Evidence of Failure of Oral Third-Generation Cephalosporin Treatment for Shigella sonnei Infection

Evidence of Failure of Oral Third-Generation Cephalosporin Treatment for Shigella sonnei Infection:

Abstract

In 2017, state health departments notified the Centers for Disease Control and Prevention about 4 patients with shigellosis who experienced persistent illness after treatment with oral third-generation cephalosporins. Given increasing antibiotic resistance among Shigella, these cases highlight the need to evaluate the efficacy of oral cephalosporins for shigellosis.

The disease is caused by Shigella bacteria, and symptoms include abdominal cramps, diarrhea that sometimes contains blood, nausea, vomiting, and fever. Shigella sonnei has a very low infectious dose, and the infection may spread from person to person or via contaminated objects, food, or water.

Outbreak of Infections Caused by Shigella sonnei with ... - NCBI