Although sequencing and other high-throughput data production technologies are increasingly affordable, data analysis and interpretation remains a significant factor in the cost of -omics studies. Despite the ...
Wed Apr 01, 2020 03:00
In Ethiopia simulation-based anesthesia education is a new way of teaching method which started in Mekelle University as of January, 2019. Hence, the purpose of this study is to evaluate whether simulation-bas...
Wed Apr 01, 2020 03:00
According to the WHO coronavirus disease (COVID-19) situation report 35, as of 24th February 2020, there was a total of 77,262 confirmed COVID-19 cases in China. That included 2595 deaths. The specific objecti...
Wed Apr 01, 2020 03:00
Right ventricular dysfunction impacts the prognosis of various heart diseases. We set-out to examine which right ventricular functional parameters after STEMI and NSTEMI have prognostic value. Of 297 eligible ...
Wed Apr 01, 2020 03:00
The early diagnosis of neonatal sepsis remains a challenge for physicians. The initiation or/and discontinuation of the empirical antibiotic therapy at neonates with sepsis is a dilemma due to the lack of defi...
Wed Apr 01, 2020 03:00
Ambulnz is a non-emergency on-demand ambulance provider that is working to improve on traditional medical transportation through the implementation and integration of various technologies. The firm describes itself as a “software-enabled medical transportation company”. When a patient needs to be moved to a new facility for treatment out of a hospital, out-patient treatment clinic, doctor, dialysis, or chemo center, a pickup can be scheduled through the Ambulnz app. The app can help...
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Ventilators are important to maintain patients with severe respiratory distress due to COVID-19, but the machines carry their own risks. An over-inflated endotracheal tube cuff could damage the trachea, while an under-inflated cuff could result in aspiration and pneumonia. AnapnoGuard, developed by Hospitech Respiration, an Israeli firm, is an endotracheal tube plus control unit meant to be used with ventilators to prevent complications of both over- and under-inflation. The company has announced...
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ZOLL Medical, now a part of Asahi Kasei Group, won FDA approval for the latest version of its TherOx System. The product is designed to deliver SuperSaturated Oxygen (SSO2) therapy to limit heart muscle loss following “widowmaker” heart attacks, aka left anterior descending ST-elevation myocardial infarction (LAD STEMI) chronic total obstruction. The system is used right after blood flow is restored during angioplasty and stent implantation to pump hyperbaric levels of oxygen straight...
Wed Apr 01, 2020 18:45
CardioQuip, a firm based in College Station, Texas, won European regulatory approval (CE Mark) for its MCH-1000 cooler-heaters that are used to control patient body temperature, typically during lung or heart procedures. This could be particularly useful during the current COVID-19 pandemic, since the MCH-1000 can be used alongside extracorporeal membrane oxygenation (ECMO) to address acute respiratory distress. “Landing the CE Mark is a tremendous milestone for CardioQuip,” said Doug Platt,...
Wed Apr 01, 2020 18:30
Investing in renewable energy research could be a big part of a post-COVID stimulus plan (Unsplash/)Last week, Congress approved a $2 trillion emergency relief bill to ease some of the effects of COVID-19 on the American economy. But this is just the start of recovering the economy after the pandemic; economists project that we might be heading into a major depression, and one estimate of future unemployment rates tops 30 percent.Meanwhile, the climate crisis hasn’t gone anywhere. Emissions may have...
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Total pup mess control. (Bruna Cervera via Unsplash/)You love your fur babies. Cleaning up after them, not so much. That’s why many big-name vacuum companies now manufacture special cleaners designed with pets owners in mind. These machine are tough on tricky pet hair, which can become matted into carpets and create tumbleweeds of fur on hard floors. Plus, with these, you won’t need to interrupt a vacuuming session to unclog the roller brush. Oh, and many models come complete with furniture attachments...
Wed Apr 01, 2020 22:21
An artist's recreation of the newly discovered Dineobellator notohesperus at the end of the Cretaceous Period in New Mexico. (Sergey Krasovskiy/)A newly discovered dinosaur was a cousin of Velociraptor but might have been an even more formidable hunter than its family member.The raptor, which the researchers have named Dineobellator notohesperus, lived in northwestern New Mexico at the end of the Cretaceous Period. When paleontologists examined a partial skeleton of Dineobellator, they found features...
Wed Apr 01, 2020 21:00
When preparation goes too far. (Brandon Lopez/Unsplash/)When it comes to making decisions, there are two kinds of people in the world: maximizers and satisficers. Maximizers strive to make the best decision possible, while satisficers look to make up their minds for something good enough that they can be happy with. Research has shown maximizers are more likely to make better decisions, but experience more regret and anxiety— around both the decision and the process—than satisficers.When we buy something,...
Wed Apr 01, 2020 19:19
You don't need to shout into your microphone. (Pixabay/)In recent weeks, our social lives have migrated to video chat. Happy hours, board games, work meetings, and just about everything else we do with our friends now involves firing up a popular video chat app. And while we’ve already outlined some tips for looking better in video calls, audio is every bit as important.Here area few tips to help make your voice sound crystal clear while avoiding familiar problems like feedback, echos, and the dreaded...
Wed Apr 01, 2020 19:07
Mirror, mirror on the wall. (Amazon/)If you’re somebody with a home assistant, a smart home, and a robot vacuum, you may want to opt into a smart mirror for your bathroom, vanity, or desktop. Tech savvy mirrors can light you well, tell you the weather, and play your music. Below, four of our favorite mirrors that will make your daily routine easier.A luxe bathroom experience. (Amazon/)This is a sophisticated smart mirror that will bring your bathroom to the next level. It has features that will make...
Wed Apr 01, 2020 15:35
Stay out of its way. (Depositphotos/)Imagine enjoying your Saturday morning coffee on the sofa and instead of spotting those dust bunnies under the media console, watching the pleasant scurrying of your robot vacuum. Half an hour later, it docks on its charger and beeps to let you know it has completed a mundane chore, and all you have to worry about is getting up to get your second cup. You can enjoy having a fluffy dog or long hair without the evidence collecting underneath your couch. While you...
Wed Apr 01, 2020 15:24
Reduced tilling, cover crops, and more trees can pull more carbon from the air and into the ground. (Patrick Leger/)Along a stretch of rural highway in the coastal plains of North Carolina sits an unusual forest. The viridian-green branches of loblolly pines rise 60 feet above a carpet of soft, tufted grasses, rippling slightly in the breeze. The trees are widely spaced, 20 to 30 feet apart, with their lower limbs removed, creating an airy, cathedral-like canopy speckled with sunlight filtering through...
Wed Apr 01, 2020 15:00
The black yeast-like fungus Arthrocladium fulminans is known from strains that cause severe, eventually fatal disseminated infections in human patients with a genetic immune disorder. Given the dramatic outcome of this clinical case, it is essential to understand the virulence potential of this species. The fungus is a member of the family Trichomeriaceae, at some phylogenetic distance from the Herpotrichiellaceae where most infectious fungi in the order Chaetothyriales are located. Main ecological...
Wed Apr 01, 2020 23:23
Calcium (Ca) is an essential plant nutrient, required for signaling, cell wall fortification and growth and development. Calcium deficiency (Ca-deficiency) in maize causes leaf tip rot and a so-called "bull-whipping" or "buggy-whipping" phenotype. Seedlings of the maize line B73 displayed these Ca-deficiency-like symptoms when grown in the greenhouse with excess fertilizer during the winter months, while seedlings of the Mo17 maize line did not display these symptoms under the same conditions. These...
Wed Apr 01, 2020 23:23
Background. Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases, which has recently been mentioned as an independent cardiovascular risk factor. Objectives. Endocan is a novel molecule of endothelial dysfunction. We aimed to evaluate the associations of serum endocan levels with the hepatic steatosis index (HSI), fatty liver index (FLI), and degrees of hepatosteatosis in patients with metabolic syndrome with NAFLD. Design and Setting. This cross-sectional prospective...
Wed Apr 01, 2020 22:35
The study addresses the benefit of tuning single harmonics with vocal tract resonances to increase vocal loudness. The loudness of theoretically constructed vocal sounds with variable levels of sound energy in the first, second, and third harmonics is computed on the basis of ISO standard 226:2003. In comparison to increased loudness with changes in overall spectral slope, it is shown that single harmonic tuning requires a greater range of SPL to produce a similar range of loudness. For example,...
Wed Apr 01, 2020 03:00
What are the normative data available on the perceptual and acoustic characteristics of the voice of adults of both sexes who have hearing-impairment and who use cochlear implants?
Wed Apr 01, 2020 03:00
Abstract Vision plays a central role in maintaining balance. When humans perceive their body as moving, they trigger counter movements. This results in body sway, which has typically been investigated by measuring the body’s center of pressure (COP). Here, we aimed to induce visually evoked postural responses (VEPR) by simulating self-motion in virtual reality (VR) using a sinusoidally oscillating “moving room” paradigm. Ten healthy subjects participated in the experiment. Stimulation...
Wed Apr 01, 2020 03:00
Abstract Endothelial dysfunction is responsible for multiple organ failure and the high mortality rate of sepsis. Nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome plays an essential role in the progression of sepsis. However, the role of NLRP3 inflammasome in the endothelial dysfunction of sepsis has not been fully elucidated. In this study, septic mice were induced by cecal ligation and puncture (CLP) operation,...
Wed Apr 01, 2020 03:00
Abstract Cardiomyopathy commonly occurs after sepsis and is closely associated with high mortality in clinic. Interferon regulatory factor-2 binding protein 2 (IRF2BP2) has been identified as a negative regulator of inflammation, but its role in septic cardiomyopathy is unknown. The current study aims to illuminate the regulatory function of IRF2BP2 on sepsis-induced cardiomyopathy and to explore the underlying mechanisms. Protein expression...
Wed Apr 01, 2020 03:00
Abstract The Nod-like receptor protein 3 (NLRP3) inflammasome is a multi-protein complex composed of NLRP3, pro-caspase-1, and apoptosis-associated speck-like protein that contains a caspase recruitment domain (ASC). After NLRP3 priming by lipopolysaccharide (LPS), the ligand of toll-like receptor 4 (TLR4), activation of the NLRP3 inflammasome triggers caspase-1 maturation, leading to pyroptosis and release of interleukin-1beta (IL-1beta)....
Wed Apr 01, 2020 03:00
Abstract Intestinal inflammatory reactions and resulting tissue injuries are two major aspects of inflammatory bowel disease (IBD). The regulatory factors involved in the pathogenesis of IBD remain unclear. Recent studies showed that musculin (MSC) as a transcription suppressor participates in the regulation of certain immune functions. The purpose of this study was to determine the impact of MSC deficiency on colonic injury and inflammatory...
Wed Apr 01, 2020 03:00
Abstract Endotoxemia induced by lipopolysaccharide (LPS) is an extremely severe syndrome identified by global activation of inflammatory responses. Neutrophil extracellular traps (NETs) play an important role in the development of endotoxemia. Histone hypercitrullination catalyzed by peptidylarginine deiminases (PADs) is a key step of NET formation. We have previously demonstrated that simultaneous inhibition of PAD2 and PAD4 with pan-PAD...
Wed Apr 01, 2020 03:00
The authors apologize for a labeling error inSupplemental Material 6of our published article [1]. The original figure switched the labels for “Steenland et al” and “Bone Party Trial Working Party”. We have resubmitted the correct file below. This error does not the affect the results of the forest plot and does not alter the conclusion of the paper.
Wed Apr 01, 2020 03:00
The epidemiology of oropharyngeal cancer is evolving. Previously, this disease was frequently observed in patients with substantial tobacco and alcohol use[1]. More recently, human papillomavirus (HPV) related oropharyngeal cancer is increasing in incidence, particularly in young and non-smoking patients.[2,3]. The prevalence of HPV related oropharynx cancer has increased from 40% of all cases in Radiation Therapy Oncology Group (RTOG) 9003 to 68% on RTOG 0129 and 73% on RTOG 0522[4,5].p16 immunohistochemistry...
Wed Apr 01, 2020 03:00
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