Effect of Deep Sedation on Mechanical Power in Moderate to Severe Acute Respiratory Distress Syndrome: A Prospective Self-Control Study:
Mechanical power (MP) is a parameter for assessing ventilator-induced lung injury (VILI) in patients with acute respiratory distress syndrome (ARDS). Deep sedation inhibits the respiratory center and reduces the excessive spontaneous breathing in ARDS patients, thereby reducing transpulmonary pressure (Ptp) and lung injury. However, the effect of sedation on MP in ARDS patients is not yet clear. Therefore, the purpose of this study was to investigate the effect of deep sedation on MP in ARDS patients. Patients with moderate to severe ARDS who required mechanical ventilation were considered. Different degrees of sedation were performed on patients in three stages after 24 hours of mechanical ventilation. The three stages are as follows: stage 1 (H+3): 0 to 3 hours of sedation; patients’ Ramsay score was 2-3 to obtain mild sedation; stage 2 (H+6): 4 to 6 hours of sedation; the sedation depth was adjusted to 5-6 points; and stage 3 (H+9): 7 to 9 hours of sedation; the sedation depth was adjusted to 2-3 points. Under deep sedation (H+6), MP, respiratory rate (RR), and Ptp were significantly lower than the ones in the patients under mild sedation (H+3) (all ) although PaO2/FiO2 (P/F) and static lung compliance (Cst) were significantly higher (both ). However, no significant difference in the above parameters was observed between H+3 and H+9. Correlation analysis showed that ΔMP was significantly and positively correlated with ΔRR and ΔPtp (both ), while no correlation was observed neither between ΔMP and ΔCst nor between ΔMP and ΔP/F. The 28-day Kaplan-Meier survival curve showed the occurrence of 19 deaths, and the overall survival rate was 63.46%. The survival rate was 53.12% in the high-MP (HMP) group and 80.95 in the low-MP (LMP) group (). In conclusion, deep sedation significantly reduced MP in patients with moderate to severe ARDS, thereby reducing the occurrence of VILI. In addition, MP monitoring in deep sedation predicted the 28-day survival of patients with moderate to severe ARDS.
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
Πληροφορίες
Ετικέτες
Δευτέρα 13 Απριλίου 2020
Effect of Deep Sedation on Mechanical Power in Moderate to Severe Acute Respiratory Distress Syndrome: A Prospective Self-Control Study
Αναρτήθηκε από
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
στις
10:29 μ.μ.
Ετικέτες
00302841026182,
00306932607174,
alsfakia@gmail.com,
Anapafseos 5 Agios Nikolaos 72100 Crete Greece,
Medicine by Alexandros G. Sfakianakis,
Telephone consultation 11855 int 1193
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Αρχειοθήκη ιστολογίου
-
►
2023
(276)
- ► Φεβρουαρίου (133)
- ► Ιανουαρίου (143)
-
►
2022
(1976)
- ► Δεκεμβρίου (116)
- ► Σεπτεμβρίου (158)
- ► Φεβρουαρίου (165)
- ► Ιανουαρίου (161)
-
►
2021
(3661)
- ► Δεκεμβρίου (161)
- ► Σεπτεμβρίου (274)
- ► Φεβρουαρίου (64)
- ► Ιανουαρίου (368)
-
▼
2020
(4554)
- ► Δεκεμβρίου (400)
- ► Σεπτεμβρίου (381)
-
▼
Απριλίου
(613)
- Medicine by Alexandros G. Sfakianakis,
- Medicine by Alexandros G. Sfakianakis,
- Medicine by Alexandros G. Sfakianakis,
- Medicine by Alexandros G. Sfakianakis
- Medicine by Alexandros G. Sfakianakis
- Medicine by Alexandros G. Sfakianakis
- M
- M
- Association between polycystic ovary syndrome and ...
- Airborne transmission of severe acute respiratory ...
- M
- Indigenous Management of Parotid Sialocele Using F...
- Synovial Chondromatosis of the Temporomandibular J...
- Prediction mode of more than 5 central lymph nodes...
- Case report of a cystic parathyroidal adenoma with...
- M
- CD44v3 protein-carrying tumor-derived exosomes in ...
- Squamous Cell and Adenoid Cystic Carcinoma Collisi...
- Cat-scratch Disease with Parinaud's Oculoglandular...
- Necrotizing Fasciitis due to Candida Infection aft...
- Ewing Sarcoma of Larynx: A Rare Case in a 5-Year-O...
- Eccrine porocarcinoma of the head and neck: Meta-a...
- Incidence and survival trends of parotid malignanc...
- M
- Usefulness of intraoperative determination of cent...
- M
- M
- The 24-inch gauge and the common gavel: an entered...
- Pediatric Patients with Previous Anaphylactic Reac...
- Targeting tumor-associated macrophages in head and...
- Vitamin D Status as a Predictor of Postoperative H...
- Anesthesia for TORS for Oropharyngeal Carcinoma: F...
- M
- Event-Related Potential Evidence of Enhanced Visua...
- M
- Evidence of Failure of Oral Third-Generation Cepha...
- Moderate to severe hyperphosphataemia as an indepe...
- Morphological study of the rabbit gustatory lingua...
- Advances and perspectives of dendritic cell-based ...
- Massive pulmonary embolism in pregnancy: intra-arr...
- Supraclavicular left neck mass: an unusual present...
- Malignant peripheral nerve sheath tumour of thyroi...
- M
- Bilateral Fan-Shaped Septal Extension Struts in Au...
- M
- M
- Correlation of p53 expression with Clinical Presen...
- The current modified technique of uvulopalatophary...
- Implantable Neurostimulation for Treatment of Slee...
- M
- Sonographic exploration for fascial exploration (S...
- M
- M
- M
- An impact of microscopic positive margin on incomp...
- M
- M
- The Postoperative Lymphocyte to Monocyte Ratio Cha...
- M
- Giant Thrombosis at Left Anterior Descending Arter...
- M
- Medicine by Alexandros G. Sfakianakis,
- Medicine
- Medicine by Alexandros G. Sfakianakis,Anapafseos 5...
- Medicine by Alexandros G. Sfakianakis,Anapafseos 5...
- Medicine
- COVID‐19 indirect contact transmission through the...
- Value of colchicine as treatment for recurrent ora...
- Cancer Medicine
- Allergy & Rhinology
- Dermatology
- Oral and Maxillofacial Surgery
- Exploding head syndrome, chronotype, parasomnias a...
- Modulation of Airway Epithelial Innate Immunity an...
- Bone Marrow Langerhans Cell Histiocytosis in Assoc...
- Sleep
- The rs11187533 C>T Variant of the FFAR4 Gene Is As...
- Integrative Medicine
- Angiolymphoid hyperplasia with eosinophilia of the...
- Microcystic Adnexal Carcinoma of the Face Treated ...
- Verrucous hyperplasia and verrucous carcinoma in h...
- An Unusual Case of Noisy Breathing in an Infant.
- The role of polysomnography in decannulation of ch...
- Periodontitis is associated with incident chronic ...
- head and neck
- Bloody Diarrhea in a 17-year-old Male......infecti...
- philosophy for medicine
- Preoperative Factors Associated with Extrathyroida...
- Traditional Chinese Medicine
- Vaccination of Mice with isteria ivanovii Expressi...
- Management of epistaxis in patients on novel oral ...
- BRC
- oral oncology
- Antibiotics
- The Utility of Genetic Testing for Familial Hyperc...
- 310 nm UV-LED Attenuates Imiquimod-Induced Psorias...
- Cancer Research
- Nonsurgical Treatments for Extramammary Paget Dise...
- 20 σπάνια γυναίκεια ονόματα και η σημασία τους
- Der Chirurg
- ► Φεβρουαρίου (638)
- ► Ιανουαρίου (691)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου