Label-Free Quantitative mass spectrometry based workflows for differential expression (DE) analysis of proteins impose important challenges on the data analysis due to peptide-specific effects and context dependent missingness of peptide intensities. Peptide-based workflows, like MSqRob, test for DE directly from peptide intensities and outperform summarization methods which first aggregate MS1 peptide intensities to protein intensities before DE analysis. However, these methods are computationally...
13m
Label-Free Quantitative mass spectrometry based workflows for differential expression (DE) analysis of proteins impose important challenges on the data analysis due to peptide-specific effects and context dependent missingness of peptide intensities. Peptide-based workflows, like MSqRob, test for DE directly from peptide intensities and outperform summarization methods which first aggregate MS1 peptide intensities to protein intensities before DE analysis. However, these methods are computationally...
8h
Abstract Saposhnikovia divaricata (Turcz.) Schischk., a perennial herb belonging to the family Umbelliferae, is widely distributed in Northeast Asia. Its dried root (Radix Saposhnikoviae) is used as a Chinese herbal medicine for the treatment of immune system, nervous system, and respiratory diseases. Phytochemical and pharmacological studies have shown that the main constituents of S. divaricata are chromones, coumarins, acid esters, and polyacetylenes, and these compounds exhibited...
20m
Abstract Aim This systematic article reviews the literature on the confounding parameters that affect short implant survival in order to establish specific surgical and prosthetic protocols that create an optimal biomechanical scenario and ensure implant longevity. Materials and methods The available literature was screened for randomized clinical trials...
37m
Abstract The serious ambient fine particulate matter (PM2.5) is one of the key risk factors for lung cancer. However, existing studies on the health effects of PM2.5 in China were less considered the regional transport of PM2.5 concentration. In this study, we aim to explore the association between lung cancer and PM2.5 and then forecast the PM2.5-induced lung cancer morbidity and mortality in China. Ridge regression (RR), partial least squares regression (PLSR), model tree-based...
37m
Abstract Microplastics are ubiquitous in the environment. The isolation and characterization of microplastics can change, enabling science to elucidate the fate of microplastics in organisms. The main objective of the present study was to develop a rapid and effective method for the isolation, characterization, and quantification of microplastics from gastropod, and then evaluate the microplastic pollution in wild freshwater snails using the developed method. The whole tissue of...
1h
Abstract A field trial was carried out to examine the influence of residual acidified biochar (a 3:100 (w/w) mixture of citric acid and citrus wood biochar) on soil properties, growth, water status, photosynthetic efficiency, metal accumulation, nutrition status, yield, and irrigation use efficiency (IUE) of maize grown under salty soil and metal-contaminated irrigation water. The acidified biochar (ABC) was applied to faba bean in 2016/2017 in saline soil (electrical conductivity...
2h
Abstract Ever since China’s “housing reform” in 1998, the level of real estate investment in its cities has continued to rise, leading to the occupation of green space, rapid population concentration, and a severe mismatching of financial resources. At the same time, urban air quality has changed drastically for the worse, with PM2.5 becoming the primary air indicator of concern for many cities in recent years. The existing literature has obtained sufficient results on the influence...
2h
Abstract Green philosophy is gaining popularity worldwide. Recycling materials from building demolitions, reutilizing by-products from industrial facilities and exploring the potential uses of waste during a second life cycle are the objectives of this philosophy. In the present article, bottom ashes from electric power generation plants using biofuel combustion were evaluated to verify their potential use as expansive clay stabilizers. Two objectives are pursued: (1) finding a...
3h
Abstract A combined approach based on multiple X-ray analytical techniques and conventional methods was adopted to investigate the distribution and speciation of Cr in a polluted agricultural soil, from the bulk-scale down to the (sub)micro-level. Soil samples were collected from two different points, together with a control sample taken from a nearby unpolluted site. The bulk characterization revealed that the polluted soils contained much higher concentrations of organic matter...
3h
Abstract A rare super-large fractured karst aquifer located in Zibo city, Shandong Province of Northern China was polluted by petroleum hydrocarbons from a petrochemical company. Over the last 30 years, it has been the focus of several remediation efforts. In this study, the contamination and natural attenuation characteristics of the petroleum hydrocarbons were elucidated using hydrogeochemical indicators (DO, DOC, Cl−, HCO3−, pH, NO3−, and SO42−), petroleum hydrocarbons elements...
8h
Abstract Until now, a number of epidemiological studies have focused on the association between ambient particulate matter pollution and chronic obstructive pulmonary disease (COPD), especially in developed countries. There are limited evidences on the association between short-term exposure to particulate matters (PM2.5, PMC, and PM10) and overall hospital outpatient visits for COPD at the same time in China. Thus, a time-series analysis on the short-term association between three...
8h
Abstract Multi-elemental C-Br-Cl compound-specific isotope analysis was applied for characterizing abiotic and biotic degradation of the environmental pollutant 1-bromo-2-chloroethane (BCE). Isotope effects were determined in the model processes following hydrolytic dehalogenation and dihaloelimination pathways as well as in a microcosm experiment by the microbial culture from the contaminated site. Hydrolytic dehalogenation of BCE under alkaline conditions and by DhaA enzyme resulted...
8h
Abstract Water level (a vital indicator for flood warnings and water management in floodplains) has been changed notably due to climatic and anthropogenic forces; however, very little is known about the relative effects of these agents. In this study, we take the Taihu Plain as an example to investigate potential factors driving changes in water level components through quantiles from 1954 to 2014. To quantify the extent of water level component changes attributable to climate...
8h
Abstract In this research, several biochemical variations in plant of Lemna minor L. were investigated to reflect Ag+ toxicity. Lemna minor L. changed colorless AgNO3 to colloidal brown at doses equal to and greater than 1 mg L−1. Optical and fluorescence microscopy revealed the presence of bright spots in roots of tested plant related to Ag/Ag2O-NPs. Photosynthetic pigment contents of Lemna minor L. declined upon exposure to Ag+ with an evidently higher decrease in chlorophyll...
9h
Abstract Cleome amblyocarpa Barr. and Murb is a medicinal plant widespread in North Africa and widely used in Tunisia to treat diabetes and colic. The non-volatile (polyphenols, flavonoids, tannins, and flavonols) and volatile compounds (GC-MS) of C. amblyocarpa leaves and stems have been studied. The antioxidant, antimicrobial, analgesic, and cytotoxic activities of hydroalcoholic extracts of C. amblyocarpa leaves and stems were also investigated. The major volatile components...
13h
Abstract The vulnerability of groundwater to pesticides is governed in part by sorption mechanisms in the vadose zone, commonly studied in soil but less well-known in the geological solids. To alleviate this lack of knowledge, adsorption of the herbicide S-metolachlor (SMOC) and of two of its metabolites—metolachlor ethane sulfonic acid (MESA) and metolachlor oxanilic acid (MOXA)—was studied with batch equilibrium method on seventeen surface soils and three geological solids of...
13h
Abstract The physiological and biochemical responses of Sorghum bicolor (L.) Moench. to cadmium (Cd) (30 mg kg−1) and oil sludge (OS) (16 g kg−1) present in soil both separately and as a mixture were studied in pot experiments. The addition of oil sludge as a co-contaminant decreased Cd entry into the plant by almost 80% and simultaneously decreased the stimulation of superoxide dismutase (SOD) and peroxidase. The decrease in glutathione reductase (GR) activity and the increase...
13h
Abstract The risk of heavy metal contamination of infiltrated water and underground soil on a permeable brick paving system was investigated. The paving system was constructed as a frame structure base on top of a 1.0-m-thick clay layer with permeable ceramic brick at the surface. The concentrations of heavy metals (Zn, Cu, and Pb) in infiltrated water and soil at different underground depths under the paving system were measured. Speciation rates of Zn, Cu, and Pb at different...
13h
Abstract Recently, the research on conversion of biodiesel by-products to high value-added products has received much attention, due to the adverse effects of large accumulations of biodiesel by-products caused by the rapid increase in biodiesel production. Herein, this study investigated the utilization of by-products crude glycerol (CG-1 and CG-2) from two different industrial methods of biodiesel production and the favorable fermentation conditions for the high yield of β-farnesene...
18h
Abstract A large number of defective mulberries are discarded each year because mulberries are easy to break. The red pigments from defective mulberries are recognized as the sustainable sources of anthocyanins extracted from nature. Cyanidin-3-O-rutinoside and cyanidin-3-O-glucoside are the main components of mulberry red pigments, accounting for 50% and 40% of the total, respectively. Cyanidin-3-O-glucoside exhibits anticancer, hypoglycemic, and liver and visceral protection...
18h
Abstract The main objective of this study is to examine the impacts of globalization, financial development, government expenditures, and institutional quality on CO2 emissions, incorporating energy consumption, and GDP per capita in the Environmental Kuznets Curve (EKC) model for 47 Emerging Market and Developing Economies (EMDEs) between 1990 and 2014. Owing to the presence of cross-sectional dependence and slope heterogeneity in the panel data, CADF and CIPS unit root tests...
18h
Abstract In this study, it was found that the CeVO4-CeO2 nanocomposite possessed remarkably selective catalytic reduction (SCR) performance and wider active temperature scope. And, the promotion principle was explored based on BET, XRD, XPS, H2-temperature-programmed reduction, NH3-temperature-programmed desorption, and in situ diffuse reflectance infrared Fourier transform (DRIFT) techniques. The characterization outcomes manifested that the CeVO4-CeO2 nanocomposite could inhibit...
21h
We studied activities of antioxidant system enzymes in tissues of rats with experimental allergic encephalomyelitis. It was shown that the development of pathology is accompanied by deformation of the neurons and axonal degeneration, intensification of free radical oxidation, exhaustion of the reduced glutathione pool, and multidirectional changes in activities of antioxidant enzymes in rat tissues. The observed imbalance in the antioxidant defense system can be associated with excessive glutathione...
42m
Spontaneous proliferative activity of splenocytes in female CBA mice and the response of these cells to antigens of allogeneic male BALB/c and DBA/2 mice in a mixed splenocyte culture were evaluated by 3H-thymidine incorporation in different pregnancy models. ♀CBA×♂BALB/c mating was used for modeling physiological pregnancy. Spontaneous abortions were reproduced by abortion-prone ♀CBA×♂DBA/2 mating. In order to simulate immunostimulant-induced and immunostimulant-potentiated abortions, 0.83 mg/kg...
42m
Pharmacokinetics of suppository forms of bacteriophages was studied on male Chinchilla rabbits. Suppositories with various composition of bacteriophages were administered once per rectum to rabbits, and the presence of phage particles was estimated in the blood, urine, and feces over 24 h. Pharmacokinetic study showed that the phages were detected in the blood, urine, and feces at various terms of the experiment irrespective of the size of viral particles, which confirmed the possibility of their...
42m
The study compared antituberculous efficacy of individual or combined administration of “free” isoniazid and liposomal form of dextrazide (a composition consisted of isoniazid and oxidized dextran) inhaled in standard (15 mg/kg) or low (3 mg/kg) dose. The therapy started 1 month after contamination of outbred ICR male mice with Mycobacterium tuberculosis strain H37Rv. Combined inhalation of liposomal form of dextrazide and isoniazid in the low dose was most effective against mycobacterium tuberculosis...
42m
We studied the effect of unstable ubiquitous endocrine disruptors (bisphenol A and triclosan) on the reproductive function of mature male Wistar rats. Animals of both experimental groups received bisphenol A and triclosan (homogeneity>97%) in a dose of 200 mg/kg daily for 2 months with food. The concentrations of disruptors were measured directly in the testicular tissue by gas chromatography with mass spectrometry (GC-MS). In both experimental groups, the concentrations of bisphenol A and triclosan...
42m
Abstract Pancreatic ductal adenocarcinoma can be a difficult imaging diagnosis early in its course given its subtle imaging findings such as focal pancreatic duct dilatation, abrupt duct cut-off, and encasement of vasculature. A variety of pancreatitidies have imaging findings that mimic pancreatic ductal adenocarcinoma and lead to mass formation making diagnosis even more difficult on imaging alone. These conditions include acute focal pancreatitis, chronic pancreatitis, autoimmune...
1h
Abstract Acute pancreatitis is an increasingly common condition and can result in significant morbidity and mortality. Contrast enhanced computed tomography (CECT) is the primary initial imaging modality in the characterization of acute pancreatitis. In this article, we provide sample CECT technical acquisition parameters for pancreatic imaging. We also review the classification systems for acute pancreatitis and give examples of common and uncommon complications of acute pancreatitis.
1h
Abstract Developmental anomalies of the pancreas include more common entities such as pancreas divisum and annular pancreas, and unusual entities such as heterotopic pancreas. While these anomalies can present a diagnostic challenge to the radiologist, when the pancreatic tissue involved in these processes develops pancreatitis, the radiographic appearance can present a diagnostic dilemma. Awareness of these pancreatic anomalies and familiarity with their appearance when inflamed...
1h
Abstract Computed tomography (CT) is the most commonly performed imaging test for acute pancreatitis. Nevertheless, magnetic resonance (MRI) imaging is useful in many specific situations. These include evaluating patients with acute pancreatitis who cannot receive iodinated CT contrast, elucidating the underlying cause of acute pancreatitis, assessing ductal disconnection and for guiding intervention of necrotic collections. Non-contrast MRI is superior to non-contrast CT and...
1h
Abstract Multidisciplinary collaboration (MDC) has been widely adopted in healthcare to optimize patient care. MDC brings several specialized healthcare providers to the table using several methods, including multidisciplinary meetings (MDMs), multidisciplinary clinics, teleconferences, and online multidisciplinary expert panels, to reach the goal of achieving the best diagnosis and treatment plan for complex diseases. Diagnosis and management of acute/chronic pancreatitis is...
1h
Abstract MRI and MRCP play an important role in the diagnosis of chronic pancreatitis (CP) by imaging pancreatic parenchyma and ducts. MRI/MRCP is more widely used than computed tomography (CT) for mild to moderate CP due to its increased sensitivity for pancreatic ductal and gland changes; however, it does not detect the calcifications seen in advanced CP. Quantitative MR imaging offers potential advantages over conventional qualitative imaging, including simplicity of analysis,...
1h
Abstract Purpose This study aims to evaluate the capacity of the clinical and radiological findings and the extrapancreatic necrotic tissue volume in early (2–6 days) computerized tomography (CT) images of patients diagnosed with AP to predict reliably the temporary or permanent organ failure and other local or systemic complications due to pancreatitis. Materials...
1h
Abstract Various pathologic neoplasms present in both childhood and adulthood. Multiple environmental and genetic factors with different targets at different ages have been implicated in prior literature. These tumors include Multi-Locular Cystic Renal Tumors (MCRT), Adrenocortical Carcinomas, Paragangliomas, Hepatic Hemangiomas, and Medullary Renal Cell Carcinomas. The pertinent imaging, pathological, and clinical features of these select entities are discussed to assist the General...
8h
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
1h
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
1h
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
1h
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