Abstract Calorie restriction without malnutrition (CR) is considered as the most effective nongenetic nor pharmacological intervention that promotes healthy aging phenotypes and can extend lifespan in most model organisms. Lifelong CR leads to an increase of cytochrome b5 reductase-3 (CYB5R3) expression and activity. Overexpression of CYB5R3 confers some of the salutary effects of CR, although the mechanisms involved might be independent because key aspects of energy metabolism...
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Publication date: Available online 21 April 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Christian R. Francom, Luv Javia, Nikolaus E. Wolter, Gi Soo Lee, Todd Wine, Tyler Morrissey, Blake C. Papsin, James M. Peyton, Clyde T. Matava, Mark S. Volk, Jeremy D. Prager, Evan J. Propst
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Publication date: Available online 21 April 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Pedro Valente, Isabel Pinto, Cristina Aguiar, Eugénia Castro, Artur Condé, João Larangeiro
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Publication date: Available online 21 April 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Cassandra Alighieri, Imke Kissel, Evelien D’haeseleer, Laura Bruneel, Kim Bettens, Daniel Sseremba, Peter Pype, Kristiane Van Lierde
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Publication date: Available online 21 April 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Michele Carr, Drew Phillips
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Publication date: Available online 22 April 2020Source: Cellular SignallingAuthor(s): Peder Öhman Fuchs, Carlemi Calitz, Nataša Pavlović, François Binet, Sara Marie Øie Solbak, U. Helena Danielson, Johan Kreuger, Femke Heindryckx, Pär Gerwins
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Publication date: Available online 21 April 2020Source: Cellular SignallingAuthor(s): Elisa Belgardt, Thorsten Steinberg, Ayman Husari, Martin Philip Dieterle, Diana Hülter-Hassler, Britta Jung, Pascal Tomakidi
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Publication date: Available online 21 April 2020Source: Cellular SignallingAuthor(s): RebeccaC. Stecky, Courtney R. Quick, Todd L. Fleming, Makenzy L. Mull, Vanessa K. Vinson, Megan S. Whitley, E. Nicole Dover, Thomas E. Meigs
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Out of hospital cardiac arrest (OHCA) carries an 86% mortality rate in Norway. Resuscitative endovascular balloon occlusion of the aorta (REBOA) is a potential adjunct in management of non-traumatic cardiac ar...
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Graphics processing unit technology provider Nvidia and King's College London...Read more on AuntMinnieEurope.com
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Molecular imaging company Blue Earth Diagnostics has completed the first commercial...Read more on AuntMinnieEurope.comRelated Reading: Bracco gets set to acquire Blue Earth Diagnostics Blue Earth promotes presentations at AUA 2019 Blue Earth's Axumin agent added to EAU guidelines Blue Earth begins producing Axumin in Italy Blue Earth signs deal with Polish firm
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Contrast developer Read more on AuntMinnieEurope.comRelated Reading: Guerbet names Hale as CEO, updates sales numbers Guerbet receives new Lipiodol indication in Denmark Guerbet forms partnership with InterSystems Guerbet secures distribution deal with Icometrix for icobrain Guerbet revenues slow in second quarter
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Researchers from Copenhagen have reported that CT image texture evaluation...Read more on AuntMinnieEurope.comRelated Reading: NELSON results give boost to lung cancer screening Software choice can dictate lung screening recall rates Biennial CT lung screening matches annual follow-up exams Video from ECR 2019: Mathias Prokop on lung cancer screening Russian AI detects lung cancer on CT in 20 seconds
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The French radiology society has published a series of recommendations for...Read more on AuntMinnieEurope.comRelated Reading: Hard truths from COVID-19 front line in Paris Imaging allows clinicians to determine severity of COVID-19 French expert offers 6 imaging tips to defeat COVID-19 VIDI joins forces with French public hospitals to deliver imaging French group calls for more coronavirus protection
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Abstract Earth observation data have revolutionized Earth science and significantly enhanced the ability to forecast weather, climate and natural hazards. The storage format of the majority of Earth observation data can be classified into swath, grid or point structures. Earth science studies frequently involve resampling between swath, grid and point data when combining measurements from multiple instruments, which can provide more insights into geophysical processes than using...
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Abstract Background For costal cartilage-based rhinoplasty, a method that could properly manage warping of the columellar strut graft and facilitate establishing a stable cartilaginous framework remains desirable. In this study, the authors present a new graft design named bilateral septal extension strut. It utilizes a pair of cartilage grafts with the shape of a fan, which are bilaterally fixated to the septum. Such “sandwiched” structure...
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Abstract Purpose Trifluridine (FTD) is the active component of the nucleoside chemotherapeutic drug trifluridine/tipiracil (FTD/TPI), which is approved worldwide for the treatment of patients with metastatic gastrointestinal cancer. FTD exerts cytotoxic effects via its incorporation into DNA, but FTD has not been detected in the tumor specimens of patients. The purpose of this study was to detect FTD in tumors resected from metastatic...
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Abstract The objective of this study was to develop a simpler and more practical quantitative evaluation method of cold flow (CF) in transdermal drug delivery systems (TDDSs). CF was forcibly induced by loading a weight on a punched-out sample (bisoprolol and tulobuterol tapes). When the extent of CF was analyzed using the area of oozed adhesive as following a previously reported method, the CF profiles were looked different between the samples 12 mm in diameter subjected to...
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by Feili Yang, Lei Huang, Alexandria Tso, Hong Wang, Li Cui, Lizhu Lin, Xiaohong Wang, Mingming Ren, Xi Fang, Jie Liu, Zhen Han, Ju Chen, Kunfu Ouyang Inositol 1,4,5‐trisphosphate receptors (IP3Rs) are a family of intracellular Ca2+ release channels located on the ER membrane, which in mammals consist of 3 different subtypes (IP3R1, IP3R2, and IP3R3) encoded by 3 genes, Itpr1, Itpr2, and Itpr3, respectively. Studies utilizing genetic knockout mouse models have demonstrated that IP3Rs are essential...
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by David Brooks, Fawwaz Naeem, Marta Stetsiv, Samantha C. Goetting, Simranjot Bawa, Nicole Green, Cheryl Clark, Arash Bashirullah, Erika R. Geisbrecht The inability to remove protein aggregates in post-mitotic cells such as muscles or neurons is a cellular hallmark of aging cells and is a key factor in the initiation and progression of protein misfolding diseases. While protein aggregate disorders share common features, the molecular level events that culminate in abnormal protein accumulation...
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by Patricia L. Earl, Jeffrey L. Americo, Bernard Moss The wild-derived inbred CAST/EiJ mouse, one of eight founder strains in the Collaborative Cross panel, is an exceptional model for studying monkeypox virus (MPXV), an emerging human pathogen, and other orthopoxviruses including vaccinia virus (VACV). Previous studies suggested that the extreme susceptibility of the CAST mouse to orthopoxviruses is due to an insufficient innate immune response. Here, we focused on the low number of natural...
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by Shella Gilbert-Girard, Annie Gravel, Vanessa Collin, Darren J. Wight, Benedikt B. Kaufer, Eros Lazzerini-Denchi, Louis Flamand Human herpesviruses 6A and 6B (HHV-6A/B) are unique among human herpesviruses in their ability to integrate their genome into host chromosomes. Viral integration occurs at the ends of chromosomes within the host telomeres. The ends of the HHV-6A/B genomes contain telomeric repeats that facilitate the integration process. Here, we report that productive infections...
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Cancers, Vol. 12, Pages 1029: A Novel Antibody-Drug Conjugate (ADC) Delivering a DNA Mono-Alkylating Payload to Chondroitin Sulfate Proteoglycan (CSPG4)-Expressing Melanoma Cancers doi: 10.3390/cancers12041029 Authors: Ricarda M. Hoffmann Silvia Crescioli Silvia Mele Eirini Sachouli Anthony Cheung Connie K. Chui Paolo Andriollo Paul J. M. Jackson Katie E. Lacy James F. Spicer David E. Thurston Sophia N. Karagiannis Despite emerging targeted...
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Cancers, Vol. 12, Pages 1031: The Mitochondrial Protein VDAC1 at the Crossroads of Cancer Cell Metabolism: The Epigenetic Link Cancers doi: 10.3390/cancers12041031 Authors: Zohar Amsalem Tasleem Arif Anna Shteinfer-Kuzmine Vered Chalifa-Caspi Varda Shoshan-Barmatz Carcinogenesis is a complicated process that involves the deregulation of epigenetics, resulting in cellular transformational events, such as proliferation, differentiation, and metastasis. Most chromatin-modifying...
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Cancers, Vol. 12, Pages 1026: Single Radiotherapy Fraction with Local Anti-CD40 Therapy Generates Effective Abscopal Responses in Mouse Models of Cervical Cancer Cancers doi: 10.3390/cancers12041026 Authors: Jana Wood Sayeda Yasmin-Karim Romy Mueller Akila N. Viswanathan Wilfred Ngwa Current treatment options for advanced cervical cancer are limited, especially for patients in poor-resource settings, with a 17% 5-year overall survival rate. Here, we report results...
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Cancers, Vol. 12, Pages 1032: The Effect of Higher Level Computerized Clinical Decision Support Systems on Oncology Care: A Systematic Review Cancers doi: 10.3390/cancers12041032 Authors: Klarenbeek Weekenstroo Sedelaar Fütterer Prokop Tummers Background: To deal with complexity in cancer care, computerized clinical decision support systems (CDSSs) are developed to support quality of care and improve decision-making. We performed a systematic review to...
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Cancers, Vol. 12, Pages 1030: PET-FDG: Impetus Cancers doi: 10.3390/cancers12041030 Authors: Cristina Nanni The International Myeloma Working Group (IMWG)recommends FDG PET/CT (Fluoro-Deoxy-glucose Positron Emission Tomography/Computed Tomography) as the gold standard imaging modality for initial evaluation and response to therapy assessment in multiple myeloma. In fact, FDG PET/CT, provides multiple useful indexes to risk-stratify patients and has significant prognostic value....
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Cancers, Vol. 12, Pages 1027: Primary Resistance to PD-1-Based Immunotherapy—A Study in 319 Patients with Stage IV Melanoma Cancers doi: 10.3390/cancers12041027 Authors: Teresa Amaral Olivia Seeber Edgar Mersi Stephanie Sanchez Ioannis Thomas Andreas Meiwes Andrea Forschner Ulrike Leiter Thomas Eigentler Ulrike Keim Claus Garbe Background: Primary resistance to immunotherapy can be observed in approximately 40–65% of the stage IV...
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Cancers, Vol. 12, Pages 1028: Changes in the Expression of Pre-Replicative Complex Genes in hTERT and ALT Pediatric Brain Tumors Cancers doi: 10.3390/cancers12041028 Authors: Aurora Irene Idilli Francesca Pagani Emanuela Kerschbamer Francesco Berardinelli Manuel Bernabé María Luisa Cayuela Silvano Piazza Pietro Luigi Poliani Emilio Cusanelli Maria Caterina Mione Background: The up-regulation of a telomere maintenance mechanism (TMM) is a common...
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Cancers, Vol. 12, Pages 1025: Establishment and Characterization of Humanized Mouse NPC-PDX Model for Testing Immunotherapy Cancers doi: 10.3390/cancers12041025 Authors: Wai Nam Liu Shin Yie Fong Wilson Wei Sheng Tan Sue Yee Tan Min Liu Jia Ying Cheng Sherlly Lim Lisda Suteja Edwin Kunxiang Huang Jerry Kok Yen Chan Narayanan Gopalakrishna Iyer Joe Poh Sheng Yeong Darren Wan-Teck Lim Qingfeng Chen Immune checkpoint blockade (ICB)...
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Publication date: 1 August 2020Source: International Journal of Biological Macromolecules, Volume 156Author(s): Huimin Yong, Ruyu Bai, Fengyu Bi, Jing Liu, Yan Qin, Jun Liu
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Publication date: 1 August 2020Source: International Journal of Biological Macromolecules, Volume 156Author(s): Raelle F. Gomes, Lais R.M. Lima, Judith P.A. Feitosa, Haroldo C.B. Paula, Regina C.M. de Paula
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Publication date: 1 August 2020Source: International Journal of Biological Macromolecules, Volume 156Author(s): Chong Liu, Mengkun Song, Lin Liu, Jing Hong, Erqi Guan, Ke Bian, Xueling Zheng
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Publication date: 1 August 2020Source: International Journal of Biological Macromolecules, Volume 156Author(s): Krister Gjestvang Grønlien, Mona Elisabeth Pedersen, Hanne Hjorth Tønnesen
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Publication date: 1 August 2020Source: International Journal of Biological Macromolecules, Volume 156Author(s): Mohib Ullah Kakar, Muhammad Naveed, Muhammad Saeed, Shicong Zhao, Madiha Rasheed, Sundas Firdoos, Robina Manzoor, Yulin Deng, Rongji Dai
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[ Advance Publication ] [ Title ] Efficacy and safety of stem cells transplantation in patients with type 1 diabetes mellitus—a systematic review and meta-analysis [ Author ] Qian Wu,Shuai Zheng,Yao Qin,Xuqin Zheng,Heng Chen,Tao Yang,Mei Zhang [ Advance Pub. date ] 2020-04-23 [ DOI ] https://doi.org/10.1507/endocrj.EJ20-0050
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Abstract Purpose A life course perspective to cancer incidence is important for understanding effects of the environment during early life on later cancer risk. We assessed spatial clusters of cancer incidence based on early life location defined as 1940 US Census Enumeration District (ED). Methods A cohort of 260,585 individuals aged 0–40 years in 1940 was...
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