Follicular dendritic cell sarcoma (FDCS) is a rare and unusual cancer that arises from sustentacular cells of the lymph node that present antigen to B cells, rather than lymphocytes themselves. While surgery for primary disease is still paramount in primary management, for unresectable, recurrent and metastatic tumours, FDCS is frequently treated with anthracycline-based lymphoma chemotherapy regimens. In recent years, it is clear that Programmed Cell Death 1 (PD1)-directed immune checkpoint inhibitors...
now
We report a case of a 46-year-old woman who has presented to a peripheral hospital with progressive exertional dyspnoea and chest discomfort. The resting ECG showed features of left-sided ventricular hypertrophy. The initial chest radiograph was reported as cardiomegaly. Initial echocardiography revealed left atrial dilatation and ‘left ventricular’ hypertrophy with normal ejection fraction. She was treated as possible coronary artery disease and was subsequently referred to our centre for CT coronary...
now
High-energy traumatic long bone defects are some of the most challenging to reconstruct. Although cases of spontaneous bone regeneration in these defects have been reported, we are aware of no management guidelines or recommendations for when spontaneous bone regeneration should be considered a viable management option. We aim to identify how certain patient characteristics and surgical factors may help predict spontaneous bone regeneration. A total of 26 cases with traumatic segmental defects were...
now
Malignant peripheral nerve sheath tumours of thyroid are rare entities that can present a diagnostic dilemma. We present the case of a patient who presented with neck mass with a history of multiple neck surgeries and airway compression. The patient’s previous histopathology was mistaken for Riedel’s thyroiditis in an outside hospital, which delayed appropriate treatment leading to suffering on part of the patient and frustration on part of the physician. We emphasise that rare malignancies should...
now
A 69-year-old woman underwent routine screening with CT scan of the chest, which showed a new right upper lobe lesion. Interval increase in size of the right upper lobe nodule over 3 months, prompted a CT-guided biopsy of the lung that confirmed a diagnosis of malignant pulmonary spindle cell carcinoma (PSCC) with 90% programmed death ligand 1 expression. Positron emission tomography CT demonstrated localised stage IIA disease. Given histologically proven PSCC and the rapid growth of her tumour,...
now
An adolescent male with a history of autoimmune enteropathy, autoimmune hypothyroidism, aphthous stomatitis and recurrent oral Candida infections only in the setting of curative antibiotic courses presented with cryptococcal pneumonia and perihilar adenitis, which was successfully treated with antifungal therapy. The patient had a complex history with several immunological anomalies. Whole exome sequencing revealed a known STAT1 pathogenic variant, associated with gain of function (GOF). This case...
now
Two male patients, aged 55 and 75 years, were referred to the ENT and haematology team respectively, with an asymptomatic left supraclavicular neck mass. Investigations revealed metastatic primary testicular seminoma. CT contrast study of the thorax, abdomen and pelvis demonstrated an additional left para-aortic nodal mass in both cases. The initial presentation of a solitary left neck lump from a metastatic testicular seminoma is extremely unusual, especially in an older age group. The pattern of...
now
Massive pulmonary embolism (PE) is a leading cause of maternal death and may require intra-arrest thrombolysis as well as resuscitative hysterotomy. The case presented is a primigravida in her mid-30s at 28 weeks gestation. The patient presented to the emergency department after out-of-hospital cardiac arrest. Return of spontaneous circulation (ROSC) was achieved but not sustained. Episodic cardiopulmonary resuscitation with epinephrine boluses was required. Resuscitative hysterotomy was performed...
now
Left ventricular assist devices (LVADs) are currently used as destination therapy or bridge to heart transplantation in patients with advanced chronic heart failure (CHF). It has been proved to reduce mortality and symptoms in these patients. Patients with advanced CHF are known to have increased risk of ventricular arrhythmias (ventricular tachycardia or ventricular fibrillation (VF)) despite the presence of LVAD. We report the case of patients with ongoing VF during LVAD treatment while being awake...
now
Remitting seronegative symmetric synovitis with pitting edema (RS3PE) is an uncommon syndrome characterised by acute onset severe synovitis of the radiocarpal and small joints of the hands, with associated pitting edema. Discussed here is the case of a 69-year-old man who presented to the emergency department of a tertiary hospital with acute bilateral hand swelling. This was on a background of a recent diagnosis of metastatic adenocarcinoma of the caecum and subsequent hemicolectomy. There was a...
now
Abstract The ADER approach to solve hyperbolic equations to very high order of accuracy has seen explosive developments in the last few years, including both methodological aspects as well as very ambitious applications. In spite of methodological progress, the issues of efficiency and ease of implementation of the solution of the associated generalized Riemann problem (GRP) remain the centre of attention in the ADER approach. In the original formulation of ADER schemes, the...
12h
Abstract We construct an approximate Riemann solver for scalar advection–diffusion equations with piecewise polynomial initial data. The objective is to handle advection and diffusion simultaneously to reduce the inherent numerical diffusion produced by the usual advection flux calculations. The approximate solution is based on the weak formulation of the Riemann problem and is solved within a space–time discontinuous Galerkin approach with two subregions. The novel generalized...
12h
12h
Abstract We extend LeVeque’s wave propagation algorithm, a widely used finite volume method for hyperbolic partial differential equations, to a third-order accurate method. The resulting scheme shares main properties with the original method, i.e., it is based on a wave decomposition at grid cell interfaces, it can be used to approximate hyperbolic problems in divergence form as well as in quasilinear form and limiting is introduced in the form of a wave limiter.
12h
Abstract We propose a numerical methodology for the simultaneous numerical simulation of four states of matter: gas, liquid, elastoplastic solids, and plasma. The distinct, interacting physical processes are described by a combination of compressible, inert, and reactive forms of the Euler equations, multi-phase equations, elastoplastic equations, and resistive MHD equations. Combinations of systems of equations are usually solved by coupling finite element for solid modelling...
12h
Abstract In this paper, we discuss the notion of discrete conservation for hyperbolic conservation laws. We introduce what we call fluctuation splitting schemes (or residual distribution, also RDS) and show through several examples how these schemes lead to new developments. In particular, we show that most, if not all, known schemes can be rephrased in flux form and also how to satisfy additional conservation laws. This review paper is built on Abgrall et al. (Computers and...
12h
Abstract In this paper, the author recounts his forty-year plus struggle to find a sound basis for understanding the computational fluid dynamics of compressible flow.
12h
Abstract One of the beneficial properties of the discontinuous Galerkin method is the accurate wave propagation properties. That is, the semi-discrete error has dissipation errors of order \(2k+1\) (\(\le Ch^{2k+1}\)) and order \(2k+2\) for dispersion (\(\le Ch^{2k+2}\)). Previous studies have concentrated on the order of accuracy, and neglected the important role that the error constant, C, plays in these estimates. In this article, we show the important role of the error constant...
12h
Abstract We show the existence of global weak solutions to the three dimensional Navier–Stokes equations with initial velocity in the weighted spaces \(L^2_{w_\gamma }\), where \(w_\gamma (x)=(1+\vert x\vert )^{-\gamma }\) and \(0<\gamma \leqq 2\), using new energy controls. As an application we give a new proof of the existence of global weak discretely self-similar solutions to the three dimensional Navier–Stokes equations for discretely self-similar initial velocities which...
14h
Abstract Substance P a neuro-immune mediator acts on Neurokinin-1 and -2 receptors (NK1R and NK2R). Inhibitors of NK1R are considered to be safe and effective approaches for cancer treatment since Aprepitant, a non-peptide antagonist of NK1R is widely used for chemotherapy-induced emesis and has cytotoxic and antitumor effects in various models for cancer. On the other hand, our previous findings demonstrated that systemic inhibition of NK1R may decrease cytotoxic anti-tumoral...
12h
Abstract Follicular lymphoma (FL) is a remarkably immune-responsive malignancy, which is still considered incurable. As, standard immunochemotherapy is complex, toxic and not curative, improvement in FL care is now a crucial topic in hemato-oncology. Recently, we and others have shown that dendritic cell (DC)-based therapies allow a specific immune response associated with sustained lymphoma regression in a proportion of low-tumor burden FL patients. Importantly, the rate of objective...
12h
The original article [1] contains errors in Table 1 in rows ktrans and Ve; the correct version of Table 1 can be viewed in this Correction article.
12h
Abstract This study aimed to investigate the postnatal morphological features of rabbit’s lingual gustatory papillae using histological, histochemical, morphometrical and scanning electron microscopical studies. A total of 48 New Zealand rabbits (1, 7, 15, 23, 30, 60 days postnatal) were used as the material. Tongue consisted of an apex, body and root with three types of gustatory papillae fungiform, vallate and foliate. Rounded to oval fungiform papillae were distributed on lingual...
12h
Vasectomy is one of the permanent methods of contraception; however, the risk of conception still exists. Early failure, defined as a postoperative semen analysis showing persistent motile sperm, occurs in 1 i...
12h
BackgroundPreoperative education may help participants to psychologically prepare themselves for surgery, but the outcomes of such preparation have rarely been assessed in patients requiring postoperative care in the intensive care unit (ICU) as well as in family members.ObjectiveTo assess the effect of a preoperative multifaceted education intervention on patient and family satisfaction levels in the ICU and measures of perioperative patients’ anxiety and depression.Trial designSingle-centre, two-armed,...
12h
Abstract Background Naldemedine is a peripherally acting μ-opioid receptor antagonist that is indicated to treat opioid-induced constipation. Objectives To assess the potential for drug-drug interactions between a single oral dose of naldemedine and the oral P-glycoprotein inhibitor cyclosporine, cytochrome P450 (CYP) 3A inhibitors itraconazole and fluconazole,...
12h
ObjectivesThe Burns and Scalds Assessment Template (BaSAT) is an evidence-based proforma coproduced by researchers and ED staff with the aim of (1) standardising the assessment of children attending ED with a burn, (2) improving documentation and (3) screening for child maltreatment. This study aimed to test whether the BaSAT improved documentation of clinical, contributory and causal factors of children’s burns.MethodsA retrospective before-and-after study compared the extent to which information...
13h
BackgroundIschaemic tissue injury caused by tissue hypoperfusion is one of the major consequences of sepsis. Phosphate concentrations are elevated in ischaemic tissue injury. This study was performed to investigate the association of phosphate concentrations with mortality in patients with sepsis.MethodsThis was a retrospective cohort study of patients with sepsis conducted at an urban, tertiary care emergency department (ED) in Korea. Patients with sepsis arriving between March 2010 and April 2017...
13h
Singapore was one of the earliest countries affected by the coronavirus disease 2019 (COVID-19) pandemic, with more laboratory-confirmed COVID-19 cases in early February 2020 than any other country outside China. This short report is a narrative review of our tertiary paediatric emergency department (ED) perspective and experience managing the evolving outbreak situation. Logistic considerations included the segregation of the ED into physically separate high-risk, intermediate-risk and low-risk...
19h
Zusammenfassung Hintergrund Das metastasierte Mammakarzinom gilt allgemein als nicht kurabel; dennoch hat die Lebenserwartung der betroffenen Patientinnen durch den Einsatz moderner Systemtherapien in den letzten Jahrzehnten zugenommen. Zum aktuellen Zeitpunkt stellt die primäre operative Resektion des Brusttumors keine Standardtherapie dar, und ihr Effekt auf ein längeres Überleben ist bislang nicht eindeutig geklärt. ...
13h
This article asks what the reasons are for the frequent linking of the image of the Holocaust with that of dementia in contemporary discursive and representational practice. In doing so, it analyses some of the numerous 21st-century examples of fiction, drama and film in which the figure of a Holocaust survivor living with dementia takes centre stage. It explores the contradictory cultural effects that arise from making such a connection, in contexts that include expressions of fear at the spectacle...
13h
Abstract Purpose Acute pain and resting arterial blood pressure (BP) are positively correlated in patients with chronic pain. However, it remains unclear whether treatment for chronic pain reduces BP. Therefore, in a retrospective study design, we tested the hypothesis that implantation of an epidural spinal cord stimulator (SCS) device to treat chronic pain would significantly reduce clinic pain ratings and BP and that these reductions...
13h
This case series describes clinical characteristics, health services use, and outcomes of patients with confirmed coronavirus disease 2019 (COVID-19) cared for at 12 hospitals of a single health system in the New York City (NYC) area.
13h
This study reports on the prevalence, intensity, and timing of an altered sense of smell or taste in patients with SARS-CoV-2 infections.
13h
Publication date: June 2020Source: European Journal of Cancer, Volume 132Author(s): Denis Maillet, Pauline Corbaux, Jean-Jacques Stelmes, Stéphane Dalle, Myriam Locatelli-Sanchez, Marie Perier-Muzet, Michaël Duruisseaux, Lize Kiakouama-Maleka, Gilles Freyer, Amélie Boespflug, Julien Péron
13h
AbstractIn 2017, state health departments notified the Centers for Disease Control and Prevention about 4 patients with shigellosis who experienced persistent illness after treatment with oral third-generation cephalosporins. Given increasing antibiotic resistance among Shigella, these cases highlight the need to evaluate the efficacy of oral cephalosporins for shigellosis.
13h
AbstractBackgroundThe value of follow-up blood cultures (FUBCs) to document clearance of bacteremia due to Gram-negative bacilli (GNB) has not been well established. Although previous studies suggested that the yield of FUBCs for GNB bacteremia is low, it remains to be elucidated for whom FUBC may be beneficial and for whom it is unnecessary.MethodsA retrospective cohort study was performed at 4 acute care hospitals to identify risk factors for positive FUBCs with GNB bacteremia and to better guide...
13h
AbstractTargeted molecular diagnostic tests and accurate immunoassays have transformed the landscape of clinical virology, calling into question the usefulness of traditional viral culture. Here we present a case where viral culture, followed by metagenomic sequencing, was central to the diagnosis of an unexpected viral infection, with significant clinical and public health implications.
13h
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου