Because of the national emergency triggered by the coronavirus disease 2019 (COVID‐19) pandemic, government‐mandated public health directives have drastically changed not only social norms but also the practice of oncologic medicine. Timely head and neck cancer (HNC) treatment must be prioritized, even during emergencies. Because severe acute respiratory syndrome coronavirus 2 predominantly resides in the sinonasal/oral/oropharyngeal tracts, nonessential mucosal procedures are restricted, and HNCs...
Wed Jul 08, 2020 16:53
Background Among patients with cervical cancer, little is known about the significance of persistent human papillomavirus (HPV) expression after chemoradiation (CRT). This study evaluated associations between early posttreatment HPV clearance and patient outcomes with an added focus on the value of posttherapy positron emission tomography (PET) imaging. Methods Included patients underwent pretreatment testing indicating a high‐risk HPV infection and posttreatment testing with a messenger RNA...
Wed Jul 08, 2020 16:51
Background Many breast cancer survivors suffer from cognitive complaints after cancer treatment, affecting their quality of life. The objective of this pilot study was to investigate the effect of a blended‐care mindfulness‐based intervention (MBI) on chemotherapy‐related cognitive impairment and functional brain changes. Furthermore, correlations between changes in cognitive functioning and self‐reported behavioral factors were investigated. Methods Breast cancer survivors (n = 33) who reported...
Wed Jul 08, 2020 16:49
Background An enhanced recovery after surgery (ERAS) pathway has shown benefit in oncologic surgery. However, literature is scarce regarding the impact of this pathway, alone or combined with prehabilitation (PreHab) programs, on outcomes after robot‐assisted radical prostatectomy (RARP). Methods Included in this study were 507 consecutive patients undergoing RARP from 2014 to 2019. The primary endpoint was duration of hospital stay. Secondary outcomes included intraoperative blood loss, operative...
Wed Jul 08, 2020 16:39
Wed Jul 08, 2020 16:39
British Journal of Cancer, Published online: 09 July 2020; doi:10.1038/s41416-020-0977-5Correction: CSN6–TRIM21 axis instigates cancer stemness during tumorigenesis
Thu Jul 09, 2020 03:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Thu Jul 09, 2020 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Thu Jul 09, 2020 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Thu Jul 09, 2020 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Thu Jul 09, 2020 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Thu Jul 09, 2020 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Thu Jul 09, 2020 10:00
Background Previous studies of the histologic correlation in women who have atypical squamous cells of undetermined significance cytology (ASC‐US) and are positive for high‐risk human papillomavirus (hrHPV+) have predominantly utilized the Hybrid Capture 2 (HC2) test, whereas the use of other US Food and Drug Administration (FDA)‐approved methods is relatively limited. Methods Cases of ASC‐US/hrHPV+ that were tested using HC2, Cervista, or Aptima were retrieved, and the immediate histologic...
Wed Jul 08, 2020 16:54
The original version of this article unfortunately contained a mistake. Complete figure captions are missing.
Thu Jul 09, 2020 22:14
The original version of this article unfortunately contained a mistake. The correct information is given below.
Thu Jul 09, 2020 22:14
Abstract Cell line‐derived xenograft (CDX) models created by implanting cancer cell lines into immunodeficient mice have been largely contributed to develop cancer drug therapies. However, cell lines often lose their original biological characteristics through many passages and cancer tissues in CDX models have many cancer cells and few cancer stromal cells, therefore, CDX models are currently considered not suitable for predicting the results of clinical studies. On the other hand, patient‐derived...
Wed Jul 08, 2020 16:40
Abstract Cancer cells are often characterized by abnormalities in DNA damage response including defects in cell cycle checkpoints and/or DNA repair. Synthetic Lethality between DNA damage repair (DDR) pathways has provided a paradigm for cancer therapy by targeting DDR. The successful example is that cancer cells with BRCA1/2 mutations are sensitized to poly (adenosine diphosphate [ADP]‐ribose) polymerase (PARP) inhibitors. Beyond the narrow scope of defects in the BRCA pathway, ‘BRCAness’ provides...
Wed Jul 08, 2020 16:40
Abstract Mesenchymal stem cells (MSCs) are multipotent stromal cells with the potential to differentiate into several cell types. MSCs‐based therapy has emerged as a promising strategy for various diseases. Accumulating evidence suggests that the paracrine effects of MSCs are partially exerted by the secretion of soluble factors, in particular exosomes. MSC‐derived exosomes are involved in the intercellular communication via transfer of proteins, RNA, DNA and bioactive lipids, which might constitute...
Wed Jul 08, 2020 16:35
Abstract Ezrin is one of the ezrin‐radixin‐moesin (ERM) proteins, which was involved in the formation of cell membrane processes, has been implicated in the promotion of cancers proliferation and metastasis. However, the possible role of Ezrin in hepatocellular carcinoma (HCC) metastasis and glycolysis reprogramming remained unclear. In this study, we found that Ezrin was upregulated in HCC tissues, and its overexpression was linked with HCC patients’ aggressive tumor characteristics and poor prognosis....
Wed Jul 08, 2020 16:35
Abstract Tirabrutinib is a second‐generation Bruton’s tyrosine kinase inhibitor with greater selectivity than ibrutinib. Here we conducted a multicenter, phase II study of tirabrutinib in patients with treatment‐naïve (Cohort A) or with relapsed/refractory (Cohort B) Waldenström’s macroglobulinemia (WM). Patients were treated with tirabrutinib 480 mg once daily. The primary endpoint was major response rate (MRR, ≥ partial response). Secondary endpoints included overall response rate (ORR, ≥ minor...
Wed Jul 08, 2020 16:35
Abstract We constructed a data set of EGFR‐mutant NSCLC patients, and compared the overall survival of first‐generation (1G), and second‐generation (2G) EGFR‐TKIs in clinical practice using propensity score. We reviewed the clinical data of consecutive EGFR‐mutated NSCLC patients who received EGFR‐TKI therapy between Jan 2008 and Aug 2017 at 11 institutions in Japan. The primary endpoint was OS. When comparing OS between 1G and 2G EGFR‐TKIs, the propensity score analyses were performed using two...
Wed Jul 08, 2020 16:34
Abstract Because advanced laryngeal squamous cell carcinoma (LSCC) is diagnosed as a malignant tumor with a poor prognosis, the associated mechanisms still need to be further investigated. As key players in the development and progression of LSCC, lncRNAs have attracted increasing attention from many researchers. In this study, a novel lncRNA termed as IGKJ2‐MALLP2 was identified and investigated for its effects on the development of LSCC. IGKJ2‐MALLP2 expression was confirmed by RT‐qPCR in 78 pairs...
Wed Jul 08, 2020 16:29
Wed Jul 08, 2020 16:03
Purpose: The tumor immune microenvironment (TIME) has an important impact on response to cancer immunotherapy using immune checkpoint inhibitors. Specifically, an "infiltrated-excluded"/"cold" TIME is predictive of poor response. The antidiabetic agent metformin may influence anti-cancer immunity in esophageal squamous cell carcinoma (ESCC). Experimental Design: We analyzed matched pre- and post-treatment ESCC specimens in a phase II clinical trial of low-dose metformin treatment (250 mg/day) to...
Thu Jul 09, 2020 16:37
The cancer mutanome has been associated with disease prognosis as well as response to interventional immunotherapy and provides a substrate for development of personalized vaccines targeting tumor neoepitopes. Recent findings suggest that neoantigen-based vaccines may represent general interventional approaches for patients with solid cancers, regardless of their inherent mutational burden.
Thu Jul 09, 2020 16:37
Publication date: September 2020Source: European Journal of Cancer, Volume 136Author(s): Lucas Moreno, Giuseppe Barone, Steven G. DuBois, Jan Molenaar, Matthias Fischer, Johannes Schulte, Angelika Eggert, Gudrun Schleiermacher, Frank Speleman, Louis Chesler, Birgit Geoerger, Michael D. Hogarty, Meredith S. Irwin, Nick Bird, Guy B. Blanchard, Sean Buckland, Hubert Caron, Susan Davis, Bram De Wilde, Hedwig E. Deubzer
Thu Jul 09, 2020 19:20
Publication date: Available online 9 July 2020Source: European Journal of Surgical OncologyAuthor(s): Trapani Renza, Rausei Stefano, Reddavid Rossella, Degiuli Maurizio, Italian Research Group for Gastric Cancer (GIRCG) Clinical Investigators, Bencivenga Maria, Dal Cero Mariagiulia, Rosa Fausto, Alfieri Sergio, Tiberio Guido Alberto, Alfano Marie Sophie, Gualtierotti Monica, Ferrari Giovanni, Persiani Roberto, Biondi Alberto, Donini Annibale, Graziosi Luigina, Sasia Diego, Geretto Paolo, Vigano Jacopo,...
Thu Jul 09, 2020 20:54
Future Oncology, Ahead of Print.
Wed Jul 08, 2020 15:45
Comprehensive analysis of multiple parameters associated with tumor immune microenvironment in ARID1A mutant cancers. Future Oncol. 2020 Jul 08;: Authors: Li Z, Lin J, Zhang L, Li J, Zhang Y, Zhao C, Wang H Abstract Aim: To verify the relationship between ARID1A and tumor immune microenvironment thus immune checkpoint inhibitors (ICIs) response. Material & methods: Several public databases were used to characterize the association between...
Thu Jul 09, 2020 15:16
Journal of Adolescent and Young Adult Oncology, Ahead of Print.
Wed Jul 08, 2020 10:00
Abstract This paper examines the effectiveness of using personal health records (PHRs), which contains detailed health information to improve the use of recommended screening mammography among women at potential risk for breast cancer. It also explores the potential of PHR in reducing disparities in recommended mammography use experienced by minority and underserved women. The primary data used for this study were obtained from the 2015 Health Information National Trends Survey,...
Thu Jul 09, 2020 03:00
Abstract Information seeking is an active health behavior that influences cancer fatalism; however, people commonly experience challenges in accessing high-quality and actionable health information that is personally relevant. This is especially common among older and rural adults who have a high cancer risk. The purpose of this study was to examine the theoretical assumption that enhancing perceived confidence to overcome health information seeking challenges will alleviate cancer...
Thu Jul 09, 2020 03:00
Abstract The aim of the present study was to evaluate the efficacy of re-irradiation (re-RT) in patients with advanced local relapses of glial tumours and to define the factors influencing the result of the hyper-fractionated external beam therapy on progression after primary management. We have analysed the data of 55 patients with brain tumours (GBM: 28) on progression, who were re-irradiated between January 2007 and December 2018. The mean volume of the recurrent tumour was...
Thu Jul 09, 2020 03:00
Abstract Aryl hydrocarbon receptor (AHR) interacting protein (AIP) is a chaperone which binds to inactive AHR in the cell cytoplasm. AHR is best known for mediating the toxicity of halogenated aromatics, but it has also been linked to carcinogenesis and tumor progression in several tumor types. Our aims are to assess the features of AIP immunohistochemical (IHC) staining and to evaluate its possible role as a prognostic marker in gastric cancer (GC). Retrospective study of 147...
Thu Jul 09, 2020 03:00
Publication date: Available online 9 July 2020Source: Practical Radiation OncologyAuthor(s): Sandra Zaky, Alvin R. Cabrera, Lisa Bradfield, Matthew M. Harkenrider, Tim J. Kruser, David J. Sher, Charles B. Simone, Grace Smith, Joshua Petit
Thu Jul 09, 2020 15:00
Publication date: July–August 2020Source: Reports of Practical Oncology & Radiotherapy, Volume 25, Issue 4Author(s):
Thu Jul 09, 2020 19:52
RNA-binding proteins (RBPs) play important roles in bacterial gene expression and physiology but their true number and functional scope remain little understood even in model microbes. To advance global RBP discovery in bacteria, we here establish glycerol gradient sedimentation with RNase treatment and mass spectrometry (GradR). Applied to Salmonella enterica, GradR confirms many known RBPs such as CsrA, Hfq and ProQ by their RNase-sensitive sedimentation profiles, and discovers the FopA protein...
Thu Jul 09, 2020 20:09
Publication date: August 2020Source: Cancer Epidemiology, Volume 67Author(s): Sophie D. Fosså, Alv A. Dahl, Tor Å. Myklebust, Cecile E. Kiserud, Ragnhild Nome, Olbjørn H. Klepp, Marianne Brydøy, Hege S. Haugnes
Thu Jul 09, 2020 13:37
Abstract Over the past years, the quantity and complexity of imaging data available for the clinical management of patients with solid tumors has increased substantially. Without the support of methods from the field of artificial intelligence (AI) and machine learning, a complete evaluation of the available image information is hardly feasible in clinical routine. Especially in radiotherapy planning, manual detection and segmentation of lesions is laborious, time consuming, and...
Thu Jul 09, 2020 03:00
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