics. Methods We conducted Mendelian randomization analyses using variants in genes that encode the protein targets of several approved lipid‐lowering drug classes: HMGCR (encoding the target for statins); PCSK9 (encoding the target for...
Tue Nov 12, 2019 17:09
ABSTRACT Objective Therapeutic drug monitoring (TDM) of antiepileptic drugs (AEDs) is widely established for older generation AEDs, whereas there is limited evidence about newer AEDs. Our aim is to assess the benefit of newer generation AEDs TDM in epilepsy. Methods We performed a randomised, controlled trial comparing systematic with rescue TDM of lamotrigine, levetiracetam, oxcarbazepine, topiramate, brivaracetam, zonisamide, or pregabalin. Participants were adults with epilepsy, in whom...
Tue Nov 12, 2019 17:03
Background Systematic evaluation of complex flow in the true lumen and false lumen (TL, FL) is needed to better understand which patients with chronic descending aortic dissection (DAD) are predisposed to complications. Purpose To develop quantitative hemodynamic maps from 4D flow MRI for evaluating TL and FL flow characteristics. Study Type Retrospective. Population In all, 20 DAD patients (age = 60 ± 11 years; 12 male) (six medically managed type B AD [TBAD], 14 repaired type...
Tue Nov 12, 2019 15:56
Globally, primary and secondary liver cancer is one of the most common cancer types, accounting 8.2% of deaths worldwide in 2018. One of the key strategies to improve the patient's prognosis is the early diagnosis, when liver function is still preserved. In hepatocellular carcinoma (HCC), the typical wash‐in/wash‐out pattern in conventional magnetic resonance imaging (MRI) reaches a sensitivity of 60% and specificity of 96–100%. However, in recent years functional MRI sequences such as hepatocellular‐specific...
Tue Nov 12, 2019 14:40
Background Four‐dimensional flow magnetic resonance imaging (4D flow MRI) enables efficient investigation of cerebral blood flow pulsatility in the cerebral arteries. This is important for exploring hemodynamic mechanisms behind vascular diseases associated with arterial pulsations. Purpose To investigate the feasibility of pulsatility assessments with 4D flow MRI, its agreement with reference two‐dimensional phase‐contrast MRI (2D PC‐MRI) measurements, and to demonstrate how 4D flow MRI can...
Tue Nov 12, 2019 14:37
Abstract Pancytopenia is a rare complication among patients with breast cancer. Here, we report a case of pancytopenia due to massive bone marrow carcinomatosis (BMC) developed after local radiotherapy following to mastectomy. A 48-year-old woman with locally advanced breast cancer underwent mastectomy and axillary lymph node dissection. During adjuvant chemotherapy, rapidly growing supraclavicular lymph node metastasis was noted, so chemotherapy was discontinued and local radiotherapy...
Tue Nov 12, 2019 02:00
Abstract Purpose This is a rare case of a post-traumatic rectus abdominis muscle tear in an adolescent female diagnosed by ultrasonography (US). Conservative management is also described. Methods A 14-year-old female presented to a chiropractic clinic with extreme pain and tenderness in the right lower quadrant (RLQ) after post-plyometric power kneel box...
Tue Nov 12, 2019 02:00
Abstract Objective The aim of this study was to assess the treatment results of 90Y radiation synovectomy for chronic exudative synovitis of knee joints. Methods The retrospective data consist of 394 consecutive knee radiation synovectomies performed using 6 mCi (222 MBq) of 90Y. The assessment included 3-point custom pain and joint mobility scale, evaluation...
Tue Nov 12, 2019 02:00
Abstract Single-domain antigen-binding fragments of camelid antibodies, known as VHHs or nanobodies, are widely used affinity reagents. However, their production involving animal immunization is time- and resource-intensive. Starting from a sequence dataset of llama VHHs, we designed a novel scaffold, based on conserved framework sequences, suitable for bacterial nanobody expression and synthetic library construction. The consensus scaffold was validated by grafting the CDRs from...
Tue Nov 12, 2019 02:00
Abstract Background Prostate cancer (PCa) is a leading cause of cancer-related death in males worldwide. Exacerbated inflammation and angiogenesis have been largely demonstrated to contribute to PCa progression. Diverse naturally occurring compounds and dietary supplements are endowed with anti-oxidant, anti-inflammatory and anti-angiogenic activities, representing valid compounds to target the aberrant cytokine/chemokine production...
Tue Nov 12, 2019 02:00
Abstract Background Circular RNAs (circRNAs) have recently been shown to play important roles in different tumors. However, their detailed roles and regulatory mechanisms in pancreatic ductal adenocarcinoma (PDAC) are not well understood. This study aimed to identify enriched circRNAs and detect their functions and mechanisms in PDAC cells and tissues. Methods ...
Tue Nov 12, 2019 02:00
Abstract Background Long non-coding RNAs (lncRNAs) are tumor-associated biological molecules and have been found to be implicated in the progression of colorectal cancer (CRC). This study aims to examine the effects of lncRNA RP11-468E2.5 and its target genes (STAT5 and STAT6) on the biological activities of CRC cells via the Janus kinase-signal transducer and activator of transcription (JAK/STAT) signaling pathway. ...
Tue Nov 12, 2019 02:00
Abstracts Background Overexpressed PES1 promotes carcinogenesis in various types of malignant tumors. However, the biological role and clinical significance of PES1 in pancreatic cancer are still unexplored. Methods The expression level of PES1 in pancreatic cancer cell lines and pancreatic cancer patient samples was determined using Western...
Tue Nov 12, 2019 02:00
Abstract Background We investigated the role of PD-L1 in the metabolic reprogramming of non-small cell lung cancer (NSCLC). Methods Changes in glycolysis-related molecules and glycolytic activity were evaluated in PD-L1low and PD-L1high NSCLC cells after transfection or knockdown of PD-L1, respectively. Jurkat T-cell activation was assessed...
Tue Nov 12, 2019 02:00
Abstract Background Hereditary transthyretin amyloid cardiomyopathy (ATTR-CM) is an increasingly recognized progressive cardiomyopathy with heterogenous clinical manifestations that lead to its misdiagnosis and poor prognosis. This study was performed to describe the clinical characteristics and natural history of Chinese patients to improve clinical awareness of this condition. ...
Tue Nov 12, 2019 02:00
Abstract Background The phenotypic spectrum of many rare disorders is much wider than previously considered. Mucopolysaccharidosis type III (Sanfilippo syndrome, MPS III), is a lysosomal storage disorder traditionally considered to be characterized by childhood onset, progressive neurocognitive deterioration with a rapidly or slowly progressing phenotype. The presented MPS III case series demonstrates adult onset phenotypes with...
Tue Nov 12, 2019 02:00
Abstract Purpose This study aimed to evaluate the usefulness of [99mTc]sestamibi ([99mTc]MIBI) single photon emission computed tomography (SPECT)/X-ray computed tomography (CT) imaging for the identification of dystonic muscles in primary cervical dystonia (PCD) patients who underwent botulinum neurotoxin type A (BoNT-A) therapy. Procedures Thirty-six...
Tue Nov 12, 2019 02:00
Journal of Palliative Medicine, Ahead of Print. (Source: Journal of Palliative Medicine)
Fri Nov 08, 2019 00:00
Journal of Palliative Medicine, Ahead of Print. (Source: Journal of Palliative Medicine)
Fri Nov 08, 2019 00:00
Abstract Background Monoclonal antibodies (mAbs) towards CGRP or the CGRP receptor show good prophylactic antimigraine efficacy. However, their site of action is still elusive. Due to lack of passage of mAbs across the blood-brain barrier the trigeminal system has been suggested a possible site of action because it lacks blood-brain barrier and hence is available to circulating molecules. The trigeminal ganglion (TG) harbors two...
Tue Nov 12, 2019 02:00
Zusammenfassung Mit dem „Gesetz zum Schutz vor nichtionisierender Strahlung bei der Anwendung am Menschen“ (NiSG) wollte der Gesetzgeber 2009 neben den schon seit Langem bestehenden Regelungen in der Anwendung ionisierender Strahlung auch diesem wachsenden Bereich Rechnung tragen und v. a. unkontrollierte Anwendungen regulieren. Details aber sollten in einer zusätzlichen Verordnung geregelt werden. Obwohl bereits 10 Jahre vorher die Strahlenschutzkommission Empfehlungen dazu abgegeben...
Tue Nov 12, 2019 02:00
This work presents a protocol to yield homogeneous cell cultures of primary oculomotor, trochlear, and spinal motor neurons. These cultures can be used for comparative analyses of the morphological, cellular, molecular, and electrophysiological characteristics of ocular and spinal motor neurons.
Tue Nov 12, 2019 19:00
This protocol demonstrates how to use an electrophysiological system for closed-loop stimulation triggered by neuronal activity patterns. Sample Matlab code that can be easily modified for different stimulation devices is also provided.
Tue Nov 12, 2019 18:00
We describe a quantitative real-time in vitro cytolysis assay system to evaluate the potency of chimeric antigen receptor T cells targeting liquid and solid tumor cells. This protocol can be extended to assess other immune effector cells, as well as combination treatments.
Tue Nov 12, 2019 17:00
Biomolecules, Vol. 9, Pages 730: Characterization and Antioxidant Activity of a Low-Molecular-Weight Xanthan Gum Biomolecules doi: 10.3390/biom9110730 Authors: Hu Wang Yu He Qiao Zhang Wang In the present work, a low-molecular-weight xanthan gum (LW-XG) was successfully obtained via biodegradation of commercial xanthan by the endophytic fungus Chaetomium globosum CGMCC 6882. The monosaccharide composition of LW-XG was glucose, mannose, and glucuronic acid in...
Tue Nov 12, 2019 02:00
Biomolecules, Vol. 9, Pages 731: Recent Trends in the Application of Chromatographic Techniques in the Analysis of Luteolin and Its Derivatives Biomolecules doi: 10.3390/biom9110731 Authors: Juszczak Zovko-Končić Tomczyk Luteolin is a flavonoid often found in various medicinal plants that exhibits multiple biological effects such as antioxidant, anti-inflammatory and immunomodulatory activity. Commercially available medicinal plants and their preparations containing luteolin...
Tue Nov 12, 2019 02:00
Biomolecules, Vol. 9, Pages 728: A Dynamic Core in Human NQO1 Controls the Functional and Stability Effects of Ligand Binding and Their Communication across the Enzyme Dimer Biomolecules doi: 10.3390/biom9110728 Authors: Vankova Salido Timson Man Pey Human NAD(P)H:quinone oxidoreductase 1 (NQO1) is a multi-functional protein whose alteration is associated with cancer, Parkinson’s and Alzheimer´s diseases. NQO1 displays a remarkable functional chemistry,...
Tue Nov 12, 2019 02:00
Biomolecules, Vol. 9, Pages 729: The Effect of Transmembrane Protein Shape on Surrounding Lipid Domain Formation by Wetting Biomolecules doi: 10.3390/biom9110729 Authors: Molotkovsky Galimzyanov Batishchev Akimov Signal transduction through cellular membranes requires the highly specific and coordinated work of specialized proteins. Proper functioning of these proteins is provided by an interplay between them and the lipid environment. Liquid-ordered lipid domains are believed...
Tue Nov 12, 2019 02:00
Biomolecules, Vol. 9, Pages 727: Anti-Atherosclerotic Effects of Fruits of Vitex rotundifolia and Their Isolated Compounds via Inhibition of Human LDL and HDL Oxidation Biomolecules doi: 10.3390/biom9110727 Authors: Jae-Yong Kim Sang Hee Shim Low-density lipoprotein (LDL) and high-density lipoprotein (HDL) oxidation are well known to increase the risk for atherosclerosis. In our ongoing research on natural products with inhibitory activities against oxidation of lipoproteins, fruits...
Tue Nov 12, 2019 02:00
Biomolecules, Vol. 9, Pages 726: Viral Infections and Interferons in the Development of Obesity Biomolecules doi: 10.3390/biom9110726 Authors: Yun Tian Jordan Jennings Yuanying Gong Yongming Sang Obesity is now a prevalent disease worldwide and has a multi-factorial etiology. Several viruses or virus-like agents including members of adenoviridae, herpesviridae, slow virus (prion), and hepatitides, have been associated with obesity; meanwhile obese patients are shown to be more...
Tue Nov 12, 2019 02:00
Biomolecules, Vol. 9, Pages 725: CRISPR/Cas9-Mediated Multiplex Genome Editing of JAGGED Gene in Brassica napus L. Biomolecules doi: 10.3390/biom9110725 Authors: Qamar U Zaman Wen Chu Mengyu Hao Yuqin Shi Mengdan Sun Shi-Fei Sang Desheng Mei Hongtao Cheng Jia Liu Chao Li Qiong Hu Pod shattering resistance is an essential component to achieving a high yield, which is a substantial objective in polyploid rapeseed cultivation. Previous studies have suggested...
Tue Nov 12, 2019 02:00
JFB, Vol. 10, Pages 49: Design of Silk-Elastin-Like Protein Nanoparticle Systems with Mucoadhesive Properties Journal of Functional Biomaterials doi: 10.3390/jfb10040049 Authors: Parker Wu McKay Xu Kaplan Transmucosal drug delivery is a promising avenue to improve therapeutic efficacy through localized therapeutic administration. Drug delivery systems that increase retention in the mucosal layer are needed to improve efficiency of such transmucosal platforms. However,...
Tue Nov 12, 2019 02:00
Abstract Background Maternal and child health (MCH) care utilization often vary with geographic location. We analyzed the geographic distribution and determinants of utilization of four or more antenatal care visits, health facility delivery, child immunization, and care utilization for common childhood illnesses across four Ethiopian regions. Methods ...
Tue Nov 12, 2019 02:00
Objective: To evaluate resonance frequency (RF) values via dehydration effects in the inner ear caused by the glycerol test, which is used as a diagnostic method for Ménière’s disease (MD). Methods: Twenty adult patients with unilateral MD were included in the study. Before, and then at 1, 2, and 3 h after administration of glycerol (1 g/kg), pure-tone hearing levels (125–8,000 kHz) and multifrequency tympanometry tests were performed. As a control, the RF values of the ears of 25 healthy subjects...
Tue Nov 12, 2019 16:56
British Journal of Nursing, Volume 28, Issue 20, Page 1292-1298, November 2019.
Tue Nov 12, 2019 07:22
British Journal of Nursing, Volume 28, Issue 20, Page S21-S26, November 2019.
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British Journal of Nursing, Volume 28, Issue 20, Page 1332-1334, November 2019.
Tue Nov 12, 2019 07:22
British Journal of Nursing, Volume 28, Issue 20, Page 1338-1339, November 2019.
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British Journal of Nursing, Volume 28, Issue 20, Page 1336-1336, November 2019.
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British Journal of Nursing, Volume 28, Issue 20, Page 1337-1337, November 2019.
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British Journal of Nursing, Volume 28, Issue 20, Page 1335-1335, November 2019.
Tue Nov 12, 2019 07:22
British Journal of Nursing, Volume 28, Issue 20, Page 1279-1279, November 2019.
Tue Nov 12, 2019 07:22
British Journal of Nursing, Volume 28, Issue 20, Page 1316-1324, November 2019.
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British Journal of Nursing, Volume 28, Issue 20, Page S10-S18, November 2019.
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British Journal of Nursing, Volume 28, Issue 20, Page S28-S32, November 2019.
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British Journal of Nursing, Volume 28, Issue 20, Page 1308-1314, November 2019.
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British Journal of Nursing, Volume 28, Issue 20, Page 1282-1287, November 2019.
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British Journal of Nursing, Volume 28, Issue 20, Page S4-S8, November 2019.
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British Journal of Nursing, Volume 28, Issue 20, Page S38-S42, November 2019.
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British Journal of Nursing, Volume 28, Issue 20, Page 1300-1306, November 2019.
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British Journal of Nursing, Volume 28, Issue 20, Page 1280-1280, November 2019.
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British Journal of Nursing, Volume 28, Issue 20, Page S3-S3, November 2019.
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British Journal of Nursing, Volume 28, Issue 20, Page S34-S37, November 2019.
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British Journal of Nursing, Volume 28, Issue 20, Page 1288-1290, November 2019.
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British Journal of Nursing, Volume 28, Issue 20, Page 1340-1341, November 2019.
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British Journal of Nursing, Volume 28, Issue 20, Page 1326-1330, November 2019.
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British Journal of Nursing, Volume 28, Issue 20, Page 1349-1349, November 2019.
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British Journal of Nursing, Volume 28, Issue 20, Page 1342-1343, November 2019.
Tue Nov 12, 2019 07:22
Bunnik and colleagues argued that financial barriers do not promote informed decision-making prior to prenatal screening and raise justice concerns. If public funding is provided, however, it would seem to be important to clarify its intentions and avoid any unwarranted appearance of a medical utility of the testing.
Tue Nov 12, 2019 19:00
Ethical arguments about assisted dying often focus on whether or not respect for an individual’s autonomy gives a reason to offer them an assisted death if they want it. In this paper, I present an argument for legalising assisted dying which appeals to the autonomy of people who don’t want to die. Adding that option can transform the nature of someone’s choice set, enabling them to pursue other options voluntarily where that would otherwise be harder or impossible. This does not contradict the more...
Tue Nov 12, 2019 19:00
IntroductionInternational sharing of health data opens the door to the study of the so-called ‘Big Data’, which holds great promise for improving patient-centred care. Failure of recent data sharing initiatives indicates an urgent need to invest in societal trust in researchers and institutions. Key to an informed understanding of such a ‘social license’ is identifying the views patients and the public may hold with regard to data sharing for health research.MethodsWe performed a narrative review...
Tue Nov 12, 2019 19:00
ACS Infectious DiseasesDOI: 10.1021/acsinfecdis.9b00224
Tue Nov 12, 2019 07:00
ACS Infectious DiseasesDOI: 10.1021/acsinfecdis.9b00263
Tue Nov 12, 2019 07:00
ACS Infectious DiseasesDOI: 10.1021/acsinfecdis.9b00190
Tue Nov 12, 2019 07:00
Authors: Lozano-Ojalvo D, Berin C, Tordesillas L Abstract Food allergies are diseases where the normal tolerance response to oral antigens is altered. Recent advances have begun to uncover mechanisms that mediate sensitization to food allergens and maintenance of the disease. Production of alarmins by epithelial cells triggers a cascade that leads to allergen-specific IgE synthesis. IL-9 has also been shown to play a role in mast cell recruitment and amplification of the allergic response....
Tue Nov 12, 2019 12:10
CONCLUSION: The incidence of diagnosis of pediatric eosinophilic esophagitis increased by an average of 19% annually. No significant association was found between incidence and pollen counts, except for a weak association with Platanus species. PMID: 29897337 [PubMed - indexed for MEDLINE] (Source: Journal of Investigational Allergology and Clinical Immunology)
Tue Nov 12, 2019 12:10
CONCLUSIONS: Heightened cough reflex sensitivity is an independent factor of daytime asthmatic cough that is refractory to ICSs. In contrast, airway hyperreactivity and less atopic status contribute to ICS-refractory nighttime cough. PMID: 29956665 [PubMed - indexed for MEDLINE] (Source: Journal of Investigational Allergology and Clinical Immunology)
Tue Nov 12, 2019 12:10
Authors: Arora P, Moll JM, Andersen D, Workman CT, Williams AR, Kristiansen K, Brix S Abstract Dendritic cells (DCs) are essential for generating T cell-based immune responses via sensing of potential inflammatory and metabolic cues in the local environment. However, there is still limited insight into the processes defining the end DC phenotype, including the type of early transcriptional changes in pro-inflammatory cues towards regulatory or type 2 immune-based cues induced by a variety...
Sat Nov 09, 2019 00:00
Publication date: Available online 11 November 2019Source: International Journal of Food MicrobiologyAuthor(s): Pauline Seguinot, Audrey Bloem, Pascale Brial, Emmanuelle Meudec, Anne Ortiz-Julien, Carole CamarasaAbstractEven though non-Saccharomyces yeasts were regarded as spoilage microorganisms for a long time, their abilities to improve and diversify the aromatic profile of wines is now well recognized. Consequently, their use in combination with S. cerevisiae strains during winemaking has attracted...
Tue Nov 12, 2019 18:36
Publication date: Available online 11 November 2019Source: International Journal of Food MicrobiologyAuthor(s): Virginie Barrere, Elizabeth Tompkins, Marcia Armstrong, Patrick Bird, Benjamin Bastin, Lawrence GoodridgeAbstractSalmonella is the causative agent of many outbreaks related to spice consumption. However, because of the antimicrobial properties of various spices which hinders recovery and detection, Salmonella detection in spices remains a challenge. The objective of this study was to optimize...
Tue Nov 12, 2019 18:36
Abstract Purpose Type 2 diabetes frequently remains undiagnosed for years, whereas early detection of affected individuals would facilitate the implementation of timely and cost-effective therapies, hence decreasing morbidity. With the intention of identifying novel diagnostic biomarkers, we characterized the miRNA profile of microvesicles isolated from retroactive serum samples of normoglycemic individuals and two groups of subjects with...
Tue Nov 12, 2019 02:00
Abstract Purpose The “block-and-replace” (BR) method involves the use of a high dose of antithyroid drugs (ATD) with levothyroxine (L-T4). Its use in the management of Graves’ disease (GD) is still debated mainly because the frequency of side effects of ATD is dose dependent. We retrospectively studied the effect of medium dose of ATD with L-T4 versus monotherapy with ATD in pediatric patients with unstable GD. ...
Tue Nov 12, 2019 02:00
Publication date: Available online 11 November 2019Source: Revue des Maladies RespiratoiresAuthor(s): E. Lorentz, T. Despreaux, A. Quignette, T. Chinet, A. DescathaRésuméIntroductionDans un contexte de sous-déclaration des maladies professionnelles, l’objectif a été d’évaluer la validité de matrices emplois-expositions silice et amiante pour le dépistage des expositions professionnelles dans le domaine de l’oncologie thoracique.MéthodesCinquante patients hospitalisés pour cancer bronchopulmonaire...
Tue Nov 12, 2019 18:26
Publication date: Available online 11 November 2019Source: Revue des Maladies RespiratoiresAuthor(s): A. Tiotiu, Y. Billon, P. Vaillant, O. Menard, P. Hofman, C. MascauxRésuméEnviron 5 % des cancers bronchiques non à petites cellules (CBNPC) sont porteurs du réarrangement ALK accessible aux thérapies ciblées de type inhibiteur de tyrosine kinase ALK (ITK ALK). À l’heure actuelle, plusieurs produits sont disponibles en première ligne thérapeutique (crizotinib, céritinib, alectinib) après avoir démontré...
Tue Nov 12, 2019 18:26
Publication date: Available online 11 November 2019Source: Revue des Maladies RespiratoiresAuthor(s): F. Vandenbos, C. Nicolaï
Tue Nov 12, 2019 18:26
Publication date: Available online 11 November 2019Source: Revue des Maladies RespiratoiresAuthor(s): O. Brun, D. Caillaud, D. Charpin, J.-C. Dalphin
Tue Nov 12, 2019 18:26
The association between total homocysteine and blood pressure in two independent Chinese populations
Journal of Human Hypertension, Published online: 12 November 2019; doi:10.1038/s41371-019-0288-6The association between total homocysteine and blood pressure in two independent Chinese populations
Tue Nov 12, 2019 02:00
Abstract The mesencephalic locomotor region (MLR) is an essential area for initiation of locomotion. Its functional roles and circuits underlying locomotion have been studied intensively in many species. Studies suggest that cuneiform nucleus and pedunculopontine nucleus (PPN) are two core regions in the MLR for locomotion. However, it remains unclear about cellular components and morphological and intrinsic membrane properties of the neurons in these regions, especially the serotonergic...
Tue Nov 12, 2019 02:00
Publication date: Available online 12 November 2019Source: Journal of EthnopharmacologyAuthor(s): Min Wang, Yao Mingjiang, Jianxun Liu, Takagi Norio, Yang Bin, Zhang Miao, Xu Li, Ren Junguo, Fan Xiaodi, Tian FangzeAbstractEthnopharmacological relevanceCerebral ischemia, also known as stroke, can stimulate the proliferation and migration of endogenous neural stem cells (NSCS) in subventricular zone of the lateral ventricle and subgranularzone of the dentate gyrus in the adult hippocampus as a defense...
Tue Nov 12, 2019 17:59
Publication date: November 2019Source: Trends in Immunology, Volume 40, Issue 11Author(s):
Tue Nov 12, 2019 17:58
Publication date: November 2019Source: Trends in Immunology, Volume 40, Issue 11Author(s):
Tue Nov 12, 2019 17:58
Publication date: Available online 12 November 2019Source: Journal of Historical GeographyAuthor(s): Catherine GibsonAbstractThe history of cartography in the nineteenth-century Russian Empire has been dominated by accounts of the military, academic establishments and elite male intellectuals. This article seeks to provide a corrective to this tendency by highlighting the involvement of women in cartography in the home and print workshops. Drawing on previously unexamined archival sources, the article...
Tue Nov 12, 2019 17:55
Publication date: Available online 11 November 2019Source: Sleep MedicineAuthor(s): Eva Feketeova, Maria Tormasiova, Katarina Klobučníková, Peter Durdik, Dominika Jarcuskova, Miroslav Benca, Marianna VitkovaAbstractObjectiveAn increase in the incidence of narcolepsy after the pandemic influenza with the H1N1 vaccination in 2009 resulted in an interest in narcolepsy epidemiology. The aim of the study was to examine the incidence and prevalence rates of narcolepsy and to describe the associated characteristics...
Tue Nov 12, 2019 17:54
Publication date: 28 December 2019Source: Journal of Controlled Release, Volume 316Author(s): Tayebeh Rezaei, Saeed Khalili, Behzad Baradaran, Jafar Mosafer, Sarah Rezaei, Ahad Mokhtarzadeh, Miguel de la GuardiaAbstractAccording to WHO (World Health Organization) reports, more than 770,000 people died from HIV and almost 1.7 million people becoming newly infected in the worldwide in 2018. Therefore, many attempts should be done to produce a forceful vaccine to control the AIDS. DNA-based vaccines...
Tue Nov 12, 2019 17:54
Publication date: Available online 12 November 2019Source: Journal of Controlled ReleaseAuthor(s): Gyeungyun Kim, Minkyung Kim, Youngki Lee, Jung Woo Byun, Do Won Hwang, Minhyung LeeAbstractAntisense miRNA oligonucleotides against miR-21 (AMO-21) have a therapeutic potential for treatment of glioblastoma. However, glioblastoma-targeted delivery through systemic injection requires development of an efficient targeting carrier. For this purpose, a glioblastoma-targeting carrier was developed using...
Tue Nov 12, 2019 17:54
Publication date: Available online 11 November 2019Source: Journal of Controlled ReleaseAuthor(s): Yu-Tong Hong, Daniel T. Bregante, Johnny Ching-Wei Lee, Yongbeom Seo, Dae-Hyun Kim, Yong Jae Lee, Lawrence B. Schook, Hojeong Jeon, Hak-Joon Sung, David W. Flaherty, Simon A. Rogers, Hyunjoon KongAbstractFibrin gels have been extensively used for three-dimensional cell culture, bleeding control, and molecular and cell therapies because the fibrous networks facilitate biomolecular and cell transport....
Tue Nov 12, 2019 17:54
Publication date: Available online 12 November 2019Source: NeuroImageAuthor(s): Yi-Fang Hsu, Weiyong Xu, Tiina Parviainen, Jarmo A. HämäläinenAbstractAccording to the predictive coding model of perception, the brain constantly generates predictions of the upcoming sensory inputs. Perception is realised through a hierarchical generative model which aims at minimising the discrepancy between predictions and the incoming sensory inputs (i.e., prediction errors). Notably, prediction errors are weighted...
Tue Nov 12, 2019 17:53
Publication date: Available online 11 November 2019Source: NeuroImageAuthor(s): William Gaetz, Edward Rhodes, Luke Bloy, Lisa Blaskey, Carissa R. Jackel, Edward S. Brodkin, Amy Waldman, David Embick, Stephen Hall, Timothy PL. RobertsAbstractAutism spectrum disorder (ASD) is primarily characterized by impairments in social communication and the appearance of repetitive behaviors with restricted interests. Increasingly, evidence also points to a general deficit of motor tone and coordination in children...
Tue Nov 12, 2019 17:53
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