Related Articles Clinical Features of Liver Injury Induced by Immune Checkpoint Inhibitors in Japanese Patients. Can J Gastroenterol Hepatol. 2019;2019:6391712 Authors: Imoto K, Kohjima M, Hioki T, Kurashige T, Kurokawa M, Tashiro S, Suzuki H, Kuwano A, Tanaka M, Okada S, Kato M, Ogawa Y Abstract Aim: Immune checkpoint inhibitors (ICIs) have improved the survival rate of patients carrying various malignant neoplasms. Despite their efficacy,...
Thu Jul 09, 2020 13:31
Related Articles The lncRNA SLNCR Recruits the Androgen Receptor to EGR1-Bound Genes in Melanoma and Inhibits Expression of Tumor Suppressor p21. Cell Rep. 2019 05 21;27(8):2493-2507.e4 Authors: Schmidt K, Carroll JS, Yee E, Thomas DD, Wert-Lamas L, Neier SC, Sheynkman G, Ritz J, Novina CD Abstract Melanoma is the deadliest form of skin cancer, affecting men more frequently and severely than women. Although recent studies suggest that differences...
Thu Jul 09, 2020 13:31
Identification and referral of patients with refractory epilepsy from the primary to the tertiary care interface in New South Wales, Australia. Epilepsy Behav. 2020 Jul 05;111:107232 Authors: Hutchinson K, Herkes G, Shih P, Francis-Auton E, Bierbaum M, Ryder T, Nikpour A, Bleasel A, Wong C, Vagholkar S, Braithwaite J, Rapport F Abstract OBJECTIVES: This mixed-method feasibility study conducted in New South Wales (NSW), Australia, aimed to explore...
Thu Jul 09, 2020 14:53
The experience of trial participation, treatment approaches and perceptions of change among participants with dissociative seizures within the CODES randomized controlled trial: A qualitative study. Epilepsy Behav. 2020 Jul 05;111:107230 Authors: Read J, Jordan H, Perdue I, Purnell J, Murray J, Chalder T, Reuber M, Stone J, Goldstein LH Abstract BACKGROUND: Nested within a large, multicenter randomized controlled trial (RCT) for people with...
Thu Jul 09, 2020 14:53
Remedial dosing recommendations for delayed or missed doses of valproic acid in patients with epilepsy based on Monte Carlo simulations. Epilepsy Behav. 2020 Jul 05;111:107265 Authors: Wang CY, Jiao Z, Ding JJ, Yu EQ, Zhu GX Abstract OBJECTIVE: Delayed or missed doses are unavoidable in the pharmacotherapy of epilepsy and significantly compromise the efficacy of antiepileptic drug treatment. An inappropriate remedial regimen can cause seizure...
Thu Jul 09, 2020 14:53
Control analysis of electrical stimulation for epilepsy waveforms in a thalamocortical network. J Theor Biol. 2020 Jul 05;:110391 Authors: Yan L, Zhang H, Sun Z, Shen Z Abstract Physiological experiments and computational models both show that the thalamic reticular nucleus (RE) participates in inducing various firing patterns of cortex. Absence seizure, featured by 2-4Hz spike-wave discharges (SWD) oscillation, is a high incidence of disease...
Thu Jul 09, 2020 14:53
Family resources moderate the relationship between seizure control and health-related quality of life in children with drug-resistant epilepsy. Epilepsia. 2020 Jul 08;: Authors: Phillips NL, Widjaja E, Smith ML Abstract OBJECTIVE: Pediatric drug-resistant epilepsy (DRE) is associated with poor health-related quality of life (HRQOL). Achieving seizure control, however, does not improve HRQOL in all children. This study sought to evaluate whether...
Thu Jul 09, 2020 14:53
Protection or susceptibility to devastating childhood epilepsy: Nodding Syndrome associates with immunogenetic fingerprints in the HLA binding groove. PLoS Negl Trop Dis. 2020 Jul 08;14(7):e0008436 Authors: Benedek G, Abed El Latif M, Miller K, Rivkin M, Ramadhan Lasu AA, Riek LP, Lako R, Edvardson S, Alon SA, Galun E, Levite M Abstract Nodding syndrome (NS) is a devastating and enigmatic childhood epilepsy. NS is accompanied by multiple neurological...
Thu Jul 09, 2020 14:53
Related Articles Neuronal Cav3 channelopathies: recent progress and perspectives. Pflugers Arch. 2020 Jul 07;: Authors: Lory P, Nicole S, Monteil A Abstract T-type, low-voltage activated, calcium channels, now designated Cav3 channels, are involved in a wide variety of physiological functions, especially in nervous systems. Their unique electrophysiological properties allow them to finely regulate neuronal excitability and to contribute to sensory...
Thu Jul 09, 2020 14:53
Related Articles Somatic SLC35A2 mosaicism correlates with clinical findings in epilepsy brain tissue. Neurol Genet. 2020 Aug;6(4):e460 Authors: Miller KE, Koboldt DC, Schieffer KM, Bedrosian TA, Crist E, Sheline A, Leraas K, Magrini V, Zhong H, Brennan P, Bush J, Fitch J, Bir N, Miller AR, Cottrell CE, Leonard J, Pindrik JA, Rusin JA, Shah SH, White P, Wilson RK, Mardis ER, Pierson CR, Ostendorf AP Abstract Objective: Many genetic studies of...
Thu Jul 09, 2020 14:53
Related Articles Choosing Anticonvulsant Medications to Manage Status Epilepticus. N Engl J Med. 2020 06 25;382(26):2569-2572 Authors: Wu K, Hirsch LJ, Babl FE, Josephson SA PMID: 32579819 [PubMed - indexed for MEDLINE]
Thu Jul 09, 2020 14:53
Related Articles Dictyostelium discoideum as a pharmacological model system to study the mechanisms of medicinal drugs and natural products. Int J Dev Biol. 2019;63(8-9-10):541-550 Authors: Schaf J, Damstra-Oddy J, Williams RSB Abstract Developing novel compounds for the treatment of diseases remains one of the highest priorities in biomedical research, where it is critical to identify their targets and how they work at a cellular level. Most...
Thu Jul 09, 2020 14:53
Related Articles Medical Eligibility for Contraception in Women at Increased Risk. Dtsch Arztebl Int. 2019 11 08;116(45):764-774 Authors: Römer T Abstract BACKGROUND: Most women of child-bearing age want a safe method of contraception. Numerous methods are available, with different modes of application. In situations involving particular risks, the selection of the right method poses a special challenge. METHODS: Contraceptive methods...
Thu Jul 09, 2020 14:53
Related Articles Self-management skills and behaviors, self-efficacy, and quality of life in people with epilepsy from underserved populations. Epilepsy Behav. 2019 09;98(Pt A):258-265 Authors: Pandey DK, Levy J, Serafini A, Habibi M, Song W, Shafer PO, Loeb JA Abstract PURPOSE: People with epilepsy (PWE) from underserved populations face significant barriers to epilepsy management and therefore may lack knowledge about epilepsy and self-management...
Thu Jul 09, 2020 14:53
Related Articles Nodding Syndrome: The Unresolved Mystery of a Pediatric Disease in Sub-Saharan Africa. Pediatr Infect Dis J. 2019 06;38(6S Suppl 1):S67-S71 Authors: Abd-Elfarag G, van Hensbroek MB Abstract Nodding syndrome is a mysterious neurologic illness of unknown etiology, presenting with distinctive clinical features often at early age. Currently, it affects children in restricted geographical areas in South Sudan, Northern Uganda and...
Thu Jul 09, 2020 14:53
Related Articles An Uncommon Case of Hyperammonemic Encephalopathy. Neurocrit Care. 2019 10;31(2):439-442 Authors: Frazzini V, Capasso M, Onofrj M PMID: 31025186 [PubMed - indexed for MEDLINE]
Thu Jul 09, 2020 14:53
Related Articles Comparison of Phase Synchronization Measures for Identifying Stimulus-Induced Functional Connectivity in Human Magnetoencephalographic and Simulated Data. Front Neurosci. 2020;14:648 Authors: Yoshinaga K, Matsuhashi M, Mima T, Fukuyama H, Takahashi R, Hanakawa T, Ikeda A Abstract Phase synchronization measures are widely used for investigating inter-regional functional connectivity (FC) of brain oscillations, but which phase...
Thu Jul 09, 2020 13:29
Related Articles Longitudinal Case Study of Regression-Based Hand Prosthesis Control in Daily Life. Front Neurosci. 2020;14:600 Authors: Hahne JM, Wilke MA, Koppe M, Farina D, Schilling AF Abstract Hand prostheses are usually controlled by electromyographic (EMG) signals from the remnant muscles of the residual limb. Most prostheses used today are controlled with very simple techniques using only two EMG electrodes that allow to control a single...
Thu Jul 09, 2020 13:29
Stress and Perception of Procedural Pain Management in Chinese Parents of Children with Cancer. J Pain Symptom Manage. 2020 Jul 05;: Authors: Yan C, Cheung R, Lee Wong C, Cheng HY, Liu F, Huang H, Ewig C, Li CK, Zhang H, Cheung YT Abstract OBJECTIVES: Children with cancer are exposed to repeated painful and invasive procedures. This study examines Chinese parents' stress and perception towards their children's procedural pain-control....
Thu Jul 09, 2020 13:05
T-cell receptor therapy (TCR) against melanoma -immunotherapy for the future? Scand J Immunol. 2020 Jul 08;:e12927 Authors: Winge-Main AK, Wälchli S, Marit Inderberg E Abstract Malignant melanoma has seen monumental changes in treatment-options the last decade from the very poor results of dacarbazine treatment to the modern-day use of targeted therapies and immune checkpoint inhibitors. Melanoma has a high mutational burden making it...
Thu Jul 09, 2020 13:05
Broadening Eligibility Criteria for Oncology Clinical Trials: Current Advances and Future Directions. Clin Pharmacol Ther. 2020 Jul 08;: Authors: Rahman NA, Ison G, Beaver JA PMID: 32640034 [PubMed - as supplied by publisher]
Thu Jul 09, 2020 13:05
LncRNA AGAP2-AS1 accelerates cell proliferation, migration, invasion and EMT process in colorectal cancer via regulating miR-4668-3p/SRSF1 axis. J Gene Med. 2020 Jul 08;:e3250 Authors: Li H, Guo S, Zhang M, Li L, Wang F, Song B Abstract BACKGROUND: Colorectal cancer (CRC) is a frequently occurring tumor. Although a number of long noncoding RNAs (lncRNAs) have been researched in CRC, the expression, function and mechanism of AGAP2-AS1 remains...
Thu Jul 09, 2020 13:05
The benefit of prehabilitation and enhanced recovery in robot-assisted radical prostatectomy and the promising future of these protocols in the field of urologic oncology. Cancer. 2020 Jul 08;: Authors: Townsend WB, Worrilow WM, Riggs SB PMID: 32639580 [PubMed - as supplied by publisher]
Thu Jul 09, 2020 13:05
Calcium channel blockers in pancreatic cancer: increased overall survival in a retrospective cohort study. Anticancer Drugs. 2020 Jul 03;: Authors: Tingle SJ, Severs GR, Moir JAG, White SA Abstract Repurposing commonly prescribed noncancer medications for use in oncology has substantial advantages over de-novo development of anticancer drugs. Calcium signalling has been implicated in many of the hallmarks of cancer. Previous in-vitro and...
Thu Jul 09, 2020 13:05
Comprehensive analysis of multiple parameters associated with tumor immune microenvironment in ARID1A mutant cancers. Future Oncol. 2020 Jul 08;: Authors: Li Z, Lin J, Zhang L, Li J, Zhang Y, Zhao C, Wang H Abstract Aim: To verify the relationship between ARID1A and tumor immune microenvironment thus immune checkpoint inhibitors (ICIs) response. Material & methods: Several public databases were used to characterize the association...
Thu Jul 09, 2020 13:05
Recent advances in inhibitors of C-terminal SRC kinase. Future Med Chem. 2020 Jul 08;: Authors: P O'Malley D PMID: 32638626 [PubMed - as supplied by publisher]
Thu Jul 09, 2020 13:05
Related Articles Chromosome Abnormalities: New Insights into Their Clinical Significance in Cancer. Mol Ther Oncolytics. 2020 Jun 26;17:562-570 Authors: Kou F, Wu L, Ren X, Yang L Abstract Chromosomal abnormalities, consisting of numerical and structural chromosome abnormalities, are a common characteristic of cancer. Numerical chromosome abnormalities, mainly including aneuploidy and chromosome instability, are caused by chromosome segregation...
Thu Jul 09, 2020 13:05
Related Articles Evolving treatment strategies of brain metastases from breast cancer: current status and future direction. Ther Adv Med Oncol. 2020;12:1758835920936117 Authors: Kim JS, Kim IA Abstract Remarkable progress in breast cancer treatment has improved patient survival, resulting in an increased incidence of brain metastasis (BM). Current treatment options for BM are limited and are generally used for palliative purposes. Historically,...
Thu Jul 09, 2020 13:05
Related Articles A phase II trial of tipifarnib for patients with previously-treated, metastatic urothelial carcinoma harboring HRAS mutations. Clin Cancer Res. 2020 Jul 07;: Authors: Lee HW, Sa JK, Gualberto A, Scholz C, Sung HH, Jeong BC, Choi HY, Kwon GY, Park SH Abstract PURPOSE: To assess the antitumor activity and safety of tipifarnib, a highly potent and selective farnesyltransferase inhibitor, we performed a phase II clinical trial...
Thu Jul 09, 2020 13:05
Related Articles DNA Repair and Prostate Cancer: A Field Ripe for Harvest. Eur Urol. 2020 Jul 04;: Authors: Bryce AH, Sartor O, de Bono J Abstract Recent data have revealed antitumor activity for four PARP inhibitors, two of which (olaparib and rucaparib) are approved by the US Food and Drug Administration for metastatic castrate-resistant prostate cancer with selected DNA repair defects. Additional clinical trials are in progress for talazoparib,...
Thu Jul 09, 2020 13:05
Related Articles Emerging functions for ANKHD1 in cancer-related signaling pathways and cellular processes. BMB Rep. 2020 Jul 08;: Authors: Almeida BO, Machado-Neto JA Abstract ANKHD1 (ankyrin repeat and KH domain containing 1) is a large protein characterized by the presence of multiple ankyrin repeats and a K-homology domain. Ankyrin repeat domains consist of widely existing protein motifs in nature, they mediate protein-protein interactions...
Thu Jul 09, 2020 13:05
Related Articles JAK-Inhibitors for the Treatment of Rheumatoid Arthritis: A Focus on the Present and an Outlook on the Future. Biomolecules. 2020 Jul 05;10(7): Authors: Angelini J, Talotta R, Roncato R, Fornasier G, Barbiero G, Dal Cin L, Brancati S, Scaglione F Abstract Janus kinase inhibitors (JAKi) belong to a new class of oral targeted disease-modifying drugs which have recently revolutionized the therapeutic panorama of rheumatoid...
Thu Jul 09, 2020 13:05
Related Articles Resectability and Ablatability Criteria for the Treatment of Liver Only Colorectal Metastases: Multidisciplinary Consensus Document from the COLLISION Trial Group. Cancers (Basel). 2020 Jul 03;12(7): Authors: Nieuwenhuizen S, Puijk RS, van den Bemd B, Aldrighetti L, Arntz M, van den Boezem PB, Bruynzeel AME, Burgmans MC, de Cobelli F, Coolsen MME, Dejong CHC, Derks S, Diederik A, van Duijvendijk P, Eker HH, Engelsman AF, Erdmann JI, Fütterer...
Thu Jul 09, 2020 13:05
Related Articles Intraabdominal Pressure Targeted Positive End-expiratory Pressure during Laparoscopic Surgery: An Open-label, Nonrandomized, Crossover, Clinical Trial. Anesthesiology. 2020 04;132(4):667-677 Authors: Mazzinari G, Diaz-Cambronero O, Alonso-Iñigo JM, Garcia-Gregorio N, Ayas-Montero B, Ibañez JL, Serpa Neto A, Ball L, Gama de Abreu M, Pelosi P, Maupoey J, Argente Navarro MP, Schultz MJ Abstract BACKGROUND: Pneumoperitoneum for...
Thu Jul 09, 2020 13:05
Related Articles Current Treatment Landscape of Nasopharyngeal Carcinoma and Potential Trials Evaluating the Value of Immunotherapy. J Natl Cancer Inst. 2019 07 01;111(7):655-663 Authors: Le QT, Colevas AD, O'Sullivan B, Lee AWM, Lee N, Ma B, Siu LL, Waldron J, Lim CM, Riaz N, Lynn J, Malik S Abstract Nasopharyngeal carcinoma (NPC) is a type of head and neck cancer with a distinctive regional and racial prevalence. It is associated with Epstein-Barr...
Thu Jul 09, 2020 13:05
Related Articles Date Palm (Phoenix dactylifera): Novel Findings and Future Directions for Food and Drug Discovery. Curr Drug Discov Technol. 2019;16(1):2-10 Authors: El-Far AH, Oyinloye BE, Sepehrimanesh M, Allah MAG, Abu-Reidah I, Shaheen HM, Razeghian-Jahromi I, Alsenosy AEA, Noreldin AE, Al Jaouni SK, Mousa SA Abstract Phoenix dactylifera is a useful traditional medicinal plant, mainly the fruit is used, which is the edible part of the...
Thu Jul 09, 2020 13:05
Related Articles Differential prognostic value of positive HER2 status determined by immunohistochemistry or fluorescence in situ hybridization in breast cancer. Breast Cancer Res Treat. 2020 Jul 07;: Authors: Stocker A, Trojan A, Elfgen C, Hilbers ML, Moskovszky L, Varga Z Abstract PURPOSE: Human epidermal growth factor-receptor-2 (HER2) is a membrane-tyrosine-kinase that is amplified/overexpressed up to 20% in breast cancer. HER2 positive...
Thu Jul 09, 2020 14:49
Related Articles Genetic mutation profile of Chinese HER2-positive breast cancers and genetic predictors of responses to Neoadjuvant anti-HER2 therapy. Breast Cancer Res Treat. 2020 Jul 07;: Authors: Li K, Liao N, Chen B, Zhang G, Wang Y, Guo L, Wei G, Jia M, Wen L, Ren C, Cao L, Mok H, Li C, Lin J, Chen X, Zhang Z, Hou T, Li M, Liu J, Balch CM, Liao N Abstract PURPOSE: Despite the therapeutic success of existing HER2-targeted therapies, tumors...
Thu Jul 09, 2020 14:49
Related Articles Neratinib-Induced Duodenal Ulcer: A Case Report. Breast Cancer (Auckl). 2020;14:1178223420935871 Authors: Moftakhar B, Kharel P, Niraula S, Gandhi S, Falkson C, Dhakal A Abstract We report a case of a 37-year-old woman who developed a duodenal ulcer while receiving adjuvant neratinib for HER2 positive breast cancer. The clinical course of abdominal pain was strongly correlated with the use of neratinib. An esophagogastroduodenoscopy...
Thu Jul 09, 2020 14:49
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