Cancers, Vol. 12, Pages 972: Therapeutic Strategies and Biomarkers to Modulate PARP Activity for Targeted Cancer Therapy Cancers doi: 10.3390/cancers12040972 Authors: Naveen Singh S. Louise Pay Snehal B. Bhandare Udhaya Arimpur Edward A. Motea Poly-(ADP-ribose) polymerase 1 (PARP1) is commonly known for its vital role in DNA damage response and repair. However, its enzymatic activity has been linked to a plethora of physiological and pathophysiological transactions...
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Cancers, Vol. 12, Pages 967: Classic and Variants APLs, as Viewed from a Therapy Response Cancers doi: 10.3390/cancers12040967 Authors: Marie-Claude Geoffroy Hugues de Thé Most acute promyelocytic leukemia (APL) are caused by PML-RARA, a translocation-driven fusion oncoprotein discovered three decades ago. Over the years, several other types of rare X-RARA fusions have been described, while recently, oncogenic fusion proteins involving other retinoic acid receptors (RARB or...
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Cancers, Vol. 12, Pages 969: Hyperthermic Intraperitoneal Chemotherapy for Primary or Recurrent Adrenocortical Carcinoma. A Single Center Study Cancers doi: 10.3390/cancers12040969 Authors: Guido Alberto Massimo Tiberio Vittorio Ferrari Zeno Ballarini Giovanni Casole Marta Laganà Michele Gritti Elisa Arici Salvatore Grisanti Riccardo Nascimbeni Sandra Sigala Alfredo Berruti Arianna Coniglio Background. This study explores the impact of...
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Cancers, Vol. 12, Pages 971: Aspartate-β-Hydroxylase: A Promising Target to Limit the Local Invasiveness of Colorectal Cancer Cancers doi: 10.3390/cancers12040971 Authors: Roberto Benelli Delfina Costa Luca Mastracci Federica Grillo Mark Jon Olsen Paola Barboro Alessandro Poggi Nicoletta Ferrari Colorectal cancer’s (CRC) ability to invade local tissues and lymph nodes and generate distant metastases is the key for TNM classification. Aspartate-β-hydroxylase...
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Cancers, Vol. 12, Pages 970: Iron Causes Lipid Oxidation and Inhibits Proteasome Function in Multiple Myeloma Cells: A Proof of Concept for Novel Combination Therapies Cancers doi: 10.3390/cancers12040970 Authors: Jessica Bordini Federica Morisi Fulvia Cerruti Paolo Cascio Clara Camaschella Paolo Ghia Alessandro Campanella Adaptation to import iron for proliferation makes cancer cells potentially sensitive to iron toxicity. Iron loading impairs multiple myeloma...
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Cancers, Vol. 12, Pages 968: Acute Promyelocytic Leukemia during Pregnancy: A Systematic Review of the Literature Cancers doi: 10.3390/cancers12040968 Authors: Andrea Santolaria Alfredo Perales Pau Montesinos Miguel A. Sanz The management of pregnant women with acute promyelocytic leukemia (APL) is a challenging situation where limited evidence-based information is available. We performed a systematic literature review to analyze the outcomes reported for both mother...
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Cancers, Vol. 12, Pages 966: Clinical Value of lncRNA MEG3 in High-Grade Serous Ovarian Cancer Cancers doi: 10.3390/cancers12040966 Authors: Marianna Buttarelli Marta De Donato Giuseppina Raspaglio Gabriele Babini Alessandra Ciucci Enrica Martinelli Pina Baccaro Tina Pasciuto Anna Fagotti Giovanni Scambia Daniela Gallo Long non-coding RNAs (lncRNAs) are emerging as regulators in cancer development and progression, and aberrant lncRNA profiles...
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Cancers, Vol. 12, Pages 965: Mesenchymal Stem Cells As Guideposts for Nanoparticle-Mediated Targeted Drug Delivery in Ovarian Cancer Cancers doi: 10.3390/cancers12040965 Authors: Buddhadev Layek Mihir Shetty Susheel Kumar Nethi Drishti Sehgal Timothy K. Starr Swayam Prabha Nanocarriers have been extensively utilized for the systemic targeting of various solid tumors and their metastases. However, current drug delivery systems, in general, suffer from a lack of...
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