Antibiotics, Vol. 9, Pages 395: Anti-Candida Activity of Essential Oils from Lamiaceae Plants from the Mediterranean Area and the Middle East Antibiotics doi: 10.3390/antibiotics9070395 Authors: Potente Bonvicini Gentilomi Antognoni Extensive documentation is available on plant essential oils as a potential source of antimicrobials, including natural drugs against Candida spp. Yeasts of the genus Candida are responsible for various clinical manifestations, from mucocutaneous...
Thu Jul 09, 2020 03:00
Antibiotics, Vol. 9, Pages 392: Oxytetracycline Pharmacokinetics After Intramuscular Administration in Cows with Clinical Metritis Associated with Trueperella Pyogenes Infection Antibiotics doi: 10.3390/antibiotics9070392 Authors: Rositsa Mileva Manol Karadaev Ivan Fasulkov Tsvetelina Petkova Nikolina Rusenova Nasko Vasilev Aneliya Milanova Systemic therapy with oxytetracycline is often used for treatment of clinical metritis although data about its penetration into...
Thu Jul 09, 2020 03:00
Antibiotics, Vol. 9, Pages 394: Ocotea glomerata (Nees) Mez Extract and Fractions: Chemical Characterization, Anti-Candida Activity and Related Mechanism of Action Antibiotics doi: 10.3390/antibiotics9070394 Authors: Mayara Nunes Vitor Anjos Luiz Nascimento de Araújo-Neto Maria Daniela Silva Buonafina Rejane Pereira Neves Edson Rubhens de Souza Isabelle Cristinne Ferraz Bezerra Magda Rhayanny Assunção Ferreira Luiz Alberto Lira Soares Henrique Douglas Melo Coutinho...
Thu Jul 09, 2020 03:00
Antibiotics, Vol. 9, Pages 393: Augmented Renal Clearance and How to Augment Antibiotic Dosing Antibiotics doi: 10.3390/antibiotics9070393 Authors: Iris H. Chen David P. Nicolau Augmented renal clearance (ARC) refers to the state of heightened renal filtration commonly observed in the critically ill. Its prevalence in this patient population is a consequence of the body’s natural response to serious disease, as well as the administration of fluids and pharmacologic therapies...
Thu Jul 09, 2020 03:00
Antioxidants, Vol. 9, Pages 598: MZe786 Rescues Cardiac Mitochondrial Activity in High sFlt-1 and Low HO-1 Environment Antioxidants doi: 10.3390/antiox9070598 Authors: Lissette Carolina Sanchez-Aranguren Homira Rezai Shakil Ahmad Faisal A. Alzahrani Anna Sparatore Keqing Wang Asif Ahmed Hypertensive disorder in pregnancy is a major cause of maternal and perinatal mortality worldwide. Women who have had preeclampsia are at three to four times higher risk in later life...
Thu Jul 09, 2020 03:00
Antioxidants, Vol. 9, Pages 600: N-Acetylcysteine Nanocarriers Protect against Oxidative Stress in a Cellular Model of Parkinson’s Disease Antioxidants doi: 10.3390/antiox9070600 Authors: Leah Mursaleen Brendon Noble Stefanie Ho Yi Chan Satyanarayana Somavarapu Mohammed Gulrez Zariwala Oxidative stress is a key mediator in the development and progression of Parkinson’s disease (PD). The antioxidant n-acetylcysteine (NAC) has generated interest as a disease-modifying...
Thu Jul 09, 2020 03:00
Antioxidants, Vol. 9, Pages 599: Inhibition of HDAC6 Attenuates Diabetes-Induced Retinal Redox Imbalance and Microangiopathy Antioxidants doi: 10.3390/antiox9070599 Authors: Hossameldin Abouhish Menaka C. Thounaojam Ravirajsinh N. Jadeja Diana R. Gutsaeva Folami L. Powell Mohamed Khriza Pamela M. Martin Manuela Bartoli We investigated the contributing role of the histone deacetylase 6 (HDAC6) to the early stages of diabetic retinopathy (DR). Furthermore, we examined...
Thu Jul 09, 2020 03:00
Antioxidants, Vol. 9, Pages 601: Adelmidrol: A New Promising Antioxidant and Anti-Inflammatory Therapeutic Tool in Pulmonary Fibrosis Antioxidants doi: 10.3390/antiox9070601 Authors: Roberta Fusco Marika Cordaro Tiziana Genovese Daniela Impellizzeri Rosalba Siracusa Enrico Gugliandolo Alessio Filippo Peritore Ramona D’Amico Rosalia Crupi Salvatore Cuzzocrea Rosanna Di Paola Background: Chronic pulmonary diseases are characterized by airway remodeling due...
Thu Jul 09, 2020 03:00
Arts, Vol. 9, Pages 76: The Contribution of the Architect Pascuala Campos to the Implementation of a Gender Perspective in the Galician Context Arts doi: 10.3390/arts9030076 Authors: Fernández Cruces Sousa Guerreiro Correia The incorporation of women in society, as active professionals, was probably one of the most important parameters of modernity in the last century. Until the beginning of the twentieth century, women who entered the world of architecture were, generally,...
Thu Jul 09, 2020 03:00
Arts, Vol. 9, Pages 77: The Past and the Future Are Now Arts doi: 10.3390/arts9030077 Authors: Sascha T. Scott Amy Lonetree On 20 June 1918, Crescencio Martinez (Ta’e), a painter and pottery designer from San Ildefonso Pueblo, died of influenza [...]
Thu Jul 09, 2020 03:00
Biology, Vol. 9, Pages 160: Insight into the Role of Dental Pulp Stem Cells in Regenerative Therapy Biology doi: 10.3390/biology9070160 Authors: Shinichiro Yoshida Atsushi Tomokiyo Daigaku Hasegawa Sayuri Hamano Hideki Sugii Hidefumi Maeda Mesenchymal stem cells (MSCs) have the capacity for self-renewal and multilineage differentiation potential, and are considered a promising cell population for cell-based therapy and tissue regeneration. MSCs are isolated from various...
Thu Jul 09, 2020 03:00
Biomedicines, Vol. 8, Pages 203: Trained Immunity Based-Vaccines as a Prophylactic Strategy in Common Variable Immunodeficiency. A Proof of Concept Study Biomedicines doi: 10.3390/biomedicines8070203 Authors: Kissy Guevara-Hoyer Paula Saz-Leal Carmen M. Diez-Rivero Juliana Ochoa-Grullón Miguel Fernández-Arquero Rebeca Pérez de Diego Silvia Sánchez-Ramón Background. A major concern in the care of common variable immunodeficiency (CVID) patients is the persistence of...
Thu Jul 09, 2020 03:00
Biomedicines, Vol. 8, Pages 202: Managing Ectopic Pregnancies by Targeting Chorionic Villi with a Transvaginal Injection of Ethanol into the Lacunar Space Biomedicines doi: 10.3390/biomedicines8070202 Authors: Hisao Osada Shokichi Teramoto Hirotsune Kaijima Tomoya Segawa Masaji Nagaishi Makio Shozu Keiichi Kato Methotrexate has been the main mode of non-surgical treatment for ectopic pregnancies. However, we have developed an easier, repeatable method that can be applied...
Thu Jul 09, 2020 03:00
Biomimetics, Vol. 5, Pages 33: Promises and Presuppositions of Biomimicry Biomimetics doi: 10.3390/biomimetics5030033 Authors: Rebecca Barbara MacKinnon Jeroen Oomen Maibritt Pedersen Zari Under the umbrella of biologically informed disciplines, biomimicry is a design methodology that proponents often assert will lead to a more sustainable future. In realizing that future, it becomes necessary to discern specifically what biomimicry’s “promises”...
Thu Jul 09, 2020 03:00
Biomolecules, Vol. 10, Pages 1021: Apoptosis-Inducing Factor, Mitochondrion-Associated 3 (AIFM3) Protein Level in the Sera as a Prognostic Marker of Cholangiocarcinoma Patients Biomolecules doi: 10.3390/biom10071021 Authors: Daraporn Chua-on Tanakorn Proungvitaya Doungdean Tummanatsakun Anchalee Techasen Temduang Limpaiboon Sittiruk Roytrakul Sopit Wongkham Chaisiri Wongkham Ongart Somintara Sakkarn Sangkhamanon Siriporn Proungvitaya Prognosis of cholangiocarcinoma...
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Biomolecules, Vol. 10, Pages 1020: Starch and Glycogen Analyses: Methods and Techniques Biomolecules doi: 10.3390/biom10071020 Authors: Brust Orzechowski Fettke For complex carbohydrates, such as glycogen and starch, various analytical methods and techniques exist allowing the detailed characterization of these storage carbohydrates. In this article, we give a brief overview of the most frequently used methods, techniques, and results. Furthermore, we give insights in the isolation,...
Thu Jul 09, 2020 03:00
Biomolecules, Vol. 10, Pages 1019: Extraction of Carotenoids from Tomato Pomace via Water-Induced Hydrocolloidal Complexation Biomolecules doi: 10.3390/biom10071019 Authors: Jayesree Nagarajan Hang Pui Kay Nagendra Prasad Krishnamurthy Nagasundara Ramanan Ramakrishnan Turki M. S. Aldawoud Charis M. Galanakis Ooi Chien Wei Agro-industrial waste is a largely untapped natural resource of bioactive compounds including carotenoids and pectin. However, conventional solvent...
Thu Jul 09, 2020 03:00
Biomolecules, Vol. 10, Pages 1018: Alternaria alternata Toxins Synergistically Activate the Aryl Hydrocarbon Receptor Pathway In Vitro Biomolecules doi: 10.3390/biom10071018 Authors: Julia Hohenbichler Georg Aichinger Michael Rychlik Giorgia Del Favero Doris Marko Alternaria molds simultaneously produce a large variety of mycotoxins, of which several were previously reported to induce enzymes of phase I metabolism through aryl hydrocarbon receptor activation. Thus, we investigated...
Thu Jul 09, 2020 03:00
Biomolecules, Vol. 10, Pages 1017: The Regulatory Role of IL-10 in Neurodegenerative Diseases Biomolecules doi: 10.3390/biom10071017 Authors: Chiara Porro Antonia Cianciulli Maria Antonietta Panaro IL-10, an immunosuppressive cytokine, is considered an important anti-inflammatory modulator of glial activation, preventing inflammation-mediated neuronal degeneration under pathological conditions. In this narrative review, we summarize recent insights about the role of IL-10 in the...
Thu Jul 09, 2020 03:00
Biomolecules, Vol. 10, Pages 1016: Dopamine D3 Receptor Heteromerization: Implications for Neuroplasticity and Neuroprotection Biomolecules doi: 10.3390/biom10071016 Authors: Federica Bono Veronica Mutti Chiara Fiorentini Cristina Missale The dopamine (DA) D3 receptor (D3R) plays a pivotal role in the control of several functions, including motor activity, rewarding and motivating behavior and several aspects of cognitive functions. Recently, it has been reported that the D3R...
Thu Jul 09, 2020 03:00
Biomolecules, Vol. 10, Pages 1015: The Interaction of Temozolomide with Blood Components Suggests the Potential Use of Human Serum Albumin as a Biomimetic Carrier for the Drug Biomolecules doi: 10.3390/biom10071015 Authors: Marta Rubio-Camacho José A. Encinar María José Martínez-Tomé Rocío Esquembre C. Reyes Mateo The interaction of temozolomide (TMZ) (the main chemotherapeutic agent for brain tumors) with blood components has not been studied at the molecular level to date,...
Thu Jul 09, 2020 03:00
Biosensors, Vol. 10, Pages 77: Overview of Recent Advances in the Design of Plasmonic Fiber-Optic Biosensors Biosensors doi: 10.3390/bios10070077 Authors: Yashar Esfahani Monfared Plasmonic fiber-optic biosensors combine the flexibility and compactness of optical fibers and high sensitivity of nanomaterials to their surrounding medium, to detect biological species such as cells, proteins, and DNA. Due to their small size, accuracy, low cost, and possibility of remote and distributed...
Thu Jul 09, 2020 03:00
Biosensors, Vol. 10, Pages 76: Screen-Printed Electrodes: Promising Paper and Wearable Transducers for (Bio)Sensing Biosensors doi: 10.3390/bios10070076 Authors: Paloma Yáñez-Sedeño Susana Campuzano José Manuel Pingarrón Screen-printing technology has revolutionized many fields, including that of electrochemical biosensing. Due to their current relevance, this review, unlike other papers, discusses the relevant aspects of electrochemical biosensors manufactured using this technology...
Thu Jul 09, 2020 03:00
Brain Sciences, Vol. 10, Pages 437: Brain Opioid Activity and Oxidative Injury: Different Molecular Scenarios Connecting Celiac Disease and Autistic Spectrum Disorder Brain Sciences doi: 10.3390/brainsci10070437 Authors: Diana Di Liberto Antonella D’Anneo Daniela Carlisi Sonia Emanuele Anna De Blasio Giuseppe Calvaruso Michela Giuliano Marianna Lauricella Celiac Disease (CD) is an immune-mediated disease triggered by the ingestion of wheat gliadin and related prolamins...
Thu Jul 09, 2020 03:00
Brain Sciences, Vol. 10, Pages 436: Effective Strategies for Managing COVID-19 Emergency Restrictions for Adults with Severe ASD in a Daycare Center in Italy Brain Sciences doi: 10.3390/brainsci10070436 Authors: Natascia Brondino Stefano Damiani Pierluigi Politi The COVID-19 pandemic has posed a serious challenge for the life and mental health of people with autism spectrum disorder (ASD). COVID-19 sanitary restrictions led to significant changes in the lives of people with ASD,...
Thu Jul 09, 2020 03:00
Cancers, Vol. 12, Pages 1853: Molecular Basis of Mismatch Repair Protein Deficiency in Tumors from Lynch Suspected Cases with Negative Germline Test Results Cancers doi: 10.3390/cancers12071853 Authors: Alisa Olkinuora Annette Gylling Henrikki Almusa Samuli Eldfors Anna Lepistö Jukka-Pekka Mecklin Taina Tuulikki Nieminen Päivi Peltomäki Some 10–50% of Lynch-suspected cases with abnormal immunohistochemical (IHC) staining remain without any identifiable...
Thu Jul 09, 2020 03:00
Cancers, Vol. 12, Pages 1854: Glutamic-Pyruvic Transaminase 1 Facilitates Alternative Fuels for Hepatocellular Carcinoma Growth—A Small Molecule Inhibitor, Berberine Cancers doi: 10.3390/cancers12071854 Authors: Wei Guo Hor-Yue Tan Sha Li Ning Wang Yibin Feng Metabolic reprogramming is an essential hallmark of cancer. Besides the “Warburg effect”, cancer cells also actively reprogram amino acid metabolism to satisfy high nutritional demands in a nutrient-poor...
Thu Jul 09, 2020 03:00
Cancers, Vol. 12, Pages 1849: The Role of Dysfunctional Adipose Tissue in Pancreatic Cancer: A Molecular Perspective Cancers doi: 10.3390/cancers12071849 Authors: Davide Brocco Rosalba Florio Laura De Lellis Serena Veschi Antonino Grassadonia Nicola Tinari Alessandro Cama Pancreatic cancer (PC) is a lethal malignancy with rising incidence and limited therapeutic options. Obesity is a well-established risk factor for PC development. Moreover, it negatively affects outcome...
Thu Jul 09, 2020 03:00
Cancers, Vol. 12, Pages 1851: Desmoid-Type Fibromatosis Cancers doi: 10.3390/cancers12071851 Authors: Dorian Yarih Garcia-Ortega Karla Susana Martín-Tellez Mario Cuellar-Hubbe Héctor Martínez-Said Alethia Álvarez-Cano Moises Brener-Chaoul Jorge Adán Alegría-Baños Jorge Luis Martínez-Tlahuel Desmoid tumors represent a rare entity of monoclonal origin characterized by locally aggressive behavior and inability to metastasize. Most cases present in a sporadic pattern...
Thu Jul 09, 2020 03:00
Cancers, Vol. 12, Pages 1850: Gas6/Axl Signaling Pathway in the Tumor Immune Microenvironment Cancers doi: 10.3390/cancers12071850 Authors: Mai Tanaka Dietmar W. Siemann Receptor tyrosine kinases have been shown to dysregulate a number of pathways associated with tumor development, progression, and metastasis. Axl is a receptor tyrosine kinase expressed in many cancer types and has been associated with therapy resistance and poor clinical prognosis and outcomes. In addition, Axl and...
Thu Jul 09, 2020 03:00
Cancers, Vol. 12, Pages 1852: A Comprehensive Review of Cancer MicroRNA Therapeutic Delivery Strategies Cancers doi: 10.3390/cancers12071852 Authors: Alexis Forterre Hiroaki Komuro Shakhlo Aminova Masako Harada In the field of molecular oncology, microRNAs (miRNAs) and their role in regulating physiological processes and cancer pathogenesis have been a revolutionary discovery over the last decade. It is now considered that miRNA dysregulation influences critical molecular pathways...
Thu Jul 09, 2020 03:00
Cancers, Vol. 12, Pages 1848: Clinical and Molecular Assessment of Patients with Lynch Syndrome and Sarcomas Underpinning the Association with MSH2 Germline Pathogenic Variants Cancers doi: 10.3390/cancers12071848 Authors: Nathália de Angelis de Carvalho Bianca Naomi Niitsuma Vanessa Nascimento Kozak Felipe D’almeida Costa Mariana Petaccia de Macedo Bruna Elisa Catin Kupper Maria Letícia Gobo Silva Maria Nirvana Formiga Sahlua Miguel Volc Samuel Aguiar Junior Edenir...
Thu Jul 09, 2020 03:00
Cancers, Vol. 12, Pages 1847: Correlation of MET and PD-L1 Expression in Malignant Melanoma Cancers doi: 10.3390/cancers12071847 Authors: Kyu Young Song Sabina Desar Thomas Pengo Ryan Shanley Alessio Giubellino The proto-oncogene MET, the hepatocyte growth factor (HGF) receptor, is a transmembrane receptor tyrosine kinase (RTK) with a prominent role in tumor metastasis and resistance to anti-cancer therapies. Melanoma demonstrates relatively frequent MET aberrations, including...
Thu Jul 09, 2020 03:00
Cancers, Vol. 12, Pages 1846: Comprehensive Assessment of TERT mRNA Expression across a Large Cohort of Benign and Malignant Thyroid Tumours Cancers doi: 10.3390/cancers12071846 Authors: Ana Pestana Rui Batista Ricardo Celestino Sule Canberk Manuel Sobrinho-Simões Paula Soares The presence of TERT promoter (TERTp) mutations in thyroid cancer have been associated with worse prognosis features, whereas the extent and meaning of the expression and activation of TERT in thyroid...
Thu Jul 09, 2020 03:00
Cells, Vol. 9, Pages 1659: “The Social Network” and Muscular Dystrophies: The Lesson Learnt About the Niche Environment as a Target for Therapeutic Strategies Cells doi: 10.3390/cells9071659 Authors: Cappellari Mantuano De Luca The muscle stem cells niche is essential in neuromuscular disorders. Muscle injury and myofiber death are the main triggers of muscle regeneration via satellite cell activation. However, in degenerative diseases such as muscular dystrophy, regeneration...
Thu Jul 09, 2020 03:00
Cells, Vol. 9, Pages 1657: Regulation of Error-Prone DNA Double-Strand Break Repair and Its Impact on Genome Evolution Cells doi: 10.3390/cells9071657 Authors: Terrence Hanscom Mitch McVey Double-strand breaks are one of the most deleterious DNA lesions. Their repair via error-prone mechanisms can promote mutagenesis, loss of genetic information, and deregulation of the genome. These detrimental outcomes are significant drivers of human diseases, including many cancers. Mutagenic...
Thu Jul 09, 2020 03:00
Cells, Vol. 9, Pages 1655: Regorafenib Regulates AD Pathology, Neuroinflammation, and Dendritic Spinogenesis in Cells and a Mouse Model of AD Cells doi: 10.3390/cells9071655 Authors: Kyung-Min Han Ri Jin Kang Hyongjun Jeon Hyun-ju Lee Ji-Soo Lee HyunHee Park Seong Gak Jeon Kyoungho Suk Jinsoo Seo Hyang-Sook Hoe The oral multi-target kinase inhibitor regorafenib, which targets the oncogenic receptor tyrosine kinase (RTK), is an effective therapeutic for patients...
Thu Jul 09, 2020 03:00
Cells, Vol. 9, Pages 1656: The Janus Face of p53-Targeting Ubiquitin Ligases Cells doi: 10.3390/cells9071656 Authors: Hao Chen Zhou The tumor suppressor p53 prevents tumorigenesis and cancer progression by maintaining genomic stability and inducing cell growth arrest and apoptosis. Because of the extremely detrimental nature of wild-type p53, cancer cells usually mutate the TP53 gene in favor of their survival and propagation. Some of the mutant p53 proteins not only lose the...
Thu Jul 09, 2020 03:00
Cells, Vol. 9, Pages 1658: Identifying the Structural Adaptations that Drive the Mechanical Load-Induced Growth of Skeletal Muscle: A Scoping Review Cells doi: 10.3390/cells9071658 Authors: Kent W. Jorgenson Stuart M. Phillips Troy A. Hornberger The maintenance of skeletal muscle mass plays a critical role in health and quality of life. One of the most potent regulators of skeletal muscle mass is mechanical loading, and numerous studies have led to a reasonably clear understanding...
Thu Jul 09, 2020 03:00
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