Abstract The Universal Declaration of Human Rights recognises stable housing as a prerequisite for an adequate standard of living. A home provides shelter and enables personal development, thus contributing to the individual’s well-being. Despite this, however, many struggle to find a place to live. In the Netherlands, people with a history of criminal or anti-social behaviour (‘ex-offenders’) are among those whose search for housing is most problematic. They are sometimes viewed...
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AbstractBackgroundUnderstanding the link between tuberculosis (TB) and diabetes is increasingly important as public health responds to the growing global burden of noncommunicable diseases. Genetic association studies have identified numerous host genetic variants linked to TB; however, potential host genetic mechanisms linking TB and diabetes remain unexplored.MethodsWe used genetic and phenotypic data from the UK Biobank to evaluate the association of 6 previously reported TB-related host genetic...
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Publication date: Available online 21 April 2020Source: Journal of Controlled ReleaseAuthor(s): Huamei He, Lanlan Liu, Shengping Zhang, Mingbin Zheng, Aiqing Ma, Ze Chen, Hong Pan, Haimei Zhou, Ruijing Liang, Lintao Cai
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Publication date: Available online 21 April 2020Source: Journal of Controlled ReleaseAuthor(s): Marion M. Deken, Marta M. Kijanka, Irati Beltrán Hernández, Maxime D. Slooter, Henriette S. de Bruijn, Paul J. van Diest, Paul M.P. van Bergen en Henegouwen, Clemens W.G.M. Lowik, Dominic J. Robinson, Alexander L. Vahrmeijer, Sabrina Oliveira
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Publication date: Available online 21 April 2020Source: Journal of Controlled ReleaseAuthor(s): Aurélie Lacroix, Hassan H. Fakih, Hanadi F. Sleiman
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Abstract Major depressive disorder (MDD) is associated with aberrant function and interaction encompassing large parts of cortical, subcortical and limbic regions that always organized into integrative networks implicated in specific tasks. And cumulative evidence suggests that MDD can be understood as a disorder of dysregulated network. Our study used resting-state fMRI and independent component analysis (ICA) to investigate intrinsic functional connectivity (FC) within and between...
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Abstract Introduction Teneligliptin, a dipeptidyl peptidase 4 inhibitor, was approved for the treatment of type 2 diabetes mellitus (T2DM) in Japan in 2012. However, clinical trials of teneligliptin involved limited numbers of elderly patients. Therefore, we investigated the safety and efficacy of teneligliptin in elderly patients with T2DM. Methods ...
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Abstract Introduction Adequate bowel preparation is a vital determinant for the success of colonoscopy. However, individuals who undergo bowel preparation for colonoscopy can experience major discomfort. To solve this problem, adding prucalopride to the prepared solution may reduce intake volume, decreasing discomfort and side effects. We performed meta-analyses and systematic review of available randomized controlled trials. ...
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Transfusion decision during the perioperative period mostly relies on the point-of-care testing for Hb measurement. This study aimed systematically compared four point-of-care methods with the central laborato...
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G-protein coupled estrogen receptor 30 (GPR30) was proved the specific estrogen receptor relating to mechanical hyperalgesia. Studies have shown that the GABAA receptor subunits α4, β1, and δ in the periaqueducta...
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Abstract Radon therapy has been traditionally performed globally for oxidative stress-related diseases. Many researchers have studied the beneficial effects of radon exposure in living organisms. However, the effects of thoron, a radioisotope of radon, have not been fully examined. In this study, we aimed to compare the biological effects of radon and thoron inhalation on mouse organs with a focus on oxidative stress. Male BALB/c mice were randomly divided into 15 groups: sham...
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Abstract Carpal tunnel syndrome (CTS) is the most frequent entrapment neuropathy of peripheral nerves, with an incidence of 1–3 patients in 1000. CTS typically occurs between 45 and 60 years of age, and it is more frequent in women than in men. The main cause of CTS is chronic compression of the median nerve and ischemic suffering secondary to increased pressure in the carpal tunnel. There are many possible causes of CTS, which can be differentiated into idiopathic causes, which...
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Σύμφωνα με Μελέτη του Πενταγώνου και άλλες σχετικές μελέτες, το Εμβόλιο της Γρίπης αυξάνει τον κίνδυνο του κορωνοϊού κατά 36%, όπως αναφέρει η σελίδα του Robert F. Kennedy, Jr., προέδρου της Children’s Health Defense Στις 12 Μαρτίου 2020, ο Anderson Cooper και ο δρ Sanjay Gupta οργάνωσαν μια εκδήλωση με θέμα «Corona: Γεγονότα και Φόβοι». […]
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JPM, Vol. 10, Pages 28: Statistical Shape Analysis of Ascending Thoracic Aortic Aneurysm: Correlation between Shape and Biomechanical Descriptors Journal of Personalized Medicine doi: 10.3390/jpm10020028 Authors: Cosentino Raffa Gentile Agnese Bellavia Pilato Pasta An ascending thoracic aortic aneurysm (ATAA) is a heterogeneous disease showing different patterns of aortic dilatation and valve morphologies, each with distinct clinical course. This study aimed...
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Ramucirumab monotherapy as a second-line treatment for advanced gastric cancer (AGC) prolongs survival compared to the best supportive care. However, in clinical practice, ramucirumab monotherapy is sometimes ...
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There is a long history of traditional/complementary medicine (T/CM) use by women during lactation. While it is important to evaluate such use within a scientific paradigm to ensure efficacy and safety, knowle...
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It’s a bitter counterpoint to the 50th anniversary of Earth Day -- Read more on ScientificAmerican.com
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The four interconnected crises now challenging the U.S. call for radical economic restructuring -- Read more on ScientificAmerican.com
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Publication date: Available online 21 April 2020Source: BiochimieAuthor(s): Martina Rooney, Teodoro Bottiglieri, Brandi Wasek-Patterson, Amy McMahon, Catherine F. Hughes, Adrian McCann, Geraldine Horigan, J.J. Strain, Helene McNulty, Mary Ward
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Publication date: Available online 21 April 2020Source: BiochimieAuthor(s): Jufei Xu, Cong Zhao, Xiangyi Huang, Weihong Du
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The objective was to assess the effect of propranolol on oxidative stress and anti-oxidant potential in patients with resistant hypertension as a secondary analysis of the APPROPRIATE trial. This randomized do...
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Publication date: Available online 21 April 2020Source: Free Radical Biology and MedicineAuthor(s): Sana Khalid, Hajime Yamazaki, Mairobys Socorro, Daisy Monier, Elia Beniash, Dobrawa Napierala
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Publication date: Available online 21 April 2020Source: Free Radical Biology and MedicineAuthor(s): Thibault Leger, Chrystele Jouve, Veronique Patrac, Valerie Batel, Damien Bouvier, Vincent Sapin, Bruno Miguel, Luc Demaison, Kasra Azarnoush
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Publication date: Available online 21 April 2020Source: Biochimica et Biophysica Acta (BBA) - Proteins and ProteomicsAuthor(s): Adriano de Freitas Fernandes, Vitor Hugo Balasco Serrão, Jéssica Fernandes Scortecci, Otavio Henrique Thiemann
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Biomarkers can play a critical role by facilitating diagnosis and stratification of disease, as well as assessment or prediction of disease severity. Urinary tissue inhibitor of metalloproteinase-2 and insulin...
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Abstract Purpose This study sought to evaluate the prevalence of menopausal symptoms in a population of reproductive-aged women remote from cancer therapy compared with a group of healthy similar-aged controls and with a cohort of late reproductive-aged (LR) controls. Methods Participants were assessed for symptoms of menopause, early follicular phase hormones,...
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In a randomized phase II trial conducted in patients with metastatic melanoma, patient-specific autologous dendritic cell vaccines (DCV) were associated with longer survival than autologous tumor cell vaccines...
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Kidney ischemia reperfusion injury (IRI) is a common cause of acute kidney injury and an unavoidable consequence of kidney transplantation and still lacks specific therapeutics. Recently, mesenchymal stem cell...
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