RSK inhibitor BI-D1870 inhibits acute myeloid leukemia cell proliferation by targeting mitotic exit.
Related Articles RSK inhibitor BI-D1870 inhibits acute myeloid leukemia cell proliferation by targeting mitotic exit. Oncotarget. 2020 Jun 23;11(25):2387-2403 Authors: Chae HD, Dutta R, Tiu B, Hoff FW, Accordi B, Serafin V, Youn M, Huang M, Sumarsono N, Davis KL, Lacayo NJ, Pigazzi M, Horton TM, Kornblau SM, Sakamoto KM Abstract The 90 kDa Ribosomal S6 Kinase (RSK) drives cell proliferation and survival in cancers, although its oncogenic...
Thu Jul 09, 2020 16:09
Related Articles Bacteriome and mycobiome and bacteriome-mycobiome interactions in head and neck squamous cell carcinoma. Oncotarget. 2020 Jun 23;11(25):2375-2386 Authors: Shay E, Sangwan N, Padmanabhan R, Lundy S, Burkey B, Eng C Abstract The etiology of head and neck squamous cell carcinoma (HNSCC) is not fully understood. While risk factors such as positive human papilloma virus (HPV) status, smoking and tobacco use have been identified,...
Thu Jul 09, 2020 16:09
Related Articles MYC'xing it up: zebrafish B ALL models provide insight into MYC-driven disease and relapse. Oncotarget. 2020 Jun 23;11(25):2372-2374 Authors: da Bandeira DS, Clements WK PMID: 32637028 [PubMed]
Thu Jul 09, 2020 16:09
Related Articles Sclerotherapy for atypical oral manifestation of Cowden syndrome. Oral Surg Oral Med Oral Pathol Oral Radiol. 2020 Jun 10;: Authors: Cherkas E, Champion AF, Gates JC Abstract Cowden syndrome is an autosomal dominant disorder characterized by hamartomas, as well as benign and malignant neoplasms that may present in organ systems throughout the body. It also poses an increased lifetime cancer risk in those with the disorder....
Thu Jul 09, 2020 14:24
Related Articles Iatrogenic cervicofacial emphysema after dental procedures: a case series and radiographic review. Oral Surg Oral Med Oral Pathol Oral Radiol. 2020 Jun 17;: Authors: Michel J, Aiken A, Abramowicz S PMID: 32636167 [PubMed - as supplied by publisher]
Thu Jul 09, 2020 14:24
Related Articles Is peripheral cortication of intraosseous lesions accurately displayed on panoramic radiography? Oral Surg Oral Med Oral Pathol Oral Radiol. 2020 Jun 17;: Authors: Gaêta-Araujo H, Moreira-Souza L, Asprino L, Oliveira-Santos C Abstract OBJECTIVE: The aim of this study was to calculate the sensitivity, specificity, and positive and negative predictive values (PPV and NPV) for the detection of the presence and continuity of...
Thu Jul 09, 2020 14:24
Related Articles Pathophysiology of Hyperkalemia Presenting as Brugada Pattern on Electrocardiogram (ECG). Am J Case Rep. 2020 Jul 08;21:e923464 Authors: Doty B, Kim E, Phelps J, Akpunonu P Abstract BACKGROUND Brugada phenocopies (BrP) are clinical and electrocardiographic (ECG) entities elicited by reversible medical conditions speculated to have pathogenesis rooted in ion current imbalances or conduction delays within the myocardial wall....
Thu Jul 09, 2020 14:40
An Unusual Case of a Filshie Clip Presenting as a Bladder Wall Abscess 12 Years After Sterilization.
Related Articles An Unusual Case of a Filshie Clip Presenting as a Bladder Wall Abscess 12 Years After Sterilization. Am J Case Rep. 2020 Jul 07;21:e923661 Authors: Poo ZX, Ng G, Siraj SHM Abstract BACKGROUND There is growing evidence suggesting that Filshie clip migration is a rare but significant late complication following tubal sterilization. Although most women are asymptomatic, clip migration can result in serious morbidity such as abscess...
Thu Jul 09, 2020 14:40
Related Articles Paraplegia Caused by Spontaneous Spinal Hemorrhage in a Patient Undergoing Rivaroxaban Therapy. Am J Case Rep. 2020 Jul 07;21:e923607 Authors: Feret WB, Kwiatkowska E, Domański L Abstract BACKGROUND Spinal hematomas can be post-traumatic, iatrogenic, or spontaneous. A spontaneous spinal hematoma is a rare finding, but one with very serious clinical implications. There are some risk factors linked to its occurrence, e.g. arteriovenous...
Thu Jul 09, 2020 14:40
Related Articles A Cancer Gene Module Mining Method Based on Bio-Network of Multi-Omics Gene Groups. Front Oncol. 2020;10:1159 Authors: Wang C, Zhao N, Sun K, Zhang Y Abstract The initiation, promotion and progression of cancer are highly associated to the environment a human lives in as well as individual genetic factors. In view of the dangers to life and health caused by this abnormally complex systemic disease, many top scientific research...
Thu Jul 09, 2020 15:24
Related Articles Long-Term Survival of Patients With Chemotherapy-Naïve Metastatic Nasopharyngeal Carcinoma Receiving Cetuximab Plus Docetaxel and Cisplatin Regimen. Front Oncol. 2020;10:1011 Authors: Zhang M, Huang H, Li X, Huang Y, Chen C, Fang X, Wang Z, Guo C, Lam S, Fu X, Hong H, Tian Y, Lu T, Lin T Abstract Purpose: Metastatic nasopharyngeal carcinoma (mNPC) remains incurable. This prospective study aimed to investigate whether adding...
Thu Jul 09, 2020 15:24
Related Articles Breast Cancer With a HER2 IHC2+ and FISH HER2/CEP17 Ratio ≥2.0 and an Average HER2 Gene Copy Number <4.0 per Tumor Cell: HER2 mRNA Overexpression Is a Rare Event. Front Oncol. 2020;10:985 Authors: Liu Y, Wu S, Shi X, Mao F, Zeng X Abstract Purpose: For breast cancer, accurately illustrating HER2 characteristics is a critical precondition for evaluating the prognosis and predicting the efficacy of anti-HER2 therapy. Our purpose...
Thu Jul 09, 2020 15:24
Related Articles A Novel Splice-Site Mutation in MSH2 Is Associated With the Development of Lynch Syndrome. Front Oncol. 2020;10:983 Authors: Li J, Li Y, Ni H, Yang Z, Chen J, Li Y, Ding S, Jiang X, Wang M, Li L, Lv X, Ruan X, Jiang Q, Lei Z, Cheng Y, Huang J, Deng A Abstract Lynch syndrome (LS) is an inherited autosomal dominant disorder caused by germline mutations of mismatch repair (MMR) genes, including MSH2, MSH6, PMS2, and MLH1. This...
Thu Jul 09, 2020 15:24
Related Articles The Distinction of Clinicopathological Characteristics, Treatment Strategy and Outcome in Colorectal Cancer Patients With Synchronous vs. Metachronous Bone Metastasis. Front Oncol. 2020;10:974 Authors: Ma CX, Guan X, Wei R, Wang S, Quan JC, Zhao ZX, Chen HP, Liu Z, Jiang Z, Wang XS Abstract Background: The impact of the timing of bone metastasis (BM) diagnosis on colorectal cancer (CRC) patients is unclear. Our study aimed to...
Thu Jul 09, 2020 15:24
Related Articles Applying Amide Proton Transfer-Weighted Imaging (APTWI) to Distinguish Papillary Thyroid Carcinomas and Predominantly Solid Adenomatous Nodules: Comparison With Diffusion-Weighted Imaging. Front Oncol. 2020;10:918 Authors: Li G, Jiang G, Mei Y, Gao P, Liu R, Jiang M, Zhao Y, Li M, Wu Y, Fu S, Liu M, Li L, Li W, Yan J Abstract Background: Amide proton transfer-weighted (ATPw) imaging is a novel MRI technique that has been used...
Thu Jul 09, 2020 15:24
Related Articles Genomics of Peripheral T-Cell Lymphoma and Its Implications for Personalized Medicine. Front Oncol. 2020;10:898 Authors: Zhang Y, Lee D, Brimer T, Hussaini M, Sokol L Abstract Peripheral T-cell lymphoma (PTCL) is a rare, heterogenous group of mature T-cell neoplasms that comprise 10-15% of non-Hodgkin lymphoma cases in the United States. All subtypes of PTCL, except for ALK+ anaplastic T-cell lymphoma, are associated with poor...
Thu Jul 09, 2020 15:24
Related Articles Prognostic Nutritional Index, Another Prognostic Factor for Extranodal Natural Killer/T Cell Lymphoma, Nasal Type. Front Oncol. 2020;10:877 Authors: Yao N, Hou Q, Zhang S, Xiao H, Liang Y, Xu X, Guo R, Li H, Lan S, Si H, Cao J Abstract Objective: The prognostic nutritional index (PNI) is a significant prognostic factor in diffuse large B cell lymphoma, follicular lymphoma, and other malignancies. The current study aimed to explore...
Thu Jul 09, 2020 15:24
Related Articles Prognostic Value of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio, and Combined Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio in Stage IV Advanced Gastric Cancer. Front Oncol. 2020;10:841 Authors: Wang H, Ding Y, Li N, Wu L, Gao Y, Xiao C, Jiang H, Zheng Y, Mao C, Deng J, Wang H, Xu N Abstract Background: The prognostic value of neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio, and the combined...
Thu Jul 09, 2020 15:24
Related Articles Salubrinal in Combination With 4E1RCat Synergistically Impairs Melanoma Development by Disrupting the Protein Synthetic Machinery. Front Oncol. 2020;10:834 Authors: Kardos GR, Gowda R, Dinavahi SS, Kimball S, Robertson GP Abstract Increased protein synthesis is a key process in melanoma, which is regulated by the ALDH18A1 gene encoding pyrroline-5-carboxylate synthase (P5CS). P5CS is involved in proline biosynthesis and targeting...
Thu Jul 09, 2020 15:24
Related Articles High Expression of the SH3TC2-DT/SH3TC2 Gene Pair Associated With FLT3 Mutation and Poor Survival in Acute Myeloid Leukemia: An Integrated TCGA Analysis. Front Oncol. 2020;10:829 Authors: Yu P, Lan H, Song X, Pan Z Abstract Fms-like tyrosine kinase 3 (FLT3) mutation is one of the most common mutations in acute myeloid leukemia (AML). However, the effect of FLT3 mutation on survival is currently still controversial and the leukemogenic...
Thu Jul 09, 2020 15:24
Related Articles Evaluation of the Anti-Tumor Activity of the Humanized Monoclonal Antibody NEO-201 in Preclinical Models of Ovarian Cancer. Front Oncol. 2020;10:805 Authors: Zeligs KP, Morelli MP, David JM, Neuman M, Hernandez L, Hewitt S, Ozaki M, Osei-Tutu A, Anderson D, Andresson T, Das S, Lack J, Abdelmaksoud A, Fantini M, Arlen PM, Tsang KY, Annunziata CM Abstract Purpose: Despite high initial response rates with cytoreductive surgery,...
Thu Jul 09, 2020 15:24
Related Articles Randomized controlled Phase III trial to evaluate omentum preserving gastrectomy for patients with advanced gastric cancer (JCOG1711, ROAD-GC). Jpn J Clin Oncol. 2020 Jul 08;: Authors: Sato Y, Yamada T, Yoshikawa T, Machida R, Mizusawa J, Katayama H, Tokunaga M, Boku N, Terashima M, Stomach Cancer Study Group/Japan Clinical Oncology Group Abstract Gastrectomy with omentectomy and D2 lymph node dissection is the current standard...
Thu Jul 09, 2020 13:20
The interhemispheric transgenual approach for microsurgical removal of third ventricle colloid cysts. Technical note. World Neurosurg. 2020 Jul 05;: Authors: Esposito V, di Russo P, Del Maestro M, Ciavarro M, Vangelista T, De Angelis M, Fava A, Morace R Abstract BACKGROUND: Colloid cysts of the third ventricle are rare benign lesions which amount to about 1% of all intracranial tumors. Since these lesions grow predominantly in the anterior...
Thu Jul 09, 2020 15:25
Indocyanine green angiography visualized by augmented reality in aneurysm surgery. World Neurosurg. 2020 Jul 05;: Authors: Carl B, Bopp M, Benescu A, Saß B, Nimsky C Abstract OBJECTIVE: We prospectively investigated how to integrate indocyanine green (ICG) angiography in an augmented reality (AR) setting for aneurysm surgery. METHODS: In 20 patients with a total of 22 aneurysms the head-up display (HUD) of the operating microscope...
Thu Jul 09, 2020 15:25
Supraorbital Craniotomy for Sellar Solitary Fibrous Tumor: Operative Technique and Literature Review. World Neurosurg. 2020 Jul 05;: Authors: Gunasekaran A, Santos JM, Vandergrift WA PMID: 32640325 [PubMed - as supplied by publisher]
Thu Jul 09, 2020 15:25
Related Articles Cerebellar Hippocampal and Basal Nuclei Transient Edema with Restricted diffusion (CHANTER) Syndrome. Neurocrit Care. 2019 10;31(2):288-296 Authors: Jasne AS, Alsherbini KH, Smith MS, Pandhi A, Vagal A, Kanter D Abstract BACKGROUND: Abnormal restricted diffusion on magnetic resonance imaging is often associated with ischemic stroke or anoxic injury, but other conditions can present similarly. We present six cases of an unusual...
Thu Jul 09, 2020 16:13
Proteostatic stress as a nodal hallmark of replicative aging. Exp Cell Res. 2020 Jul 05;:112163 Authors: Moreno DF, Aldea M Abstract Aging is characterized by the progressive decline of physiology at the cell, tissue and organism level, leading to an increased risk of mortality. Proteotoxic stress, mitochondrial dysfunction and genomic instability are considered major universal drivers of cell aging, and accumulating evidence establishes...
Thu Jul 09, 2020 13:31
Synthetic Lethality strategies: Beyond BRCA1/2 mutations in pancreatic cancer. Cancer Sci. 2020 Jul 08;: Authors: Hu Y, Guo M Abstract Cancer cells are often characterized by abnormalities in DNA damage response including defects in cell cycle checkpoints and/or DNA repair. Synthetic Lethality between DNA damage repair (DDR) pathways has provided a paradigm for cancer therapy by targeting DDR. The successful example is that cancer cells...
Thu Jul 09, 2020 13:31
Rebound lymphocytosis in a patient with chronic lymphocytic leukemia after cessation of a CDK 4/6 inhibitor for concomitant breast cancer. Breast J. 2020 Jul 08;: Authors: Doucette K, Lai C, Pohlmann PR Abstract Herein, we present the case of a female with co-occurring chronic lymphocytic leukemia (CLL) and metastatic ER/PR-positive breast cancer, who when taken off palbociclib for severe neutropenia and infectious complications, experienced...
Thu Jul 09, 2020 13:31
Characterization of TNNC1 as a Novel Tumor Suppressor of Lung Adenocarcinoma. Mol Cells. 2020 Jul 08;: Authors: Kim S, Kim J, Jung Y, Jun Y, Jung Y, Lee HY, Keum J, Park BJ, Lee J, Kim J, Lee S, Kim J Abstract In this study, we describe a novel function of TNNC1 (Troponin C1, Slow Skeletal and Cardiac Type), a component of actin-bound troponin, as a tumor suppressor of lung adenocarcinoma (LUAD). First, the expression of TNNC1 was strongly...
Thu Jul 09, 2020 13:31
Related Articles LukS-PV Inhibits Hepatocellular Carcinoma Progression by Downregulating HDAC2 Expression. Mol Ther Oncolytics. 2020 Jun 26;17:547-561 Authors: Wang Z, Yu W, Qiang Y, Xu L, Ma F, Ding P, Shi L, Chang W, Mei Y, Ma X Abstract Hepatocellular carcinoma (HCC) is a common malignant tumor. LukS-PV is the S component of Panton-Valetine leukocidin (PVL), which is secreted by Staphylococcus aureus. This study investigated the effects...
Thu Jul 09, 2020 13:31
Related Articles MiR-1587 Regulates DNA Damage Repair and the Radiosensitivity of CRC Cells via Targeting LIG4. Dose Response. 2020 Apr-Jun;18(2):1559325820936906 Authors: Liu R, Shen L, Lin C, He J, Wang Q, Qi Z, Zhang Q, Zhou M, Wang Z Abstract DNA is subject to a range of endogenous and exogenous insults that can impair DNA replication and lead to DNA double-strand breaks (DSBs). The repair capacity of cancer cells mediates their radiosensitivity,...
Thu Jul 09, 2020 13:31
Related Articles Exploring the Interaction of Cobalt Oxide Nanoparticles with Albumin, Leukemia Cancer Cells and Pathogenic Bacteria by Multispectroscopic, Docking, Cellular and Antibacterial Approaches. Int J Nanomedicine. 2020;15:4607-4623 Authors: Arsalan N, Hassan Kashi E, Hasan A, Edalat Doost M, Rasti B, Ahamad Paray B, Zahed Nakhjiri M, Sari S, Sharifi M, Shahpasand K, Akhtari K, Haghighat S, Falahati M Abstract Aim: The interaction...
Thu Jul 09, 2020 13:31
Related Articles Synthesis and Biological Evaluations of Monocarbonyl Curcumin Inspired Pyrazole Analogues as Potential Anti-Colon Cancer Agent. Drug Des Devel Ther. 2020;14:2517-2534 Authors: Min Z, Zhu Y, Hong X, Yu Z, Ye M, Yuan Q, Hu X Abstract Purpose: The monocarbonyl analogs of curcumin (MCACs) have been widely studied for their promising antitumor activity. Pyrazole is a five-membered aromatic heterocyclic system with various bioactivities...
Thu Jul 09, 2020 13:31
Related Articles Chemopreventive Property of Sencha Tea Extracts towards Sensitive and Multidrug-Resistant Leukemia and Multiple Myeloma Cells. Biomolecules. 2020 Jul 04;10(7): Authors: Lu X, Saeed MEM, Hegazy MF, Kampf CJ, Efferth T Abstract The popular beverage green tea possesses chemopreventive activity against various types of tumors. However, the effects of its chemopreventive effect on hematological malignancies have not been defined....
Thu Jul 09, 2020 13:31
Related Articles Novel Chrysin-De-Allyl PAC-1 Hybrid Analogues as Anticancer Compounds: Design, Synthesis, and Biological Evaluation. Molecules. 2020 Jul 04;25(13): Authors: Al-Oudat BA, Ramapuram H, Malla S, Audat SA, Hussein N, Len JM, Kumari S, Bedi MF, Ashby CR, Tiwari AK Abstract New chrysin-De-allyl-Pac-1 hybrid analogues, tethered with variable heterocyclic systems (4a-4o), were rationally designed and synthesized. The target compounds...
Thu Jul 09, 2020 13:31
Related Articles Reversible Growth-Arrest of a Spontaneously-Derived Human MSC-Like Cell Line. Int J Mol Sci. 2020 Jul 03;21(13): Authors: Melzer C, Jacobs R, Dittmar T, Pich A, von der Ohe J, Yang Y, Hass R Abstract Life cycle limitation hampers the production of high amounts of primary human mesenchymal stroma-/stem-like cells (MSC) and limits cell source reproducibility for clinical applications. The characterization of permanently growing...
Thu Jul 09, 2020 13:31
Related Articles A Novel Combination Treatment with Honokiol and Rapamycin Effectively Restricts c-Met-Induced Growth of Renal Cancer Cells, and also Inhibits the Expression of Tumor Cell PD-L1 Involved in Immune Escape. Cancers (Basel). 2020 Jul 03;12(7): Authors: Sabarwal A, Chakraborty S, Mahanta S, Banerjee S, Balan M, Pal S Abstract The mTOR inhibitor Rapamycin has tumor inhibitory properties; and it is also used as an immunosuppressive...
Thu Jul 09, 2020 13:31
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