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Abstract Atopic dermatitis (AD) is a chronic inflammatory skin disease that is characterized by complex pathophysiology involving both skin barrier dysfunction and aberrant type 2 inflammation/immune responses. AD can be a debilitating condition that drastically impairs quality of life, especially in patients with moderate-to-severe disease. Currently, topical therapies such as corticosteroids and non-steroidal immunomodulatory therapy provide limited efficacy for patients with...
Introduction: Osteotomy of nasal bones in rhinoplasty is associated with postsurgical morbidities. Recent evidence has suggested that a surgical method applying piezoelectric ultrasound waves for nasal osteotomies in rhinoplasty reduces soft tissue damage and causes less postsurgical morbidities compared to conventional methods. The purpose of this study is to compare clinical outcomes of piezoelectric and conventional lateral nasal osteotomies in rhinoplasty. Methods: We searched PubMed, CENTRAL,...
Abstract Medical advancements have extended human life expectancy, which is not always accompanied by an improved quality of life or healthspan. A decline in muscle mass and function is a consequence of ageing and can result in a loss of independence in elderly individuals while increasing their risk of falls. Multiple cellular pathways have been implicated in age-related muscle atrophy, including the contribution of reactive oxygen species (ROS) and disrupted redox signalling....
Abstract Contact dermatitis linked to cosmetic products is a very common reason for visits to the dermatologist, and in more than half the cases, it is due to an allergic reaction. Fragrances are most often the culprit. The aim of the study was to describe the common fragrance allergens in different categories of cosmetic products available on the European market. We wanted to assess the influence of cosmetic type and distribution channel on the presence of fragrance allergens....
Abstract Background We review here our substantial experience in using Alexis Carrel’s technique with a geometrical optimization for microsurgical end-to-end anastomoses. Methods The technique used for microsurgical end-to-end anastomoses is described. We performed a retrospective analysis of head and neck free flaps where we used the described microsurgical...
Abstract Background Optimizing esthetics in delayed breast reconstruction is a challenge, as there is a lack of breast volume and native breast skin. Abdominal flaps are commonly used for patients desiring autologous reconstruction, but the result is an unnatural appearing breast as non-breast skin is used to recreate the breast mound. To improve esthetics for these patients, we propose a two-staged approach utilizing prepectoral tissue...
Abstract Aim The objective of the study was to assess the efficacy of xenograft (BIO-OSS) and platelet-rich fibrin in maxillary sinus augmentation using lateral window approach. Materials and Methods A total of 22 direct sinus lifts were done within a period of two years, and the results were analyzed using two parameters: (1) augmented bone...
Abstract Background Information on the dimensions of the anterior loop of mental nerve is important for dental implant placement. Aims The purpose of this study was to determine the total length of anterior loop of mental nerve from the mental foramen. Materials and Methods ...
Abstract Purpose To evaluate the correlation between the position of inferior alveolar nerve canal and the angulation of impacted mandibular third molars using cone beam computed tomography (CBCT) in a hospital-based study in the state of Odisha, India. Materials and Methodology Three hundred cases of impacted third molars in 200 patients (154...
Abstract Background Maxillofacial surgeries are known to have difficulty in airway management due to anatomical and functional reasons. Tumors of maxillofacial region and diseases of TM joint limit mouth opening as well as airway space. Various methods have been tried with success for nasotracheal intubation including fiberoptic-aided as well as blind nasal and light-guided intubation. Video laryngoscopy-assisted intubation uses...
Abstract Introduction New technological advances have revolutionized the field of oral and maxillofacial surgery. The three-dimensional (3D) models are new technological breakthroughs which have equipped the oral and maxillofacial surgeon to effectively reproduce or improve preoperative form and function. They have also allowed the surgeon to achieve minimal operative and postoperative morbidity. ...
Abstract Aim The aim of this study is to evaluate the efficacy of sodium bicarbonate as an additive alkalizing agent to local anesthetic solutions in inflamed and infected pulpal and periapical tissues. Type of Study A prospective, randomized crossover double-blinded study was carried out in a university-affiliated hospital in Chennai. ...
Abstract Purpose To ascertain the complications arising from open reduction and internal fixation of mandibular fractures and to elucidate if different osteosynthesis plating systems vary in treatment outcome. Materials and Methods This is a retrospective study. Parameters such as patient data, injury details, osteosynthesis implant system information,...
Abstract Introduction The risk of osteonecrosis of the jaw is greater for patients receiving intravenous bisphosphonates for cancer than for patients receiving oral bisphosphonates for osteoporosis or Paget’s disease. Materials and Methods This article provides a review of the treatment of Bisphosphonate induced osteonecrosis of jaws. ...
Abstract Synovial chondromatosis is a rare condition characterized by the presence of loose cartilaginous bodies, due to the abnormal proliferation of synovial membrane. However, its manifestation in the temporomandibular joint is a rare finding, occurring predominantly in females. This case report describes the clinical features, diagnosis and management of a case of synovial chondromatosis.
Abstract Background Oral submucous fibrosis (OSMF) has been extensively researched for its etiopathogenesis, malignant potential, and various available treatment modalities, but its effect on different domains of patient’s life has not been thoroughly investigated. The present study aimed to clearly construe the effects of OSMF like severity and demographic variables on different domains of quality of life in OSMF patients. ...
Abstract Introduction Orthognathic surgery can account for a considerable amount of blood loss since the vascularization of maxillofacial region is such that major bleeding can occur. Intra-bony bleed is often involved as a major aspect of blood loss associated with osteotomies, especially LeFort I osteotomy when performed during orthognathic surgery. This study evolved as a result of the increasing concern to attain a clear surgical...
In this randomized international trial, the hematologic and clinical toxicities of irinotecan were least following dosing in the morning for men and in the afternoon for women with colorectal cancer. Sex‐specific least toxic times of anticancer drugs need further identification in prospective clinical trials. Abstract The least toxic time (LTT) of irinotecan varied by up to 8 hours according to sex and genetic background in mice. The translational relevance was investigated within a randomized...
While previous studies suggested that colonoscopy nonadherence was an important issue mitigating the efficiency of colonoscopy promotion programs in China, this study investigated the spatial inequity of colonoscopy accessibility in a capital city in South China as well as its relationship with colonoscopy adherence and adverse intestinal outcomes. Abstract Background Colonoscopy is an important procedure for early colorectal cancer (CRC) detection, however, patients with positive preliminary...
High‐volume facilities have been observed to be associated with improved outcomes compared to low‐volume facilities for non‐small cell lung cancer surgery. We found that controlling for surgical quality measures minimizes outcome differences between facility types, suggesting that high‐quality care provision for lung cancer surgery requires compliance with surgical quality measures. Abstract Background Clinical outcomes for resected early‐stage non‐small cell lung cancer (NSCLC) are superior...
In this large population‐based cohort of Norwegian men and women, we have examined relations between lifestyle associated factors (e.g. BMI, physical activity and metabolic disorders) and risk of bladder cancer, with thorough adjustments for smoking and occupational exposure. We found that relations between lifestyle associated factors and BC risk were dependent on smoking status, being most evident in never and former smokers, suggesting that smoking dominates the relation in current smokers. Abstract...
We developed and validated a prognostic nomogram for non‐metastatic colorectal cancer incorporating routinely available factors. Nomogram based risk stratification successfully discriminated patients within each AJCC stage. The nomogram outperformed the 8th AJCC staging and the MSKCC model. Abstract Background We aimed to develop a clinical applicable nomogram to predict overall survival (OS) for patients with curatively resected nonmetastatic colorectal cancer. Methods Records from a...
Our research identified specific signatures related to the tumor microenvironment (TME) of ccRCC using the transcriptome profiles. Besides, we further discussed the associations of TME‐related signature with tumor‐infiltrating immune cells, which shed light on a comprehensive understanding of TME and future individualized therapy. Abstract Emerging evidence has highlighted that the immune and stromal cells formed the majority of tumor microenvironment (TME) which are served as important roles in...
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