Eosinophilic esophagitis, once considered a rare disorder, has been increasingly recognized as a leading cause of dysphagia and food impaction in children and adults over the last few decades. It predominantly...
Tue Sep 03, 2019 03:00
CRISPR-Cas9 technology provides an efficient method to precisely edit the mammalian genome in any cell type and represents a novel means to perform genome-wide genetic screens. A detailed protocol discussing the steps required for the successful performance of pooled genome-wide CRISPR-Cas9 screens is provided here.
Wed Sep 04, 2019 20:41
An experimental design was developed to investigate the real-time influences of an examination experience to assess the emotional realities students experience in higher education settings and tasks. This design is the result of a cross-disciplinary (e.g., educational psychology, biology, physiology, engineering) and multi-modal (e.g., salivary markers, surveys, electrodermal sensor) approach.
Wed Sep 04, 2019 21:42
This protocol aims to demonstrate how to microinject a DNA/DOTAP mixture into eyebuds of one day old Xenopus laevis embryos, and how to image and reconstruct individual green fluorescent protein (GFP) expressing optic axonal arbors in tectal midbrains of intact, living Xenopus tadpoles.
Wed Sep 04, 2019 22:44
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b07170
Wed Sep 04, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b05197
Wed Sep 04, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b07508
Wed Sep 04, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b06142
Wed Sep 04, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b07891
Wed Sep 04, 2019 07:00
Abstract Endoscopic dilatation is the recommended primary therapy for chronic corrosive esophageal strictures (ES), and surgery is reserved for failed dilatation. Through this study, we intend to analyze the efficacy and long-term outcomes of both endoscopic and surgical interventions in corrosive ES. A retrospective cohort analysis of patients with chronic corrosive ES, managed with endoscopic or surgical procedures at a tertiary teaching institute in North India from December...
Wed Sep 04, 2019 03:00
Wed Sep 04, 2019 03:00
Oncogenesis, Published online: 04 September 2019; doi:10.1038/s41389-019-0159-6EPHA2 mutations with oncogenic characteristics in squamous cell lung cancer and malignant pleural mesothelioma
Wed Sep 04, 2019 03:00
Abstract Sexually reproducing populations with self‐incompatibility bear the cost of limiting potential mates to individuals of a different type. Rare mating types escape this cost since they are unlikely to encounter incompatible partners, leading to the deterministic prediction of continuous invasion by new mutants and an ever increasing number of types. However, rare types are also at an increased risk of being lost by random drift. Calculating the number of mating types that a population can...
Tue Sep 03, 2019 20:33
Abstract Adaptive phenotypic plasticity is a potent but not ubiquitous solution to environmental heterogeneity, driving interest in what factors promote and limit its evolution. Here a novel computational model representing stochastic information flow in development is used to explore evolution from a constitutive phenotype to an adaptively plastic response. Results show that populations tend to evolve robustness to developmental stochasticity, but this evolved robustness limits evolvability; specifically,...
Tue Sep 03, 2019 20:34
Related ArticlesComparison of the clinicopathological features of pancreatic solid pseudopapillary neoplasms between males and females: gender does matter. Histol Histopathol. 2019 Sep 03;:18156 Authors: Zou Y, Huang Y, Hong B, Xiang X, Zhou B, Wei S Abstract BACKGROUND: Solid pseudopapillary neoplasms (SPN) of the pancreas are a rare and low-grade malignant entity with a female predominance. However, it also occurs in males, but the rarity and lack...
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A geoscientist calls the unearthed fossils, including the bodies and trails left by an ancient animal species, the most convincing sign of ancient animal mobility, dating back about 550 million years.
Wed Sep 04, 2019 20:06
The evolutionary pressure to pass on DNA can produce behavior that otherwise makes no sense in a struggle to survive. Rams bash heads in fights over females; peacocks grow elaborate tail feathers that attract mates and predators alike. Sexual selection can sometimes explain phenomena that natural selection alone cannot. But could bacteria exhibit sexual selection? Researchers argue that some bacteria might.
Wed Sep 04, 2019 18:32
Triplophysa stoliczkae is the most widespread species in the genus Triplophysa and may have originated from morphological convergence. To understand the evolutionary history of T. stoliczkae, we employed a multil...
Wed Sep 04, 2019 03:00
Amid concerns about high and rising drug prices, policymakers are considering options for modifying the Medicare Part D prescription-drug benefit to reduce spending by beneficiaries and taxpayers. Medicare beneficiaries without low-income subsidies currently face high and unlimited out-of-pocket…
Wed Sep 04, 2019 03:00
Drug spending, price, and affordability problems in the United States stem directly from insufficient competition. In prescription-drug markets in which competition is weak, Medicare’s purchasing rules tilt the bargaining process in favor of the pharmaceutical industry at the expense of consumers…
Wed Sep 04, 2019 03:00
Soft Robotics, Ahead of Print.
Wed Sep 04, 2019 10:00
The Clinical Practice Guidelines for Dementia in Australia provide evidence-based recommendations for the assessment, diagnosis, and care of people with dementia and their informal carers. The extent to which ...
Wed Sep 04, 2019 03:00
Medical records are critical to patient care, but often contain incomplete information. In UK hospitals, record-keeping is traditionally undertaken by junior doctors, who are increasingly completing early-care...
Wed Sep 04, 2019 03:00
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