Abstract Purpose Although functional brain imaging has been used for the early and objective assessment of cognitive dysfunction, there is a lack of generalized image-based biomarker which can evaluate individual’s cognitive dysfunction in various disorders. To this end, we developed a deep learning-based cognitive signature of FDG brain PET adaptable for Parkinson’s disease (PD) as well as Alzheimer’s disease (AD). ...
02:00
Journal of International Medical Research, Ahead of Print.
07:04
Abstract Purpose of Review We aim to evaluate the epidemiology, racial and gender disparity, etiology, and treatment of stroke in the younger population. Recent Findings The younger age group without vascular risk factors exhibits an increased prevalence of cardio-embolism in context of patent foramen ovale/atrial septal aneurysm strokes, from...
02:00
Abstract Purpose of Review To summarize the molecular and clinical findings of KMT2B-related dystonia (DYT-KMT2B), a newly identified genetic dystonia syndrome. Recent Findings Since first described in 2016, 66 different KMT2B-affecting variants, encompassing a set of frameshift, nonsense, splice-site, missense, and deletion mutations, have...
02:00
Abstract Aging is a major risk factor for the majority of human diseases, and the development of interventions to reduce the intrinsic rate of aging is expected to reduce the risk for age-related diseases including cardiovascular disease, cancer, and dementia. In the skin, aging manifests itself in photodamage and dermal atrophy, with underlying tissue reduction and impaired barrier function. To determine whether rapamycin, an FDA-approved drug targeting the mechanistic target...
02:00
British Journal of Cancer, Published online: 25 November 2019; doi:10.1038/s41416-019-0631-2Sporadic implementation of UK familial mammographic surveillance guidelines 15 years after original publication
02:00
British Journal of Cancer, Published online: 25 November 2019; doi:10.1038/s41416-019-0643-yAssociation of the prognostic model iSEND with PD-1/L1 monotherapy outcome in non-small-cell lung cancer
02:00
British Journal of Cancer, Published online: 25 November 2019; doi:10.1038/s41416-019-0622-3Relationship between the immune microenvironment of different locations in a primary tumour and clinical outcomes of oesophageal squamous cell carcinoma
02:00
Xp11 renal cell carcinoma (RCC) with different gene fusions may have different clinicopathologic features. We sought to identify variant fusions in TFEB translocation RCC. A total of 31 cases of TFEB RCCs were selected for the current study; MALAT1-TFEB fusion was identified in 25 cases (81%, 25/31) using fusion probes. The remaining 6 cases (19%, 6/31) were further analyzed by RNA sequencing and 5 of them were detected with TFEB-associated gene fusions, including 2 ACTB-TFEB, 1 EWSR1-TFEB, 1 CLTC-TFEB,...
Fri Nov 22, 2019 02:00
The diagnosis of nodal marginal zone lymphoma (NMZL) can be challenging, with the differential diagnosis including other low-grade B-cell lymphomas, reactive hyperplasia, and even some cases of peripheral T-cell lymphoma (PTCL). PTCL may have a perifollicular growth pattern mimicking NMZL. We and others have noted an atypical distribution of T-follicular helper (TFH) cells in some cases of NMZL. This study was prompted by the diagnosis of NMZL in several cases in which a marked increase of TFH cells,...
Fri Nov 22, 2019 02:00
No abstract available
Fri Nov 22, 2019 02:00
Salivary duct carcinoma (SDC) is a rare, aggressive malignancy that histologically resembles high-grade mammary duct carcinoma. Because of the rarity of this entity, data verifying the association between histologic features and patient survival are limited. We conducted a comprehensive histologic review of 151 SDC cases and performed an analysis of the association between various histomorphologic parameters and the clinical outcome with the aim of developing a histologic risk stratification model...
Fri Nov 22, 2019 02:00
Until today, classic human astroviruses have not been associated with central nervous system infections in immunocompetent patients.
Sat Nov 23, 2019 02:00
The best outcomes after injury to the facial nerve are seen after immediate direct coaptation, but in practice, this happens infrequently. We ask whether late repair (between 3 weeks and 18 months) is comparable to immediate repair. In this prospective observational study over a two-year period (2016–18), we identified 18 patients (11 male and 7 female, mean (range) age 58 (23–94) years), who had sustained extracranial injuries to the facial nerve. Eight were identified in the acute phase (within...
Sun Nov 24, 2019 02:00
Autologous costal cartilage graft is optimal for augmentation rhinoplasty but with complications including markedly visible graft margins and dorsal contour irregularities. Therefore, the authors introduced the diced costal cartilage graft to smoothen the margins of bilateral spreader graft for nasal dorsum augmentation. A total of 6 patients were recruited for this augmentation rhinoplasty. The pre- and postoperative photographs were taken for improvement evaluation. During a mean follow-up of 15...
Thu Nov 21, 2019 02:00
Titanium mesh was widely used for cranium defect repair but associated with high complication rates. In this study, the authors describe a method using latissimus dorsi-myocutaneous flap in the repair of titanium mesh exposure and scalp defect after cranioplasty, and the plate retaining is also achieved. Fifteen patients from April 2012 to May 2016 underwent this procedure, the age ranged from 32 to 62 years and 47 years old on average, and all the patient had plate exposure combined with surgical...
Thu Nov 21, 2019 02:00
In this study, nonmineralized silk fibroin/gelatin (SF/G) hybrid scaffolds and the mineralized SF/G/hydroxyapatite (SF/G/HA) hybrid scaffolds were fabricated using vacuum freeze-drying method and biomineralization technique. The morphology and mechanical properties of the 2 hybrid scaffolds were characterized. Furthermore, the cytotoxic profiles of the hybrid scaffolds were investigated in vitro by seeding the human osteoblast cells (hFOB1.19). The 2 hybrid scaffolds were both highly porous and the...
Thu Nov 21, 2019 02:00
In 2008, the authors presented their Security Hi-tech Individual Extra-Light Device Mask (SHIELD), a customizable protective shield based on the (soccer) player's face cast. In 2017, the authors presented an update in the realization process, based on computer-aided design/computer-aided manufacturing technology, and called it SHIELD 2.0. Now, the authors present a further update in the realization process. Address correspondence and reprint requests to Valentino Vellone, MD, Via Pietro da...
Thu Nov 21, 2019 02:00
Virtual simulation surgical system is a good way to develop surgical instruments, make surgical plan, and train surgeons. At present, due to the deformation of intraoperative soft tissue after retraction and the lack of effective data collection, the surgical simulation of facial contour surgery can only be conducted according to the preoperative computed tomography data. Due to the difficulty of obtaining real operative spatial data, it is difficult for the virtual surgery trajectory planning process...
Thu Nov 21, 2019 02:00
Crainoplasty following decompressive craniotomy is widely applied clinically. Here, a 55-year-old male had clinical presentation of fever, headache, and ulceration at the anterior scalp of left ear, with 4 to 5 mL pus induction per day, where he accepted cranioplastic surgery 17 years ago using the material of medical silicone rubber. The results of experimental test and magnetic resonance imaging indicated a sign of infection. The authors reported a rarely delayed infection 17 years after cranioplastic...
Thu Nov 21, 2019 02:00
The facelift is one of the most popular cosmetic surgery methods of antiaging. There are many complications in facelift, but infections rarely occur relatively. The authors would like to introduce a patient who developed infection after a facelift procedure. The cause of the infection was preauricular sinus, one of the congenital anomalies. The patient was treated with complete excision of sinus tract and the patient was treated without any further complications. Based on this clinical report, surgeons...
Thu Nov 21, 2019 02:00
No abstract available
Thu Nov 21, 2019 02:00
We applied the classical Chinese wood joinery mortise-and-tenon principle to repair widening surface scars caused by incision tension. Along the outer margin of surface scars, the top half of the scar tissue was cut and removed. The authors designed serial tenon structures on the retained dermal surface of the scar and a series of corresponding mortise structures in the dermal tissue on the opposite side of the incision. Finally, the mortise and tenon structures were integrated and sutured, resulting...
Thu Nov 21, 2019 02:00
This study aimed to evaluate 2 advanced methods for presurgical calculation of bilateral alveolar cleft defect volume using 3-dimensional (3D) printing and computer-aided engineering (CAE) software. Twelve patients with bilateral alveolar cleft (4 females, 8 males, age range 8–11 years) were enrolled in the study. All patients underwent preoperative helical computed tomography scans, and the digital imaging and communications in medicine (DICOM) data of the computed tomography images were analyzed...
Thu Nov 21, 2019 02:00
Purpose: Despite many advances in the knowledge of vascular malformations, extracranial arteriovenous malformations (AVMs) remain an enigma and are usually misdiagnosed and mismanaged due to their associated rare morbidity. This study aimed to describe the clinical course and emphasize the progressive nature of AVMs through a retrospective study of 446 patients. Methods: Patients with cutaneous and soft-tissue AVMs presenting to our Vascular Anomalies Center between March 2011 and March 2017...
Thu Nov 21, 2019 02:00
Introduction and objectives: Nose is considered to be a conspicuous feature of human face. Its different parameters like shape, size, nasal angles etc may indicate one's gender, age, race, adapted climatic conditions, and the environment to which one belongs to. Furthermore, it is an important component and determinant of an individual's physical outlook and appearance. The current study provides a new approach for the assistance of anthropologists and forensic experts in human identification...
Thu Nov 21, 2019 02:00
This study was aimed at examining the relationship between the horizontal upper eyelid peak position (Δpeak-pupil) and the difference between the medial and lateral canthal heights (Δcanthi) in Japanese individuals. Images of the left eyelid of 71 participants without eyelid disease were acquired with a camera with a slit-lamp microscope. Multivariate linear regression analysis was performed to determine the influence of age, sex, distance from the pupil center to the upper eyelid margin (margin...
Thu Nov 21, 2019 02:00
Craniosynostosis is usually diagnosed in early infancy. Treatment almost always involves surgery and care is optimally organized around an interdisciplinary team of specialists at a craniofacial center. This study aimed to investigate Swedish parents’ experiences of having a child with craniosynostosis and their perceptions of the initial care process. Semistructured telephone interviews were conducted with 20 parents (10 fathers and 10 mothers) of children with nonsyndromic craniosynostosis who...
Thu Nov 21, 2019 02:00
Introduction: Adenoidectomy is one of the most common surgical procedures performed in children in otorhinolaryngology practice. This study aims to compare the conventional curettage adenoidectomy (CCA) and the endoscope-assisted coblation adenoidectomy (EACA) in terms of the postoperative Eustachian tube function and the surgical outcomes. Methods: A prospective, randomized, controlled study was carried out at a tertiary referral center and private hospital. Seventy-two adenoid hypertrophy...
Thu Nov 21, 2019 02:00
Background: While there has been ample interest and literature published regarding craniosynostosis surgical technique, there are few reports on adverse hospital and health system outcomes. The purpose of this study was to describe rate of and risk factors for complications, and adverse outcomes following craniosynostosis reconstruction. Methods: This study retrospectively reviewed the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) Pediatric database and...
Thu Nov 21, 2019 02:00
The aims of this retrospective case series were to investigate whether twins born with craniosynostosis mirrored each other regarding operative surgery performed, age of undertaking surgery; outcomes in speech, language, and developmental milestones and what environmental factors were present for each set of twins. Case selection was based on clinical and radiographical evidence of craniosynostosis amongst twin sets. The twin sets included were those with craniosynostosis who had different sutures...
Thu Nov 21, 2019 02:00
Objective: To summarize the prognosis of pediatric patients with mucoepidermoid carcinoma (MEC) of the parotid gland. Methods: Pediatric patients with MEC of parotid gland who were surgically treated at the Capital Medical University School of Stomatology from 2000 to 2014 were retrospectively analyzed. Clinical characteristics, pathology reports, and operation records were reviewed and analyzed. Results: In total, 33 patients with an average age of 13.2 years were enrolled. The 5-year...
Thu Nov 21, 2019 02:00
Objective: The purpose of this study was to evaluate the use of a modified template system and double computed tomography scan procedure to maintain mandibular width in cases of mandibular reconstruction. Study Design: Ten patients who underwent mandibular reconstruction with a fibular flap were enrolled. The surgeries were planned with a computer-aided surgical simulation (CASS) planning method. Following double computed tomography scan procedure, the template system was designed in a computer...
Thu Nov 21, 2019 02:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου