Bone lesions are an important public health problem, with high socioeconomic costs. Bone tissue repair is coordinated by an inflammatory dynamic process mediated by osteoprogenitor cells of the periosteum and endosteum, responsible for the formation of a new bone matrix. Studies using antioxidant products from plants for bone lesion treatment have been growing worldwide. We developed a systematic review to compile the results of works with animal models investigating the anti-inflammatory activity...
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Background: This study represents a single surgeon's 10 years of experience addressing unilateral cleft lip and palate nose deformity. The purpose was to compare surgical outcomes and related complications using 3 different techniques to improve nasal shape in primary unilateral cleft rhinoplasty. Methods: This retrospective study with Institutional Ethical Committee approval compares 3 groups of patients with unilateral cleft lip nose and palate who were operated on using different techniques...
Thu Nov 21, 2019 02:00
Patients with syndromic craniosynostosis (CS) can present with both intracranial and extracranial manifestations. Extracranial features include proptosis, exorbitism, and midface hypoplasia. Intracranial manifestations can include elevated intracranial pressure (ICP), brainstem compression, foramen magnum stenosis or jugular foramen hypoplasia with resultant venous hypertension and anomalous drainage. While fronto-orbital advancement, cranial vault remodeling, and posterior fossa decompression are...
Thu Nov 21, 2019 02:00
Biological organisms are modular. Theory predicts that natural selection would steadily improve modules towards their performance optima up to the margin of effective neutrality. This classical theory may break down for populations evolving in the clonal interference regime because natural selection may focus on some modules while adaptation of others stalls. Such evolutionary stalling has not been observed and it is unclear whether it limits the power of natural selection to optimize module performance....
Sun Nov 24, 2019 02:00
Introduction: Small cell prostate cancer (SCPC) is a rare histologic subtype of prostate cancer, for which the optimal staging strategy remains unclear. Method: The Surveillance, Epidemiology, and End Results database was used to analyze the incidence and outcomes of SCPC between the years 2004 through 2016. Limited-stage SCPC (LS-SCPC) was defined as SCPC without any metastasis regardless of local invasion. Extensive stage SCPC (ES-SCPC) was defined as any metastasis to lymph nodes...
Thu Nov 21, 2019 02:00
Objective: To investigate the clinical outcomes and failure patterns of patients with unresectable cholangiocarcinoma (CC) who had been treated with proton beam therapy (PBT). Methods: The authors retrospectively examined 30 patients with unresectable CC who had undergone PBT between November 2015 and December 2017. Survival curves were plotted with the Kaplan-Meier method. Independent predictors of survival were identified by multivariate Cox proportional hazard regression analyses....
Thu Nov 21, 2019 02:00
Objectives: National Comprehensive Cancer Network (NCCN) guidelines for stage III colon cancer define low-risk versus high-risk patients based on T (1 to 3 vs. 4) and N (1 vs. 2) status, with some variations in treatment. This study analyzes the impact of tumor deposits (TDs), T and N status, poor differentiation (PD), perineural invasion (PNI), and lymphovascular invasion (LVI) on survival. Materials and Methods: A retrospective analysis (2010-2015) of the National Cancer Database...
Thu Nov 21, 2019 02:00
Objective: To assess the overall survival (OS) and prognostic factors in patients with cervix cancer treated by different modalities. Material and Methods: The authors studied a cohort of patients with cervix cancer International Federation of Gynecology and Obstetrics stage I-IVa treated in the last 15 years. Patients were treated with surgery followed by radiotherapy (S+RT), or surgery plus chemoradiation (S+CRT), or radiotherapy alone (RT), or chemoradiation alone (CRT). Univariate...
Thu Nov 21, 2019 02:00
Gynecologic clear cell carcinoma is a rare histology, accounting for ~5% of all ovarian and endometrial cancers in the United States. Compared to other types of gynecologic cancer, they are generally less responsive to standard therapy and have an overall worse prognosis. In addition, mounting evidence suggests that the landscape of genetic and molecular abnormalities observed in these tumors is distinct from other cancers that arise from the same sites of origin. On a molecular level, these tumors...
Thu Nov 21, 2019 02:00
Objective: Radiation therapy (RT) is the primary treatment of intracranial metastasis (ICM) from lung cancer (LC). Radiation necrosis (RN) has been reported post-RT with an incidence of 5% to 24%. We reviewed the spectrum of imaging changes in patients treated with RT for ICM from LC in an effort to identify potential risk factors for RN. Methods: We reviewed 63 patients with LC and ICM who received RT (radiosurgery [stereotactic radiosurgery] with/without whole brain radiation therapy)...
Thu Nov 21, 2019 02:00
Objectives: Bevacizumab with chemotherapy improved overall survival (OS) in the E4599 trial in metastatic nonsquamous non–small cell lung cancer (NS-NSCLC). A meta-analysis demonstrated an OS benefit with bevacizumab only in a subset of nonwhite patients. We explored the efficacy of antivascular endothelial growth factor antibodies (AVA) in a diverse cohort. Materials and Methods: Patients with advanced (stage IIIB/IV, American Joint Committee Cancer 7th edition) recurrent or metastatic...
Thu Nov 21, 2019 02:00
Objectives: The role of local disease control in the oligometastatic setting is evolving. Stereotactic body radiation therapy (SBRT) is a noninvasive treatment option for oligometastases; however, using ablative radiation doses for adrenal metastases raises concern given the proximity to radiosensitive organs. Novel treatment techniques may allow for selective dose escalation to improve local control (LC) while minimizing dose to nearby critical structures. Materials and Methods: We...
Thu Nov 21, 2019 02:00
Objectives: We examined the impact of brachytherapy boost (BB) and external beam radiotherapy (EBRT) dose-escalation on overall survival (OS) for women with cervical cancer receiving postoperative chemotherapy and radiation (CRT) for a positive margin following hysterectomy. Materials and Methods: The National Cancer Database (NCDB) was queried from 2004 to 2015 for women with nonmetastatic squamous cell carcinoma or adenocarcinoma of the cervix who had a positive margin following hysterectomy...
Thu Nov 21, 2019 02:00
Objectives: The objective of this study is to assess the reliability of intraoperative uterine assessment compared with the final pathologic evaluation in patients with endometrial cancer (EC) and whether assessment improves with experience. Methods: After Institutional Review Board approval, a prospective cohort study of women surgically managed with biopsy-proven complex atypical hyperplasia (CAH) or EC between March 2015 and December 2016 was performed. Demographics, preoperative...
Thu Nov 21, 2019 02:00
Objectives: Natural killer/T-cell lymphoma (NKTCL) is aggressive, and carries a poor prognosis worldwide. This retrospective study aimed to evaluate the clinical efficacy and safety of the LVD regimen (L-asparaginase, vincristine, and dexamethasone) combined with intensity-modulated radiation therapy (IMRT) for the treatment of early-stage nasal NKTCL in a Chinese population. Methods: The clinical data were collected from patients treated between March 2010 and January 2017. Patients...
Thu Nov 21, 2019 02:00
Publication date: Available online 23 November 2019Source: World NeurosurgeryAuthor(s): Li Zhenzhu, Xu Ruiyu, Chen Wei, Wang Henglu, Ding Jinke, Shao Wei, Du Hongpeng, Gao Wenbo, Liu Pengfei, Liu Yongliang, Li Meng, Li Jianmin, Li ZefuAbstractBackgroundIntracerebral hematomas (ICH) is a common disease in the developing countries, and minimally invasive transportal resection of ICH is a widely accepted surgical technique. Many port systems are available, but most are disposable and expensive. We present...
Sun Nov 24, 2019 20:06
Publication date: Available online 23 November 2019Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Vikram Shetty, Nandakishore P, Adeeba Khanum, Anirudh Yadav, Hermann F. SailerAbstractObjectiveTemporomandibular joint ankylosis (TMJa) is a debilitating condition that causes difficulty in mastication, speech and mouth opening. Its treatment poses surgical and rehabilitative challenges along with a high incidence of reankylosis. This study was designed to assess the long-term outcomes with...
Sun Nov 24, 2019 20:01
Publication date: Available online 23 November 2019Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): N. Leibig, A. Ha-Phuoc, G.B. Stark, R. Schmelzeisen, M.C. Metzger, S.U. Eisenhardt, P.J. VossSummaryThe Cook-Swartz-Doppler probe is an easy to handle and reliable tool for free flap monitoring. In the head and neck region different confounders can affect the read out. We therefore analyzed the use of the Doppler probe regarding these potential difficulties and to compare the diagnostic accuracy...
Sun Nov 24, 2019 20:01
Publication date: Available online 23 November 2019Source: Sleep MedicineAuthor(s): Pei-Wen Lin, Hsin-Ching Lin, Michael Friedman, Hsueh-Wen Chang, Anna M. Salapatas, Meng-Chih Lin, Yung-Che ChenAbstractObjectiveObstructive sleep apnea/hypopnea syndrome (OSA) could compromise oxygenation of the optic nerve and cause glaucomatous optic neuropathy; there has been no study to investigate the microstructure changes of the optic nerve and retina in OSA patients before and after continuous positive airway...
Sun Nov 24, 2019 19:46
Publication date: Available online 23 November 2019Source: Academic RadiologyAuthor(s): Tushar Garg
Sun Nov 24, 2019 18:45
Publication date: Available online 23 November 2019Source: Behavioural Brain ResearchAuthor(s): Kaili Jiao, Huazhen Xu, Changjun Teng, Xiu Song, Chaoyong Xiao, Peter T. Fo, Ning Zhang, Chun Wang, Yuan ZhongAbstractBackgroundCognitive dysfunctions, such as impaired cognitive control, are frequently observed in patients with major depressive disorder (MDD). Although the cognitive control network (CCN) is widely considered a core feature of major depressive disorder (MDD), the relationship between cognitive...
Sun Nov 24, 2019 18:22
Publication date: December 2019Source: Cancer/Radiothérapie, Volume 23, Issue 8Author(s):
Sun Nov 24, 2019 18:00
Publication date: December 2019Source: Cancer/Radiothérapie, Volume 23, Issue 8Author(s):
Sun Nov 24, 2019 18:00
Risk Assessment Methodology for Trajectory Planning in Keyhole Neurosurgery using Genetic Algorithms
Abstract Background Preoperative assessment to find the safest trajectory in keyhole neurosurgery can reduce post operative complications. Methods We introduced a novel preoperative risk assessment semi‐automated methodology based on the sum of N maximum risk values using a generic genetic algorithm for the safest trajectory search. Results A set of candidates trajectories were found for two surgical procedures. The trajectories search is done using a risk map considering the proximity...
Sat Nov 23, 2019 19:24
What is New? 1. The [Ca2+]/[Mg2+] in buffers are usually calculated using one of eight programs. These all give different values, thus [Ca2+]/[Mg2+] must be measured. 2. The Ligand Optimisation Method (LOM) using electrodes is an accurate method to do this. The limitations of the method are described. 3. The LOM has been generalised to include calibration of fluorochromes and Aequorin. It is the method of choice to measure intracellular equilibrium constants. 4. Because of the uncertainties...
Sat Nov 23, 2019 21:34
Publication date: Available online 23 November 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Fayez Hussain Niazi, Pradeep Koppolu, Syed Bilal Tanvir, Abdulaziz Samran, Ali AlqerbanAbstractAimTo evaluate clinical periodontal and microbiological parameters after the treatment with adjunctive antimicrobial photodynamic therapy (APDT) among HIV seropositive and seronegative patients with necrotizing ulcerative periodontitis (NUP).Materials and MethodsSeropositive patients (Group-I) and...
Sun Nov 24, 2019 16:42
Related ArticlesMVP promotes hepatocellular carcinoma via targeting IRF2 and decreasing p53 activity. Hepatology. 2019 Nov 23;: Authors: Yu H, Li M, He R, Fang P, Wang Q, Yu Y, Wang F, Zhou L, Zhang Y, Chen A, Peng N, Liu D, Trilling M, Broering R, Wiemer EAC, Lu M, Zhu Y, Liu S Abstract Major vault protein (MVP) is up regulated during infections with hepatitis B and C virus. Here, we found that MVP deficiency inhibited hepatocellular carcinoma (HCC)...
Sun Nov 24, 2019 16:38
Related ArticlesInfluence of fetal sex on perinatal outcomes in women with gestational diabetes mellitus. Diabetes Metab Res Rev. 2019 Nov 22;:e3245 Authors: Hu J, Ge Z, Xu Q, Shen S, Wang Y, Zhu D, Bi Y Abstract OBJECTIVE: Fetal sex has recently been considered to be related to maternal glucose homeostasis and perinatal outcomes during pregnancy. Here, we investigated the effects of fetal sex on the perinatal outcomes of pregnancies with normal glucose...
Sun Nov 24, 2019 16:38
Related ArticlesImmunoproteasome subunit β5i regulates diet-induced atherosclerosis through altering MerTK-mediated efferocytosis in Apoe knockout mice. J Pathol. 2019 Nov 22;: Authors: Liao J, Xie Y, Lin Q, Yang X, An X, Xia Y, Du J, Wang F, Li HH Abstract The immunoproteasome contains three catalytic subunits (β1i, β2i and β5i) that are important modulators of immune cell homeostasis. A previous study showed a correlation between β5i and human atherosclerotic...
Sun Nov 24, 2019 16:38
Related ArticlesMetabolic impairments, metal traffic, and dyshomeostasis caused by the antagonistic interaction of cadmium and selenium using organic and inorganic mass spectrometry. Environ Sci Pollut Res Int. 2019 Nov 22;: Authors: Rodríguez-Moro G, Roldán FN, Baya-Arenas R, Arias-Borrego A, Callejón-Leblic B, Gómez-Ariza JL, García-Barrera T Abstract Cadmium (Cd) has become one of the most important environmental pollutants in the world, derived from...
Sun Nov 24, 2019 16:38
Related ArticlesHigher body mass index is linked to altered hypothalamic microstructure. Sci Rep. 2019 Nov 22;9(1):17373 Authors: Thomas K, Beyer F, Lewe G, Zhang R, Schindler S, Schönknecht P, Stumvoll M, Villringer A, Witte AV Abstract Animal studies suggest that obesity-related diets induce structural changes in the hypothalamus, a key brain area involved in energy homeostasis. Whether this translates to humans is however largely unknown. Using a...
Sun Nov 24, 2019 16:38
Related ArticlesAir pollution-derived particulate matter dysregulates hepatic Krebs cycle, glucose and lipid metabolism in mice. Sci Rep. 2019 Nov 22;9(1):17423 Authors: Reyes-Caballero H, Rao X, Sun Q, Warmoes MO, Penghui L, Sussan TE, Park B, Fan TW, Maiseyeu A, Rajagopalan S, Girnun GD, Biswal S Abstract Exposure to ambient air particulate matter (PM2.5) is well established as a risk factor for cardiovascular and pulmonary disease. Both epidemiologic...
Sun Nov 24, 2019 16:38
Related ArticlesElevated glucose acts directly on osteocytes to increase sclerostin expression in diabetes. Sci Rep. 2019 Nov 22;9(1):17353 Authors: Pacicca DM, Brown T, Watkins D, Kover K, Yan Y, Prideaux M, Bonewald L Abstract Bone quality in diabetic patients is compromised, leading to weaker bones and increased fracture risk. However, the mechanism by which this occurs in diabetic bone remains to be fully elucidated. We hypothesized that elevated...
Sun Nov 24, 2019 16:38
Related ArticlesEnhancing human emotions with interoceptive technologies. Phys Life Rev. 2019 Oct 25;: Authors: Schoeller F, Haar AJH, Jain A, Maes P Abstract Historically, multiple theories have posited an active, causal role for perceived bodily states in the creation of human emotion. Recent evidence for embodied cognition, i.e. the role of the entire body in cognition, and support for models positing a key role of bodily homeostasis in the creation...
Sun Nov 24, 2019 16:38
Related ArticlesNew insights into human beta cell biology using human pluripotent stem cells. Semin Cell Dev Biol. 2019 Nov 19;: Authors: Amirruddin NS, Low BSJ, Lee KO, Tai ES, Teo AKK Abstract Pancreatic β-cells are responsible for maintaining glucose homeostasis. Therefore, their dysregulation leads to diabetes. Pancreas or islet transplants can be used to treat diabetes but these human tissues remain in short supply. Significant progress has now...
Sun Nov 24, 2019 16:38
Related ArticlesAlternate expression of PEPT1 and PEPT2 in epidermal differentiation is required for NOD2 immune responses by bacteria-derived muramyl dipeptide. Biochem Biophys Res Commun. 2019 Nov 19;: Authors: Kudo M, Kobayashi-Nakamura K, Kitajima N, Tsuji-Naito K Abstract Peptide transporters 1 and 2 (PEPT1 and PEPT2) are proton-coupled oligopeptide transporter members of the solute carrier 15 family and play a role in the cellular uptake of di/tri-peptides...
Sun Nov 24, 2019 16:38
Related ArticlesProbing the Interactions of Sulfur-Containing Histidine Compounds with Human Gamma-Glutamyl Transpeptidase. Mar Drugs. 2019 Nov 20;17(12): Authors: Milito A, Brancaccio M, Lisurek M, Masullo M, Palumbo A, Castellano I Abstract Gamma-glutamyl transpeptidase (GGT) is a cell surface enzyme involved in glutathione metabolism and maintenance of redox homeostasis. High expression of GGT on tumor cells is associated with an increase of cell...
Sun Nov 24, 2019 16:38
Publication date: Available online 23 November 2019Source: Journal of Bodywork and Movement TherapiesAuthor(s): Zohreh Shafizadegan, Hamzeh Baharlouei, Omid Khoshavi, Zahra Garmabi, Niloofar FereshtenejadAbstractIntroductionThe ability to maintain balance is essential for both remaining in the standing position and preventing falls. Physical therapy techniques such as kinesiology taping (KT) and stretching are considered to be effective measures in ameliorating balance issues. However, there is no...
Sun Nov 24, 2019 15:48
36 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: ALCOHOL These pubmed results were generated on 2019/11/24PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sun Nov 24, 2019 15:16
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