Cancers, Vol. 12, Pages 961: Targeting Aldehyde Dehydrogenases to Eliminate Cancer Stem Cells in Gynecologic Malignancies Cancers doi: 10.3390/cancers12040961 Authors: Vaishnavi Muralikrishnan Thomas D. Hurley Kenneth P. Nephew Gynecologic cancers cause over 600,000 deaths annually in women worldwide. The development of chemoresistance after initial rounds of chemotherapy contributes to tumor relapse and death due to gynecologic malignancies. In this regard, cancer stem...
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Cancers, Vol. 12, Pages 963: Analysis of the Circadian Regulation of Cancer Hallmarks by a Cross-Platform Study of Colorectal Cancer Time-Series Data Reveals an Association with Genes Involved in Huntington’s Disease Cancers doi: 10.3390/cancers12040963 Authors: Müge Yalçin Rukeia El-Athman Koliane Ouk Josef Priller Angela Relógio Accumulating evidence points to a link between circadian clock dysfunction and the molecular events that drive tumorigenesis. Here, we...
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Cancers, Vol. 12, Pages 958: Neutrophil to Lymphocyte Ratio as Prognostic and Predictive Factor in Breast Cancer Patients: A Systematic Review Cancers doi: 10.3390/cancers12040958 Authors: Iléana Corbeau William Jacot Séverine Guiu Inflammatory blood markers (IBM), such as the neutrophil to lymphocyte ratio (NLR), have emerged as potential prognostic factors in various cancers, including breast cancer (BC), potentially allowing an easy, minimally invasive evaluation of a...
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Cancers, Vol. 12, Pages 964: SOX2 Expression and Transcriptional Activity Identifies a Subpopulation of Cancer Stem Cells in Sarcoma with Prognostic Implications Cancers doi: 10.3390/cancers12040964 Authors: Sofia T. Menendez Veronica Rey Lucia Martinez-Cruzado M. Victoria Gonzalez Alvaro Morales-Molina Laura Santos Verónica Blanco Carlos Alvarez Oscar Estupiñan Eva Allonca Juan Pablo Rodrigo Javier García-Castro Juana Maria Garcia-Pedrero...
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Cancers, Vol. 12, Pages 960: Clinical Relevance of Liquid Biopsy in Melanoma and Merkel Cell Carcinoma Cancers doi: 10.3390/cancers12040960 Authors: Magali Boyer Laure Cayrefourcq Olivier Dereure Laurent Meunier Ondine Becquart Catherine Alix-Panabières Melanoma and Merkel cell carcinoma are two aggressive skin malignancies with high disease-related mortality and increasing incidence rates. Currently, invasive tumor tissue biopsy is the gold standard for their...
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Cancers, Vol. 12, Pages 959: MR Thermometry Data Correlate with Pathological Response for Soft Tissue Sarcoma of the Lower Extremity in a Single Center Analysis of Prospectively Registered Patients Cancers doi: 10.3390/cancers12040959 Authors: Michaela Unsoeld Ulf Lamprecht Frank Traub Barbara Hermes Marcus Scharpf Vlatko Potkrajcic Daniel Zips Frank Paulsen Franziska Eckert Background: There is a strong biologic rationale for using locoregional hyperthermia...
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Cancers, Vol. 12, Pages 962: Towards Physiologically and Tightly Regulated Vectored Antibody Therapies Cancers doi: 10.3390/cancers12040962 Authors: Audrey Page Floriane Fusil François-Loïc Cosset Cancers represent highly significant health issues and the options for their treatment are often not efficient to cure the disease. Immunotherapy strategies have been developed to modulate the patient’s immune system in order to eradicate cancerous cells. For instance,...
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Cancers, Vol. 12, Pages 956: Multigene Panel Germline Testing of 1333 Czech Patients with Ovarian Cancer Cancers doi: 10.3390/cancers12040956 Authors: Klara Lhotova Lenka Stolarova Petra Zemankova Michal Vocka Marketa Janatova Marianna Borecka Marta Cerna Sandra Jelinkova Jan Kral Zuzana Volkova Marketa Urbanova Petra Kleiblova Eva Machackova Lenka Foretova Jana Hazova Petra Vasickova Filip Lhota Monika Koudova Leona...
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Cancers, Vol. 12, Pages 957: Pan-Cancer Analysis of Radiotherapy Benefits and Immune Infiltration in Multiple Human Cancers Cancers doi: 10.3390/cancers12040957 Authors: Pengbo Wen Yang Gao Bin Chen Xiaojing Qi Guanshuo Hu An Xu Junfeng Xia Lijun Wu Huayi Lu Guoping Zhao Response to radiotherapy (RT) in cancers varies widely among patients. Therefore, it is very important to predict who will benefit from RT before clinical treatment. Consideration...
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Cancers, Vol. 12, Pages 955: Targeted Assessment of the EGFR Status as Reflex Testing in Treatment-Naive Non-Squamous Cell Lung Carcinoma Patients: A Single Laboratory Experience (LPCE, Nice, France) Cancers doi: 10.3390/cancers12040955 Authors: Sandra Lassalle Véronique Hofman Simon Heeke Jonathan Benzaquen Elodie Long Michel Poudenx Elisabeth Lantéri Jacques Boutros Virginie Tanga Katia Zahaf Salomé Lalvée Virginie Lespinet Olivier Bordone...
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Cancers, Vol. 12, Pages 954: Novel Liquid Biomarker Panels for A Very Early Response Capturing of NSCLC Therapies in Advanced Stages Cancers doi: 10.3390/cancers12040954 Authors: Florian Janke Farastuk Bozorgmehr Sabine Wrenger Steffen Dietz Claus P. Heussel Gudula Heussel Carlos F. Silva Stephan Rheinheimer Manuel Feisst Michael Thomas Heiko Golpon Andreas Günther Holger Sültmann Thomas Muley Sabina Janciauskiene Michael Meister...
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Cancers, Vol. 12, Pages 953: High Galectin-7 and Low Galectin-8 Expression and the Combination of both are Negative Prognosticators for Breast Cancer Patients Cancers doi: 10.3390/cancers12040953 Authors: Trebo Ditsch Kuhn Heidegger Zeder-Goess Kolben Czogalla Schmoeckel Mahner Jeschke Hester Galectins are commonly overexpressed in cancer cells and their expression pattern is often associated with the aggressiveness and metastatic...
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Cancers, Vol. 12, Pages 951: EGCG Mediated Targeting of Deregulated Signaling Pathways and Non-Coding RNAs in Different Cancers: Focus on JAK/STAT, Wnt/β-Catenin, TGF/SMAD, NOTCH, SHH/GLI, and TRAIL Mediated Signaling Pathways Cancers doi: 10.3390/cancers12040951 Authors: Ammad Ahmad Farooqi Marina Pinheiro Andreia Granja Fulvia Farabegoli Salette Reis Rukset Attar Uteuliyev Yerzhan Sabitaliyevich Baojun Xu Aamir Ahmad Decades of research have enabled...
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Cancers, Vol. 12, Pages 946: TERT Promoter Mutations Differently Correlate with the Clinical Outcome of MAPK Inhibitor-Treated Melanoma Patients Cancers doi: 10.3390/cancers12040946 Authors: Paola Del Bianco Camilla Stagni Silvia Giunco Alessio Fabozzi Lisa Elefanti Stefania Pellegrini Antonella Vecchiato Jacopo Pigozzo Carolina Zamuner Anita De Rossi Arcangela De Nicolo Chiara Menin Resistance is a major challenge in the management of...
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Cancers, Vol. 12, Pages 952: Natural Killer Cells: Tumor Surveillance and Signaling Cancers doi: 10.3390/cancers12040952 Authors: Meza Guzman Keating Nicholson Natural killer (NK) cells play a pivotal role in cancer immunotherapy due to their innate ability to detect and kill tumorigenic cells. The decision to kill is determined by the expression of a myriad of activating and inhibitory receptors on the NK cell surface. Cell-to-cell engagement results in either self-tolerance...
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Cancers, Vol. 12, Pages 948: Reconstruction of Ewing Sarcoma Developmental Context from Mass-Scale Transcriptomics Reveals Characteristics of EWSR1-FLI1 Permissibility Cancers doi: 10.3390/cancers12040948 Authors: Henry E. Miller Aparna Gorthi Nicklas Bassani Liesl A. Lawrence Brian S. Iskra Alexander J. R. Bishop Ewing sarcoma is an aggressive pediatric cancer of enigmatic cellular origins typically resulting from a single translocation event t (11; 22) (q24;...
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Cancers, Vol. 12, Pages 947: Genomic Profiling of Circulating Tumor DNA Predicts Outcome and Demonstrates Tumor Evolution in ALK-Positive Non-Small Cell Lung Cancer Patients Cancers doi: 10.3390/cancers12040947 Authors: Anne Tranberg Madsen Anne Winther-Larsen Tine McCulloch Peter Meldgaard Boe Sandahl Sorensen With the rapid development of targeted therapies for the treatment of cancer, methods for predicting response and outcome are in high demand. Non-small cell...
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Cancers, Vol. 12, Pages 950: Validating the ACOSOG Z0011 Trial Result: A Population-Based Study Using the SEER Database Cancers doi: 10.3390/cancers12040950 Authors: Jiwoong Jung Byoung Hyuck Kim Jongjin Kim Sohee Oh Su-jin Kim Chang-Sup Lim In Sil Choi Ki-Tae Hwang The Z0011 trial demonstrated that axillary lymph node dissection (ALND) could be omitted in spite of 1–2 metastatic sentinel lymph nodes. This study aimed to validate the results...
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Cancers, Vol. 12, Pages 949: The Role of Alternative Lengthening of Telomeres Mechanism in Cancer: Translational and Therapeutic Implications Cancers doi: 10.3390/cancers12040949 Authors: Marta Recagni Joanna Bidzinska Nadia Zaffaroni Marco Folini Telomere maintenance mechanisms (i.e., telomerase activity (TA) and the alternative lengthening of telomere (ALT) mechanism) contribute to tumorigenesis by providing unlimited proliferative capacity to cancer cells. Although...
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Cancers, Vol. 12, Pages 945: Glucocorticoids Promote the Onset of Acute Experimental Colitis and Cancer by Upregulating mTOR Signaling in Intestinal Epithelial Cells Cancers doi: 10.3390/cancers12040945 Authors: Zhengguo Zhang Lin Dong Anna Jia Xi Chen Qiuli Yang Yufei Wang Yuexin Wang Ruichen Liu Yejin Cao Ying He Yujing Bi Guangwei Liu The therapeutic effects of glucocorticoids on colitis and colitis-associated cancer are unclear. In...
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Cancers, Vol. 12, Pages 944: Haute Couture or Ready-to-Wear? Tailored Pelvic Radiotherapy for Prostate Cancer Based on Individualized Sentinel Lymph Node Detection Cancers doi: 10.3390/cancers12040944 Authors: Anne-Victoire Michaud Benoit Samain Ludovic Ferrer Vincent Fleury Mélanie Doré Mathilde Colombié Claire Dupuy Emmanuel Rio Valentine Guimas Thierry Rousseau Maelle Le Thiec Grégory Delpon Caroline Rousseau Stéphane Supiot Prostate...
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Cancers, Vol. 12, Pages 943: Outcomes of Radiotherapy for Mesenchymal and Non-Mesenchymal Subtypes of Gastric Cancer Cancers doi: 10.3390/cancers12040943 Authors: Jeong Il Yu Hee Chul Park Jeeyun Lee Changhoon Choi Won Ki Kang Se Hoon Park Seung Tae Kim Tae Sung Sohn Jun Ho Lee Ji Yeong An Min Gew Choi Jae Moon Bae Kyoung-Mee Kim Heewon Han Kyunga Kim Sung Kim Do Hoon Lim Background: The purpose of this study was to...
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Cancers, Vol. 12, Pages 941: Efficacy of the EDP-M Scheme Plus Adjunctive Surgery in the Management of Patients with Advanced Adrenocortical Carcinoma: The Brescia Experience Cancers doi: 10.3390/cancers12040941 Authors: Marta Laganà Salvatore Grisanti Deborah Cosentini Vittorio Domenico Ferrari Barbara Lazzari Roberta Ambrosini Chiara Sardini Alberto Dalla Volta Carlotta Palumbo Pietro Luigi Poliani Massimo Terzolo Sandra Sigala Guido Alberto...
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Cancers, Vol. 12, Pages 940: Hyaluronic Acid-Based Theranostic Nanomedicines for Targeted Cancer Therapy Cancers doi: 10.3390/cancers12040940 Authors: So Yun Lee Moon Sung Kang Woo Yeup Jeong Dong-Wook Han Ki Su Kim Hyaluronic acid (HA) is a natural mucopolysaccharide and has many useful advantages, including biocompatibility, non-immunogenicity, chemical versatility, non-toxicity, biodegradability, and high hydrophilicity. Numerous tumor cells overexpress several...
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Cancers, Vol. 12, Pages 939: S100A4 is a Biomarker of Tumorigenesis, EMT, Invasion, and Colonization of Host Organs in Experimental Malignant Mesothelioma Cancers doi: 10.3390/cancers12040939 Authors: Joëlle S. Nader Jordan Guillon Coralie Petit Alice Boissard Florence Franconi Stéphanie Blandin Sylvia Lambot Marc Grégoire Véronique Verrièle Béatrice Nawrocki-Raby Philippe Birembaut Olivier Coqueret Catherine Guette Daniel L. Pouliquen...
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Cancers, Vol. 12, Pages 942: Brigatinib and Alectinib for ALK Rearrangement-Positive Advanced Non-Small Cell Lung Cancer With or Without Central Nervous System Metastasis: A Systematic Review and Network Meta-Analysis Cancers doi: 10.3390/cancers12040942 Authors: Koichi Ando Kaho Akimoto Hiroki Sato Ryo Manabe Yasunari Kishino Tetsuya Homma Sojiro Kusumoto Toshimitsu Yamaoka Akihiko Tanaka Tohru Ohmori Hironori Sagara To date, no head-to-head...
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Cancers, Vol. 12, Pages 938: BCL-2 Proteins in Pathogenesis and Therapy of B-Cell Non-Hodgkin Lymphomas Cancers doi: 10.3390/cancers12040938 Authors: Magdalena Klanova Pavel Klener The ability to inhibit mitochondrial apoptosis is a hallmark of B-cell non-Hodgkin lymphomas (B-NHL). Activation of mitochondrial apoptosis is tightly controlled by members of B-cell leukemia/lymphoma-2 (BCL-2) family proteins via protein-protein interactions. Altering the balance between anti-apoptotic...
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Cancers, Vol. 12, Pages 937: Glioblastoma: Pathogenesis and Current Status of Chemotherapy and Other Novel Treatments Cancers doi: 10.3390/cancers12040937 Authors: Vilashini Rajaratnam Mohammad Mohiminul Islam Maixee Yang Rachel Slaby Hilda Martinez Ramirez Shama Parveen Mirza Glioblastoma is one of the most common and detrimental forms of solid brain tumor, with over 10,000 new cases reported every year in the United States. Despite aggressive multimodal treatment...
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Cancers, Vol. 12, Pages 936: Circulating miR-21 as a Potential Biomarker for the Diagnosis of Oral Cancer: A Systematic Review with Meta-Analysis Cancers doi: 10.3390/cancers12040936 Authors: Mario Dioguardi Giorgia Apollonia Caloro Luigi Laino Mario Alovisi Diego Sovereto Vito Crincoli Riccardo Aiuto Erminia Coccia Giuseppe Troiano Lorenzo Lo Muzio Head and neck squamous cell carcinoma (HNSCC) is one of the main neoformations of the head–neck...
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Cancers, Vol. 12, Pages 925: Prognostic Impact of Sarcopenia and Skeletal Muscle Loss During Neoadjuvant Chemoradiotherapy in Esophageal Cancer Cancers doi: 10.3390/cancers12040925 Authors: Han Gyul Yoon Dongryul Oh Yong Chan Ahn Jae Myoung Noh Hongryull Pyo Won Kyung Cho Yun Mi Song Minsu Park Na Young Hwang Jong-Mu Sun Hong Kwan Kim Jae Ill Zo Young Mog Shim Backgrounds: The relationship between sarcopenia, characterized by loss...
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Cancers, Vol. 12, Pages 935: Future Challenges in Cancer Resistance to Immunotherapy Cancers doi: 10.3390/cancers12040935 Authors: Marit J. van Elsas Thorbald van Hall Sjoerd H. van der Burg Cancer immunotherapies, including checkpoint inhibitors, adoptive T cell transfer and therapeutic cancer vaccines, have shown promising response rates in clinical trials. Unfortunately, there is an increasing number of patients in which initially regressing tumors start to regrow due...
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Cancers, Vol. 12, Pages 933: Magnetic-Based Enrichment of Rare Cells from High Concentrated Blood Samples Cancers doi: 10.3390/cancers12040933 Authors: Junhao Wu Katharina Raba Rosa Guglielmi Bianca Behrens Guus Van Dalum Georg Flügen Andreas Koch Suraj Patel Wolfram T. Knoefel Nikolas H. Stoecklein Rui P. L. Neves Here, we tested two magnetic-bead based systems for the enrichment and detection of rare tumor cells in concentrated blood products....
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Cancers, Vol. 12, Pages 934: Thrombotic Risk Detection in Patients with Polycythemia Vera: The Predictive Role of DNMT3A/TET2/ASXL1 Mutations Cancers doi: 10.3390/cancers12040934 Authors: Adrián Segura-Díaz Ruth Stuckey Yanira Florido Jesús María González-Martín Juan Francisco López-Rodríguez Santiago Sánchez-Sosa Elena González-Pérez María Nieves Sáez Sáez Perdomo María del Mar Perera Silvia de la Iglesia Teresa Molero-Labarta María Teresa Gómez-Casares...
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Cancers, Vol. 12, Pages 924: PD-L1–PD-1 Pathway in the Pathophysiology of Multiple Myeloma Cancers doi: 10.3390/cancers12040924 Authors: Hideto Tamura Mariko Ishibashi Mika Sunakawa-Kii Koiti Inokuchi PD-L1 expressed on tumor cells contributes to disease progression with evasion from tumor immunity. Plasma cells from multiple myeloma (MM) patients expressed higher levels of PD-L1 compared with healthy volunteers and monoclonal gammopathy of undetermined significance...
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Cancers, Vol. 12, Pages 923: Ex Vivo Organoid Cultures Reveal the Importance of the Tumor Microenvironment for Maintenance of Colorectal Cancer Stem Cells Cancers doi: 10.3390/cancers12040923 Authors: Xingru Li Pär Larsson Ingrid Ljuslinder Daniel Öhlund Robin Myte Anna Löfgren-Burström Carl Zingmark Agnes Ling Sofia Edin Richard Palmqvist Colorectal cancer (CRC) is a heterogeneous disease, with varying clinical presentations and patient prognosis....
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Cancers, Vol. 12, Pages 931: Population Pharmacokinetics/Pharmacodynamics of Dabrafenib Plus Trametinib in Patients with BRAF-Mutated Metastatic Melanoma Cancers doi: 10.3390/cancers12040931 Authors: David Balakirouchenane Sarah Guégan Chantal Csajka Anne Jouinot Valentine Heidelberger Alicja Puszkiel Ouidad Zehou Nihel Khoudour Perrine Courlet Nora Kramkimel Coralie Lheure Nathalie Franck Olivier Huillard Jennifer Arrondeau Michel...
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Cancers, Vol. 12, Pages 920: Inhibition of Kv10.1 Channels Sensitizes Mitochondria of Cancer Cells to Antimetabolic Agents Cancers doi: 10.3390/cancers12040920 Authors: Ileana Hernández-Reséndiz David Pacheu-Grau Araceli Sánchez Luis A. Pardo Reprogramming of energy metabolism constitutes one of the hallmarks of cancer and is, therefore, an emerging therapeutic target. We describe here that the potassium channel Kv10.1, which is frequently overexpressed in primary and...
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Cancers, Vol. 12, Pages 930: 53BP1 Accumulation in Circulating Tumor Cells Identifies Chemotherapy-Responsive Metastatic Breast Cancer Patients Cancers doi: 10.3390/cancers12040930 Authors: Fabienne Schochter Kim Werner Cäcilia Köstler Anke Faul Marie Tzschaschel Barbara Alberter Volkmar Müller Hans Neubauer Tanja Fehm Thomas W.P. Friedl Bernhard Polzer Wolfgang Janni Brigitte Rack Lisa Wiesmüller Evidence suggests that the DNA...
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Cancers, Vol. 12, Pages 921: The Glasgow Prognostic Score at Diagnosis Is a Predictor of Clinical Outcome in Patients with Multiple Myeloma Undergoing Autologous Haematopoietic Stem Cell Transplantation Cancers doi: 10.3390/cancers12040921 Authors: Hanno M. Witte Bastian Bonorden Armin Riecke Harald Biersack Konrad Steinestel Hartmut Merz Alfred C. Feller Veronica Bernard Sebastian Fetscher Nikolas von Bubnoff Niklas Gebauer Background: Immunity...
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