Publication date: 15 January 2020Source: Talanta, Volume 207Author(s): Fanping Shi, Jiao Li, Jingjing Sun, Hui Huang, Xingguang Su, Zonghua WangAbstractHerein, a sodium hexametaphosphate ((NaPO3)6) modulated fluorescence responsive probe based on the integration of reduced graphene quantum dots (rGQDs) and chitosan (CS) via self-assembly/disassembly for label-free alkaline phosphatase assay was constructed. The cationic-charged CS can couple with anionic rGQDs and quench their fluorescence intensity...
Wed Sep 18, 2019 12:21
Abstract Objectives Intimate partner violence (IPV) around the time of pregnancy is a risk factor for adverse pregnancy and birth outcomes. The supplemental nutrition program for women, infants, and children (WIC), available to low income pregnant women, may provide an opportunity to identify victims of IPV and refer them to services. This cross-sectional study aims to determine whether WIC participants are more likely than non-WIC participants...
Wed Sep 18, 2019 03:00
Background: Surgery is still the preferred treatment for tongue cancer. Reconstruction should be performed immediately after extensive resection of the tumor. The purpose of this study was to investigate the clinical effect, advantages, and disadvantages of radial forearm free (RFF) flap and anterolateral thigh (ALT) flap in tongue reconstruction after radical resection of tongue cancer. Methods: Thirty-nine cases of tongue reconstruction with RFF flap or ALT flap from 2014 to 2018 were analyzed....
Wed Sep 18, 2019 12:28
A new form of gene therapy termed genetic editing or gene targeting has become possible owing to advances in genetic engineering technology. The intent of genetic editing is to alter the DNA code in cells with single base-pair specificity, and thus it can be considered to be an ultimate form of…
Wed Sep 11, 2019 03:00
Publication date: Available online 17 September 2019Source: Allergology InternationalAuthor(s): Naomi Matsumoto, Takashi Yorifuji, Kazue Nakamura, Masanori Ikeda, Hirokazu Tsukahara, Hiroyuki DoiAbstractBackgroundAlthough breastfeeding has been well-established as the preferred method for infant nutrition, its prophylactic effects on food allergy remain controversial. Infantile eczema has been linked to food allergy via percutaneous sensitization; however, this relationship has not been considered...
Wed Sep 18, 2019 12:52
Publication date: Available online 17 September 2019Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Ariharan Anantharachagan, Roweida Sammour, Pavaladurai Vijayadurai
Wed Sep 18, 2019 12:58
Publication date: Available online 17 September 2019Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Mirna Chehade
Wed Sep 18, 2019 12:58
Publication date: Available online 18 September 2019Source: Clinical TherapeuticsAuthor(s): Sanjay Sarkar, Mark T. HeiseAbstractMouse models are important tools both for studying the pathogenesis of infectious diseases and for the preclinical evaluation of vaccines and therapies against a wide variety of human pathogens. The use of genetically defined inbred mouse strains, humanized mice, and gene knockout mice has allowed the research community to explore how pathogens cause disease, define the...
Wed Sep 18, 2019 13:06
Publication date: Available online 17 September 2019Source: The Journal of Prosthetic DentistryAuthor(s): Chan Park, Wonjin Kee, Hyun-Pil Lim, Sang-Won ParkAbstractMost digitally fabricated removable dentures are currently available in resin only. To overcome this limitation, digitally fabricated dentures were designed by using general purpose software rather than dental computer-aided design (CAD) software. The functional cusps were made in metal and the denture base in resin with a 3-dimensional...
Wed Sep 18, 2019 13:21
Abstract Purpose Serum cortisol measurements after ACTH stimulation are currently used to evaluate for adrenal insufficiency in children. We aim to determine if salivary cortisol measured by liquid chromatography–tandem mass spectrometry (LC–MS/MS) can confirm or replace serum cortisol during high dose ACTH stimulation test to improve test compliance and interpretation. We also aim to gain preliminary understanding of normal ranges of...
Wed Sep 18, 2019 03:00
Publication date: Available online 17 September 2019Source: European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): O. Vella, D. Blanchard, D. de Raucourt, J.P. Rame, E. BabinAbstractTreatment of small laryngeal cancerous lesions (T1 and T2) is based on partial endoscopic or open surgery and radiotherapy. In addition to the oncological imperative, these techniques must optimally preserve the functions of breathing, swallowing and phonation.ObjectiveTo analyze the above functions...
Wed Sep 18, 2019 13:27
Publication date: Available online 17 September 2019Source: European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): O. Laccourreye, H. MaisonneuveAbstractThe present review article details developments in medical writing and the ongoing transformation of the scientific medical press. With these twin revolutions, French-language scientific medical journals are at a crossroads: are they going to become vehicles of teaching, of popularization, of liaison between members of medical societies,...
Wed Sep 18, 2019 13:27
By using biphenyl‐2‐ylphosphines functionalized with a remote tertiary amino group as ligand, readily available acetylenic amides are directly converted into 2‐aminofurans devoid of any electron‐withdrawing and hence deactivating/stabilizing substituents. These highly electron‐rich furans have rarely been prepared, let alone being applied in synthesis, due to the high reactivities and low stabilities associated with their exceedingly electron‐rich nature of the furan ring. In this work, these reactive...
Tue Sep 17, 2019 18:25
Surface plasmon resonance microscopy (SPRM) is a versatile platform for chemical and biological sensing and imaging. Great progress in exploring its applications, ranging from single‐molecule sensing to single‐cell imaging, has been made. In this Minireview, we introduce the principles and instrumentation of SPRM. We also summarize the broad and exciting applications of SPRM to the analysis of single entities. Finally, we discuss the challenges and limitations associated with SPRM and potential solutions.
Wed Sep 18, 2019 11:14
Four in a row: The combination of polyhomologation, ring‐opening polymerization, and an organic/metal catalyst switch strategy led to the tetracrystalline tetrablock quarterpolymer polyethylene‐b‐poly(ethylene oxide)‐b‐poly(ϵ‐caprolactone)‐b‐poly(l‐lactide). The existence of four different crystalline domains in the polymer was confirmed by differential scanning calorimetry, X‐ray diffraction, and wide‐line separation solid‐state NMR spectroscopy. Abstract Multicrystalline block polymers having...
Wed Sep 18, 2019 11:44
NIR light‐responsive nanoplatforms hold great promise for on‐demand drug release in precision cancer medicine. However, currently available systems utilize “always‐on” photothermal transducers that lack target specificity, thus inaccurately differentiating tumors from normal tissues. Here, we develop a theranostic nanoplatform endowing H2S‐mediated in situ production of NIR photothermal agents for imaging‐guided and photocontrolled drug release with targeting ability for H2S‐rich cancers. This nanoplatform...
Wed Sep 18, 2019 12:26
Understanding the mechanism of chirality recognition of molecules at surfaces would help to rationally design and construct advanced chiral nanostructures. In previous reports, chiral molecular self‐assemblies were generally achieved using short‐range intermolecular interactions, such as hydrogen‐, metal‐organic and covalent bonding. However, unavoidable surface defects, such as step edges, surface reconstructions, or site dislocations may limit the applicability of short‐range chirality recognition....
Wed Sep 18, 2019 12:29
On the surface: The selectivity for either hydrogen evolution of CO2 reduction can be controlled by using either electrical energy or photon energy. Competition between hydrogen evolution and CO2 reduction was observed under electrochemical conditions for both glassy carbon and CuInS2 electrodes. However, electrochemical hydrogen evolution was suppressed under photoelectrochemical conditions, showing selectivity for CO2 reduction using an identical electrode/electrolyte system. Abstract Electrochemical...
Wed Sep 18, 2019 13:36
We report Plateau‐Rayleigh (P‐R) instability occurring on Brownian colloidal particles and demonstrate that this instability can be used for the surface patterning of Brownian colloidal rings. This idea was realized by employing polystyrene(PS)/SiO2 core/shell rings, for which PS layer was selectively grown onto the interior surface of SiO2 rings. The P‐R instability was initiated in the ring’s dispersion by adding a good solvent of PS. By using both experiments and theory, we show that the number...
Wed Sep 18, 2019 13:36
Charging ahead: The development of anion–ion batteries is possible by combining the benefits of p‐type organic redox‐active materials and molecular engineering to tune their working potentials. The pairing of an aromatic diamine as the positive electrode with a zwitterionic bipyridinium carboxylate compound as the negative electrode resulted in the assembly of an all‐organic anionic battery. Abstract The ever‐increasing demand for rechargeable batteries induces significant pressure on the worldwide...
Wed Sep 18, 2019 13:36
The first quarter century: The Buchwald–Hartwig amination enables the formation of C(sp2)−N bonds through the Pd‐catalyzed coupling of (hetero)aryl halides and pseudohalides with amines. This Minireview discusses the development of this methodology over the past 25 years, including highlights of some of the most recent applications. Abstract The Pd‐catalyzed coupling of aryl (pseudo)halides and amines is one of the most powerful approaches for the formation of C(sp2)−N bonds. The pioneering...
Wed Sep 18, 2019 13:36
Not to be underestimated: A tetrameric pentacene (see structure) was designed as a model system to explore the influence of exciton delocalization on singlet fission (SF) and subsequent triplet decorrelation by exciton diffusion following intramolecular SF. Experiment and theory showed the delocalization of singlet and triplet excitons among the four pentacenes and highlighted spin catalysis as a substantial obstacle to quantitative harvesting of SF products. Abstract A tetrameric pentacene,...
Wed Sep 18, 2019 13:36
Tuning the microenvironment of nanoreactors achieves the transformation from an inactive to active state of ruthenium nanoparticles (NPs) for benzoic acid hydrogenation in organic solvent. In their Communication (DOI: https://doi.org/10.1002/anie.20190860210.1002/anie.201908602), L. Yu, J. Liu, Q. Yang, and co‐workers show that metal NPs in nanoreactors with a precise microenvironment mimicking the process of natural catalysts is an efficient strategy to improve catalytic performance.
Wed Sep 18, 2019 13:36
Testing the liquids: Two‐dimensional molecular crystals can be produced by evaporation of a solution applied to a liquid surface. When the surface tension and viscosity of the liquid surface are adjusted, the thickness of the applied solution, and thus the thickness of the resulting crystalline organic semiconductors can be controlled. Abstract Two‐dimensional molecular crystals (2DMCs) open a new door for the controllable growth of 2D materials by molecular design with a energy gap and solution...
Wed Sep 18, 2019 13:36
Atomically precise chiral CuI alkynyl nanoclusters R/S‐Cu14 with inherent chirality were synthesized for the first time. Crystallization‐ and aggregation‐induced emission (CIE and AIE, respectively) trigger circularly polarized luminescence (CPL) with an unprecedented luminescence anisotropy factor (g lum). Abstract Atomically precise enantiomeric metal clusters are scarce, and copper(I) alkynyl clusters with intense circularly polarized luminescence (CPL) responses have not been reported....
Wed Sep 18, 2019 13:36
Interaction skills: Chiral nitrogen‐containing compounds have been synthesized with excellent enantioselectivity (95–98 % ee) and high productivity (up to 2000 TON) by the Co‐catalyzed asymmetric hydrogenation of C=N bonds. The reaction is facilitated by coordination of an NHBz group in the substrates to the cobalt atom and a nonbonding interaction with the ligand. Abstract An efficient cobalt‐catalyzed asymmetric hydrogenation of C=N bonds has been realized. Chiral hydrazines were obtained...
Wed Sep 18, 2019 13:36
Mixer event: A two‐component metal‐free catalytic system comprising a Lewis acid and base in unequal molar amounts allows monomer‐selective and switchable polymerization of mixed epoxides and cyclic esters. The method challenges the existing limitation of the enchainment order of the two types of monomers and fulfills sequence‐controlled synthesis of ether‐ester‐type block copolymers. Abstract Polymerizing epoxides after cyclic esters remains a major challenge, though their block copolymers...
Wed Sep 18, 2019 13:36
To sum up: A carbon‐coupled nickel nitride nanosheet was employed as an efficient electrocatalyst for 5‐hydroxymethylfurfural (HMF) oxidation. In situ sum frequency generation (SFG) spectroscopy was used to explore the HMF electrooxidation process, and confirmed that the oxidation pathway proceeds via 5‐hydroxymethyl‐2‐furancarboxylic acid (HMFCA). Abstract 2,5‐Furandicarboxylic acid was obtained from the electrooxidation of 5‐hydroxymethylfurfural (HMF) with non‐noble metal‐based catalysts....
Wed Sep 18, 2019 13:36
Divergent pathways: Vinylidene boronic esters can be obtained by the homologation of boronic esters with lithiated epoxysilane in a process where the selectivity for the vinyl boronic ester or vinyl silane product depends on the anion stabilizing ability of the R group. The methodology was applied in a short stereoselective synthesis of the proposed structure of machillene, however, synthetic and reported data did not match. Abstract Alkenyl boronic esters are important reagents in organic...
Wed Sep 18, 2019 13:36
Fine‐tuning: Three‐dimensional N‐doped and hierarchical carbon foam (CF) with a specific ratio of sp3‐ and sp2‐hybridized carbon atoms can be prepared from an ionic liquid by simple pyrolysis. This porous carbon material exhibited superior electrocatalytic performance for oxygen reduction reaction (ORR) in the Zn–air battery. Abstract The development of highly efficient metal‐free carbon electrocatalysts for the oxygen reduction reaction (ORR) is one very promising strategy for the exploitation...
Wed Sep 18, 2019 13:36
Publication date: Available online 17 September 2019Source: Brain Research BulletinAuthor(s): Yue Liang, Fang Tong, Lin Zhang, Longlong Zhu, Wenhe Li, Weisheng Huang, Shuquan Zhao, Guanglong He, Yiwu ZhouAbstractDiffuse axonal injury (DAI) is one of the most common and severe pathological consequences of traumatic brain injury (TBI). The molecular mechanism of DAI is highly complicated and still elusive, yet a clear understanding is crucial for the diagnosis, treatment, and prognosis of DAI. In our...
Wed Sep 18, 2019 13:39
Publication date: Available online 17 September 2019Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): M.E. Polat, S. YanikAbstractThis study was performed to determine whether arthrocentesis therapy has different outcomes in three groups of patients with different temporomandibular disorders (TMDs). A clinical trial was conducted including 45 patients with 45 unilaterally affected joints divided into three groups (n = 15): osteoarthritis (OA), disc displacement with reduction...
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Nature Communications, Published online: 18 September 2019; doi:10.1038/s41467-019-12314-2Defect-free monolayers of graphene and hexagonal boron nitride are highly permeable to thermal protons, but are impenetrable to gases. Here the authors show that mechanically exfoliated crystals exhibit perfect proton selectivity, corroborating proton transport through the bulk without atomic-scale defects.
Wed Sep 18, 2019 03:00
Nature Communications, Published online: 18 September 2019; doi:10.1038/s41467-019-12243-0Allergic asthma symptoms may be controlled, but currently no effective therapy exist to address the underlying pathology. Here the authors show, using mouse model of adoptive cell transfer, that CD4-CD8- T cells can suppress the function of dendritic cells and T follicular helper cells via Lag3 to provide allergen-specific protection from asthma.
Wed Sep 18, 2019 03:00
Nature Communications, Published online: 18 September 2019; doi:10.1038/s41467-019-12170-0Sense of agency (SoA) refers to the experience that one's own actions caused an external event. Here, the authors present a model of SoA in terms of optimal Bayesian cue integration taking into account reliability of action and outcome sensory signals and judging if the action caused the outcome.
Wed Sep 18, 2019 03:00
Nature Communications, Published online: 18 September 2019; doi:10.1038/s41467-019-12057-0Working memory involves a fronto-parietal brain network, but how the parts of this network are coordinated is unclear. Here, the authors show that fast brain activity at posterior sites is nested into prefrontal slow brain waves, with cognitive demand determining the slow wave phase involved.
Wed Sep 18, 2019 03:00
Nature Communications, Published online: 18 September 2019; doi:10.1038/s41467-019-12162-0Due to active geological resurfacing, the record of large impact basins (e.g. in Chryse Planitia) on Mars seems to be widely absent. Based on high-quality global datasets, the authors here propose a buried impact basin, covered by up to 1 km of sediments or lava flows after its formation more than 4 billion years ago.
Wed Sep 18, 2019 03:00
Nature Communications, Published online: 18 September 2019; doi:10.1038/s41467-019-12247-wMetabolic enzymes often form supramolecular complexes to improve product yield. Here the authors use short peptide tags to create scaffold-free assemblies and synthetic metabolic nodes.
Wed Sep 18, 2019 03:00
Nature Communications, Published online: 18 September 2019; doi:10.1038/s41467-019-12257-8There lacks systematic analysis on the importance of vegetation structural change in the global terrestrial carbon cycle. Here the authors conducted a multi-model comparison analysis and find that the increase in leaf area index has been responsible for 12.4% of the accumulated terrestrial carbon sink from 1981 to 2016.
Wed Sep 18, 2019 03:00
Nature Communications, Published online: 18 September 2019; doi:10.1038/s41467-019-12109-5Iron is essential for growth of Mycobacterium tuberculosis, but most of the iron in the human body is stored in heme within hemoglobin. Here, Mitra et al. identify two heme uptake mechanisms in M. tuberculosis, one dependent on the inner-membrane Dpp importer and the other dependent on host albumin.
Wed Sep 18, 2019 03:00
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