Publication date: October 2019Source: Neoplasia, Volume 21, Issue 10Author(s): Lynn M Frydrych, Peter Ulintz, Armand Bankhead, Christopher Sifuentes, Joel Greenson, Lillias Maguire, Regina Irwin, Eric R. Fearon, Karin M HardimanAbstractTreatment of locally advanced rectal cancer includes chemotherapy, radiation, and surgery but patient responses to neoadjuvant treatment are variable. We have shown that rectal tumors are comprised of multiple genetically distinct sub-clones. Unique sub-clones within...
Fri Sep 13, 2019 13:51
Publication date: October 2019Source: Neoplasia, Volume 21, Issue 10Author(s): Allegra G. Hawkins, Claire M. Julian, Sonja Konzen, Sydney Treichel, Elizabeth R. Lawlor, Kelly M. BaileyAbstractEwing sarcoma is a bone tumor most commonly diagnosed in adolescents and young adults. Survival for patients with recurrent or metastatic Ewing sarcoma is dismal and there is a dire need to better understand the mechanisms of cell metastasis specific to this disease. Our recent work demonstrated that microenvironmental...
Fri Sep 13, 2019 13:51
Condition: Muscular Atrophy, SpinalIntervention: Drug: NusinersenSponsor: BiogenNot yet recruiting
Fri Sep 13, 2019 14:02
Conditions: Breast Cancer; Gut Microbiome; Exercise; FatigueInterventions: Other: Aerobic Exercise Training; Other: Attention ControlSponsors: University of Alabama at Birmingham; National Cancer Institute (NCI)Not yet recruiting
Fri Sep 13, 2019 14:02
Capnocytophaga canimorsus is a Gram-negative rods frequently isolated as commensal in the saliva of pets that can be transmitted to humans. We report a case of septic shock caused by this pathogen. A 78-year-old man affected by diabetes and hypertension was admitted for fever in our Emergency Department. He reported fever (37.7°C) with normal values of blood pressure, heart rate and saturation of oxygen. Laboratory studies showed increased values of procalcitonin and normal white-cell level. Blood...
Fri Sep 13, 2019 13:45
OBJECTIVE: Parkinson’s disease is a neurodegenerative disease that typically results in the loss of dopaminergic neurons, especially in an area of the brain known as the substantia nigra. Here, we investigated the roles of two important neuronal development proteins, dysbindin-1 and SATB2, at different stages of Parkinson’s disease. MATERIALS AND METHODS: Using various concentrations of a neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), we established the mouse models at initial...
Fri Sep 13, 2019 13:45
Related ArticlesTumour heterogeneity: does it matter? Expert Rev Anticancer Ther. 2019 Sep 11;: Authors: Turnquist C, Watson RA, Protheroe A, Verrill C, Sivakumar S Abstract Introduction: It has long been recognised that tumours are composed of a mosaic of cells and numerous methods have been developed to detect tumour heterogeneity, including in situ hybridisation, multi-regional sampling, cytological assays, and whole genome and single cell sequencing....
Fri Sep 13, 2019 14:04
Related ArticlesOpioids and their endocrine effects: A systematic review and meta-analysis. J Clin Endocrinol Metab. 2019 Sep 12;: Authors: de Vries F, Bruin M, Lobatto DJ, Dekkers OM, Schoones JW, van Furth WR, Pereira AM, Karavitaki N, Biermasz NR, Zamanipoor Najafabadi AH Abstract CONTEXT: The increased use of opioids has resulted in an unprecedented opioid epidemic. Chronic opioid use causes hypogonadism, but its frequency, as well as the effects...
Fri Sep 13, 2019 14:09
Related ArticlesMitochondrial dysfunction induced by high estradiol concentrations in endometrial epithelial cells. J Clin Endocrinol Metab. 2019 Sep 12;: Authors: Chou CH, Chen SU, Chen CD, Shun CT, Wen WF, Tu YA, Yang JH Abstract CONTEXT: A supraphysiological estradiol (E2) concentration after ovarian stimulation is known to result in lower embryo implantation rates in in vitro fertilization (IVF). Endometrial epithelial cells (EECs) apoptosis occurs...
Fri Sep 13, 2019 14:09
Related ArticlesA Novel Anti-Cd40 Monoclonal Antibody, Iscalimab, for Control of Graves' Hyperthyroidism - A Proof-Of-Concept Trial. J Clin Endocrinol Metab. 2019 Sep 12;: Authors: Kahaly GJ, Stan MN, Frommer L, Gergely P, Colin L, Amer A, Schuhmann I, Espie P, Rush JS, Basson C, He YL Abstract CONTEXT: The CD40-CD154 co-stimulatory pathway plays an important role in the pathogenesis of Graves' disease (GD) by promoting auto-reactive B cell activation....
Fri Sep 13, 2019 14:09
Related ArticlesA Novel Anti-Cd40 Monoclonal Antibody, Iscalimab, for Control of Graves' Hyperthyroidism - A Proof-Of-Concept Trial. J Clin Endocrinol Metab. 2019 Sep 12;: Authors: Kahaly GJ, Stan MN, Frommer L, Gergely P, Colin L, Amer A, Schuhmann I, Espie P, Rush JS, Basson C, He YL Abstract CONTEXT: The CD40-CD154 co-stimulatory pathway plays an important role in the pathogenesis of Graves' disease (GD) by promoting auto-reactive B cell activation....
Fri Sep 13, 2019 14:09
Related ArticlesAMPK subunits harbor largely non-overlapping genetic determinants for body fat mass, glucose- and cholesterol metabolism. J Clin Endocrinol Metab. 2019 Sep 12;: Authors: Randrianarisoa E, Lehn-Stefan A, Krier J, Böhm A, Heni M, Hrabě de Angelis M, Fritsche A, Häring HU, Stefan N, Staiger H Abstract CONTEXT: AMP-activated protein kinase (AMPK) is a heterotrimeric enzyme and central regulator of cellular energy metabolism. The impact of...
Fri Sep 13, 2019 14:09
Related ArticlesUterine fluid proteins for minimally invasive assessment of endometrial receptivity. J Clin Endocrinol Metab. 2019 Sep 12;: Authors: Kasvandik S, Saarma M, Kaart T, Rooda I, Meikas AV, Ehrenberg A, Gemzell K, Lalitkumar PG, Salumets A, Peters M Abstract CONTEXT: Clinically used endometrial (EM) receptivity assays are based on transcriptomic patterning of biopsies at mid-secretory endometrium (MSE) to identify the possible displacement...
Fri Sep 13, 2019 14:09
Related ArticlesOpioids and their endocrine effects: A systematic review and meta-analysis. J Clin Endocrinol Metab. 2019 Sep 12;: Authors: de Vries F, Bruin M, Lobatto DJ, Dekkers OM, Schoones JW, van Furth WR, Pereira AM, Karavitaki N, Biermasz NR, Zamanipoor Najafabadi AH Abstract CONTEXT: The increased use of opioids has resulted in an unprecedented opioid epidemic. Chronic opioid use causes hypogonadism, but its frequency, as well as the effects...
Fri Sep 13, 2019 14:09
Related ArticlesUterine fluid proteins for minimally invasive assessment of endometrial receptivity. J Clin Endocrinol Metab. 2019 Sep 12;: Authors: Kasvandik S, Saarma M, Kaart T, Rooda I, Meikas AV, Ehrenberg A, Gemzell K, Lalitkumar PG, Salumets A, Peters M Abstract CONTEXT: Clinically used endometrial (EM) receptivity assays are based on transcriptomic patterning of biopsies at mid-secretory endometrium (MSE) to identify the possible displacement...
Fri Sep 13, 2019 14:09
Related ArticlesOpioids and their endocrine effects: A systematic review and meta-analysis. J Clin Endocrinol Metab. 2019 Sep 12;: Authors: de Vries F, Bruin M, Lobatto DJ, Dekkers OM, Schoones JW, van Furth WR, Pereira AM, Karavitaki N, Biermasz NR, Zamanipoor Najafabadi AH Abstract CONTEXT: The increased use of opioids has resulted in an unprecedented opioid epidemic. Chronic opioid use causes hypogonadism, but its frequency, as well as the effects...
Fri Sep 13, 2019 14:09
Related ArticlesDifferential resting state connectivity responses to glycemic state in type 1 diabetes. J Clin Endocrinol Metab. 2019 Sep 12;: Authors: Parikh L, Seo D, Lacadie C, Belfort-DeAguiar R, Groskreutz D, Hamza M, Dai F, Scheinost D, Sinha R, Constable RT, Sherwin R, Hwang JJ Abstract CONTEXT: Individuals with type 1 diabetes (T1DM) have alterations in brain activity which have been postulated to contribute to the adverse neurocognitive consequences...
Fri Sep 13, 2019 14:09
Related ArticlesDifferential resting state connectivity responses to glycemic state in type 1 diabetes. J Clin Endocrinol Metab. 2019 Sep 12;: Authors: Parikh L, Seo D, Lacadie C, Belfort-DeAguiar R, Groskreutz D, Hamza M, Dai F, Scheinost D, Sinha R, Constable RT, Sherwin R, Hwang JJ Abstract CONTEXT: Individuals with type 1 diabetes (T1DM) have alterations in brain activity which have been postulated to contribute to the adverse neurocognitive consequences...
Fri Sep 13, 2019 14:09
Related ArticlesUterine fluid proteins for minimally invasive assessment of endometrial receptivity. J Clin Endocrinol Metab. 2019 Sep 12;: Authors: Kasvandik S, Saarma M, Kaart T, Rooda I, Meikas AV, Ehrenberg A, Gemzell K, Lalitkumar PG, Salumets A, Peters M Abstract CONTEXT: Clinically used endometrial (EM) receptivity assays are based on transcriptomic patterning of biopsies at mid-secretory endometrium (MSE) to identify the possible displacement...
Fri Sep 13, 2019 16:14
Related ArticlesAMPK subunits harbor largely non-overlapping genetic determinants for body fat mass, glucose- and cholesterol metabolism. J Clin Endocrinol Metab. 2019 Sep 12;: Authors: Randrianarisoa E, Lehn-Stefan A, Krier J, Böhm A, Heni M, Hrabě de Angelis M, Fritsche A, Häring HU, Stefan N, Staiger H Abstract CONTEXT: AMP-activated protein kinase (AMPK) is a heterotrimeric enzyme and central regulator of cellular energy metabolism. The impact of...
Fri Sep 13, 2019 16:14
Related ArticlesMitochondrial dysfunction induced by high estradiol concentrations in endometrial epithelial cells. J Clin Endocrinol Metab. 2019 Sep 12;: Authors: Chou CH, Chen SU, Chen CD, Shun CT, Wen WF, Tu YA, Yang JH Abstract CONTEXT: A supraphysiological estradiol (E2) concentration after ovarian stimulation is known to result in lower embryo implantation rates in in vitro fertilization (IVF). Endometrial epithelial cells (EECs) apoptosis occurs...
Fri Sep 13, 2019 16:14
Related ArticlesA Novel Anti-Cd40 Monoclonal Antibody, Iscalimab, for Control of Graves' Hyperthyroidism - A Proof-Of-Concept Trial. J Clin Endocrinol Metab. 2019 Sep 12;: Authors: Kahaly GJ, Stan MN, Frommer L, Gergely P, Colin L, Amer A, Schuhmann I, Espie P, Rush JS, Basson C, He YL Abstract CONTEXT: The CD40-CD154 co-stimulatory pathway plays an important role in the pathogenesis of Graves' disease (GD) by promoting auto-reactive B cell activation....
Fri Sep 13, 2019 16:14
Related ArticlesEfficacy and Safety of First- and Second-Line Drugs to Prevent Glucocorticoid-Induced Fractures: A Network Meta-Analysis. J Clin Endocrinol Metab. 2019 Sep 12;: Authors: Ding L, Hu J, Wang D, Liu Q, Mo Y, Tan X, Wen F Abstract CONTEXT: The evidence about benefits and harms of drugs for glucocorticoid-induced osteoporosis (GIOP) is limited, and the comparative efficacy and safety of first-line and second-line agents to prevent glucocorticoid-induced...
Fri Sep 13, 2019 16:14
Related ArticlesHigh-fat overfeeding impairs peripheral glucose metabolism and muscle microvascular eNOS Ser1177 phosphorylation. J Clin Endocrinol Metab. 2019 Sep 12;: Authors: Parry SA, Turner MC, Woods RM, James LJ, Ferguson RA, Cocks M, Whytock KL, Strauss JA, Shepherd SO, Wagenmakers AJM, van Hall G, Hulston CJ Abstract CONTEXT: The mechanisms responsible for dietary fat-induced insulin resistance of skeletal muscle and its microvasculature are...
Fri Sep 13, 2019 16:14
Related ArticlesDevelopment of an Adrenocortical Cancer Humanized Mouse Model to Characterize Anti-PD1 Effects on Tumor Microenvironment. J Clin Endocrinol Metab. 2019 Sep 12;: Authors: Lang J, Capasso A, Jordan KR, French JD, Kar A, Bagby SM, Barbee J, Yacob BW, Head LS, Tompkins KD, Freed BM, Somerset H, Clark TJ, Pitts TM, Messersmith WA, Eckhardt SG, Wierman ME, Leong S, Kiseljak-Vassiliades K Abstract CONTEXT: While the development of immune checkpoint...
Fri Sep 13, 2019 16:14
OBJECTIVE: This study aims to investigate whether HOX transcript antisense RNA (HOTAIR) can participate in the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) by regulating the Wnt/β-catenin pathway, thereby participating in the pathogenesis of osteoporosis. PATIENTS AND METHODS: We detected the expression level of HOTAIR in 60 osteoporosis patients and 60 normal controls by Quantitative Real-Time Polymerase Chain Reaction (qRT-PCR). Meanwhile, BMSCs derived from human or...
Fri Sep 13, 2019 13:45
OBJECTIVE: This study aimed to investigate the expression of miR-373 in osteoporosis patients and rat models induced by estrogen deficiency and to detect whether miR-373 can regulate the ability of osteogenic differentiation of bone marrow mesenchymal stem cells in the osteoporosis microenvironment caused by estrogen deficiency. PATIENTS AND METHODS: Bone tissues and blood samples were collected from 20 osteoporotic patients and 20 controls. PCR analysis was used to detect the expression of miR-373...
Fri Sep 13, 2019 13:45
OBJECTIVE: Osteoporosis (OP) has a high incidence and can be found in multiple age groups. The bone marrow mesenchymal stem cells (BMSCs) have the potential for self-renewal and multi-directional differentiation, which are often used for investigating the differentiation function of osteoporosis bone marrow mesenchymal stem cells. γ-glutamyl carboxylase (GGCX) is a carboxylase-related carboxylase and was observed to be abnormally expressed in osteoarthritis. However, the role and related mechanisms...
Fri Sep 13, 2019 13:45
Related ArticlesManagement of unpredictable outcomes of costochondral grafts. Int J Surg Case Rep. 2019 Aug 16;62:144-149 Authors: Sekhoto MG, Rikhotso RE, Rajendran S Abstract INTRODUCTION: Temporomandibular joint (TMJ) ankylosis is a debilitating mandibular hypomobility disorder that may be associated with serious functional and aesthetic deformities including limited mouth opening, impaired mastication and disturbances of facial and mandibular growth....
Fri Sep 13, 2019 14:37
Related ArticlesEvaluation of a Bioengineered Honey and Its Synthetic Equivalent as Novel Staphylococcus aureus Biofilm-Targeted Topical Therapies in Chronic Rhinosinusitis. Am J Rhinol Allergy. 2019 Sep 11;:1945892419874700 Authors: Papadopoulou D, Dabrowska A, Harries PG, Webb JS, Allan RN, Salib RJ PMID: 31510757 [PubMed - as supplied by publisher]
Fri Sep 13, 2019 14:41
Related ArticlesHigh-Altitude Treatment in Rhinitis Patients. Am J Rhinol Allergy. 2019 Sep 11;:1945892419875591 Authors: Kang G PMID: 31510758 [PubMed - as supplied by publisher]
Fri Sep 13, 2019 14:41
Publication date: Available online 13 September 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): Karishma Rosann Pereira, Ramen SinhaAbstractRecent decades have witnessed the genesis and progressive application of intelligent machines and computer programs that have the ability to process information and execute cognitive functions similar to those of human logic and reasoning such as problem solving and decision making. That is artificial intelligence (AI) in a nutshell as...
Fri Sep 13, 2019 14:42
Publication date: Available online 13 September 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): H. Liu, Y. Wang, C. Wu, X. Sun, L. Li, C. Li, Q. Chen, E. LuoAbstractTo compare the effectiveness and safety of robotic surgery with that of open operations for patients with cancers of the head and neck we made an electronic search of the CENTRAL, MEDLINE, EMBASE, CNKI, CBM, Opengray and Sciencepaper Online databases, and then made a manual search of specific online databases and...
Fri Sep 13, 2019 14:42
Related ArticlesFragment-based screening with natural products for novel anti-parasitic disease drug discovery. Expert Opin Drug Discov. 2019 Sep 12;:1-13 Authors: Liu M, Quinn RJ Abstract Introduction: Fragment-based drug discovery can identify relatively simple compounds with low binding affinity due to fewer binding interactions with protein targets. FBDD reduces the library size and provides simpler starting points for subsequent chemical optimization...
Fri Sep 13, 2019 14:44
Related ArticlesInduced degradation of protein kinases by bifunctional small molecules: a next-generation strategy. Expert Opin Drug Discov. 2019 Sep 12;:1-17 Authors: Groppe JC Abstract Introduction: Protein kinases are a major target for small-molecule drug development. However, relatively few compounds are free of off-target toxicity and reach the clinic. Because the 500-plus kinases share conserved ATP-binding clefts, the site targeted by competitive...
Fri Sep 13, 2019 14:44
Related Articles4D- quantitative structure-activity relationship modeling: making a comeback. Expert Opin Drug Discov. 2019 Sep 12;:1-9 Authors: Fourches D, Ash J Abstract Introduction: Predictive Quantitative Structure-Activity Relationship (QSAR) modeling has become an essential methodology for rapidly assessing various properties of chemicals. The vast majority of these QSAR models utilize numerical descriptors derived from the two- and/or three-dimensional...
Fri Sep 13, 2019 14:44
Fri Sep 13, 2019 03:00
Fri Sep 13, 2019 03:00
Fri Sep 13, 2019 03:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου