Publication date: August 2020Source: Clinical Neurology and Neurosurgery, Volume 195Author(s): Tadayuki Takata, Hideki Kobara, Kazushi Deguchi, Tsutomu Masaki
Thu Jul 09, 2020 18:54
Abstract Purpose of Review Despite the increase in the number of novel antiseizure medications over the past 20 years, approximately one-third of patients will not have adequate seizure control on medications. For these patients, additional options need to be considered, including dietary, device, and surgical treatments. In addition, many complementary therapies can be considered as adjunctive treatment, with the intent of improving...
Thu Jul 09, 2020 03:00
Abstract Deep brain stimulation is being used not only for movement disordes, but also to treat a growing number of neurological and psychiatric conditions. It is know to have a variety of effects upon oculomotor function, depending not only on the location of the stimulation, but also the underlying pathology being treated. Understanding how it affects eye movements is important, given the widespread nature of eye movements control and its inevitable overlap with many of the networks targeted by...
Wed Jul 08, 2020 20:15
Abstract Calcitonin gene‐related peptide (CGRP), substance‐P and dural mast cells are main contributors in neurogenic inflammation underlying migraine pathophysiology. Modulation of endocannabinoid system attenuates migraine pain, but its mechanisms of action remains unclear. We investigated receptor mechanisms mediating anti‐neuroinflammatory effects of endocannabinoid system modulation in in‐vivo migraine model and ex‐vivo hemiskull preparations in rats. To induce acute model of migraine, a single...
Wed Jul 08, 2020 12:33
Abstract Action observation (AO) and motor imagery (MI) are potential methods to improve various motor functions. AO and MI facilitate corticospinal excitability. Additionally, the combination of AO and MI (AO + MI) facilitates greater corticospinal excitability than AO alone. However, it is unclear whether AO + MI facilitates the excitability of spinal motor neurons better than AO alone. Thus, in this study, we compared the excitability of spinal motor neurons between AO + MI...
Thu Jul 09, 2020 03:00
Publication date: Available online 9 July 2020Source: Journal of Neuroscience MethodsAuthor(s): Hasan Al-Nashash, Shiyu Luo, Xiaogang Liu, Angelo H. All
Thu Jul 09, 2020 20:01
Publication date: Available online 8 July 2020Source: Journal of Neuroscience MethodsAuthor(s): Greer McKendrick, Hannah Garrett, Sreehasa Tanniru, Sarah Ballard, Dongxiao Sun, Yuval Silberman, Patricia S. Grigson, Nicholas M. Graziane
Thu Jul 09, 2020 20:01
Journal of Neurotrauma, Ahead of Print.
Wed Jul 08, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Wed Jul 08, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Wed Jul 08, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Wed Jul 08, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Wed Jul 08, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Wed Jul 08, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Wed Jul 08, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Wed Jul 08, 2020 10:00
Thu Jul 09, 2020 03:00
Publication date: 15 October 2020Source: NeuroImage, Volume 220Author(s): Sang-Han Choi, Gangwon Jeong, Young-Bo Kim, Zang-Hee Cho
Thu Jul 09, 2020 18:48
Thu Jul 09, 2020 21:08
BACKGROUND AND PURPOSE:A uniform policy on parental leave in radiology training programs is lacking. Although previous publications have addressed the status of parental leave policy among radiology residency programs, the state of parental leave in radiology fellowships has not been addressed to date. Our aim was to determine the state of parental leave policies in American neuroradiology fellowship programs.MATERIALS AND METHODS:An Internet survey was sent to the directors of neuroradiology fellowship...
Thu Jul 09, 2020 19:06
Thu Jul 09, 2020 17:56
SUMMARY:Spontaneous intracranial hypotension is a condition characterized by low CSF volume secondary to leakage through a dural defect with no identifiable cause. Patients classically present with orthostatic headaches, but this symptom is not specific to spontaneous intracranial hypotension, and initial misdiagnosis is common. The most prominent features of spontaneous intracranial hypotension on intracranial MR imaging include "brain sag" and diffuse pachymeningeal enhancement, but these characteristics...
Thu Jul 09, 2020 17:24
BACKGROUND AND PURPOSE:Brain MRI of newborns with congenital heart disease show signs of immaturity relative to healthy controls. Our aim was to determine whether the semiquantitative fetal total maturation score can detect abnormalities in brain maturation in fetuses with congenital heart disease in the second and third trimesters.MATERIALS AND METHODS:We analyzed data from a prospective study of fetuses with and without congenital heart disease who underwent fetal MR imaging at 25–35 weeks’ gestation....
Thu Jul 09, 2020 17:06
BACKGROUND AND PURPOSE:Preclinical evidence points toward a metabolic reprogramming in isocitrate dehydrogenase (IDH) mutated tumor cells with down-regulation of the expression of genes that encode for glycolytic metabolism. We noninvasively investigated lactate and Cr concentrations, as well as intracellular pH using 1H/phosphorus 31 (31P) MR spectroscopy in a cohort of patients with gliomas.MATERIALS AND METHODS:Thirty prospectively enrolled, mostly untreated patients with gliomas met the spectral...
Thu Jul 09, 2020 17:02
BACKGROUND:Severe carotid stenosis carries a high risk of stroke. However, the risk of stroke with nonstenotic carotid plaques (<50%) is increasingly recognized.PURPOSE:We aimed to summarize the risk of TIA or stroke in patients with nonstenotic carotid plaques.DATA SOURCES:We performed a comprehensive systematic review and meta-analysis in patients with acute ischemic stroke in whom carotid imaging was performed using MEDLINE and the Cochrane Database, including studies published up to December...
Thu Jul 09, 2020 17:01
Standard clinical reconstructions usually require several minutes to complete, which is mostly independent of the duration of the data being reconstructed. Applications such as data-driven motion estimation which require many short frames over the duration of the scan become unfeasible with such long reconstruction times. In this work we present an infrastructure whereby ultra-fast list-mode reconstructions of very short frames (≤ 1 sec) are performed. With this infrastructure it is possible to have...
Thu Jul 09, 2020 23:00
[18F]-FAC (2'-deoxy-2'-[18F] fluoro-β-D-arabinofuranosylcytosine) has close structural similarity to gemcitabine, and thus offers the potential to image drug delivery to tumors. We compared tumor [18F]-FAC PET images to [14C]-gemcitabine levels, established ex vivo, in three mouse models of pancreatic cancer. We further modified tumor gemcitabine levels with injectable hyaluronidase (PEGPH20) to test whether changes in gemcitabine would be tracked by [18F]-FAC. Methods: [18F]-FAC was synthesized...
Thu Jul 09, 2020 23:00
The Nuclear Medicine Global Initiative (NMGI) was formed in 2012 by 13 international organizations to promote human health by advancing the field of nuclear medicine and molecular imaging by supporting the practice and application of nuclear medicine. The first project focused on standardization of administered activities in pediatric nuclear medicine and resulted in two manuscripts. For its second project the NMGI chose to explore issues impacting on access and availability of radiopharmaceuticals...
Thu Jul 09, 2020 23:00
Purpose: Prostate-specific membrane antigen (PSMA)-targeted radionuclide therapy (RNT) may increase tumor immunogenicity. We aimed at exploiting this effect by combining RNT with immunotherapy in a mouse model of prostate cancer (PC). Experimental Design: C57BL/6-mice bearing syngeneic RM1-PGLS tumors were treated with 225Ac-PSMA617, an anti-PD-1 antibody, or both. Therapeutic efficacy was assessed by tumor volume measurements (computed tomography), time to progression (TTP) and survival. Results:...
Thu Jul 09, 2020 23:00
Purpose: To identify correlations of gliomas between 18F-fluorodihydroxyphenylalanine (FDOPA) uptake and physiological magnetic resonance imaging (MRI) including relative cerebral blood volume (rCBV) and apparent diffusion coefficient (ADC) with different molecular subtypes, and to evaluate their prognostic values. Methods: Sixty-eight treatment-naïve glioma patients who underwent FDOPA positron emission tomography (PET) and physiological MRI were retrospectively selected (isocitrate dehydrogenase...
Thu Jul 09, 2020 23:00
The aim of this work was to determine a minimal tumor perfusion and receptor density for 177Lu-DOTATATE therapy using physiologically based pharmacokinetic (PBPK) modeling considering 1) a desired tumor control probability (TCP) of 99% and 2) a maximal tolerated biologically effective dose (BEDmax) for organs at risk (OARs) in the treatment of neuroendocrine tumors and meningioma. Methods: A recently developed PBPK model was employed. Nine virtual patients (i.e. individualized PBPK models) were...
Thu Jul 09, 2020 23:00
Reactive astrocytes play a key role in the pathogenesis of various neurodegenerative diseases. Monoamine oxidase-B (MAO-B) is one of the promising targets for the imaging of astrogliosis in the human brain. A novel selective and reversible MAO-B tracer, (S)-(2-methylpyrid-5-yl)-6-[(3-[18F]fluoro-2-hydroxy)propoxy]quinoline, (18F-SMBT-1), was successfully developed via lead optimization from first-generation tau positron-emission tomography (PET) tracer 18F-THK-5351. Methods: SMBT-1 was radiolabeled...
Thu Jul 09, 2020 23:00
11C-UCB-J is a PET tracer for synaptic vesicle glycoprotein 2A which may be a marker of synaptic density. To simplify the scan protocol, standardized uptake value ratios (SUVR) were compared to model-based binding potential (BPND) to select the optimal time window in healthy and neuropsychiatric subjects. Methods: A total of 141 scans were acquired for 90 min. Arterial blood sampling and metabolite analysis were conducted. SUVR-1 (centrum semiovale reference region) was computed for six 30-min...
Thu Jul 09, 2020 23:00
Receptor tyrosine kinase (RTK) co-expression facilitates tumor resistance due to redundancies in the PI3K-AKT and KRAS-ERK signaling pathways, among others. Crosstalk between the oncogenic RTKs hepatocyte growth factor receptor (MET), epidermal growth factor receptor (EGFR), and human epidermal growth factor receptor 2 (HER2) are involved in tumor resistance to RTK-targeted therapies. Methods: In a relevant renal cell carcinoma (RCC) patient derived xenograft (PDX) model, we use zirconium-89 (89Zr)-labeled...
Thu Jul 09, 2020 23:00
Thu Jul 09, 2020 23:00
Publication date: September 2020Source: World Neurosurgery, Volume 141Author(s): Kevin D. Waits, Craig R. Kelman, Brian M. Cameron
Thu Jul 09, 2020 13:13
Publication date: September 2020Source: World Neurosurgery, Volume 141Author(s): Keaton Piper, Ryan Screven, Sivero Agazzi, Waldo R. Guerrero, Keith Dombrowski
Thu Jul 09, 2020 13:13
Publication date: September 2020Source: World Neurosurgery, Volume 141Author(s): Aurélie Degeneffe, Michaël Bruneau, Julien Spitaels, Nathalie Gilis, Olivier De Witte, Alphonse Lubansu
Thu Jul 09, 2020 13:13
Publication date: August 2020Source: World Neurosurgery, Volume 140Author(s): Guy Talmor, Jordon G. Grube, Jean Anderson Eloy, James K. Liu, Wayne D. Hsueh
Thu Jul 09, 2020 13:13
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου