Signia has launched Signia Xperience, a new platform that introduces the world's first combination of advanced acoustic sensors with a built-in motion sensor. Signia Xperience hearing aids provide a complete analysis of the wearer's dynamic soundscape, allowing for automatic adjustments between sounds in front of and all around the wearer for a personalized listening experience. With YourSound technology, Signia Xperience hearing aids can identify more variables from the environment than ever before...
Tue Sep 17, 2019 16:27
ABSTRACT Ehlers‐Danlos syndromes (EDS) are a clinically and genetically heterogeneous group of connective tissue disorders. Overlapping features including arterial aneurysms/dissections in both classical and vascular EDS are a major challenge in the clinical diagnosis of these subtypes. The COL1A1 p.(Arg312Cys) variant leads to a phenotype of classical EDS with a propensity to arterial complications. Our report describes a two‐generation family with one individual presenting with a dissection...
Wed Sep 18, 2019 13:56
Wed Sep 18, 2019 11:19
Abstract Objectives We aimed to investigate the bone mineral density (BMD) in a group of Swedish patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) with or without asthma, as well as to evaluate if the treatment of this patient group is in accordance with the EPOS recommendations. Design, settings and participants Adult patients with a diagnosis of CRSwNP, and a history of at least two courses of oral corticosteroids (OCS) during the last year, were consecutively included...
Tue Sep 17, 2019 18:08
Abstract Background A somatic mutation of GNAQ (c.548G>A, p.Arg183Gln) plays a key role in capillary malformation development. The present study aimed to evaluate clinical manifestations of port‐win stain (PWS) associated with this genetic mutation. Methods Skin tissue was obtained from 70 patients with capillary malformation who had been treated with excision for lesions. Droplet digital polymerase chain reaction was used to quantify the abundance of cells with the GNAQ mutation. ...
Wed Sep 18, 2019 12:32
Wed Sep 18, 2019 10:14
Wed Sep 18, 2019 13:09
Related ArticlesResearch update for articles published in EJCI in 2017. Eur J Clin Invest. 2019 Sep 16;:e13163 Authors: Arellano-Orden E, Bacopoulou F, Baicus C, Bonfrate L, Broadbent J, Buechler C, Carbone F, Charmandari E, Davis GR, Dullaart RPF, Efthymiou V, Goeser F, Goswami N, Jong GP, Lichtenauer M, Liou YS, Lutz P, Maeng M, Mert GÖ, Mert KU, Montecucco F, Ndrepepa G, Olesen KKW, Oliveira P, Perton FG, Portincasa P, Rodriguez-Panadero F, Schernthaner C, Schutte...
Wed Sep 18, 2019 14:15
Publication date: Available online 17 September 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Tero Puustinen, Joona Tervonen, Cecilia Avellan, Henna-Kaisa Jyrkkänen, Jussi J. Paterno, Päivi Hartikainen, Ulla Vanhanen, Ville Leinonen, Soili M. Lehto, Antti-Pekka Elomaa, Terhi J. HuttunenAbstractObjectiveIdiopathic intracranial hypertension (IIH) is aetiologically unknown disorder that associates with endocrinological disturbances, including dysfunction of hypothalamic-pituitary-adrenal-axis....
Wed Sep 18, 2019 14:17
Publication date: Available online 17 September 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Victor Constantinescu, Catalina Arsenescu-Georgescu, Daniela Matei, Mihaela Moscalu, Calin Corciova, Dan CuciureanuAbstractObjectivesAutonomic nervous system dysfunction after ischemic stroke predisposes to cardiovascular complications. We aimed to investigate cardiac autonomic activity in ischemic stroke patients using heart rate variability analysis, illustrating the sympathovagal balance at...
Wed Sep 18, 2019 14:17
Publication date: Available online 18 September 2019Source: Journal of Plastic, Reconstructive & Aesthetic SurgeryAuthor(s): Loren Moller, Juan Enrique Berner, Baljit DheansaAbstractIntroductionAutologous breast reconstruction, on its own, is a complex microsurgical procedure. However, this operation is usually just one of a series of steps along a patient's reconstructive journey. This includes not just a primary major surgical event, but also the consequent recovery, potential complications...
Wed Sep 18, 2019 14:20
Publication date: Available online 17 September 2019Source: Archives of Oral BiologyAuthor(s): Lu Yuanyuan, Wenbing Wang, Xianhui Ding, Xiaolei ShiAbstractObjectivesTo assess the association between the promoter region of serotonin transporter (5-HTTLPR) gene polymorphism and recurrent aphthous stomatitis (RAS) occurrence.DesignsWe performed the meta-analysis to determine the potential association between 5-HTTLPR polymorphism and RAS. We retrieved revelant studies from the PubMed, Scopus, Embase,...
Wed Sep 18, 2019 14:24
Publication date: Available online 17 September 2019Source: Archives of Oral BiologyAuthor(s): Melissa Lancia, Renato Assis Machado, Thiago José Dionísio, Daniela Gamba Garib, Carlos Ferreira dos Santos, Ricardo D. Coletta, Lucimara Teixeira das NevesAbstractObjectivesTo investigate the association of MSX1 rs12532 polymorphism with the risk of nonsyndromic unilateral complete cleft lip and palate (NSCLP) and tooth agenesis.Materials and methodsThe study is comprised of 384 individuals divided into...
Wed Sep 18, 2019 14:24
Publication date: Available online 17 September 2019Source: Archives of Oral BiologyAuthor(s): Jarinya Pathomburi, Sakarat Nalampang, Anupong Makeudom, Jeerawan Klangjorhor, Chayarop Supanchart, Suttichai KrisanaprakornkitAbstractObjectiveTo investigate the effects of dental x-ray on proliferation and mineralization in human primary osteoblasts as well as on proliferation and apoptotic potential in human periodontal ligament (PDL) cells.DesignPrimary osteoblasts and PDL cells were irradiated with...
Wed Sep 18, 2019 14:24
Abstract Background Evidence for the efficacy of immunotherapy in biliary tract cancer (BTC) is limited and unsatisfactory. Methods Chinese BTC patients receiving a PD-1 inhibitor with chemotherapy, PD-1 inhibitor monotherapy or chemotherapy alone were retrospectively analyzed. The primary outcome was overall survival (OS). The key secondary outcomes were...
Wed Sep 18, 2019 03:00
Background: In patients with bilateral vestibulopathy, the regular treatment options, such as medication, surgery, and/or vestibular rehabilitation, do not always suffice. Therefore, the focus in this field of vestibular research shifted to electrical vestibular stimulation (EVS) and the development of a system capable of artificially restoring the vestibular function. Key Message: Currently, three approaches are being investigated: vestibular co-stimulation with a cochlear implant (CI), EVS with...
Wed Sep 18, 2019 12:32
Publication date: Available online 17 September 2019Source: Radiotherapy and OncologyAuthor(s): Kai Joachim Borm, Markus Oechsner, Mathias Düsberg, Gabriel Buschner, Wolfgang Weber, Stephanie Elisabeth Combs, Marciana-Nona DumaAbstractObjectiveThe purpose of this study was to estimate the dose distribution from randomized trials (MA.20, EORTC 22922-10925 (EORTC), AMAROS and the Z0011 trial) on lymph node (LN) irradiation on a large LN atlas.Methods580 F18-FDG-PET/CT positive LN metastases of 235...
Wed Sep 18, 2019 14:37
Publication date: Available online 17 September 2019Source: Radiotherapy and OncologyAuthor(s): Daniel A. Hamstra, Stephanie L. Pugh, Herbert Lepor, Seth A. Rosenthal, Kenneth J. Pienta, Leonard Gomella, Christopher Peters, David Paul D'Souza, Kenneth L. Zeitzer, Christopher U. Jones, William A. Hall, Eric Horwitz, Thomas M. Pisansky, Luis Souhami, Alan C. Hartford, Michael Dominello, Felix Feng, Howard M. SandlerAbstractBackground/purposeStratification of Gleason score (GS) into three categories...
Wed Sep 18, 2019 14:37
Publication date: Available online 17 September 2019Source: Radiotherapy and OncologyAuthor(s): Yang Tang, Li Yang, Wan Qin, Min'xiao Yi, Bo Liu, Xiang'lin YuanAbstractBackground and purposeRecent researches demonstrated that single nucleotide polymorphisms (SNPs) of genes involving inflammation, DNA repair, etc. were associated with risk of radiation pneumonitis (RP). However, these studies were single-centered, from single ethnic origin, without validation from independent cohort studies from other...
Wed Sep 18, 2019 14:37
Publication date: Available online 18 September 2019Source: Radiotherapy and OncologyAuthor(s): Michael John Parkes, Stuart Green, Warren Kilby, Jason Cashmore, Qamar Ghafoor, Thomas Henry Clutton-BrockAbstractBackground & purposeMultiple, short breath-holds are now used in single radiotherapy treatment sessions. Here we investigated the feasibility and safety of multiple prolonged breath-holds in a single session. We measured how long is a second breath-hold if we prematurely terminate a single,...
Wed Sep 18, 2019 14:37
Publication date: Available online 17 September 2019Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Florian K. Enzmann, Patrick Nierlich
Wed Sep 18, 2019 14:41
Publication date: Available online 17 September 2019Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Jasmin Zeindler, Sabine Richarz, Marco Franchin, Savas D. Soysal, Lorenz Gürke, Andrej IsaakObjectiveThe aim was to evaluate the safety and feasibility of endoscopic superficialisation (ES) in patients with deeply located cephalic veins in well matured arteriovenous fistulae (AVF) and to present functional outcomes.MethodsAll patients with cannulation difficulties due to a deep...
Wed Sep 18, 2019 14:41
Publication date: December 2019Source: Brain and Language, Volume 199Author(s): Paula Ríos-López, Nicola Molinaro, Marie LallierAbstractThis longitudinal study was aimed at testing the relation between rhythm sensitivity and behavioural and neural orthographic sensitivity in pre-reading stages. Basque-speaking children performed several behavioural and EEG tasks at two time points prior to formal reading acquisition (T1: 4 years old; T2: 5 years old). Neural sensitivity to print was measured via...
Wed Sep 18, 2019 14:42
Background Unilateral sinus disease (USD) carries a broader differential diagnosis than bilateral sinus disease, including various inflammatory and neoplastic conditions. Odontogenic sinusitis (ODS) is a common cause of unilateral maxillary sinusitis, but few studies have examined its incidence among all USD etiologies. The main purposes of this prospective study were to determine the incidences of ODS and other etiologies causing USD with complete maxillary sinus opacification on computed tomography...
Tue Sep 17, 2019 17:55
Tue Sep 17, 2019 18:59
Publication date: Available online 17 September 2019Source: Auris Nasus LarynxAuthor(s): Şule Kaya, Betül Çiçek Çınar, Merve Özbal Batuk, Burçe Özgen, Gonca Sennaroğlu, Gülsüm Aydan Genç, Levent SennaroğluAbstractObjectiveThe deficits in the cochlea which is at the one end of the ear sound transfer system, may effect middle ear functions. Wideband typanometry (WBT) is frequently used to evaluate these transfer functions which play a crucial role in setting the impedance matching between the external...
Wed Sep 18, 2019 14:45
Publication date: Available online 17 September 2019Source: Ultrasound in Medicine & BiologyAuthor(s): Nadiya Y. Mohammed, Giovanni Di Domenico, Erica Menegatti, Francesco Sisini, Maria Elena Vannini, Mauro Gambaccini, Mirko Tessari, Paolo ZamboniAbstractBecause the internal jugular vein (IJV) valve is the only protective valve between the brain and heart, recent studies have focused on the dynamic behaviour of the valve and its importance in regulating the cerebral blood outflow pathway. However,...
Wed Sep 18, 2019 14:48
Publication date: Available online 17 September 2019Source: Ultrasound in Medicine & BiologyAuthor(s): Alina Karki, Emily Giddings, Ana Carreras, Devin Champagne, Karen Fortner, Mercedes Rincon, Junru WuAbstractDelivery of small interfering RNAs (siRNAs) into primary T cells is quite challenging because they are non-proliferating cells and are difficult to transfect with non-viral approaches. Because sonoporation is independent of the proliferation status of cells and siRNA acts in the cell cytoplasm,...
Wed Sep 18, 2019 14:48
Publication date: Available online 18 September 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Jonathan A. Berken, Elizabeth Miller, Deborah MoncrieffAbstractBackgroundNumerous reports have linked language impairment, academic underachievement, and attention disorder to misbehavior in adolescence. Recent studies have found an association between deficits in hearing and auditory processing and involvement in the juvenile justice system. In fact, the existence of an auditory...
Wed Sep 18, 2019 14:49
Publication date: Available online 17 September 2019Source: Behavioural Brain ResearchAuthor(s): Rinaldo Livio PerriAbstractIn cognitive neuroscience, an extensive debate concerns the mechanisms of inhibition and the relationship between inhibitory and behavioural control. Since the proactive mode of inhibition was first described, several studies have aimed to distinguish this form of inhibitory control from the reactive one. In fact, according to the dualistic models of cognitive control, the two...
Wed Sep 18, 2019 14:55
Publication date: Available online 17 September 2019Source: Behavioural Brain ResearchAuthor(s): Ellen Scotton, Rafael Colombo, Jéssica C. Reis, Gabriela M.P. Possebon, Gabriel H. Hizo, Fernanda E. Valiati, Luiza P. Géa, Giovana Bristot, Mirian Salvador, Tuani M. Silva, Alessandra E. Guerra, Tiago F. Lopez, Adriane R. Rosa, Maurício KunzAbstractProlonged activation of the hypothalamic-pituitary-adrenal (HPA) axis and sustained increase of glucocorticoids have been evidenced in major depression and...
Wed Sep 18, 2019 14:55
Publication date: Available online 17 September 2019Source: Behavioural Brain ResearchAuthor(s): Julia Zaccarelli-Magalhães, Maysa Amato Santoro, Gabriel Ramos de Abreu, Esther Lopes Ricci, André Rinaldi Fukushima, Thiago Berti Kirsten, Paula A. Faria Waziry, Helenice de Souza SpinosaAbstractFluoxetine is one of the most commonly prescribed drugs for treatment of depression during pregnancy as well as postpartum. Nevertheless, fluoxetine can cross the placental barrier and/or be secreted through...
Wed Sep 18, 2019 14:55
Publication date: November 2019Source: Clinical Neurophysiology, Volume 130, Issue 11Author(s): Michel JAM van Putten, Jan A. Gorter, Cees van Huffelen, Walter van Emde Boas, Piotr Suffczynski
Wed Sep 18, 2019 14:57
Publication date: Available online 17 September 2019Source: Gait & PostureAuthor(s): Paulo Cezar Rocha dos Santos, Tibor Hortobágyi, Inge Zijdewind, Lilian Teresa Bucken Gobbi, Fabio Augusto Barbieri, Claudine LamothAbstractBackgroundGait adaptability in old age can be examined by responses to various perturbations. Fatigability due to mental or muscle exercises can perturb internal cognitive and muscle resources, necessitating adaptations in gait.Research questionWhat are the effects of age...
Wed Sep 18, 2019 15:00
Publication date: Available online 18 September 2019Source: Medical Image AnalysisAuthor(s): Simon Graham, Quoc Dang Vu, Shan E Ahmed Raza, Ayesha Azam, Yee Wah Tsang, Jin Tae Kwak, Nasir RajpootAbstractNuclear segmentation and classification within Haematoxylin & Eosin stained histology images is a fundamental prerequisite in the digital pathology work-flow. The development of automated methods for nuclear segmentation and classification enables the quantitative analysis of tens of thousands...
Wed Sep 18, 2019 15:00
Publication date: Available online 17 September 2019Source: Pathology - Research and PracticeAuthor(s): Gino Marioni, Stella Blandamura, Lorenzo Nicolè, Luca Denaro, Diego Cazzador, Chiara Pavone, Luciano Giacomelli, Vincenza Guzzardo, Ambrogio Fassina, Antonio Mazzoni, Domenico D’Avella, Alessandro Martini, Elisabetta ZanolettiAbstractAlthough the diagnosis and treatment of sporadic vestibular schwannoma has improved in recent years, no factors capable of predicting its growth have been identified...
Wed Sep 18, 2019 15:04
Publication date: Available online 17 September 2019Source: Pathology - Research and PracticeAuthor(s): Banita Thakur, Yashwant Kumar, Alka BhatiaAbstractBreast cancer is one of the major causes of cancer related deaths in women worldwide. A major factor responsible for treatment failure in breast cancer is the development of resistance to commonly used chemotherapeutic drugs leading to disease relapse. Several studies have shown dysregulation of molecular machinery of apoptosis, the major programmed...
Wed Sep 18, 2019 15:04
Publication date: Available online 17 September 2019Source: Pathology - Research and PracticeAuthor(s): Yoo Jin Lee, Harim Oh, Eojin Kim, Bokyung Ahn, Jeong Hyeon Lee, Youngseok Lee, Yang Seok Chae, Sung Gu Kang, Chul Hwan KimAbstractHOXA transcript at the distal tip (HOTTIP) is a long noncoding RNA (lncRNA), which is >200 nucleotides in length. HOTTIP expression has been demonstrated to play a crucial oncogenic role in cancer pathogenesis, and is said to be associated with poor human cancer prognosis....
Wed Sep 18, 2019 15:04
Publication date: Available online 17 September 2019Source: Pathology - Research and PracticeAuthor(s): Meiping Li, Bo Lu, Xiaoqian Dong, Ying Zhou, Yao He, Tao Zhang, Lei BaoAbstractCervical cancer (CVC) is one of the most common types of gynecologic malignant tumor in the world. Unfortunately, current treatments including chemo-/radiotherapy still show the limitation on CVC progress. It is well known that cancer stem cells (CSCs) plays a critical role in drug resistance and metastasis. Furthermore,...
Wed Sep 18, 2019 15:04
Publication date: Available online 17 September 2019Source: Pathology - Research and PracticeAuthor(s): Yao Song, Bin Ji, Chen-xia Jiang, Zhi-ming Chen, Ning-hua Yao, Naofumi Mukaida, Hua HuangAbstractBackground(Interleukin 17 Receptor Beta) IL17RB has been implicated in several malignancies. However, its role in the progression of and chemosensitivity in pancreatic cancer remains unknown. We aimed to determine the clinical significance of IL17RB expression in the prognosis of resectable pancreatic...
Wed Sep 18, 2019 15:04
Publication date: Available online 17 September 2019Source: Pathology - Research and PracticeAuthor(s): Xiao-tong Wang, Ru Fang, Sheng-bing Ye, Ru-song Zhang, Rui Li, Xuan Wang, Rong-hao Ji, Zhen-feng Lu, Heng-hui Ma, Xiao-jun Zhou, Qiu-yuan Xia, Qiu RaoAbstractAnaplastic lymphoma kinase (ALK)-rearranged renal cell carcinoma (RCC) is a novel entity of rare tumors with only 10 cases reported in the literature. Three RCC cases bearing VCL-ALK gene fusion were all young African American patients and...
Wed Sep 18, 2019 15:04
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