Nasally delivered VEGFD mimetics mitigate stroke-induced dendrite loss and brain damage [Neuroscience]

Nasally delivered VEGFD mimetics mitigate stroke-induced dendrite loss and brain damage [Neuroscience]:

In the adult brain, vascular endothelial growth factor D (VEGFD) is required for structural integrity of dendrites and cognitive abilities. Alterations of dendritic architectures are hallmarks of many neurologic disorders, including stroke-induced damage caused by toxic extrasynaptic NMDA receptor (eNMDAR) signaling. Here we show that stimulation of eNMDARs causes a...