Abstract Background This study assessed the maximum tolerated dose (MTD) of the PI3K inhibitor buparlisib given concurrently with cetuximab in recurrent and metastatic (R/M) head and neck squamous cell carcinoma (HNSCC). Methods Twelve patients with R/M HNSCC were enrolled. Patients were given oral buparlisib starting day 7 and daily thereafter. The dose of buparlisib was escalated in a 3 + 3 design followed by a dose expansion cohort of 6 patients. The MTD of buparlisib per protocol was...
Wed Sep 04, 2019 20:03
New England Journal of Medicine, Volume 381, Issue 10, Page 945-955, September 2019.
Wed Sep 04, 2019 12:00
New England Journal of Medicine, Volume 381, Issue 10, Page 979-979, September 2019.
Wed Sep 04, 2019 12:00
New England Journal of Medicine, Volume 381, Issue 10, Page 982-985, September 2019.
Wed Sep 04, 2019 12:00
New England Journal of Medicine, Volume 381, Issue 10, September 2019.
Wed Sep 04, 2019 12:00
New England Journal of Medicine, Volume 381, Issue 10, Page 903-911, September 2019.
Wed Sep 04, 2019 12:00
New England Journal of Medicine, Volume 381, Issue 10, September 2019.
Wed Sep 04, 2019 12:00
New England Journal of Medicine, Volume 381, Issue 10, Page 923-932, September 2019.
Wed Sep 04, 2019 12:00
Abstract Itch is a multidimensional experience involving various brain regions associated with sensory perception and emotion, as well as an urge to scratch employing the motor system. Scratch temporarily relieves itch sensation in healthy subjects. However, in patients with chronic itch, rather than inhibit, scratch may aggravate itch. Patients with chronic itch, such as those with atopic dermatitis, experience severe itch and a strong desire to scratch. This urge to scratch is the driving force...
Wed Sep 04, 2019 22:40
A new research has published the Victorian Childhood Hearing Impairment Longitudinal Databank (VicCHILD), which promises to help researchers across the globe in understanding why some children with hearing loss adapt and thrive better than others. The databank containing profiles children with hearing loss shows that language development and speech in hearing-impaired children are slower compared with the development of children with normal hearing, despite advancements in earlier detection...
Tue Sep 03, 2019 17:02
Cerambycidae is one of the most diversified groups within Coleoptera and includes nearly 35,000 known species. The relationships at the subfamily level within Cerambycidae have not been convincingly demonstrated and the gene rearrangement of mitochondrial genomes in Cerambycidae remains unclear due to the low numbers of sequenced mitogenomes. In the present study, we determined five complete mitogenomes of Cerambycidae and investigated the phylogenetic relationship among the subfamilies of Cerambycidae...
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Background Thirteen-lined ground squirrels (Ictidomys tridecemlineatus) experience dramatic changes in physiological and molecular parameters during winter hibernation. Notably, these animals experience reduced blood circulation during torpor, which can put numerous stresses on their hearts. The present study evaluates the role played by the epidermal growth factor receptor (EGFR) in signal transduction during hibernation at low body temperature to evaluate signaling mechanisms. By investigating...
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Summary Osimertinib is a key drug for cancer patients with EGFR mutations. However, there is little information about its safety in cancer patients who require hemodialysis (HD) for chronic renal failure, despite notable increases in their numbers. Herein, we examined osimertinib safety in such a patient via pharmacokinetics analysis. A 66-year-old man was diagnosed with relapsed stage IV non-small cell lung cancer with an EGFR mutation in exon 21 (L858R) 2 years after stereotactic...
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Abstract Purpose Recent advances in targeted therapy have prolonged overall survival (OS) for patients with lung cancer. The impact of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKI) on brain metastases (BM) treated with stereotactic radiosurgery (SRS) has not, however, been fully elucidated. We investigated the influence of post-SRS EGFR-TKI use on the efficacy and toxicity of SRS for BM from lung adenocarcinoma....
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