As a classic prescription, Huangqin Tang (HQT) has been widely applied to treat ulcerative colitis (UC), although its pharmacological mechanisms are not clear. In this study, urine metabolomics was first analysed to explore the therapeutic mechanisms of HQT in UC rats induced by TNBS. We identified 28 potential biomarkers affected by HQT that might cause changes in urine metabolism in UC rats, mapped the network of metabolic pathways, and revealed how HQT affects metabolism of UC rats. The results...
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To improve the accurate and sufficient recognition of abnormal points on the workpiece, a multidimensional anomaly point identification approach based on an improved eigenvalue method is proposed in this paper. Whether a point is normal or not depends on the angle between the two adjacent vectors which consisted of four adjacent points around the current focus. The comprehensive judgment is carried out by multidimensional approximation. The numerical simulation and actual experiment validate the...
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Calcium nitrate (CN) is used widely as an effectively inorganic setting accelerator and antifreeze admixture in concrete structures. In this paper, the multiscale investigation of CN on the hydration of C3S was studied by scanning transmission X-ray microscopy (STXM) combined with near-edge X-ray absorption fine structure (NEXAFS), 29Si MAS NMR, calorimetry, scanning electron microscope, and N2 absorption. It was concluded that the calcium silicate hydrate (C-S-H) surrounds the unhydrated C3S at...
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Recycled asphalt pavement (RAP) can be used in highway engineering again by cold recycled technology. Due to the aged asphalt on the surface of RAP, some problems such as poor adhesion between emulsified asphalt and RAP and the low properties of emulsified asphalt recycling mixture are easy to occur. This work aims at analyzing the aging degree of asphalt from RAP surface and improving the poor adhesion between RAP and emulsified asphalt by modifying the surface characteristics of RAP. In this work,...
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Objective. To investigate the temporal trends in mortality and disease burden of injuries in Anhui province from 2008 to 2017, so as to provide reference for injury control and prevention. Methods. Data of mortality were collected from 9 national surveillance points in Anhui province during 2008-2017 in the Information System for Death Cause Register and Management. The surveillance data were analyzed by using crude mortality, standardized mortality rate (SMR), potential year of life lost (PYLL),...
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Hepatocellular carcinoma (HCC) is one of the most common malignant tumors, and its prognosis is still poor. Mesencephalic astrocyte-derived neurotrophic factor (MANF) plays a key role in endoplasmic reticulum stress. ER stress plays a key role in HCC carcinogenesis. To confirm the clinical and prognostic value of MANF in HCC, we investigated the expression level of MANF in HCC as recorded in databases, and the results were verified by experiment. Survival analysis was probed by the Kaplan–Meier method....
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In the last years, increasing efforts have been devoted to investigating the role of small extracellular vesicles (sEVs) in cardiovascular diseases. These nano-sized particles (30-150 nm), secreted by different cell types, contain signalling molecules that enable participation in intercellular communication processes. In this study, we examined the course of circulating sEVs in patients undergoing surgical aortic valve replacement (SAVR) and correlated them with echocardiographic and standard blood...
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Network embedding is a frontier topic in current network science. The scale-free property of complex networks can emerge as a consequence of the exponential expansion of hyperbolic space. Some embedding models have recently been developed to explore hyperbolic geometric properties of complex networks—in particular, symmetric networks. Here, we propose a model for embedding directed networks into hyperbolic space. In accordance with the bipartite structure of directed networks and multiplex node information,...
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Objective. Inflammation plays an extremely considerable role in the development and progression of malignancies. Absolute neutrophil count (ANC) and mean platelet volume (MPV) in blood are associated with various inflammatory conditions and resulted in independent prognostic factors for lung cancer. However, whether ANC and MPV can be diagnostic markers for lung cancer remains unknown. This retrospective study investigated the roles of ANC and MPV, either alone or combined, in diagnosing lung cancer....
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Background. Combination therapy with Chinese herbal medicines (CHMs) and conventional medical treatment (CMT) was proposed as a therapeutic strategy for chronic heart failure (CHF) patients complicated with depression. Therefore, we performed a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess effects of this combination therapy on CHF complicated with depression. Methods. RCTs comparing the combination of CHMs and CMT to CMT were retrieved in seven electrical databases...
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The principle aim of the current communication is to scrutinize the impact of distinguished effects like variable thermal conductivity and variable molecular diffusivity on non-Newtonian Reiner–Philippoff fluid moving over a stretchable surface. The process of heat transfer is carried out in the presence of nonlinear thermal radiation, variable thermal conductivity, and heat generation/absorption. Furthermore, the study of mass transfer phenomena is carried out in the existence of variable molecular...
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In this paper, zero prime factorizations for matrices over a unique factorization domain are studied. We prove that zero prime factorizations for a class of matrices exist. Also, we give an algorithm to directly compute zero left prime factorizations for this class of matrices.
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Bouea macrophylla Griffith, locally known as maprang, has important economic value as a Thai fruit tree. The maprang seed extract (MPSE) has been shown to exhibit antibacterial and anticancer activities. However, the bioactive constituents in MPSE and the molecular mechanisms underlying these anticancer activities remain poorly understood. This study aims to identify the active compounds in MPSE and to investigate the mechanisms involved in MPSE-induced apoptosis in MCF-7 treated cancer cells. The...
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A robust receding horizon control (RHC) with free control moves is applied to polytopic parametric uncertainty systems with multiple input delays and unstable system matrices. A difficulty in the previous robust RHC work is that the free control moves are unsuitable for the system with input time delay, which is overcome in this paper by the design based on the augmented state. As a result, the synthesis of local control based on augmented feedback is given offline to alleviate the online computation...
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The combination of traditional retail channel with direct channel adds a new dimension of competition to manufacturers’ distribution system. In this paper, we consider a make-to-order manufacturer with two channels of sale, sale through retailers and online direct sale. The customers are classified into different classes, based on their sensitivity to price and due date. The orders of traditional retail channel customers are fulfilled in the same period of ordering. However, price and due date are...
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Background. Cardiogenic shock is associated with high mortality, despite new strategies for reperfusion therapy. Short-term circulatory support devices may provide adequate support for appropriate myocardial and organ perfusion. Objectives. This review is aimed at evaluating the impact on survival when using venoarterial extracorporeal membrane oxygenation (V-A ECMO) in patients with cardiogenic shock due to acute myocardial infarction (AMI). Methods. We performed a systematic review that included...
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Introduction. Tissue engineering is an elementary necessity for several applications in the biomedical field through the use of several biopolymers derived from plants. Larrea tridentata (LT) is a very used plant for various medicinal applications with interesting properties; however, its use into cellulose hydrogels for possible regenerative therapeutics is still limited. Cellulose films could be applied in medical field as wound healing, scaffold for connective tissue for periodontal applications,...
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Cardiolipin oxidation and degradation by different factors under severe cell stress serve as a trigger for genetically encoded cell death programs. In this context, the interplay between cardiolipin and another mitochondrial factor—cytochrome c—is a key process in the early stages of apoptosis, and it is a matter of intense research. Cytochrome c interacts with lipid membranes by electrostatic interactions, hydrogen bonds, and hydrophobic effects. Experimental conditions (including pH, lipid composition,...
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This paper investigates the synchronization problem in a new 5D hyperchaotic system. Firstly, the existence of two types of synchronization problems in the new 5D hyperchaotic system is proved. Then, by the dynamic feedback control method, one complete synchronization problem and three coexistence of complete synchronization and antisynchronization problems in such system are realized. Finally, numerical simulations are used to verify the validity and effectiveness of the theoretical results.
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Background. Pakistan is a country with one of the highest burden of tuberculosis (TB) in the world, and therefore, it is imperative to revisit the design of behaviour change interventions in the program. This study was designed to understand and assess the knowledge, awareness, perceptions, and health-seeking behaviour of general and specifically TB-affected population and to determine the presence and level of stigma and discrimination toward TB patients. Methods. A mixed-method study was conducted...
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Heart diseases remain the major cause of death worldwide. Advances in pharmacological and biomedical management have resulted in an increasing proportion of patients surviving acute heart failure (HF). However, many survivors of HF in the early stages end up increasing the disease to chronic HF (CHF). HF is an established frequent complication of myocardial infarction (MI), and numerous influences including persistent myocardial ischemia, shocked myocardium, ventricular remodeling, infarct size,...
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Background. Tuberculous peritonitis is difficult to diagnose due to its varying clinical features, in addition to the low yield on bacterial culture or polymerase chain reaction using ascitic fluid samples. This study aimed to investigate the sensitivity and specificity of elevated adenosine deaminase (ADA) levels as a diagnostic marker for tuberculous peritonitis. Methods. A retrospective cohort of 181 adult patients who underwent ascitic fluid ADA level examination at Jichi Medical University Hospital...
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Background. Undernutrition is one of the most widespread public health problems that affect both developed and developing countries. In Ethiopia, it is one of the factors leading to unacceptable high morbidity and mortality among women. However, little is documented on undernutrition among lactating women particularly in such a purely pastoral community. Therefore, this study was designed to assess prevalence of undernutrition and its associated factors among lactating women living in pastoral community...
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In this paper, the fractional order models are used to study the propagation of ion-acoustic waves in ultrarelativistic plasmas in nonplanar geometry (cylindrical). Firstly, according to the control equations, (2 + 1)-dimensional (2D) cylindrical Kadomtsev–Petviashvili (CKP) equation and 2D cylindrical-modified Kadomtsev–Petviashvili (CMKP) equation are derived by using multiscale analysis and reduced perturbation methods. Secondly, using the semi-inverse method and the fractional variation principle,...
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To satisfy security concerns including infrastructure as a service (IaaS) security framework, security service access, network anomaly detection, and virtual machine (VM) monitoring, a layered security framework is built which composes of a physical layer, a virtualization layer, and a security management layer. Then, two security service access methods are realized for various security tools from the perspective of whether security tools generate communication traffic. One without generating traffic...
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With the concept of sharing economic entering into our lives, many parking Apps are designed for connecting the drivers and vacated parking spaces. However, there are not many drivers who use the mobile Apps to reserve and find available parking spaces, which is largely due to the insufficient information provided by the parking App. In order to better explain, predict, and improve drivers’ acceptance of parking App, the conceptual framework based on technology acceptance model was developed to establish...
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Background. Nipah belongs to the genus Henipavirus and the Paramyxoviridae family. It is an endemic most commonly found at South Asia and has first emerged in Malaysia in 1998. Bats are found to be the main reservoir for this virus, causing disease in both humans and animals. The last outbreak has occurred in May 2018 in Kerala. It is characterized by high pathogenicity and fatality rates which varies from 40% to 70% depending on the severity of the disease and on the availability of adequate healthcare...
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