Abstract The present study is focused on the detailed foliar epidermal anatomy of some selected wild edible fruits (WEFs) from Pakistan using light microscopy (LM) and scanning electron microscopy (SEM). The studied species are Ficus racemosa L., Solanum nigrum L., Capparis spinosa L., Physalis divaricata D.Don, Rosa moschata Herrm. and Ribes orientale Desf. collected from various localities of Pakistan. The objective of the present study is to investigate qualitative and quantitative anatomical...
Tue Nov 12, 2019 12:04
Abstract The current study deals with the detailed morphology investigation of eight Cypsela species belonging to tribe Cichoreae. The different Cypsela types were described, explained, compared, and their taxonomic significance is discussed in detail. Light microscopy (LM) and scanning electron microscopy (SEM) have been used to highlight quantitative and qualitative characters of underestudied species. Cypsela exhibit great diversity in macro and micromorphological features such as shape,...
Tue Nov 12, 2019 11:53
Publication date: 1 January 2020Source: Molecular and Cellular Endocrinology, Volume 499Author(s):
Tue Nov 12, 2019 17:36
Child maltreatment has been linked to lower health, education, and income later in life, and is associated with increased engagement in delinquent or criminal behaviors. This paper explores trajectories of the...
Tue Nov 12, 2019 02:00
Dyslipidemia is a modifiable risk factor for cardiovascular disease (CVD). We investigated the prevalence and associated risk factors of dyslipidemia- raised total cholesterol (TC), raised triglycerides (TG), ...
Mon Nov 11, 2019 02:00
The burden of cervical cancer continues to rise in developing economies. Women in the sub-Saharan African region have higher chances of developing cervical cancer due to a greater prevalence of related risk fa...
Mon Nov 11, 2019 02:00
Bacille Calmette-Guérin (BCG) vaccination against tuberculosis (TB) is widespread in high-TB-burden countries, however, BCG vaccination policies in low-burden countries vary. Considering the uncertainties surr...
Mon Nov 11, 2019 02:00
Cyberbullying among children and adolescents is a major public health concern. However, research has not yet definitively identified the risk factors associated with cybervictimization. The purpose of this stu...
Mon Nov 11, 2019 02:00
Alpha-hemolysin of uropathogenic <i>Escherichia coli</i> induces GM-CSF-mediated acute kidney injury
Mucosal Immunology, Published online: 12 November 2019; doi:10.1038/s41385-019-0225-6Alpha-hemolysin of uropathogenic Escherichia coli induces GM-CSF-mediated acute kidney injury
Tue Nov 12, 2019 02:00
Mucosal Immunology, Published online: 12 November 2019; doi:10.1038/s41385-019-0223-8Anti-commensal Ig—from enormous diversity to clear function
Tue Nov 12, 2019 02:00
Nature, Published online: 13 November 2019; doi:10.1038/s41586-019-1699-9Author Correction: Maternal vitamin C regulates reprogramming of DNA methylation and germline development
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Nature, Published online: 13 November 2019; doi:10.1038/s41586-019-1697-yAuthor Correction: Metastatic-niche labelling reveals parenchymal cells with stem features
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Nature, Published online: 12 November 2019; doi:10.1038/d41586-019-03491-7Adam Levy talks to 2019 John Maddox Prize winner Bambang Hero Saharjo and Olivier Bernard, the Canadian pharmacist whose campaign against vitamin C injections for cancer patients earned him the early career stage prize.
Tue Nov 12, 2019 02:00
Nature, Published online: 12 November 2019; doi:10.1038/d41586-019-03486-4Ipshita Mandal-Johnson teamed up with other graduate students to set up an annual forum to develop tomorrow’s biotechnology leaders. This is what she learnt.
Tue Nov 12, 2019 02:00
Nature, Published online: 12 November 2019; doi:10.1038/d41586-019-03456-wA trawl through the global tide of cast-offs shows how we might avoid drowning in them. Edward Humes reviews.
Tue Nov 12, 2019 02:00
Nature, Published online: 12 November 2019; doi:10.1038/d41586-019-03457-9Andy Greenberg’s book Sandworm is trenchant on the mounting capacity of malware to wreak havoc. Brian Nussbaum reviews.
Tue Nov 12, 2019 02:00
Nature, Published online: 12 November 2019; doi:10.1038/d41586-019-03496-2Once thought lost to science, the silver-backed chevrotain has been spotted again. Plus, explore the gender gap in chemistry publishing and hear from the astronauts who crewed the first all-female spacewalk.
Tue Nov 12, 2019 02:00
Nature, Published online: 12 November 2019; doi:10.1038/d41586-019-03476-6A 150-year-old idea could hinder Suez Canal invasions
Tue Nov 12, 2019 02:00
Nature, Published online: 12 November 2019; doi:10.1038/d41586-019-03475-7Overhaul intensive farming systems to meet emissions goals
Tue Nov 12, 2019 02:00
Nature, Published online: 12 November 2019; doi:10.1038/d41586-019-03455-xEngineers are miniaturizing pharmaceutical production in the hope of making it portable and inexpensive.
Tue Nov 12, 2019 02:00
Nature, Published online: 12 November 2019; doi:10.1038/d41586-019-03474-8WHO sticks to 2020 governance plan for human-genome editing
Tue Nov 12, 2019 02:00
Nature, Published online: 12 November 2019; doi:10.1038/d41586-019-03490-8The drug, which has already been given to hundreds of thousands of people in the Democratic Republic of the Congo, can now be distributed more widely.
Tue Nov 12, 2019 02:00
Nature, Published online: 12 November 2019; doi:10.1038/d41586-019-03371-0The practice was probably used to improve the children’s chances of securing a university place.
Tue Nov 12, 2019 02:00
Nature, Published online: 12 November 2019; doi:10.1038/d41586-019-03430-6How Nature reported historic changes in medical practice in 1919, and call for doctors and nurses to receive computer training in 1969.
Tue Nov 12, 2019 02:00
Nature, Published online: 12 November 2019; doi:10.1038/d41586-019-03452-0Ebola uncovered policy flaws. A bioweapons treaty might show a fix, says Rebecca Katz.
Tue Nov 12, 2019 02:00
Nature, Published online: 12 November 2019; doi:10.1038/d41586-019-03466-8Research culture must be kinder for all, not just royalty
Tue Nov 12, 2019 02:00
Nature, Published online: 12 November 2019; doi:10.1038/d41586-019-03488-2Indigenous communities must be compensated for their knowledge and treated as equals in research.
Tue Nov 12, 2019 02:00
Nature Chemistry, Published online: 12 November 2019; doi:10.1038/s41557-019-0383-xAddendum: Synthesis and reactivity of precolibactin 886
Tue Nov 12, 2019 02:00
Nature Communications, Published online: 12 November 2019; doi:10.1038/s41467-019-12631-6Parks have a previously unquantified economic value attributable to mental health, a health services value. Here, the authors proposed three methods to estimate this, and applied one of these methods to show that this value is at least US$6 trillion per annum worldwide.
Tue Nov 12, 2019 02:00
Nature Communications, Published online: 12 November 2019; doi:10.1038/s41467-019-12882-3Assembly-Disassembly-Organization-Reassembly (ADOR) is a valuable method to prepare zeolites of predictable topologies, but has yet to be successfully applied on open framework zeolites. Here, the authors show that non-contact vapour-phase-transport rearrangement allows access to new zeolite topologies from open framework zeolites.
Tue Nov 12, 2019 02:00
Nature Communications, Published online: 12 November 2019; doi:10.1038/s41467-019-12832-zNon-small cell lung cancer (NSCLC) is often associated with metastasis to the lungs. Here, the authors perform independent screens and identify NuRD as a co-repressor of ZEB1, and demonstrate TBC1D2b as a downstream target of ZEB1/NuRD complex regulating NSCLC metastasis.
Tue Nov 12, 2019 02:00
Nature Communications, Published online: 12 November 2019; doi:10.1038/s41467-019-13171-9Specific sequences are essential for the development of cationic polymers that can adhere to negatively charged surfaces in saline environments. Here, the authors show that copolymers with adjacent cation–aromatic sequences can be synthesized through cation–π complex-aided free-radical polymerization, which exhibit fast, strong, but reversible adhesion.
Tue Nov 12, 2019 02:00
Nature Communications, Published online: 12 November 2019; doi:10.1038/s41467-019-13152-yTranscription and translation are coupled in bacteria. Here, the authors show that the movement of a gene locus to the nucleoid periphery correlates with transcription, and the effect is potentiated by translation.
Tue Nov 12, 2019 02:00
Nature Communications, Published online: 12 November 2019; doi:10.1038/s41467-019-13146-wN1-methyladenosine (m1A) was recently reported as a new mRNA modification but its prevalence has been controversial. Here the authors showed that m1A, if present in mRNA, is at very low stoichiometry, with the notable exception of MT-ND5. Further, they show that the previously reported enrichment of m1A near the start of transcripts are false-positive identifications due to cross-reactivity of the commonly used...
Tue Nov 12, 2019 02:00
Nature Communications, Published online: 12 November 2019; doi:10.1038/s41467-019-13109-1Warmer temperatures could increase the growth and metabolic rates of microbes. Here, the authors assemble a dataset of thermal performance curves for over 400 bacteria and archaea, showing that metabolic rates are likely to increase under warming, with implications for global carbon cycling.
Tue Nov 12, 2019 02:00
Nature Communications, Published online: 12 November 2019; doi:10.1038/s41467-019-12860-9Models of mate choice have mainly focused on the implications of female mate choice for reproductive isolation. Here, Aubier et al. develop a population genetic model of coevolution between female and male mate choice, which can lead the population to oscillate between assortative and random mating.
Tue Nov 12, 2019 02:00
Nature Communications, Published online: 12 November 2019; doi:10.1038/s41467-019-12958-0Sleep duration is associated with an adverse lipid profile. Here, the authors perform genome-wide gene-by-sleep interaction analysis and find 49 previously unreported lipid loci when considering short or long total sleep time.
Tue Nov 12, 2019 02:00
Nature Medicine, Published online: 12 November 2019; doi:10.1038/s41591-019-0662-5Author Correction: Reporting guidelines for clinical trials evaluating artificial intelligence interventions are needed
Tue Nov 12, 2019 02:00
Nature Neuroscience, Published online: 12 November 2019; doi:10.1038/s41593-019-0524-yZhou et al. show that the reward and context information of cocaine-associated memory is stored in selectively strengthened inter-engram connections from the ventral CA1 to the nucleus accumbens core, forming an ‘engram circuit’ that mediates memory recall.
Tue Nov 12, 2019 02:00
Nature Neuroscience, Published online: 12 November 2019; doi:10.1038/s41593-019-0540-yEmerging intersections between neuroscience and glioma biology
Tue Nov 12, 2019 02:00
Nature Reviews Drug Discovery, Published online: 12 November 2019; doi:10.1038/d41573-019-00195-5Five anti-cancer KRAS inhibitors, with three different modes of action, are in the clinic. More are on the way.
Tue Nov 12, 2019 02:00
Nature Reviews Drug Discovery, Published online: 12 November 2019; doi:10.1038/d41573-019-00194-6Vertex’s goal over much of the past decade has been on treating cystic fibrosis, targeting the dysfunctional CFTR chloride channel at the root of the disease. Following the speedy approval in October of its triple combination therapy Trikafta, nearly 90% of people with cystic fibrosis now stand to benefit from the firm’s CFTR potentiators and correctors. With this landmark success in hand — and the lucrative...
Tue Nov 12, 2019 02:00
Aim: The aim of this study was to evaluate the corticospinal tract (CST) diffusion profile in pure lower motor neuron disease (pLMND) patients who at baseline did not show any clinical or electrophysiological involvement of upper motor neurons (UMN), and in amyotrophic lateral sclerosis (ALS) patients. Materials and Methods: Fifteen ALS patients with delayed central motor conduction time (CMCT) and 14 pLMND patients with normal CMCT were enrolled together with 15 healthy controls. Fractional anisotropy...
Tue Nov 12, 2019 16:50
Introduction/Objective: In most cases, abnormal cardiac 123I-meta-iodobenzylguanidine (MIBG) scintigraphy increases the probability of a diagnosis of Parkinson’s disease (PD) in patients with parkinsonian features. In our study, we validated the additional value of 123I-MIBG scintigraphy beyond providing information on neurological findings and response to dopaminergic therapy for the diagnosis of PDin the early phase. Methods: We investigated 77 cases of PD (Hoehn and Yahr Stages I–III) and 73 cases...
Tue Nov 12, 2019 11:10
Publication date: Available online 11 November 2019Source: Neurobiology of DiseaseAuthor(s): Katalin Solti, Wei-Li Kuan, Balázs Fórizs, Gergely Kustos, Mihály Judith, Zoltán Varga, Balázs Herberth, Éva Moravcsik, Róbert Kiss, Manuela Kárpáti, Anna Mikes, Yanyan Zhao, Tímea Imre, Jean-Christophe Rochet, Franklin Aigbirhio, Caroline H. Williams-Gray, Roger A. Barker, Gergely TóthAbstractThe loss of native function of the DJ-1 protein has been linked to the development of Parkinson's (PD) and other...
Tue Nov 12, 2019 18:16
Publication date: Available online 12 November 2019Source: Neurochemistry InternationalAuthor(s): Utcharaporn Kamsrijai, Prapimpun Wongchitrat, Chutikorn Nopparat, Jutamaad Satayavivad, Piyarat GovitrapongAbstractDiabetes mellitus (DM) is increasingly recognized as a risk for developing of Alzheimer's disease (AD). Accordingly, it has been reported that melatonin level is disturbed in both DM and AD which indicates its involvement in the pathophysiology of these diseases. In this study, the neuroprotective...
Tue Nov 12, 2019 17:54
Publication date: Available online 11 November 2019Source: Neuroimaging Clinics of North AmericaAuthor(s): Suresh K. Mukherji
Tue Nov 12, 2019 11:03
Publication date: Available online 11 November 2019Source: Neuroimaging Clinics of North AmericaAuthor(s): Elena I. Ivleva, Halide B. Turkozer, John A. Sweeney
Tue Nov 12, 2019 11:03
Publication date: Available online 11 November 2019Source: Neuroimaging Clinics of North AmericaAuthor(s): Hesheng Liu, William J. Liu, Danhong Wang, Louisa Dahmani
Tue Nov 12, 2019 11:03
Publication date: Available online 11 November 2019Source: Neuroimaging Clinics of North AmericaAuthor(s): Jessica B. Girault, Joseph Piven
Tue Nov 12, 2019 11:03
Publication date: Available online 11 November 2019Source: Neuroimaging Clinics of North AmericaAuthor(s): Qiyong Gong
Tue Nov 12, 2019 11:03
Publication date: Available online 11 November 2019Source: Neuroimaging Clinics of North AmericaAuthor(s): Matcheri S. Keshavan, Guusje Collin, Synthia Guimond, Sinead Kelly, Konasale M. Prasad, Paulo Lizano
Tue Nov 12, 2019 11:03
Publication date: Available online 11 November 2019Source: Neuroimaging Clinics of North AmericaAuthor(s): Anouk Schrantee, Henricus Gerardus Ruhé, Liesbeth Reneman
Tue Nov 12, 2019 11:03
Mental health is becoming a public health priority worldwide. Anorexia nervosa and autism spectrum disorders are 2 important types of childhood disorders with a bad prognosis. They share cognitive impairments and, in both cases, the microbiota appears to be a crucial factor. Alteration of the microbiota-gut-brain axis is an appealing hypothesis to define new pathophysiological mechanisms. Mucosal immunity plays a key role between the microbiota and the brain. The mucosal immune system receives and...
Tue Nov 12, 2019 17:11
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Tue Nov 12, 2019 14:15
Viruses, Vol. 11, Pages 1052: Characterization of Brain Inflammation, Apoptosis, Hypoxia, Blood-Brain Barrier Integrity and Metabolism in Venezuelan Equine Encephalitis Virus (VEEV TC-83) Exposed Mice by In Vivo Positron Emission Tomography Imaging Viruses doi: 10.3390/v11111052 Authors: Thomas M. Bocan Robert G. Stafford Jennifer L. Brown Justice Akuoku Frimpong Falguni Basuli Bradley S. Hollidge Xiang Zhang Natarajan Raju Rolf E. Swenson Darci R. Smith Traditional...
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Viruses, Vol. 11, Pages 1051: Detection and Cellular Tropism of Porcine Astrovirus Type 3 on Breeding Farms Viruses doi: 10.3390/v11111051 Authors: Gaurav Rawal Franco Matias Ferreyra Nubia R. Macedo Laura K. Bradner Karen M. Harmon Adam Mueller Grant Allison Daniel C. L. Linhares Bailey L. Arruda Astroviruses cause disease in a variety of species. Yet, little is known about the epidemiology of a majority of astroviruses including porcine astrovirus type 3 (PoAstV3),...
Tue Nov 12, 2019 02:00
Background: The treatment of kidney cancer usually involves surgery, and in some cases systemic therapy. Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used to control postsurgical pain in patients undergoing nephrectomy for renal cancer. Nevertheless, the association between these drugs and adverse postsurgical outcomes, including deterioration of renal function, is not fully established. Methods: This retrospective cohort study included patients #x3e;18 years old with kidney cancer...
Tue Nov 12, 2019 17:00
Publication date: Available online 11 November 2019Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): Shivani Shah-BeckerMost benign tumors of the larynx are epithelial in origin, with nearly 85% being laryngeal papilloma. Nonepithelial laryngeal tumors are uncommon and more than 50% of these are malignant. Therefore, benign nonepithelial solid tumors of the larynx are quite rare. The management of these tumors varies based on the site of origin, specific pathology, tumor...
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Publication date: Available online 8 November 2019Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): Ashley P. O'Connell FersterThe use of lasers in laryngology has evolved over the last several decades. With improving optics, instrumentation, and applications for treatment, lasers are now routinely used during laryngeal surgery performed in both the operating room and clinic settings. A variety of laser types, including carbon dioxide (CO2), potassium-titanyl-phosphate...
Sun Nov 10, 2019 01:09
Publication date: Available online 8 November 2019Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): Bridget D. Burgess, Simon Best, Alexander Hillel, Lee AkstVascular lesions of the larynx are those created by phonotrauma resulting in subepithelial bleeding. These are typically divided into 2 categories, hemorrhagic polyps and fibrovascular lesions (vocal nodules). Both of these types of lesions can disrupt the natural vibration of the vocal folds and cause dysphonia....
Sun Nov 10, 2019 01:09
ConclusionConsequently a combination of one microplate and one miniplate is efficient for the management of isolated parasymphyseal mandibular fracture in the same way as two miniplates. (Source: Oral and Maxillofacial Surgery)
Tue Nov 12, 2019 00:00
ConclusionsClinical work-up is necessary to look for a cause of a spontaneous sublingual hematoma. Idiopathic spontaneous hematoma is only a rare entity. Aggressive airway management should be the first step in treatment. To date, there is no consensus about the management regarding the hematoma itself. Mostly, clinicians start with observation for spontaneous resolution of the hematoma and when possible to treat causative factors. Surgical drainage is performed when conservative treatment is not...
Tue Nov 12, 2019 00:00
Background: Distant metastasis of esophageal cancer (EC) is prone to be neglected, so it is necessary to screen out the high-risk population for more sensitive and rigorous pretreatment imaging evaluations. Objective: The aim of this study was to evaluate the risk factors for distant metastasis in patients with EC and to construct a clinical nomogram. Methods: Eligible patients diagnosed from 2010 to 2015 were selected from the Surveillance, Epidemiology and End Results (SEER) database. Multivariable...
Tue Nov 12, 2019 11:29
The prognostic value of the immune cell infiltrate in the breast carcinoma microenvironment is still uncertain. We reviewed published articles analysing the infiltration of inflammatorycells in the microenvironment of breast carcinoma. Data revealed the importance of infiltration of these immune cells in the prognosis of breast carcinoma, particularly the triple-negative and HER2-positive phenotypes. Tumour-infiltrating lymphocytes and their subtypes play a fundamental role in predicting the pathological...
Tue Nov 12, 2019 16:46
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