There are hundreds of groups around the world making face masks as fast as they can to help slow the spread of COVID-19. While face masks can help to block particulates from entering the nose and mouth, they also make it impossible to see the mouth moving when the wearer is talking. This is actually a considerable limitation for people who are deaf or hard of hearing and who use visual cues to help them understand what a speaker is saying. A college student who studies Education for the Deaf...
Fri Apr 03, 2020 18:39
GD2 targeting by dinutuximab beta is a promising immunotherapeutic approach against malignant glioma
Abstract Purpose Disialoganglioside GD2 is expressed by glioblastoma multiforme (GBM) cells representing a promising target for anti-GD2 immunotherapeutic approaches. The aim of the present study was to investigate anti-tumor efficacy of the chimeric anti-GD2 antibody (Ab) dinutuximab beta against GBM. Methods Expression levels of GD2 and complement...
Fri Apr 03, 2020 03:00
Abstract Purpose To investigate the effects of adalimumab pretreatment on the lipopolysaccharide-mediated myocardial injury. Methods Twenty-eight Wistar rats were randomized into four groups (n=7). Control (C) group animals were injected once a day with intraperitoneal (i.p) 0.9 % saline for two days. In the Adalimumab (Ada) group, adalimumab was injected at a dose of 10 mg/kg/ day (i.p) for two days. Lipopolysaccharide (Lps) group rats were injected with a dose of 5 mg/kg (i.p) lipopolysaccharide....
Fri Apr 03, 2020 23:20
The early recognition of invasive bacterial infections (IBI) in children can be difficult. Clinically it is often challenging to differentiate between the early stages of an IBI and a benign self-limiting vira...
Thu Apr 02, 2020 03:00
Alzheimer’s disease (AD) is a neurodegenerative disorder commonly associated with deficits of cognition and changes in behavior. Mild cognitive impairment (MCI) is the prodromal stage of AD that is defined by ...
Thu Apr 02, 2020 03:00
Dedicated air ambulance services provide a vital link for critically ill and injured patients to higher levels of care. The recent developments of pre-hospital and retrieval medicine create an opportunity for ...
Thu Apr 02, 2020 03:00
Occlusive atherosclerotic disease of the anterior cerebral circulation is one of the most common causes of anterior circulation ischemia and stroke. Treatment options include medical therapies (including antip...
Thu Apr 02, 2020 03:00
Internet gaming disorder (IGD) was included in the DSM-5 in 2013 as a condition requiring further research, and gaming disorder (GD) was included in the ICD-11 in 2018. Given the importance of including these ...
Thu Apr 02, 2020 03:00
ABSTRACT A recent breakthrough in the classification of soft tissue tumors (STT) has been a significant expansion in the number of neoplasms associated with NTRK and other kinase related fusions. This is important not only for diagnostic purposes, but also because it opens new avenues for targeted therapy. Indeed, recent clincal trials have shown significant benefit across multiple tumor‐types, prompting approval of NTRK inhibitors for clinical use in the setting of advanced/metastatic NTRK‐rearranged...
Fri Apr 03, 2020 18:34
Publication date: Available online 2 April 2020Source: Human PathologyAuthor(s): J. Kenneth Schoolmeester, Kay Minn, William R. Sukov, Kevin C. Halling, Amy C. Clayton
Fri Apr 03, 2020 21:13
ABSTRACT Introduction The anterior cruciate ligament (ACL) prevents the anterior translocation and medial rotation of the tibia against the femur. It is typically composed of dense regular connective tissue (DRCT), small amount of loose connective tissue, little vasculature, and few nerve endings. The objective of the current study was to evaluate the details of histological changes in ACLs of patients with clinically diagnosed osteoarthritis (OA). Materials and Methods The ACLs...
Fri Apr 03, 2020 19:24
Abstract Introduction : International experience with COVID‐19 suggests it poses a significant risk of infectious transmission to skull base surgeons, due to high nasal viral titers and the unknown potential for aerosol generation during endonasal instrumentation. The purpose of this study was to simulate aerosolization events over a range of endoscopic procedures to gain an evidence‐based aerosol risk assessment. Methods : Aerosolization was simulated in a cadaver using fluorescein...
Fri Apr 03, 2020 19:59
Abstract Age‐related macular degeneration (AMD) is a complex, multifactorial, progressive disease, which represents a leading cause of irreversible visual impairment and blindness in older individuals. Human cytomegalovirus (HCMV), which infects 50 to 80% of humans, is usually acquired during early life and persists in a latent state for the life of the individual. In view of its previously described pro‐angiogenic properties, we hypothesized that cytomegalovirus might be a novel risk factor for...
Fri Apr 03, 2020 19:18
Publication date: Available online 3 April 2020Source: Academic RadiologyAuthor(s): Ning Wang, Lin-Xue Qian
Fri Apr 03, 2020 20:44
Abstract A substantial proportion of epithelial ovarian cancer (EOC) arises in the fallopian tube and other epithelia of the upper genital tract; these epithelia may incur damage and neoplastic transformation following sexually transmitted infections (STI) and pelvic inflammatory disease. We investigated the hypothesis that past STI infection, particularly Chlamydia trachomatis, is associated with higher EOC risk in a nested case‐control study within the European Prospective Investigation into...
Fri Apr 03, 2020 19:20
Abstract Introduction Cancer patients receiving chemotherapy are a high risk of VTE, yet the importance of thromboprophylaxis for cancer patients that are at high risk of developing VTE is still controversial. Aim To calculate the benefits and harms of thromboprophylaxis, compared to placebo, in ambulatory high-risk cancer patients that are receiving...
Fri Apr 03, 2020 03:00
Abstract Early data from Wuhan, China show that patients with COVID‐19 are typically male, aged 40 to 60 years, and about one‐third have comorbidities. Moreover, of 138 COVID‐19 patients hospitalized in Wuhan and treated in an intensive care unit (ICU), 25% had cardiovascular disease and 58% hypertension; the respective figures for non‐ICU‐treated COVID‐19 patients were 10% and 22% [1]. Based on these early data, a predisposition to acute cardiac complications related to underlying atherosclerotic...
Fri Apr 03, 2020 18:27
Publication date: Available online 3 April 2020Source: European Journal of Surgical OncologyAuthor(s): Meike J. van Harten, Emma B. Greenwood, Sergei Bedrikovetski, Nagendra N. Dudi-Venkata, Ronald A. Hunter, Hidde M. Kroon, Tarik Sammour
Fri Apr 03, 2020 20:06
Publication date: Available online 2 April 2020Source: Allergologia et ImmunopathologiaAuthor(s): Mara Giavina-Bianchi, Luiz Vicente Rizzo, Pedro Giavina-Bianchi
Fri Apr 03, 2020 19:54
Publication date: Available online 2 April 2020Source: Allergologia et ImmunopathologiaAuthor(s): Andrea Angel, Gustavo Falbo Wandalsen, Dirceu Solé, Fernanda C. Lanza, Carolina L.N. Cobra, Cintia Johnston, Josefina Aparecida Pellegrini Braga
Fri Apr 03, 2020 19:54
Abstract Objectives We compared δ15N and δ13C values from bone and dentine collagen profiles of individuals interred in famine‐related and attritional burials to evaluate whether individuals in medieval London who experienced nutritional stress exhibit enriched nitrogen in bone and tooth tissue. Dentine profiles were evaluated to identify patterns that may be indicative of famine during childhood and were compared with the age of enamel hypoplasia (EH) formation to assess whether isotopic...
Fri Apr 03, 2020 19:14
AbstractA 16-year-old female with a history of left recurrent patellar dislocation underwent medial patellofemoral ligament (MPFL) reconstruction surgery. Two months postoperatively, the patient presented with medial patellar pain. Left medial plica syndrome was suspected, and we performed a partial arthroscopic resection of the medial synovial plica. The symptom gradually improved after surgery. To the best of our knowledge, there are no reports that discuss the relationship between postoperative...
Fri Apr 03, 2020 03:00
AbstractThe prevalence of abdominal aortic aneurysms (AAA) in the nonagenarian and centenarian populations is set to increase. Endovascular aneurysm repair (EVAR) has been shown to be achievable with excellent outcomes in carefully selected nonagenarians. However, experience with centenarians is limited. We report the case of a 100-year-old who presented with a tender 8-cm AAA and successfully underwent EVAR. This report describes the second case of AAA repair in a centenarian in the literature and...
Fri Apr 03, 2020 03:00
AbstractImplantation of an intrauterine device (IUD) is a common method for long-term contraception. However, IUDs can cause colon perforation and fistula formation. We report a case of cecal perforation and ileocecal fistula secondary to IUD migration. The present study investigated incidental identification of a missing IUD after 9 years of deployment in a 35-year-old female with a three-year history of infertility. Abdominal imaging revealed a missing IUD. Intracecal perforation and ileocecal...
Fri Apr 03, 2020 03:00
AbstractTesticular germ cell tumours (TGCTs) are relatively rare overall and are mainly encountered in young adults and teenagers. The ‘burned-out’ phenomenon refers to the spontaneous regression of the primary testicular lesion, generally with the presence of a metastatic germ cell tumour. Regressed tumours with retroperitoneal metastasis, as the first manifestation, represent difficult cases prone to misdiagnosis. Burned-out TGCT is a rare but well-recognized entity, with defined clinical features...
Thu Apr 02, 2020 03:00
AbstractBisphosphonate-related osteonecrosis of the jaw (BRONJ) is an adverse drug reaction represented by destruction and/or death of bone. Fibrous dysplasia (FD) is a rare bony disorder characterised by abnormal fibro-osseous tissue that has lowered resistance to infection. Effective treatments for BRONJ that follows FD are unclear. Here, we report that advanced BRONJ associated with FD was successfully treated by surgical resection. A 69-year-old woman, whose left maxillary bone showed a ground...
Sat Mar 28, 2020 02:00
AbstractMesenchymal chondrosarcoma (MCS) is a rare high-grade sarcoma of bone and soft tissue with highly aggressive behavior and a peak incidence in the second and third decades. We report a case of primary orbital MCS in a 30 year-old female, with radiological and clinicopathological features. Orbital MCS is an entity that should be considered in the differential diagnosis of calcified orbital lesions.
Sat Mar 28, 2020 02:00
Abstract Introduction A single‐phase dual‐bolus CT (DB‐CT) simultaneously opacifies both arterial and venous systems and can be utilised in the trauma setting to aid in the diagnosis of active bleeding while also allowing for optimal assessment of the abdominal and pelvic viscera. Active bleeding can be venous or arterial, the latter being amenable to angiography and potentially embolisation. We aimed to establish the accuracy of single‐phase DB‐CT vs commonly performed portal venous CT (PV‐CT)...
Fri Apr 03, 2020 19:16
Abstract Introduction Multi‐parametric magnetic resonance imaging of the prostate is crucial in detecting prostate cancer (CaP) and staging local disease. The Prostate Imaging Reporting and Data System (PIRADS) scoring system is used to assess and classify lesions and enables communication between clinicians and radiologists. This study aimed to assess the accuracy of PIRADSv2 in detecting CaP using histopathology specimens within our local service. Methods This retrospective study...
Fri Apr 03, 2020 19:16
Abstract Introduction Australia’s first proton beam therapy (PBT) service, The Australian Bragg Centre for Proton Therapy and Research, is scheduled to open in the near future providing PBT for patients closer to home. Patients currently access Commonwealth funding for PBT via the Medicare Medical Treatment Overseas Program (MTOP). Proton versus photon treatment planning is a pre‐requisite for the MTOP application. The Royal Adelaide Hospital (RAH) Department of Radiation Oncology has been...
Fri Apr 03, 2020 19:15
Publication date: May 2020Source: Gait & Posture, Volume 78Author(s): Jefferson Rodrigues Dorneles, Frederico Ribeiro Neto, Carlos Wellington Gonçalves, Rodrigo Rodrigues Gomes Costa, Rodrigo Luiz Carregaro
Sun Apr 05, 2020 17:43
Publication date: Available online 2 April 2020Source: Archives of Oral BiologyAuthor(s): Alejandra Maldonado, Luca Pirracchio, Jean-Claude Imber, Walter Bürgin, Burkhard Möller, Anton Sculean, Sigrun Eick
Fri Apr 03, 2020 18:46
Fri Apr 03, 2020 18:04
Publication date: Available online 2 April 2020Source: Brain and LanguageAuthor(s): Rene L. Utianski, Joseph R. Duffy, Heather M. Clark, Edythe A. Strand, Hugo Botha, Christopher G. Schwarz, Mary M. Machulda, Matthew L. Senjem, Anthony J. Spychalla, Clifford R. Jack, Ronald C. Petersen, Val J. Lowe, Jennifer L. Whitwell, Keith A. Josephs
Fri Apr 03, 2020 18:12
Publication date: June 2020Source: Annals of Diagnostic Pathology, Volume 46Author(s): Martina Baněčková, Abbas Agaimy
Sat Apr 04, 2020 18:01
Conditions: Buccal Mucosa Squamous Cell Carcinoma; Floor of Mouth Squamous Cell Carcinoma; Gingival Squamous Cell Carcinoma; Hard Palate Squamous Cell Carcinoma; Lip Squamous Cell Carcinoma; Lower Alveolar Ridge Squamous Cell Carcinoma; Oral Cavity Squamous Cell Carcinoma; Retromolar Trigone Squamous Cell Carcinoma; Stage I Lip and Oral Cavity Cancer AJCC v8; Stage II Lip and Oral Cavity Cancer AJCC v8; Tongue Squamous Cell Carcinoma; Upper Alveolar Ridge Squamous Cell CarcinomaInterventions:...
Fri Apr 03, 2020 17:43
Washington dentists and other dental care providers who were unable to secure a slot for the School of Dentistry’s March 20 live webinar on patient care during the COVID-19 outbreak can now view a new recorded version. The post COVID-19 webinar recorded for dental providers appeared first on UW School of Dentistry.
Fri Apr 03, 2020 16:34
Publication date: May 2020Source: European Journal of Cancer, Volume 131Author(s): Xiaocong Pang, Xian Su, Zhuo Zhang, Yimin Cui
Fri Apr 03, 2020 17:27
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