Medicine by Alexandros G. Sfakianakis,Αλέξανδρος Γ. Σφακιανάκης

[ASAP] Breaching the 10 Second Barrier of Total Analysis Time for Complex Matrices via Automated Coated Blade Spray

Analytical ChemistryDOI: 10.1021/acs.analchem.9b03225

[ASAP] ODX: A Fitness Tracker-Based Device for Continuous Bacterial Growth Monitoring

Thu Sep 12, 2019 07:00

Analytical ChemistryDOI: 10.1021/acs.analchem.9b02628

[ASAP] Two-Photon Fluorescent Nanoprobe for Glutathione Sensing and Imaging in Living Cells and Zebrafish Using a Semiconducting Polymer Dots Hybrid with Dopamine and ß-Cyclodextrin

Thu Sep 12, 2019 07:00

Analytical ChemistryDOI: 10.1021/acs.analchem.9b03010

[ASAP] Enrichment–Stowage–Cycle Strategy for Ultrasensitive Electrochemiluminescent Detection of HIV-DNA with Wide Dynamic Range

Thu Sep 12, 2019 07:00

Analytical ChemistryDOI: 10.1021/acs.analchem.9b01969

[ASAP] I-Motif-Based in Situ Bipedal Hybridization Chain Reaction for Specific Activatable Imaging and Enhanced Delivery of Antisense Oligonucleotides

Thu Sep 12, 2019 07:00

Analytical ChemistryDOI: 10.1021/acs.analchem.9b03420

[ASAP] Identification of Luminescent Markers for Gunshot Residues: Fluorescence, Raman Spectroscopy, and Chemometrics

Thu Sep 12, 2019 07:00

Analytical ChemistryDOI: 10.1021/acs.analchem.9b03079

[ASAP] Composite Conformational Changes of Signaling Proteins upon Ligand Binding Revealed by a Single Approach: Calcium-Calmodulin Study

Thu Sep 12, 2019 07:00

Analytical ChemistryDOI: 10.1021/acs.analchem.9b03491

[ASAP] Ratiometric Fluorescent Strategy for Localizing Alkaline Phosphatase Activity in Mitochondria Based on the ESIPT Process

Thu Sep 12, 2019 07:00

Analytical ChemistryDOI: 10.1021/acs.analchem.9b02917

Thu Sep 12, 2019 07:00

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Predictors of successful separation from high-flow nasal oxygen therapy in patients with acute respiratory failure: a retrospective monocenter study

High-flow nasal oxygen therapy (HFOT) is a promising first-line therapy for acute respiratory failure. However, its weaning has never been investigated and could lead to unnecessary prolonged intensive-care un...

Recruiting the microcirculation in septic shock

Wed Sep 11, 2019 03:00

Association of endothelial and glycocalyx injury biomarkers with fluid administration, development of acute kidney injury, and 90-day mortality: data from the FINNAKI observational study

Wed Sep 11, 2019 03:00

Injury to endothelium and glycocalyx predisposes to vascular leak, which may subsequently lead to increased fluid requirements and worse outcomes. In this post hoc study of the prospective multicenter observat...

Endoscopic Versus Open Resection of Non‐Squamous Cell Carcinoma Sinonasal Malignancies

Wed Sep 11, 2019 03:00

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The Laryngoscope

Objective Non‐squamous cell carcinoma (non‐SCC) variants of sinonasal cancer are rare cancers which are optimally managed with complete surgical resection. This study aims to assess the impact of surgical approach on outcomes by comparison of cases managed with open versus endoscopic resection. Methods The National Cancer Database 2004–2015 datasets were queried for all cases of non‐SCC initially managed with definitive surgery. Patients were grouped according to surgical approach (endoscopic...

The Laryngoscope

Thu Sep 12, 2019 17:29

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Journal of the American Chemical Society: Latest Articles (ACS Publications)

[ASAP] Cation Disorder and Lithium Insertion Mechanism of Wadsley–Roth Crystallographic Shear Phases from First Principles

Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b06316

Journal of the American Chemical Society: Latest Articles (ACS Publications)

Thu Sep 12, 2019 07:00

[ASAP] Robust, Highly Luminescent Au<sub>13</sub> Superatoms Protected by N-Heterocyclic Carbenes

Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b07854

Journal of the American Chemical Society: Latest Articles (ACS Publications)

Thu Sep 12, 2019 07:00

[ASAP] Catalytic Enantioselective Synthesis of Cyclobutenes from Alkynes and Alkenyl Derivatives

Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b07885

Journal of the American Chemical Society: Latest Articles (ACS Publications)

Thu Sep 12, 2019 07:00

[ASAP] Redox-Noninnocent Ligand-Supported Vanadium Catalysts for the Chemoselective Reduction of C-X (X = O, N) Functionalities

Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b07062

Journal of the American Chemical Society: Latest Articles (ACS Publications)

Thu Sep 12, 2019 07:00

[ASAP] Internal Catalysis in Covalent Adaptable Networks: Phthalate Monoester Transesterification As a Versatile Dynamic Cross-Linking Chemistry

Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b07269

Journal of the American Chemical Society: Latest Articles (ACS Publications)

Thu Sep 12, 2019 07:00

[ASAP] Room-Temperature Ferroelectricity in Group-IV Metal Chalcogenide Nanowires

Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b03201

Journal of the American Chemical Society: Latest Articles (ACS Publications)

Thu Sep 12, 2019 07:00

[ASAP] Strategies for Enhancing the Rate Constant of C–H Bond Cleavage by Concerted Proton-Coupled Electron Transfer

Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b06849

Journal of the American Chemical Society: Latest Articles (ACS Publications)

Thu Sep 12, 2019 07:00

[ASAP] Polymorphism in the Assembly of Phase-Segregated Block Molecules: Pathway Control to 1D and 2D Nanostructures

Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b08733

Journal of the American Chemical Society: Latest Articles (ACS Publications)

Thu Sep 12, 2019 07:00

[ASAP] Gold(I)-Mediated Cycloisomerization/Cycloaddition Enables Bioinspired Syntheses of Neonectrolides B–E and Analogues

Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b06355

Journal of the American Chemical Society: Latest Articles (ACS Publications)

Thu Sep 12, 2019 07:00

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International Forum of Allergy & Rhinology

Associations among air pollutants, grass pollens, and daily number of grass pollen allergen‐positive patients: a longitudinal study from 2012 to 2016

Background Grass pollen is the most prevalent sensitizing aeroallergen to cause respiratory allergies in northern China. Air pollutants have a substantial effect on respiratory health and some pollens. This study aimed to investigate relationships among airborne grass pollen, air pollutants and allergic diseases, in order to determine their effects on patients with grass pollen allergies in Beijing, China, during the period from 2013 to 2016. Methods Data regarding autumnal grass pollens and...

International Forum of Allergy & Rhinology

Thu Sep 12, 2019 21:08

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RBE-weighted dose in carbon ion therapy for ACC patients: Impact of the RBE model translation on treatment outcomes

Carbon ion radiation therapy (CIRT) combines radiobiological and physical properties, with respect to other sources of external beam radiation therapy, that have a potential advantage for eradication of radioresistant tumours [1]. The high linear energy transfer (LET) of carbon ions provides a higher relative biological effectiveness (RBE) and a lower oxygen enhancement ratio, while physical properties as the sharp dose falloff in the Bragg peak region and minimal lateral scattering allow the delivery...

RBE-weighted doses in target volumes of chordoma and chondrosarcoma patients treated with carbon ion radiotherapy: Comparison of local effect models I and IV

Thu Sep 12, 2019 03:00

Carbon ion radiotherapy of tumors of the skull base has gained increasing interest throughout the last two decades. Similar to protons, carbon ions allow for highly conformal irradiation of the tumor while sparing the surrounding normal tissue structures like brain stem, optic nerves and the chiasma due to their “inverted” depth dose profile, the so-called Bragg-peak [1]. An additional rationale for selecting carbon ions results from their higher relative biological effectiveness (RBE) relative to...

Results of 15 Gy HDR-BT boost plus EBRT in intermediate-risk prostate cancer: Analysis of over 500 patients

Thu Sep 12, 2019 03:00

Prostate cancer is the most common non-skin malignancy diagnosed in men. Approximately 40% of patients with newly diagnosed prostate cancer are categorized in the intermediate-risk group [1]. Patients in this group have a broad spectrum of cancer aggressiveness and further subcategorization has been previously proposed [2].

Lower doses to hippocampi and other brain structures for skull-base meningiomas with intensity modulated proton therapy compared to photon therapy

Thu Sep 12, 2019 03:00

Meningiomas represent 13–26% of all symptomatic primary brain tumours and are considered benign in 90% of the cases [1]. For treatment of meningiomas several options are available, including observation, surgical resection and external beam radiotherapy. Generally, radiotherapy (RT) is used when surgery is not feasible, or in case of a recurrent tumour after surgical intervention [2,3]. Patients treated with RT have a long life expectancy, making it very important to minimize any adverse effects...

The New England Journal of Medicine: Search Results in Primary Care\Hospitalist\Clinical Practice

Thu Sep 12, 2019 03:00

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Medical Marijuana Miscalculation

To the Editor: Pennsylvania legalized medical marijuana in 2016, and since then its use has skyrocketed. The doses of the active ingredients of marijuana — tetrahydrocannabinol (THC) and cannabidiol (CBD) — are not standardized, product concentrations are not regulated, and prescribing practices…

The New England Journal of Medicine: Search Results in Primary Care\Hospitalist\Clinical Practice

Thu Sep 12, 2019 03:00

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Treatment of Hypertension in Patients with Asthma

Asthma and hypertension are common chronic diseases, each with attendant morbidity, mortality, and economic effects. It is estimated that 300 million people worldwide have asthma, and an increase in prevalence to 400 million is anticipated by 2025. Approximately 250,000 asthma-related deaths occur…

The New England Journal of Medicine: Search Results in Primary Care\Hospitalist\Clinical Practice

Thu Sep 12, 2019 03:00

Breaching the Professional–Personal Boundary — An Unrecognized Risk for Burnout

I recently received a call from a friend and palliative care colleague whose mother had metastatic uterine cancer. She had developed jaundice and escalating pain and needed to be admitted to our hospital. A flurry of phone calls followed between members of our team: How would we provide palliative…

The New England Journal of Medicine: Search Results in Primary Care\Hospitalist\Clinical Practice

Thu Sep 12, 2019 03:00

Caught in the Web — U.S. Immigration and Compound Disadvantage

Three years ago, Mr. V. made his way on foot from Honduras to the United States, leaving his family behind. When he left home, he’d had a globus sensation and occasional anxiety for 2 or 3 years, and since his arrival in the United States, the globus sensation had been coming on more frequently,…

The New England Journal of Medicine: Search Results in Primary Care\Hospitalist\Clinical Practice

Thu Sep 12, 2019 03:00

Palmar Squamous-Cell Carcinoma

Figure 1.

The New England Journal of Medicine: Search Results in Primary Care\Hospitalist\Clinical Practice

Thu Sep 12, 2019 03:00

Case 28-2019: A 22-Year-Old Woman with Dyspnea and Chest Pain

Presentation of Case. Dr. Bethany L. Bartley (Pediatrics): A 22-year-old woman was seen in the pediatric pulmonary clinic of this hospital because of chest pain, cough, and dyspnea on exertion. The patient had been well until she was 2 months of age, when an episode of bronchiolitis occurred. After…

The New England Journal of Medicine: Search Results in Primary Care\Hospitalist\Clinical Practice

Thu Sep 12, 2019 03:00

Disseminated Varicella Infection

Figure 1.

The New England Journal of Medicine: Search Results in Primary Care\Hospitalist\Clinical Practice

Thu Sep 12, 2019 03:00

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The New England Journal of Medicine: Allergy\Immunology

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Why Is My Panel on Thursday Morning?

Not sure why your 2019 AAA/CASCA Annual Meeting session is scheduled for a particular date or time? An executive program co-chair shares their experience. For many years, I wondered how the AAA Annual Meeting was scheduled—how was my panel assigned a day and time, and why was my paper accepted as a poster, or not at all? For the past year, I’ve worked with AAA, CASCA, and the executive program chairs from 2018–2020 to set the conference schedule. I have learned a lot about the rituals and structures...

Thu Sep 12, 2019 17:00

The Addis Five

Our eagle-eyed editor, Sue Kenyon, always on the lookout for material for columns for our section news column, asked me to say more about the folks in this picture, previously published in “Moonwalk Memories.” I am delighted to. As I look at it, over and over, I am gratified at its success as a photo capturing dear friends and contributors at a crucial time in our lives and in the development of anthropology in Ethiopia. Herb Lewis and anthropology friends in Addis Ababa, sometime in the 1960s....

Thu Sep 12, 2019 21:00

Rapping Blackness

As a biracial man, there’s something visceral about being in a room full of black people of all shades, from across the United States—all of whom have dressed up to experience a space of music, intellectualism, indulgence, and fun—that makes you stand up straighter. Hip hop is an exemplary black space, and its constituent cultural activities exist in widespread and influential opposition to the systems and ideologies enacted by the powerful that propagate white ways of being at the expense of colored...