Abstract Lymphomatoid papulosis (LyP) is a self‐limiting cutaneous T‐cell lymphoproliferative disorder that may progress into malignant lymphoma. Most of the previously reported associated lymphomas are primary cutaneous anaplastic large‐cell lymphoma and mycosis fungoides with a low mortality rate. We report a case of primary cutaneous peripheral T‐cell lymphoma, not otherwise specified (pcPTCL‐NOS), associated with LyP after long‐term follow up. The patient was a 79‐year old Japanese man followed...
9m
Subcutaneous granuloma annulare on the heel: A case report and review of the Japanese published work
Abstract Subcutaneous granuloma annulare is a rare variant of granuloma annulare. It mostly presents as painless subcutaneous nodule(s) with or without annular lesions on the lower legs and scalp of children. We herein report a case of a 5‐year‐old Japanese girl with subcutaneous granuloma annulare on the right heel. The lesions improved in 15 months without any therapy. We also review 85 reported cases of subcutaneous granuloma annulare between 1 and 85 years of age in the Japanese published work....
9m
Abstract Background This study is to explore the role of curcumin and GLUT‐1 antisense oligodeoxynucleotides (AS‐ODN) on autophagy modulation‐initiated radiosensitivity. Methods BALB/c mice were employed to establish xenograft model using Tu212 cell. The expression of autophagy‐ and apoptosis‐related proteins was determined by WB. Autophagosome was observed under transmission electron microscope. Apoptosis of tumor tissue were detected by TUNEL staining. Results Combinations...
22h
Abstract Background There is a paucity of information regarding the incidence and survival of parotid malignancies over time. Methods The Surveillance, Epidemiology, and End Results population‐based cancer registry was queried for parotid malignancies from 1973 to 2015. Results The age‐adjusted incidence of parotid malignancies has increased by 58.1% (7.87‐12.44 per 1 000 000). Analysis of histologic type revealed an increased annual percent change (APC) of acinar cell...
22h
Abstract Background The aim of the study is to analyze potential prognostic factors and to evaluate therapy strategies regarding clinical outcome in patients with eccrine porocarcinoma (EPC) of the head and neck. Methods One hundred and sixteen EPC cases from ninety studies and four authors' EPC cases were included in the meta‐analysis. Results At an average follow up of 20.48 months, the 3‐year overall survival and regional recurrence rate were 70.3% and 19.0%, respectively....
22h
Abstract It is widely accepted that hydrogeochemistry of saline springs is extremely important to understand the water circulation and evolution of saline basins and to evaluate the potential of potassiumrich evaporites. The Kuqa Basin, located in the northern part of the Tarim Basin in Northwest China, is a saline basin regarded as the most potential potash-seeking area. However, the origin and water circulation processes of saline springs have yet to be fully characterized in...
22h
Summary Background Plaque psoriasis affects children and adults, but treatment options for paediatric psoriasis are limited. Objectives Evaluate the efficacy and safety of ixekizumab (IXE), a high‐affinity monoclonal antibody that selectively targets interleukin‐17A, for moderate‐to‐severe paediatric psoriasis. Methods In a randomised, double‐blind, placebo‐controlled, Phase 3 study (IXORA‐PEDS), patients (age 6 to <18 years) with moderate‐to‐severe plaque psoriasis...
22h
Background The National Cancer Institute's Patient‐Reported Outcomes Version of the Common Terminology Criteria for Adverse Events, collected alongside the clinician‐reported Common Terminology Criteria for Adverse Events, enables comparisons of patient and clinician reports on treatment toxicity. Methods In a multisite study of women receiving chemotherapy for early‐stage breast cancer, symptom reports were collected on the same day from patients and their clinicians for 17 symptoms;...
23h
Background Solitary fibrous tumor (SFT) is a rare mesenchymal malignancy. Although surgery is potentially curative, the local relapse risk is high after marginal resections. Given the lack of prospective clinical trial data, the objective of the current study was to better define the role of perioperative radiotherapy (RT) in various SFT presentations by location. Methods This was retrospective study performed across 7 sarcoma centers. Clinical information was retrieved from all adult...
23h
Background Emerging evidence has suggested that DNA repair gene alterations may be important in prostate cancer pathogenesis. In the current study, the authors sought to characterize alterations in DNA repair pathway genes in both primary and metastatic prostate tumors with attention to tissue distribution as well as specific genomic alterations. Methods The authors studied the distribution and type of alterations in 24 genes that are considered important for DNA repair in 944 prostate...
23h
Background Intratumoral heterogeneity is defined by subpopulations with varying genotypes and phenotypes. Specialized, highly invasive leader cells and less invasive follower cells are phenotypically distinct subpopulations that cooperate during collective cancer invasion. Because leader cells are a rare subpopulation that would be missed by bulk sequencing, a novel image‐guided genomics platform was used to precisely select this subpopulation. This study identified a novel leader cell mutation...
23h
Background Linked population‐based registries provide a unique source for identification of new family cancer syndromes and for elucidating risk of early‐onset cancer in close relatives of cancer patients. Methods Using the Finnish Cancer Registry, we identified 9078 probands who had been diagnosed with cancer at <21 years of age between 1970 and 2012. Siblings, offspring, parents, nephews, and nieces of probands were identified from the Population Registry. Childhood and young adult...
23h
Background Initiating screening at an earlier age based on cancer family history is one of the primary recommended strategies for the prevention and detection of early‐onset colorectal cancer (EOCRC), but data supporting the effectiveness of this approach are limited. The authors assessed the performance of family history–based guidelines for identifying individuals with EOCRC. Methods The authors conducted a population‐based, case‐control study of individuals aged 40 to 49 years with...
23h
Abstract α‐L‐fucosidase 1 (FUCA1), a lysosomal enzyme that catalyses the hydrolytic cleavage of the terminal fucose residue, has been reported to be involved in tumorigenesis. However, the clinical significance and biological roles of FUCA1 in glioma remain largely unknown. We analysed FUCA1 expression according to data in the Oncomine, The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA) databases and further verified FUCA1 expression with immunohistochemistry and real‐time PCR...
23h
Abstract Nasopharyngeal Carcinoma (NPC) is a common malignant tumor and a major cause of mortality and morbidity in southern China. However, the mechanism is still elusive. Here, we focused on studying the role of Squalene epoxidase (SQLE), a key enzyme of cholesterol biosynthesis, in the progression of NPC. Clinical study revealed that SQLE expression was significantly up‐regulated in NPC tissues compared to normal tissues from mRNA level and patients with high expression of SQLE showed a poor...
23h
Abstract To elucidate dynamic changes in native BCR‐ABL and alternatively spliced tyrosine kinase inhibitor (TKI)‐resistant but function‐dead BCR‐ABLIns35bp variant, following commencement or discontinuation of TKI therapy, each transcript was serially quantified in patients with chronic myeloid leukemia (CML) by deep sequencing. Since both transcripts are measured together by conventional polymerase chain reaction as a common International Scale (IS), deep sequencing method was used for quantifying...
23h
Abstract Formalin‐fixed paraffin‐embedded (FFPE) tissues used for routine pathological diagnosis are valuable for cancer genomic analysis; however, the association between mutation status derived from these specimens and prognosis in pancreatic ductal adenocarcinoma (PDAC) remains unclear. We analyzed 50 cancer‐related gene mutations including driver genes in PDAC, using next‐generation sequencing (NGS) to clarify the association between gene mutations and prognosis. DNA was extracted from FFPE...
23h
Abstract Cancer cells with cancer stem cell (CSC) properties initiate both primary tumor formation and metastases at distant sites. Acquisition of CSC properties is highly associated with epigenetic alterations, including those mediated by microRNAs (miRNAs). We have previously established the breast cancer patient‐derived tumor xenograft (PDX) mouse model in which CSC marker CD44+ cancer cells formed spontaneous microscopic metastases in the liver. In this PDX mouse, we found that the expression...
23h
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