Allergy and Clinical Immunology

APRIL-dependent life-long plasmacyte maintenance and immunoglobulin production in humans

Interactions between TNF ligand superfamily and TNF receptor superfamily play critical roles in B cell development and maturation. A proliferation-inducing ligand (APRIL), a member of the TNF ligand superfamily, is secreted from myeloid cells and known to induce the differentiation of memory B cells to plasmacytes.

Allergy and Clinical Immunology

8h

Distinct associations of sputum and oral microbiota with atopic, immunologic, and clinical features in mild asthma

In mild atopic asthma, sputum bacterial microbiome characteristics associate with several immunologic features, including type 2-low airway inflammation, and display differential changes related to response to inhaled corticosteroid treatment.

Allergy and Clinical Immunology

8h

Ara h 2 is the dominant peanut allergen despite similarities with Ara h 6

Ara h 2 is a greater inhibitor of IgE binding and a more potent elicitor of mast cell activation than Ara h 6.

Allergy and Clinical Immunology

8h

Molecular profiling of allergen-specific antibody responses may enhance success of specific immunotherapy

Molecular diagnosis of IgE sensitization profiles and molecular monitoring of allergen-specific IgG responses may be a personalized medicine approach for enhancing success of HDM-specific AIT in real life.

Allergy and Clinical Immunology

8h

A rare case of selective Igκ chain deficiency: Biologic and clinical implications

Selective Igκ and Igλ deficiencies are extremely rare. So far, there have been few reported cases of Igκ deficiency in the English literature, and all but 2 of them are partial in nature.1-3 The first reported case of complete Igκ deficiency was that of a male patient with concurrent cystic fibrosis, diabetes mellitus, malabsorption, and IgA deficiency4; notably, 1 of the patient’s sisters had only trace amounts of κ+ immunoglobulins. Sequencing of the κ constant region (IGKC) in this patient identified...

Allergy and Clinical Immunology

9h

Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan

The estimated mortality was 32.5% in patients with severe COVID-19 during the average 32 days of follow-up period. Patients with elder age, hypertension, and high LDH level need careful observation and early intervention for the potential development of severe COVID-19.

Allergy and Clinical Immunology

1d

Early life acetaminophen exposure, Glutathione S-Transferase genes and development of adolescent asthma in a high-risk birth cohort

Our findings strengthen the evidence implicating acetaminophen as a possible cause for asthma and reduced lung function, particularly in those with susceptible genetic polymorphisms. Further research is needed before altering guidelines on acetaminophen use.

Allergy and Clinical Immunology

2d

A toxic palmitoylation of Cdc42 enhances NF-κB signaling and drives a severe autoinflammatory syndrome

CDC42 gene mutations arise in large clinical spectra. The de novo R186C variant results in Cdc42 palmitoylation, retention in the Golgi apparatus, and NF-κB hyperactivation, leading to a severe psoriasiform dermatitis, hematological abnormalities and autoinflammation.

Allergy and Clinical Immunology

3d

The role of neutrophils in host defense and disease

Neutrophils mediate pathogen defense and inflammation through multiple mechanisms. We provide a discussion of the current understanding of neutrophil biology, host defense mechanisms, and the role of neutrophils in inflammatory, autoimmune and malignant diseases.

Allergy and Clinical Immunology

3d

Bronchial mucosal inflammation and illness severity in response to experimental rhinovirus infection in COPD

Rhinovirus-induced bronchial mucosal eosinophils, neutrophils, macrophages and lymphocytes in COPD subjects are related to experimental rhinovirus-induced COPD exacerbation severity. Anti-viral/anti-inflammatory therapies could attenuate bronchial inflammation and ameliorate virus-induced COPD exacerbation severity.

Allergy and Clinical Immunology

3d

Characterization of the clinical and immunological phenotype and management of 157 individuals with 56 distinct heterozygous NFKB1 mutations

We describe the clinical and immunological features of the to date largest cohort of patients with deleterious heterozygous NFKB1 mutations. To provide evidence for pathogenicity, we used a combined in silico and in vitro approach.

Allergy and Clinical Immunology

4d