Abstract Insomnia Disorder is the most prevalent sleep disorder, and it involves both sleep difficulties and daytime complaints. The neural underpinnings of Insomnia Disorder are poorly understood. Several existing neuroimaging studies focused on local measures and specific regions of interests, which makes it difficult to judge their whole‐brain significance. We therefore here applied a data‐driven approach to assess differences in whole‐brain structural connectivity between adults with Insomnia...
Thu Sep 12, 2019 15:49
Abstract Not getting enough sleep is a common problem in our society and contributes to numerous health problems, including high blood pressure, diabetes and obesity. Related to these observations, a wealth of studies has underscored the negative impact of both acute and chronic sleep deprivation on cognitive function. More recently it has become apparent that the gut microbiota composition can be rapidly altered, modulates brain function and is affected by the aforementioned health problems. As...
Thu Sep 12, 2019 15:51
Publication date: Available online 12 September 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Tsuyoshi Matsuoka, Shotaro Kawano, Kenta Fujimoto, Makoto Kawahara, Hiroyuki HashimotoAbstractObjectivesThough the Japanese version of the Montreal Cognitive Assessment (MoCA-J) scores change after a cerebrospinal fluid tap test (CSFTT), their characteristics remain unclear.To compare patient response rate to changes in cognitive function observed in the cerebrospinal fluid tap test, and to determine...
Fri Sep 13, 2019 15:07
21 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Ann Plast Surg"[jour] These pubmed results were generated on 2019/09/13PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Fri Sep 13, 2019 13:13
21 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Ann Plast Surg"[jour] These pubmed results were generated on 2019/09/13PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Fri Sep 13, 2019 15:18
Abstract Identifying inbreeding depression early in small and declining populations is essential for management and conservation decisions. Correlations between heterozygosity and fitness (HFCs) provide a way to identify inbreeding depression without prior knowledge of kinship among individuals. In Northern Quebec and Labrador, the size of two herds of migratory caribou (Rivière‐George; RG, and Rivière‐aux‐Feuilles; RAF) has declined by one to two orders of magnitude in the last three decades. This...
Thu Sep 12, 2019 14:08
The major symptoms of Ménière’s disease are episodic vertigo, fluctuating hearing loss, and tinnitus. Direction-changing spontaneous nystagmus is a characteristic vestibular finding in Ménière’s disease. In the acute stage, spontaneous nystagmus beating to the affected side (irritative nystagmus) is often observed, while paralytic nystagmus beating to the healthy side is found in the chronic stage. This direction-changing nystagmus can be reproduced in guinea pigs by increasing the potassium ion...
Fri Sep 13, 2019 12:06
Zusammenfassung Hintergrund Dichotisches Sprachverstehen seitengetrennter Sprachstimuli erfordert deren zentralnervöse Verarbeitung und wurde seit den 1950er-Jahren bei verschiedenen klinischen Fragestellungen eingesetzt. Ziel der Arbeit Ziel war es, das dichotische Sprachverstehen von normalhörenden (NH) Probanden, Cochleaimplantat (CI)-Trägern mit einseitiger...
Fri Sep 13, 2019 03:00
Dihydroartemisinin (DHA) has been shown to exert anticancer activity through iron-dependent reactive oxygen species (ROS) generation, which is similar to ferroptosis, a novel form of cell death. However, wheth...
Fri Sep 13, 2019 03:00
Metabolic reprogramming is an important characteristic of tumors. In the progression of pituitary adenomas (PA), abnormal glucose metabolism has been confirmed by us before. However, whether cholesterol metabo...
Fri Sep 13, 2019 03:00
Iron, an indispensable element for life, is involved in all kinds of important physiological activities. Iron promotes cell growth and proliferation, but it also causes oxidative stress damage. The body has a ...
Fri Sep 13, 2019 03:00
Skin cutaneous melanoma (SKCM) is the most lethal form of skin cancer and while incidence rates are declining for most cancers, they have been steadily rising for SKCM. Serine protease inhibitor, kunitz-type, ...
Fri Sep 13, 2019 03:00
T cells play important roles in anti-tumor immunity. Emerging evidence has revealed that distinct metabolic changes impact the activation and differentiation of T cells. Tailoring immune responses by manipulat...
Fri Sep 13, 2019 03:00
Abstract We prospectively validate the efficacy of the frailty discriminant score (FDS) in individuals with urological cancers, as there has been growing importance in evaluating frailty in clinical practice. A prospective, multicenter study was conducted from February 2017 to April 2019. We enrolled 258 patients with urological cancers and 301 community-dwelling participants who were assessed for frailty. Frailty was assessed using FDS that includes ten items, such as physical,...
Fri Sep 13, 2019 03:00
Abstract Several clinical studies have examined circulating tumour cells (CTCs). However, the application of CTCs as a predictive/prognostic marker for breast cancer patients has yet to be established, particularly the selection of suitable markers for detecting CTCs. We recently investigated CTCs, including mesenchymal status, from metastatic breast cancer patients who had received eribulin-based treatment. We found that assessment of both mesenchymal and epithelial CTCs might...
Fri Sep 13, 2019 03:00
Related ArticlesC/EBPα regulates FOXC1 to modulate tumor growth by interacting with PPARγ in Hepatocellular carcinoma. Curr Cancer Drug Targets. 2019 Sep 12;: Authors: Xu Z, Meng SH, Bai JG, Sun C, Zhao LL, Tang RF, Yin ZL, Ji JW, Yang W, Ma GJ Abstract BACKGROUND: Forkhead box C1 (FOXC1) is an important cancer associated gene in tumor. PPAR-γ and C/EBPα are both transcriptional regulators involved in tumor development. OBJECTIVE: We aimed to...
Fri Sep 13, 2019 16:48
Already trusted by 150+ major California hospitals, the company announces a $15M Series A today led by Andreessen Horowitz to build a community for health care professionals across the US. SAN FRANCISCO, Calif. (Sept 12, 2019) Incredible Health – the company powering one of the country’s fastest-growing health care hiring platforms – today announced $15 million in Series A funding led by Andreessen Horowitz with participation from NFX, Obvious Ventures, Precursor Ventures, and...
Fri Sep 13, 2019 16:46
Smartwatches and dedicated wrist-based activity trackers have become popular over the past few years. They’re decent at counting steps during walking and running, but they’re not very good at tracking most athletic activities. At Carnegie Mellon University researchers have developed a camera-based system that simply watches people at the gym doing exercises and automatically classifies their activities and counts the repetitions. The computer vision software recognizes repetitive motions and...
Fri Sep 13, 2019 16:51
Publication date: November 2019Source: Annals of Anatomy - Anatomischer Anzeiger, Volume 226Author(s):
Fri Sep 13, 2019 17:13
Abstract Blast‐induced Traumatic Brain Injury (TBI) has been affecting combatants and civilians. The blast pressure wave is thought to have a significant contribution to blast related TBI. Due to the limitations and difficulties of conducting blast tests on surrogates, computational modelling has been used as a key method for exploring this field. However, the blast wave modelling methods reported in current literature have drawbacks. They either cannot generate the desirable blast pressure wave...
Fri Sep 13, 2019 16:15
In January 2018, 10 members from an Ainu traditional performance group, Sapporo Upopo Hozonkai (Sapporo Upopo Preservation Society, hereafter SUH), traveled from Sapporo, the capital city of Hokkaido prefecture, to Honolulu in Hawai’i for a one-day performance at the Ala Moana Centerstage. This performance promoted Upopoy, a state-funded National Ainu Museum and Park (also known as Symbolic Space for Ethnic Harmony) due to open on April 24, 2020 in Hokkaido to coincide with the Tokyo Olympics. This...
Fri Sep 13, 2019 17:00
Abstract Background The development of Endoscopic Sinus Surgery (ESS) training simulators for clinical environment applications have reduced the existing shortcomings in conventional teaching methods, creating a standard environment for trainers and trainees in a more accurate and repeatable fashion. Materials and methods In this research, the validation study of an ESS training simulator has been addressed. It is important to consider components which guide trainees to improve their hand...
Fri Sep 13, 2019 18:12
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01361J, PaperChao Han, Shu-Mu Li, Qingwei Yue, Na Li, Hui Yang, Zhenwen ZhaoMatrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) is a powerful tool for the characterization and localization of analytes without extraction, purification, separation or labeling of samples. However, in tissue...The content of this RSS Feed (c) The Royal Society of Chemistry
Fri Sep 13, 2019 02:00
Publication date: Available online 12 September 2019Source: BrachytherapyAuthor(s): Peter Hass, Konrad Mohnike, Siegfried Kropf, Thomas B. Brunner, Mathias Walke, Dirk Albers, Cordula Petersen, Robert Damm, Franziska Walter, Jens Ricke, Maciej Powerski, Stefanie CorradiniAbstractPurposeInterstitial high-dose-rate brachytherapy (BT) is an alternative treatment option to stereotactic body radiotherapy (SBRT) for the ablative treatment of liver malignancies. The aim of the present comparative planning...
Fri Sep 13, 2019 18:20
Τα συμπτώματα του εμφράγματος μπορεί να εκδηλωθούν αιφνίδια ή να εξελιχθούν σταδιακά, αλλά και στις δυο περιπτώσεις αποτελούν επείγον ιατρικό περιστατικό. Αυτό είναι το κύριο μήνυμα έρευνας που δημοσιεύθηκε στο European Journal of Cardiovascular Nursing. Η μελέτη βρήκε ότι στους ασθενείς με βαθμιαία εκδήλωση των συμπτωμάτων χορηγήθηκε ιατρική φροντίδα σε οχτώ ώρες, συγκριτικά με 2,6 ώρες που χρειάστηκαν για να χορηγηθεί ιατρική φροντίδα σε ανθρώπους με αιφνίδια συμπτώματα. Η βαθμιαία εκδήλωση των...
Fri Sep 13, 2019 08:00
Μία νέα γονιδιακή θεραπεία μετατρέπει τα νευρογλοιακά κύτταρα – υποστηρικτικά κύτταρα στον εγκέφαλο – σε νευρώνες, επιδιορθώνοντας τις βλάβες του εγκεφαλικού επεισοδίου και βελτιώνοντας την κινητική λειτουργία σε ζωικά μοντέλα (ποντίκια). Μία δημοσίευση που έγινε στο Molecular Therapy περιγράφει τη νέα θεραπεία η οποία χρησιμοποιεί το γονίδιο NeuroD1 η οποία εφόσον αναπτυχθεί περαιτέρω, θα μπορούσε να χρησιμοποιηθεί για την αντιμετώπιση του εγκεφαλικού επεισοδίου, το οποίο είναι η κυριότερη αιτία...
Fri Sep 13, 2019 08:15
Ο κιρκάδιανος ρυθμός αποτελεί τον… μαέστρο για ένα σημαντικό αριθμό λειτουργιών του οργανισμού στη διάρκεια του 24ώρου. Η έκκριση ορμονών, η αρτηριακή πίεση, οι κύκλοι ύπνου και αφύπνισης, ακόμα και ο συγχρονισμός της χειμερίας νάρκης σε ζώα όπως οι αρκούδες ελέγχονται από αυτό το βιολογικό ρολόι. Μία ομάδα ερευνητών από το Πανεπιστήμιο της Πενσυλβάνια εξέτασε το κιρκαδιανό ρολόι και τη σχέση του με τον καφέ λιπώδη ιστό που θεωρείται η «καλή» μορφή λίπους και συσχετίζεται με τη διατήρηση του φυσιολογικού...
Fri Sep 13, 2019 08:50
Οι άνθρωποι άνω των 60 ετών μπορούν να μειώσουν τον κίνδυνο εμφάνισης ασθενειών που σχετίζονται με την ηλικία, όπως για παράδειγμα η άνοια, κάνοντας μόνο δύο λεπτά άσκησης την εβδομάδα, σύμφωνα με μελέτη που δημοσιεύθηκε στο Sport Sciences for Health. Στη μελέτη που διενήργησαν ερευνητές από το Πανεπιστήμιο Abertay συμμετείχαν 17 άνθρωποι ηλικίας 60-75 ετών, οι οποίοι κλήθηκαν να πραγματοποιήσουν δύο προγράμματα προπόνησης την εβδομάδα για διάστημα 10 εβδομάδων. Η ομάδα έλαβε μέρος σε μια διαλειμματική...
Fri Sep 13, 2019 09:20
Η χρήση ηλεκτρονικού τσιγάρου μπορεί να επιφέρει προβλήματα στη γονιμότητα και την εγκυμοσύνη σύμφωνα με έρευνα του Πανεπιστημίου της Βόρειας Καρολίνα που πραγματοποιήθηκε σε ζωικά μοντέλα (ποντίκια) και δημοσιεύθηκε στο Journal of the Endocrine Society. Πολλές νεαρές και έγκυες γυναίκες χρησιμοποιούν ηλεκτρονικά τσιγάρα θεωρώντας τα ασφαλέστερη επιλογή για κάπνισμα. Εντούτοις πολύ λίγα πράγματα είναι γνωστά για τις επιδράσεις του ατμίσματος στη γονιμότητα αλλά και την εγκυμοσύνη. Σύμφωνα με τα...
Fri Sep 13, 2019 09:30
Το αντανακλαστικό «πάλης ή φυγής» που ενεργοποιείται σε καταστάσεις ξαφνικής απειλής, ρυθμίζεται από μια ορμόνη που παράγουν τα οστά και όχι από την παραγόμενη από τα επινεφρίδια αδρεναλίνη, σύμφωνα με νέα ερευνητικά δεδομένα. Μελέτη που διεξήχθη από ερευνητές του Πανεπιστημίου Κολούμπια και δημοσιεύτηκε στο Cell Metabolism, ανέδειξε την ύπαρξη μιας νέας ορμόνης, της οστεοκαλσίνης, η οποία εκλύεται από τα οστά και ρυθμίζει την αντίδραση του οργανισμού σε απειλητικές καταστάσεις. Τα νέα δεδομένα...
Fri Sep 13, 2019 13:26
Δημιουργήθηκε ένα νέο όπλο κατά της ανάπτυξης αντοχής στα αντιβιοτικά, το οποίο εξετάζει την αναπνοή ενός ασθενούς και τον ενημερώνει μέσα σε πέντε λεπτά εάν η λοίμωξη από την οποία πάσχει αντιμετωπίζεται με αντιβιοτικά. Η νέα αυτή συσκευή, που ονομάζεται BreathSpec, παρουσιάστηκε στο Βρετανικό Φεστιβάλ Επιστημών, από τον δημιουργό της Τζέιμς Κόνβιγκτον. Ο Δρ. Κόβιγκτον, καθηγητής ηλεκτρονικής μηχανικής στο Πανεπιστήμιο Warwick της Βρετανίας εξηγεί ότι το εργαλείο αυτό διακόπτει την υπερβολική χρήση...
Fri Sep 13, 2019 15:34
Η λήψη αντιβιοτικού πριν από την έναρξη ανοσοθεραπείας σε ασθενείς με καρκίνο μειώνει δραματικά τις πιθανότητες επιβίωσής τους, σύμφωνα με νέα έρευνα. Η μελέτη αυτή που δημοσιεύτηκε στο Jama Oncology, αναδεικνύει την ανάγκη να είμαστε ιδιαίτερα προσεκτικοί σε ό,τι αφορά τη χορήγηση αντιβιοτικών, ιδιαίτερα σε συγκεκριμένες ομάδες ασθενών. «Τα αντιβιοτικά διαταράσσουν τη μικροχλωρίδα του εντέρου» δηλώνει ο δρ. Ντέιβιντ Πινάτο από το τμήμα χειρουργικής και καρκίνου του Πανεπιστημίου Imperial του Λονδίνου...
Fri Sep 13, 2019 15:39
Publication date: November 2019Source: Brain and Language, Volume 198Author(s): Sahil Luthra, Pamela Fuhrmeister, Peter J. Molfese, Sara Guediche, Sheila E. Blumstein, Emily B. MyersAbstractResearch has implicated the left inferior frontal gyrus (LIFG) in mapping acoustic-phonetic input to sound category representations, both in native speech perception and non-native phonetic category learning. At issue is whether this sensitivity reflects access to phonetic category information per se or to explicit...
Fri Sep 13, 2019 18:48
Publication date: Available online 12 September 2019Source: Journal of Communication DisordersAuthor(s): Beatriz K. de Almeida, Gabriela Z. Ferreira, Homero C. Aferri, Viviane C.C. Marino, Jeniffer de C.R. Dutka, Maria Inês Pegoraro-KrookAbstractThe objective of this study was to investigate the occurrence of Passavant's ridge in patients with history of cleft palate presenting with velopharyngeal insufficiency (VPI) after primary palatal surgery. Twenty-five adult patients (mean age of 32 years),...
Fri Sep 13, 2019 18:56
Publication date: Available online 12 September 2019Source: Journal of Communication DisordersAuthor(s): Miriam A. Carroll-AlfanoAbstractPurposeStudies over a 40 year period have reported inadequate education and counseling for persons with laryngectomy; however, several long-term trends, including centralization of laryngectomy surgeries in major teaching hospitals, the rise of the internet, and the increased use of the tracheoesophageal prosthesis (TEP) for voice all have the potential to improve...
Fri Sep 13, 2019 18:56
Publication date: Available online 12 September 2019Source: Clinical ImagingAuthor(s): Hongmei Li, Abudusaimaiti Ayinuer, Jiankang HuangAbstractBackground and purposeSubarachnoid hemorrhage (SAH) is a severe cerebrovascular condition. Some cases present with typical signs of SAH on head computed tomography (CT), whereas other cases have a condition known as pseudo-SAH, with no bleeding actually present. In our clinical experience, we noted that cases of hyperhemoglobinemia often also had pseudo-SAH....
Fri Sep 13, 2019 19:43
Publication date: Available online 12 September 2019Source: Clinical ImagingAuthor(s): Kevin Yuqi Wang, Joshua Carlton, Danielle Guffey, George J. Hutton, Fanny E. MoronAbstractPurposeThis study evaluates the diagnostic performance of apparent diffusion coefficient (ADC) and T2 fluid-attenuation inversion recovery (T2 FLAIR) in discriminating between new white matter (WM) enhancing lesions (ELs) and non-enhancing lesions (NELs) in multiple sclerosis (MS) patients.MethodsThirty MS patients with a...
Fri Sep 13, 2019 19:43
Publication date: Available online 13 September 2019Source: Clinical ImagingAuthor(s): Filippo Pesapane, Chloë Standaert, Pieter De Visschere, Geert VilleirsAbstractObjectivesTo determine the prevalence and predictive value of a series of commonly used MRI criteria for posterolateral extraprostatic extension (EPE) of prostate cancer (PCa).MethodsThe presence of EPE in index lesions visible on prebiopsy mpMRI (T2w, DWI and DCE on a 3 Tesla-system) of biopsy-proven PCa patients was blindly assessed...
Fri Sep 13, 2019 19:43
Publication date: Available online 13 September 2019Source: Clinical ImagingAuthor(s): Christine Boatright, Christopher M. Walker, Joseph Donald, Wei Cui, Alykhan S. NagjiAbstractFat-containing mediastinal masses, particularly mediastinal liposarcomas, are rare neoplasms that can grow to large sizes before becoming symptomatic and may be incidentally found on radiology examinations.In this case report, a 67-year-old male with a history of prostate cancer status post prostatectomy presented for an...
Fri Sep 13, 2019 19:43
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