The resistance of malaria parasites to the current antimalarial drugs has led to the search for novel effective drugs. Betula alnoides has been traditionally used for the treatment of malaria, but the scientific evidence to substantiate this claim is still lacking. Therefore, the present study aimed at evaluating the antimalarial activity and toxicity of an aqueous stem extract of B. alnoides in a mouse model. The in vivo antimalarial activity of an aqueous stem extract of B. alnoides was determined...
08:05
Inflammation plays a pivotal role in the development of pulmonary arterial hypertension (PAH). Meanwhile, serum glucocorticoid-regulated kinase-1 (SGK1) has been considered to be an important factor in the regulation of inflammation in some vascular disease. However, the role of SGK1 in hypoxia-induced inflammation and PAH is still unknown. WT and SGK1-/- mice were exposed to chronic hypoxia to induce PAH. The quantitative PCR and immunohistochemistry were used to determine the expression of SGK1....
07:05
This study presents a comparative analysis of the deformation control effect of the hydraulic servo steel struts and ordinary steel struts of a foundation pit based on the measured axial force of the steel struts, lateral wall deflection, and ground surface settlement due to pit excavation. The results indicate that ordinary steel struts installed via axial preloading exhibit a disadvantageous axial force loss with a maximum value equal to 86.7% of the axial preloading force. When compared with ordinary...
07:05
We examined factors related to the uptake of two malaria prevention measures, insecticide-treated bed-nets and prophylactic sulphadoxine-pyrimethamine (SP), among pregnant women in Nnewi, Nigeria. The survey had a quantitative and qualitative part. For each part, the subjects meeting our inclusion criteria were systematically identified in a population-based manner. For the qualitative part, focused group discussions, in-depth interviews with a wide variety of stakeholders (e.g., health workers,...
06:05
The most common postoperative complication after reconstructive surgery is flap necrosis. Adipose-derived stem cells (ADSCs) and their secretomes are reported to mediate skin repair. This study was designed to investigate whether conditioned media from ADSCs (ADSC-CM) protects ischemia/reperfusion- (I/R-) induced injury in skin flaps by promoting cell proliferation and increasing the number of hair follicles. The mouse flap model of ischemia was ligating the long thoracic vessels for 3 h, followed...
06:05
Objectives. This study was to investigate the association of melatonin (MTN) pathway gene’s single-nucleotide polymorphisms (SNPs) with susceptibility to systemic lupus erythematosus (SLE). Methods. We recruited 495 SLE patients and 493 healthy controls, 11 tag SNPs in MTN receptor 1a (MTNR1a), MTNR1b, and arylalkylamine N-acetyltransferase (AANAT) genes were genotyped and analyzed. Serum MTN concentration was determined by enzyme-linked immunosorbent assay (ELISA) kits. Results. Two SNPs of AANAT...
03:05
Background and Aim. Aspartate aminotransferase-to-platelet ratio index (APRI) is widely used in the assessment of fibrosis and cirrhosis, especially in patients with chronic hepatitis. However, the prognostic value of APRI in patients with chronic hepatitis with regard to the prediction of hepatocellular carcinoma (HCC) occurrence remains controversial. The objective of this meta-analysis is to investigate the association between APRI and HCC risk on the basis of cohort studies. Methods. We systematically...
03:05
The main pathological symptoms of Alzheimer’s disease (AD) are β-amyloid (Aβ) lesions and intracellular neurofibrillary tangles of hyperphosphorylated tau protein. Unfortunately, existing symptomatic therapies targeting Aβ and tau remain ineffective. In addition to these pathogenic factors, oxidative DNA damage is one of the major threats to newborn neurons. It is necessary to consider in detail what causes neurons to be extremely susceptible to oxidative damage, especially in the early stages of...
02:05
Accumulation of allelic variants in genes that regulate cellular proliferation, differentiation, and apoptosis may result in expansion of the aberrant intestinal epithelium, generating adenomas. Herein, we compared the mutation profiles of conventional colorectal adenomas (CNADs) across stages of progression towards early carcinoma. DNA was isolated from 17 invasive adenocarcinomas (ACs) and 58 large CNADs, including 19 with low-grade dysplasia (LGD), 21 with LGD adjacent to areas of high-grade dysplasia...
Tue Nov 12, 2019 18:05
This paper studies the effect of continuous gusts on the initial disturbance of the airborne missile’s horizontal backward derailment on large transport aircraft. The longitudinal fluctuation of the airborne launching platform under continuous gust was obtained with different calculation methods, and the finite element model of the derailing process was established then verified by experiments. Finally, combined with the longitudinal fluctuation of the launching platform and the finite element model...
Tue Nov 12, 2019 18:05
The fly-by-wire system plays an important role in modern civil aircraft. As a typical safety-critical system, its reliability will affect the safety of aircraft significantly. In the paper, stochastic Petri nets are applied in the reliability modeling and analysis for the fly-by-wire system to represent its dynamic (time-dependent) failure behaviors. Stochastic Petri net-based reliability models are established for all kinds of architectures including series, parallel, -out-of-, warm standby, cold...
Tue Nov 12, 2019 18:05
Schwannomas represent only 5% of all soft tissue tumors. As a variant of this tumor, the plexiform schwannoma is rare accounting for less than 5% of all schwannomas. Herein, we report a rare case of a 49-year-old athlete who suffered from a pain in the posterior aspect of the right leg one year before his presentation. Initially, a radiograph of his right leg showed no abnormality, and so, the emergency physician discharged him on analgesics and anti-inflammatory medications, and rest was advised....
Tue Nov 12, 2019 18:05
Patients with spinal cord injury (SCI) face devastating health, social, and financial consequences, as well as their families and caregivers. Reducing the levels of reactive oxygen species (ROS) and oxidative stress are essential strategies for SCI treatment. Some compounds from traditional medicine could be useful to decrease ROS generated after SCI. This review is aimed at highlighting the importance of some natural compounds with antioxidant capacity used in traditional medicine to treat traumatic...
Tue Nov 12, 2019 17:05
This paper proposes an over-the-air (OTA) testing setup for millimeter-wave (mmWave) massive multiple-input multiple-output (MIMO) equipment using cascaded amplitude and phase modulation (APM) network and channel emulator. Compared with the existing test setup with mechanical switch, the proposed testing setup enables more accurate reconstruction of the radio channel environment under the multiprobe anechoic chamber (MPAC) setup without increasing the number of channel emulators (CEs) to control...
Tue Nov 12, 2019 17:05
Impaired sarcoplasmic reticulum (SR) calcium transport ATPase (SERCA) gives rise to Ca2+ alternans and changes of the Ca2+release amount. These changes in Ca2+ release amount can reveal the mechanism underlying how the interaction between Ca2+ release and Ca2+ uptake induces Ca2+ alternans. This study of alternans by calculating the values of Ca2+ release properties with impaired SERCA has not been explored before. Here, we induced Ca2+ alternans by using an impaired SERCA pump under ischemic conditions....
Tue Nov 12, 2019 16:05
Radiotherapy (RT) is currently one of the leading treatments for various cancers; however, it may cause damage to healthy tissue, with both short-term and long-term side effects. Severe radiation-induced normal tissue damage (RINTD) frequently has a significant influence on the progress of RT and the survival and prognosis of patients. The redox system has been shown to play an important role in the early and late effects of RINTD. Reactive oxygen species (ROS) and reactive nitrogen species (RNS)...
Tue Nov 12, 2019 15:05
Shear strength deterioration of rock joints and its induced instability of key blocks subjected to dynamic disturbance constitute the mechanism of many geological disasters such as rockburst, landslide, and rockfall. In this study, the influence of dynamic disturbance on rock joints was quantified in the form of stress, of which model was established by quasistatic method. The dynamic shear strength of rock joints was analyzed theoretically following the Coulomb-Navier criterion and further investigated...
Tue Nov 12, 2019 15:05
Evaluation of Buruli Ulcer Disease Surveillance System in the Ga West Municipality, Ghana, 2011–2015
Background. Buruli ulcer (BU) is one of the most neglected tropical diseases caused by Mycobacterium ulcerans. M. ulcerans infection may manifest initially as a pre-ulcerative nodule, a plaque, or oedema which breaks down to form characteristic ulcers with undermined edges. The Ga West Municipality is an endemic area for Buruli ulcer, and we evaluated the BU surveillance system to determine whether the system is meeting its objectives and to assess its attributes. Materials and Methods. We used a...
Tue Nov 12, 2019 14:05
Background. Chronic mesenteric ischemia (CMI) is characterized by long-standing abdominal symptoms due to insufficient mesenteric circulation. Data on the effect of revascularisation on quality of life (QoL) for CMI are scarce. This study is the first to evaluate the impact of revascularisation on quality of life. Methods. Seventy-nine patients with CMI or acute-on-chronic mesenteric ischemia (AoCMI) underwent an intervention of one or more mesenteric arteries between January 2010 and July 2012....
Tue Nov 12, 2019 14:05
Diabetes-induced oxidative stress and apoptosis is regarded as a critical role in the pathogenesis of diabetic nephropathy (DN). Treating diabetes-induced kidney damage and renal dysfunction has been thought a promising therapeutic option to attenuate the development and progression of DN. In this study, we investigated the renoprotective effect of ethyl vanillin (EVA), an active analogue of vanillin isolated from vanilla beans, on streptozotocin- (STZ-) induced rat renal injury model and high glucose-induced...
Tue Nov 12, 2019 14:05
Objective. Atherogenic lipoproteins may impair vascular reactivity consecutively causing tissue damage in multiple organs via abnormal perfusion and excessive reactive oxygen species generation. We tested the hypothesis that chronic hypercholesterolemia causes endothelial dysfunction and cell loss in the retina. Methods. Twelve-month-old apolipoprotein E-deficient (ApoE-/-) mice and age-matched wild-type controls were used in this study ( per genotype for each experiment). Intraocular pressure, blood...
Tue Nov 12, 2019 14:05
Peptides derived from buffalo dairy products possess multiple healthy properties that cannot be exerted as long as they are encrypted in parent proteins. To evaluate the biological activities of encrypted peptide sequences from buffalo ricotta cheese, we performed a simulated gastrointestinal (GI) digestion. Chemical and pharmacological characterization of the digest led to the identification of a novel peptide endowed with antioxidant and antihypertensive action. The GI digest was fractionated by...
Tue Nov 12, 2019 14:05
The MT·G-Joint (grouted mortise-tenon joint), invented as the connection between the large prefabricated elements, is the most important component in the prefabricated underground structures. Its shear performance is critical to the overall mechanical performance of the prefabricated structure. This paper carries out four-point pure shear experiment to investigate the shear performance of the MT·G-Joint. The shear key method is then proved to be suitable for MT·G-Joint when the axial load is 0 kN...
Tue Nov 12, 2019 14:05
It has been recognized that iron overload may harm the body’s health. Vascular endothelial cells (VECs) are one of the main targets of iron overload injury, and the mechanism involved was thought to be related to the excessive generation of reactive oxygen species (ROS). However, the subcellular and temporal characteristics of ROS generation, potential downstream mechanisms, and target organelles in VECs injured by iron overload have not been expounded yet. In this study, we elucidated the abovementioned...
Tue Nov 12, 2019 13:05
Peroxisome proliferator-activated receptor- (PPAR-) γ is a ligand-dependent transcription factor, and it has become evident that PPAR-γ agonists have renoprotective effects, but their influence and mechanism during the development of calcium oxalate (CaOx) nephrolithiasis remain unknown. Rosiglitazone (RSG) was used as a representative PPAR-γ agonist in our experiments. The expression of transforming growth factor-β1 (TGF-β1), hepatocyte growth factor (HGF), c-Met, p-Met, PPAR-γ, p-PPAR-γ (Ser112),...
Tue Nov 12, 2019 13:05
Miscanthus x giganteus stalks were used to make organosolvent pulp and nanocellulose. The organosolvent miscanthus pulp (OMP) was obtained through thermal treatment in the mixture of glacial acetic acid and hydrogen peroxide at the first stage and the alkaline treatment at the second stage. Hydrolysis of the never-dried OМP was carried out by a solution of sulfuric acid with concentrations of 43% and 50% and followed by ultrasound treatment. Structural changes and the crystallinity index of OMP and...
Tue Nov 12, 2019 13:05
In this paper, the two-stage sintering process as a promising strategy has been adopted to prepare high-performance porous ceramics with high porosity. Sewage sludge and waste coal ash were used as raw materials and added were starch and CaCO3 as a mixed foaming agent. The chemical composition of the raw materials and mixed foaming agents were analyzed by standard techniques. All mixtures were prepared from fixed solid materials mixed at a ratio of 48 : 32 : 10 : 10 (wt.%) for coal ash, sludge, starch,...
Tue Nov 12, 2019 13:05
China’s soybean price fluctuates due to the current economic and trade frictions between China and the United States. Brazil and the United States are regarded as two oligarchs in China’s soybean import market. A dynamic price game model is established, and price elasticity parameters are estimated by using statistical data and Rotterdam model. The stability of Nash equilibrium point is discussed through bifurcation diagram, maximum Lyapunov exponent, evolutionary trajectory, and time series diagram....
Tue Nov 12, 2019 13:05
Background. Sepsis-associated encephalopathy (SAE) is a transient and reversible brain dysfunction, that occurs when the source of sepsis is located outside of the central nervous system; SAE affects nearly 30% of septic patients at admission and is a risk factor for mortality. In our study, we sought to determine whether metabolite changes in plasma could be a potential biomarker for the early diagnosis and/or the prediction of the prognosis of sepsis. Method. A total of 31 SAE patients and 28 healthy...
Tue Nov 12, 2019 13:05
In 1932 and again in 1947, the Scottish Council for Research in Education conducted the Scottish Mental Surveys. Testing two cohorts, one in 1932 and another in 1947, researchers set out to measure—using the same validated test each time—the intelligence of every Scottish child 11 years of age. The stated impetus for the Surveys was a fear that average Scottish intelligence was declining. But when investigators compared the results of the 1947 Survey with those from 1932 their predictions were completely...
Tue Nov 12, 2019 12:05
A novel identification algorithm for the correlation analysis-based multiple-input single-output (MISO) neurofuzzy Wiener model with noise is proposed. Firstly, several sets of Gaussian signals are utilized to realize the decoupling between the dynamic linear blocks and the static nonlinear blocks of a MISO Wiener system. Then, the correlation analysis is adopted to identify the parameters of the linear parts, and the problem that the output of static nonlinear block is immeasurable can be solved....
Tue Nov 12, 2019 12:05
The recent years have witnessed a growth in the number of users connected to computer networks, due mainly to megatrends such as Internet of Things (IoT), Industry 4.0, and Smart Grids. Simultaneously, service providers started offering vertical services related to a specific business case (e.g., automotive, banking, and e-health) requiring more and more scalability and flexibility for the infrastructures and their management. NFV and SDN technologies are a clear way forward to address these challenges...
Tue Nov 12, 2019 12:05
Background. Whole medicine and health systems like traditional and complementary medicine systems (T&CM) are part of healthcare around the world. One key feature of T&CM is its focus on patient-centered and multimodal care and the integration of intercultural perspectives in a wide range of settings. It may contribute to good health and well being for people as part of the Sustainable Development Goals of the United Nations. The authentic, rigorous, and fair evaluation of such a medical system,...
Tue Nov 12, 2019 11:05
Paraganglioma is a rare neuroendocrine tumor that arises from the autonomic nervous system. The urinary bladder paraganglioma accounts for less than 0.1% of bladder tumors. It remains a challenging entity to diagnose and treat due to its rareness and the lack of specific symptoms. Treatment modalities include transurethral resection and cystectomy (partial or total). The authors report a new case of an isolated paraganglioma of the urinary bladder in a 52-year-old female patient that underwent partial...
Tue Nov 12, 2019 11:05
Cutaneous involvement of multiple myeloma (MM) is uncommon, typically occurs in late stage disease, and is a poor prognostic indicator with an approximate eight month median survival. We present a 51-year-old man with relapsed lambda light chain MM who developed abrupt asymptomatic skin metastases. Biopsy revealed a dermis replete of atypical plasma cells, positive for CD138 and CD45. In situ hybridization confirmed lambda light chain restriction. Despite rescue antimyeloma therapy with the anti-CD38...
Tue Nov 12, 2019 11:05
Background. β-Thalassemia is a common inherited hemolytic disorder in Palestine. Red blood cell (RBC) transfusion is the principal treatment but it may cause RBC alloimmunization. This study was conducted to determine the prevalence and characteristics of RBC alloimmunization among thalassemic patients in northern governorates of Palestine. Methods. A prospective multicenter observational study was conducted in the thalassemia transfusion centers in the northern governorates of Palestine. The study...
Tue Nov 12, 2019 11:05
Bladed disks of engine rotors usually operate at harsh conditions of high rotating speeds, which may lead to nonnegligible rotordynamic effects, including Coriolis force, spin softening, and stress stiffening effects. These effects on the vibration of mistuned bladed disks are seldom discussed in available investigations. In this paper, the vibration characteristics of rotating mistuned bladed disks are addressed by considering these rotordynamic effects. First, finite element (FE) models of bladed...
Tue Nov 12, 2019 11:05
In this paper, an instantaneous optimal control performance index for active control of structures under seismic excitation is analytically proposed. Absolute velocity and absolute displacement terms are implemented to the conventional state vector terms and eventually to the resulting performance index expression. The seismic response reduction effectiveness of the proposed performance index is compared with the linear quadratic regulator control (LQR). For numerical verification of the performance...
Tue Nov 12, 2019 11:05
The body’s autoimmune process is involved in the development of Graves’ disease (GD), which is manifested by an overactive thyroid gland. In some patients, autoreactive inflammatory reactions contribute to the development of symptoms such as thyroid ophthalmopathy, and the subsequent signs and symptoms are derived from the expansion of orbital adipose tissue and edema of extraocular muscles within the orbit. The autoimmune process, production of antibodies against self-antigens such as TSH receptor...
Tue Nov 12, 2019 11:05
The ethanol-induced toll-like receptor 4 (TLR4) signal activation of microglia and neuroinflammation are observed in both adolescent and adult rat brains, but the regulatory mechanisms of some TLR4 signaling-related factors in this process are still unclear. SUMO-specific protease 6 (SENP6) inhibits neuroinflammation by dampening nuclear factor kappa-B (NF-κB) activation via the de-SUMOylation of NF kappa-B essential modulator (NEMO). This study investigates the effects of long-term ethanol consumption...
Tue Nov 12, 2019 10:05
Mesenchymal stem/stromal cells (MSCs) are known to be useful for treating local bone diseases. However, it is not known if MSCs are effective for treating systemic bone diseases, as the risk for mortality following intravenous MSC administration has hindered research progress. In this study, we compared the safety and efficacy of intra-bone marrow and intravenous administration of MSCs for the treatment of ovariectomy- (OVX-) induced osteoporosis. Cells capable of forming bone were isolated from...
Tue Nov 12, 2019 10:05
During the last decade, Rapidly-exploring Random Tree star (RRT∗) algorithm based on sampling has been widely used in the field of unmanned aerial vehicle (UAV) path planning for its probabilistically complete and asymptotically optimal characteristics. However, the convergence rate of RRT∗ as well as B-RRT∗ and IB-RRT∗ is slow for these algorithms perform pure exploration. To overcome the weaknesses above, Biased Sampling Potentially Guided Intelligent Bidirectional RRT∗ (BPIB-RRT∗) algorithm is...
Tue Nov 12, 2019 10:05
Osteoporosis is a civilization disease which is still challenging for contemporary medicine in terms of treatment and prophylaxis. It results from excessive activation of the osteoclastic cell line and immune cells like macrophages and lymphocytes. Cell-to-cell inflammatory information transfer occurs via factors including cytokines which form a complex network of cell humoral correlation, called cytokine network. Recently conducted studies revealed the participation of CX3CL1 chemokine in the pathogenesis...
Tue Nov 12, 2019 10:05
Leptin resistance is either a condition induced by human obesity or a natural phenomenon associated with seasonality in ruminants. In the cardiovascular system, the leptin resistance state presence is a complex issue. Moreover, the perivascular adipose tissue (PVAT) appears to be crucial as a source of proinflammatory cytokines and as a site of interaction for leptin contributing to endothelium dysfunction and atherosclerosis progression. So the aim of this study was to examine the influence of the...
Tue Nov 12, 2019 10:05
Purpose. To report the application of 14-MHz ultrasonography with tissue harmonic imaging (14 MHz + THI) to determine the integrity of the posterior capsule (PC) in traumatic cataract (TC). Methods. Patients with TC who were scheduled to undergo cataract extraction and whose PC could not be observed by slit lamp examination were included in the study. The status of the PC was determined by 14 MHz + THI before cataract extraction and confirmed during surgery. The results regarding PC integrity obtained...
Tue Nov 12, 2019 10:05
Fetus acardius amorphus is a rare congenital malformation characterized by the lack of a functional heart, the presence of a bivascular umbilical cord, as well as a developed and organized skeletal system and partially organized inner organs. Fetus acardii mostly occur in multiple gestations. The pathogenesis of this entity is not clarified yet. It has been hypothesized that, although formation of anastomosing vessels between the co-twin and the anomalous embryo as well as reverse directed blood...
Tue Nov 12, 2019 10:05
Objective. MiR-133b was dysregulated in myocardial infarction. However, the role and mechanism of miR-133b in myocardial infarction remains unclear. This study was aimed to explore the role of miR-133b in H9c2 cell injury induced by hypoxia and to investigate the underlying molecular mechanism. Methods. Cell injury was assessed by cell viability, migration, invasion, and apoptosis assays. The expression of miR-133b and nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) mRNA...
Tue Nov 12, 2019 09:05
The literature shows that phenolic compounds possess important antioxidant and anti-inflammatory activities; however, the mechanism underlying these effects is not elucidated yet. The genus Calea is used in folk medicine to treat rheumatism, respiratory diseases, and digestive problems. In this context, some phenolic compounds were isolated with high purity from Calea uniflora Less. and identified as noreugenin (NRG) and α-hydroxy-butein (AH-BU). The aim of this study was to analyze the effect of...
Tue Nov 12, 2019 09:05
Background. Psoriasis has been reported as a high-risk factor for quality of life and survival rate in patients with metabolic disorder. However, there is no animal model for studying this disease. This study aimed to establish and evaluate mouse models of psoriasis with blood stasis syndrome (which is a key to psoriasis pathogenesis, according to Chinese Medicine) complicated with metabolic disorders. Method. Forty-five C57BL/6 mice were randomly divided into the blank control (Control), psoriasis...
Tue Nov 12, 2019 09:05
Many researchers have tried to optimize pairs trading as the numbers of opportunities for arbitrage profit have gradually decreased. Pairs trading is a market-neutral strategy; it profits if the given condition is satisfied within a given trading window, and if not, there is a risk of loss. In this study, we propose an optimized pairs-trading strategy using deep reinforcement learning—particularly with the deep Q-network—utilizing various trading and stop-loss boundaries. More specifically, if spreads...
Tue Nov 12, 2019 09:05
Background: Floating-Harbor syndrome (FHS) is a rare condition characterized by dysmorphic facial features, short stature, and expressive language delay. Objective: The aim of this study was to describe a cohort of patients with FHS and review the literature about the response to recombinant human growth hormone (rhGH) therapy. Methods: Anthropometric and laboratory data from 7 patients with FHS were described. The molecular diagnosis was established by multigene analysis. Moreover, we reviewed the...
Tue Nov 12, 2019 16:36
29 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human homeostasis These pubmed results were generated on 2019/11/12PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Tue Nov 12, 2019 17:05
Authors: Mahmoudi M, Taghavi-Farahabadi M, Namaki S, Baghaei K, Rayzan E, Rezaei N, Hashemi SM Abstract Severe congenital neutropenia (SCN) is described by the absolute neutrophil counts less than 500 cells/mm3, bacterial infections, and an arrest of neutrophil differentiation. So, effective strategies for improving the function and lifespan of the existing neutrophils in these patients are necessary. Mesenchymal stem cells (MSCs) have supportive effects on neutrophils. Recently, it was...
Wed Nov 06, 2019 00:00
We present here the results for the classical HLA Loci: HLA-A, B, C, DRA, DRB1, DRB3, DRB4, DRB5, DPA1, DPB1, DQA1, and DQB1 to the third field of resolution for synonymous alleles and type the likely four field resolution alleles from the subset of whole genome sequences. Allele frequencies, and haplotype frequencies at up to five loci, are presented as well as measures of population structure and heterozygosity. We define a core set of HLA variation that approximates the distribution for the Paleo-Indians...
Wed Nov 06, 2019 00:00
109 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human physiology These pubmed results were generated on 2019/11/12PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Tue Nov 12, 2019 16:49
Οι εργαζόμενες στην Υγεία και σε ορισμένα άλλα επαγγέλματα μπορεί να διατρέχουν αυξημένο κίνδυνο για καρδιαγγειακά προβλήματα, σύμφωνα με μία νέα, μεγάλη μελέτη. The post Γυναίκες: Ποια επαγγέλματα είναι «εχθρικά» για την καρδιά appeared first on Iatropedia.
07:30
Εικόνα εγκατάλειψης, με κλειστές ολόκληρες κλινικές και τμήματα επειδή δεν υπάρχουν γιατροί και νοσηλευτές. Στο Νοσοκομείο Θώρακος “η Σωτηρία” δεσπόζουν πλέον τα ράντζα και μάλιστα πριν μπει ο χειμώνας και εμφανιστούν τα πρώτα κρούσματα γρίπης. The post “Σωτηρία”: Ράντζα πριν έρθει η γρίπη – Χωρίς προσωπικό το μεγαλύτερο Νοσοκομείο για αναπνευστικά νοσήματα appeared first on Iatropedia.
07:02
Διάρκειας 40 λεπτών ήταν η εισήγηση του Κωνσταντίνου Φρουζή ενώπιον της ειδικής επιτροπής προκαταρκτικής εξέτασης της Βουλής. The post Στην προανακριτική της Βουλής ο Κωνσταντίνος Φρουζής appeared first on Iatropedia.
Tue Nov 12, 2019 10:13
Σε απειλητικά επίπεδα για την Δημόσια Υγεία φτάνει η υπερκατανάλωση αντιβιοτικών στην Ελλάδα, η οποία συνεχίζει να κατέχει την πρώτη θέση στην Ευρώπη. The post Στοιχεία σοκ για τη μικροβιακή αντοχή: 7 στους 10 έλληνες καταναλώνουν άσκοπα αντιβιοτικά appeared first on Iatropedia.
Tue Nov 12, 2019 17:03
Θετικός εμφανίζεται ο Σύνδεσμος Φαρμακευτικών Επιχειρήσεων Ελλάδος (ΣΦΕΕ) απέναντι στις εξαγγελίες της κυβέρνησης για πάγωμα των αυξήσεων των τιμών φαρμάκων και μείωσή τους σε ποσοστό έως 7%. The post ΣΦΕΕ: Θετική κατ’ αρχήν η φαρμακοβιομηχανία για τη μείωση έως 7% στις τιμές φαρμάκων appeared first on Iatropedia.
Tue Nov 12, 2019 16:19
Ο καρκίνος του μαστού, σύμφωνα με πρόσφατες στατιστικές, αποτελεί τη συνηθέστερη κακοήθεια στις γυναίκες. Η πιθανότητα να νοσήσει μία γυναίκα στη διάρκεια της ζωής της είναι περίπου 13% ,δηλαδή μία στις οκτώ γυναίκες θα προσβληθεί από την πάθηση, με την στατιστική πιθανότητα να αυξάνεται καθώς εκείνη μεγαλώνει. The post Μεταστατικός καρκίνος του μαστού: Ποιες είναι οι νέες θεραπευτικές τεχνικές appeared first on Iatropedia.
Tue Nov 12, 2019 12:49
Συνάντηση είχαν νωρίς το πρωί της Τρίτης στο Μέγαρο Μαξίμου ο πρωθυπουργός Κυριάκος Μητσοτάκης και ο υπουργός Υγείας, Βασίλης Κικίλιας με βασικό θέμα την κατάθεση τροπολογίας του Υπουργείου Υγείας που απαγορεύει τις αυξήσεις στις τιμές των φαρμάκων. The post Συνάντηση Μητσοτάκη – Κικίλια: «Το καλύτερο φάρμακο στην καλύτερη τιμή – Μειώνεται η συμμετοχή των ασφαλισμένων» appeared first on Iatropedia.
Tue Nov 12, 2019 12:15
Η διατήρηση της μυϊκής μάζας μειώνει τον μελλοντικό καρδιαγγειακό κίνδυνο ενός υγιούς ανθρώπου μέσης ηλικίας, σύμφωνα με μια νέα έρευνα Ελλήνων επιστημόνων. The post Έμφραγμα και εγκεφαλικό: Η μείωση της μυϊκής μάζας αυξάνει τον κίνδυνο μελλοντικού επεισοδίου appeared first on Iatropedia.
Tue Nov 12, 2019 11:02
Με τροπολογία που κατέθεσε ο Υπουργός Υγείας Βασίλης Κικίλιας, βάζει φρένο στις αυξήσεις των τιμών των φαρμάκων. Μια τροπολογία που είχε προωθήσει προεκλογικά και ο πρώην υπουργός Υγείας Ανδρέας Ξανθός, αλλά δεν πρόλαβε να υλοποιήσει. The post Τέλος στις αυξήσεις των Φαρμάκων – Νέο σύστημα τιμολόγησης appeared first on Iatropedia.
Tue Nov 12, 2019 10:05
Η πνευμονία ευθύνεται για τον θάνατο περισσότερων από 800.000 παιδιών κάτω των 5 ετών πέρυσι –ένα παιδί κάθε 39 δευτερόλεπτα--, παρότι πρόκειται για μια ιάσιμη ασθένεια, η οποία συνήθως μπορεί να προληφθεί, προειδοποίησαν σήμερα έξι οργανώσεις, μεταξύ των οποίων και η Unicef. The post Η πνευμονία σκοτώνει ένα παιδί κάτω των 5 ετών κάθε 39 δευτερόλεπτα! appeared first on Iatropedia.
Tue Nov 12, 2019 09:45
Το μονοκλωνικό αντίσωμα dupilumab, που είναι ήδη εγκεκριμένο για το άσθμα και την ατοπική δερματίτιδα, έλαβε έγκριση και για τη χρόνια ρινοκολπίτιδα. The post Εγκρίθηκε βιολογική θεραπεία για τη σοβαρή χρόνια ρινοκολπίτιδα appeared first on Iatropedia.
Tue Nov 12, 2019 09:31
Η πρώτη αντικειμενική εξέταση για τη νόσο Πάρκινσον άρχισε να διατίθεται στην Ευρώπη. Είναι μια συσκευή που καταγράφει τα κινητικά συμπτώματα των ασθενών. The post Πάρκινσον: Δημιούργησαν συσκευή που αξιολογεί την κινητικότητα των ασθενών appeared first on Iatropedia.
Tue Nov 12, 2019 08:30
Περισσότερες από 30 ελληνικές φαρμακευτικές εταιρείες, με σημαντική εξαγωγική δραστηριότητα, συμμετείχαν στην διεθνή έκθεση CPhI. The post ΠΕΦ: Δυναμική παρουσία της ελληνικής φαρμακοβιομηχανίας στο CPhI 2019 appeared first on Iatropedia.
Tue Nov 12, 2019 08:25
Publication date: Available online 11 November 2019Source: Journal of NeuroradiologyAuthor(s): Martin Bretzner, Renaud Lopes, Ray McCarthy, Delphine Corseaux, Florent Auger, Gillian Gunning, Nicolas Beauval, Antonino Bongiovanni, Meryem Tardivel, Charlotte Cordonnier, Jean-Pierre Pruvo, Sophie Susen, Xavier Leclerc, Grégory KuchcinskiAbstractBackground and purpose: Previous studies have suggested that mechanical revascularization in acute ischemic stroke (AIS) patients could be affected by clot histology....
Tue Nov 12, 2019 15:03
Publication date: Available online 11 November 2019Source: Journal of NeuroradiologyAuthor(s): Kevin Janot, François Zhu, Basile Kerleroux, Grégoire Boulouis, Eimad Shotar, Kevin Premat, François Eugene, Cyril Dargazanli, Vanessa Chalumeau, Vincent L’allinec, Wagih Benhassen, Gaultier Marnat, Anthony Lebras, Lili Detraz, Julien Ognard, Thomas Personnic, Cyril Chivot, Matteo Cappucci, Géraud Forestier, Sébastien SoizeABSTRACTA correlation between the susceptibility vessel sign (SVS) and red thrombi...
Tue Nov 12, 2019 15:03
[ Advance Publication ] [ Title ] Long-term safety and treatment outcomes of pegvisomant in Japanese patients with acromegaly: results from the post-marketing surveillance [ Author ] Hiromi Yamaguchi,Akira Shimatsu,Akifumi Okayama,Takahiro Sato [ Advance Pub. date ] 2019-11-13 [ DOI ] https://doi.org/10.1507/endocrj.EJ19-0266
Tue Nov 12, 2019 17:00
Anti-neutrophil cytoplasmic autoantibodies (ANCAs) are directed against lysosomal components of neutrophils. ANCAs directed to proteinase 3 and myeloperoxidase (MPO) in particular are associated with distinct forms of small vessel vasculitides. MPO is an abundant neutrophil-derived heme protein that is part of the antimicrobial defense system. The protein is typically present in the azurophilic granules of neutrophils, but a large portion may also enter the extracellular space. It remains unclear...
Tue Nov 12, 2019 23:30
Endothelial nitric oxide (NO) synthase (eNOS) plays a critical role in the maintenance of blood vessel homeostasis. Recent findings suggest that cytoskeletal dynamics play an essential role in regulating eNOS expression and activation. Here, we sought to test whether modulation of cytoskeletal dynamics through pharmacological regulation of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation affects eNOS expression and endothelial function in vitro and in vivo. We found that tubulin acetylation...
Tue Nov 12, 2019 23:30
Monocarboxylate transporter 4 (MCT4) is an H+-coupled symporter highly expressed in metastatic tumors and at inflammatory sites undergoing hypoxia or the Warburg effect. At these sites, extracellular lactate contributes to malignancy and immune response evasion. Intriguingly, at 30–40 mM, the reported Km of MCT4 for lactate is more than one order of magnitude higher than physiological or even pathological lactate levels. MCT4 is not thought to transport pyruvate. Here we have characterized cell lactate...
Tue Nov 12, 2019 22:31
Activation and suppression of the complement system compete on every serum-exposed surface, host or foreign. Potentially harmful outcomes of this competition depend on surface molecules through mechanisms that remain incompletely understood. Combining surface-plasmon resonance (SPR) with atomic-force microscopy (AFM), here we studied two complement system proteins at the single-molecule level: C3b, the proteolytically activated form of C3, and factor H (FH), the surface-sensing C3b-binding complement...
Tue Nov 12, 2019 22:31
Chronic recurrent multifocal osteomyelitis (CRMO) in humans can be modeled in Pstpip2cmo mice, which carry a missense mutation in the proline-serine-threonine phosphatase-interacting protein 2 (Pstpip2) gene. As cmo disease in mice, the experimental model analogous to human CRMO, is mediated specifically by interleukin (IL)-1β, and not by IL-1α, delineating the molecular pathways contributing to pathogenic IL-1β production is crucial to developing targeted therapies. In particular, our earlier findings...
Tue Nov 12, 2019 22:31
Hemocyanins are widely used as carriers, adjuvants, and nonspecific immunostimulants in cancer because they promote Th1 immunity in mammals. Hemocyanins also interact with glycan-recognizing innate immune receptors on antigen-presenting cells, such as the C-type lectin immune receptors MR and MGL and the Toll-like receptors (TLRs), stimulating proinflammatory cytokine secretion. However, the role of N-linked oligosaccharides on the structural and immunological properties of hemocyanin is unclear....
Tue Nov 12, 2019 22:31
ATP-binding cassette (ABC) subfamily G member 2 (ABCG2) belongs to ABC transporter superfamily and has been implicated in multidrug resistance of cancers. Although the structure and function of ABCG2 have been extensively studied, little is known about its biogenesis and the regulation thereof. In this study, using mutagenesis and several biochemical analyses we show that the positive charges in the vicinity of the RKR motif downstream of the ABC signature drive trafficking of nascent ABCG2 out of...
Tue Nov 12, 2019 20:30
I'm not sure who came up with the expression "Knowledge is Power" but whoever thought of it was a genius. Those three simple words are true in many different ways. By bringing knowledge into the equation, we become much more powerful in ways we never considered.Research and development in a myriad of subjects is rapidly increasing the “bottom line” of our knowledge base. Now that we have computers and machine learning, the curve continues to accelerate.According to Industry Tap Into News, Buckminster...
Tue Nov 12, 2019 14:00
Aim: Glucose fluctuations may be responsible for, or further the onset of arterial hypertension, but the exact mechanisms remain unclear. The purpose of this study was to investigate the mechanisms behind and related to aortic fibrosis and aortic stiffening induced by glucose fluctuations. Methods: Sprague-Dawley rats were injected with streptozotocin (STZ) and randomly divided into three treatment groups: controlled STZ-induced diabetes (C-STZ); uncontrolled STZ-induced diabetes (U-STZ); and STZ-induced...
Tue Nov 12, 2019 16:30
Abstract The potential anti-cariogenic effect of blue light was evaluated using an oral biofilm model. Two species, Streptococcus mutans and Streptococcus sanguinis, were cultivated ex vivo on bovine enamel blocks for 24 h, either separately or mixed together, then exposed to blue light (wavelengths 400–500 nm) using 112 J/cm2. Twenty four or 48 h after exposure to light the biofilm structure and biomass were characterized and quantified using SEM and qPCR, respectively. Bacterial...
Tue Nov 12, 2019 02:00
Mon Nov 11, 2019 22:03
Ophthalmic epidemiology
Sun Nov 10, 2019 00:19
Tue Nov 12, 2019 10:05
Tue Nov 12, 2019 10:05
Researchers justify disclosure of adult-onset-only conditions in newborns to parents on the grounds of family benefit; we show why this position fails morally and legally.
Tue Nov 12, 2019 10:05
Στο μυθιστόρημα με τίτλο «The Brooklyn Follies» ο Paul Auster αφηγείται μια συγκινητική ιστορία για τον συγγραφέα Φραντς Κάφκα και τη σχέση του με ένα μικρό κορίτσι και την κούκλα της. Στα 1923, κατά τη διάρκεια ενός περιπάτου στο Στέγκλιτζ του Βερολίνου, ο Φραντς Κάφκα και η αρραβωνιαστικιά του Φελίτσε Μπάουερ συνάντησαν στο πάρκο ένα κοριτσάκι που έκλαιγε με λυγμούς, επειδή είχε χάσει την αγαπημένη της κούκλα. Ο Κάφκα είπε στο κοριτσάκι να μην στεναχωριέται γιατί η κούκλα είχε πάει ταξίδι και...
00:02
Publication date: Available online 11 November 2019Source: Advances in Life Course ResearchAuthor(s): S.G.A. van de Weijer, H.S. Smallbone, V. BouwmanAbstractWhile it is widely recognized that imprisonment affects the lives of prisoners, there is increasing evidence that the consequences also extend to prisoners’ children. Recently, several studies showed that the experience of parental imprisonment could also have an impact on family formation processes when children grow older. These previous studies,...
Tue Nov 12, 2019 17:33
Publication date: Available online 11 November 2019Source: Magnetic Resonance ImagingAuthor(s): Ali Fatehi Hassanabad, Fiona Burns, Michael S. Bristow, Carmen Lydell, Andrew G. Howarth, Bobak Heydari, Xuexin Gao, Paul W.M. Fedak, James A. White, Julio GarciaAbstractBackgroundThe influence of complex bicuspid aortic valve (BAV) flow patterns on net intraluminal aortic pressure, both among patients with and without significant aortic stenosis, is unknown. Pressure drop (PD), as estimated by 4D Flow...
Tue Nov 12, 2019 17:27
Publication date: Available online 11 November 2019Source: Magnetic Resonance ImagingAuthor(s): Mehran Azimbagirad, Fabrício H. Simozo, Antonio C.S. Senra Filho, Luiz O. Murta JuniorAbstractQuantifying the intracranial tissue volume changes in magnetic resonance imaging (MRI) assists specialists to analyze the effects of natural or pathological changes. Since these changes can be subtle, the accuracy of the automatic compartmentalization method is always criticized by specialists. We propose and...
Tue Nov 12, 2019 17:27
Publication date: Available online 11 November 2019Source: Magnetic Resonance ImagingAuthor(s): Ze Wang, Di Cui, Jian Zhang, Ed.X. Wu, Edward S. HuiAbstractIn magnetic resonance fingerprinting (MRF), tissue parameters are determined by finding the best-match to the acquired MR signal from a predefined signal dictionary. This dictionary searching (DS) process is generally performed in an exhaustive manner, which requires a large predefined dictionary and long searching time. A fast MRF DS algorithm,...
Tue Nov 12, 2019 17:27
AbstractPatients with advanced stage ovarian clear cell carcinoma (OCCC) have a poor prognosis due to resistance to conventional platinum chemotherapy. Recent studies have demonstrated that PI3K/AKT/mTOR and ERK1/2 signaling pathways are involved in this chemoresistance. Progranulin (PGRN) overexpression contributes to cisplatin resistance of epithelial ovarian cancer cell lines. Also, PGRN expression is regulated by AKT/mTOR and ERK1/2 signaling pathways in different cell types. Thus, the present...
Tue Nov 12, 2019 00:00
AbstractReproducible patient positioning is essential for precision in radiation therapy (RT) delivery. We tested the hypothesis that a structured daily pre-treatment stretching regimen is both feasible and effective for minimizing variability in positioning, as measured by sacral slope angles (SSA). Eight female subjects undergoing pelvic radiotherapy performed a structured daily hip exercise regimen (extension and external rotation) immediately prior to both simulation imaging and daily treatment,...
Tue Nov 12, 2019 00:00
2491 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: medical science These pubmed results were generated on 2019/11/12PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Tue Nov 12, 2019 16:34
A kappa opioid receptor agonist is safe and effective for the treatment of pruritus associated with chronic kidney disease, researchers report.Medscape Medical News (Source: Medscape Allergy Headlines)
Tue Nov 12, 2019 06:19
Deviations from guidelines should be viewed not as an irregularity, but as individualized and human-oriented medicine, argues Talal Hilal, MD.Medscape Oncology (Source: Medscape Hematology-Oncology Headlines)
Tue Nov 12, 2019 21:51
New study suggests that a'threshold'of weight loss must be reached after bariatric surgery to see a reduced risk of obesity-related cancer. Another indicates risk may be reduced by around 20%.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Tue Nov 12, 2019 17:51
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