This retrospective study investigated whether podocalyxin expression in renal biopsies and urine of patients with diabetic nephropathy (DN) is associated with renal function. This retrospective study included 32 patients with nephropathy, secondary to type 2 diabetes treated at the First Hospital of Lanzhou University (January 2010 to January 2015). Compared with the control group, the DN group had a significantly lower renal expression of podocalyxin and higher urinary podocalyxin/creatinine ratio....
Fri Apr 03, 2020 11:05
Objective. A survival risk assessment model associated with a lung adenocarcinoma (LUAD) microenvironment was established and evaluated to identify effective independent prognostic factors for LUAD. Methods. The public data were downloaded from the TCGA database, and ESTIMATE prediction software was used to score immune cells and stromal cells for tumor purity prediction. The samples were divided into the high-score group and the low-score group by the median value of the immune score (or stromal...
Fri Apr 03, 2020 10:50
Gastric glomus tumors (GGTs) are rare mesenchymal tumors. Most glomus tumors occur in the distal parts of the extremities. Here, we retrospectively analyzed the features of GGTs from two institutions. The histologic and clinical findings of all GGT cases from 2009 to 2018 were reviewed. The most common location was the antrum, the mean age of patients was 49.3 years, and the mean tumor size was 2.1 cm. Microscopically, small, round cell nodules surrounded the expansion of blood vessels in a nest...
Fri Apr 03, 2020 10:35
Background. The Lateral Step-Up Test (LSUT) has been used to evaluate the closed kinetic chain functional muscle strength in people with orthopaedic or neurological conditions. No study has systematically investigated the intrarater, interrater, and test-retest reliabilities of this measure in stroke survivors. In addition, correlations of the LSUT count with other stroke-specific impairment and function measurements remain unidentified. Objectives. This study was aimed at investigating (1) the interrater,...
Fri Apr 03, 2020 10:20
Peroxiredoxin 2 (PRDX2), a member of the peroxiredoxin family of antioxidant enzymes, has been revealed to be an important player in cancer progression. However, the biological role of PRDX2 in the progression of non-small cell lung cancer (NSCLC) is poor reported. In the present study, the loss-of-function experiments were performed to investigate the specific role of PRDX2 in the growth and invasion of NSCLC. The results revealed that knockdown of PRDX2 by siRNA interference significantly suppressed...
Fri Apr 03, 2020 10:20
Journal of International Medical Research, Volume 48, Issue 4, April 2020.
Fri Apr 03, 2020 12:48
Journal of International Medical Research, Volume 48, Issue 4, April 2020.
Fri Apr 03, 2020 12:39
Journal of International Medical Research, Volume 48, Issue 4, April 2020.
Fri Apr 03, 2020 11:01
Future Oncology, Ahead of Print.
Fri Apr 03, 2020 13:53
Stem Cells and Development, Ahead of Print.
Fri Apr 03, 2020 10:00
Introduction: Pneumonia is one of the most frequently occurring complications after esophagectomy and is associated with increased operative mortality. Chronic obstructive pulmonary disease (COPD) is known to be a risk factor for pulmonary complications and operative mortality. However, in COPD patients preparing for esophagectomy, preventive measures against postoperative pneumonia have not yet been discovered. In this study, we evaluate the effect of perioperative inhaled tiotropium, a long-acting,...
Fri Apr 03, 2020 10:18
Thyroid, Ahead of Print.
Fri Apr 03, 2020 10:00
Thyroid, Ahead of Print.
Fri Apr 03, 2020 10:00
Abstract Transposable elements are a nearly ubiquitous component of eukaryotic genomes. While often described as parasitic genetic elements, other evidence suggests that transposable elements can become domesticated and contribute to organismal function. There is little empirical data on the positive or negative contribution of transposable elements to organismal traits. We hypothesized that mutations in transposable element genes would have less deleterious effects than mutations...
Sat Apr 04, 2020 03:00
Sat Apr 04, 2020 01:14
Bone metastases are common, especially in more prevalent malignancies such as breast and prostate cancer. They cause significant morbidity and draw on healthcare resources. Molecular and hybrid imaging techniques, including single photon emission computed tomography with computed tomography (SPECT/CT), positron emission tomography / CT and whole-body MRI with diffusion-weighted imaging (WB-MRI), have improved diagnostic accuracy in staging the skeleton compared to previous standard imaging methods,...
Sat Apr 04, 2020 01:14
A data-driven method for respiratory gating in PET has recently been commercially developed. We sought to compare the performance of the algorithm to an external, device-based system for oncological [18F]-FDG PET/CT imaging. Methods: 144 whole-body [18F]-FDG PET/CT examinations were acquired using a Discovery D690 or D710 PET/CT scanner (GE Healthcare), with a respiratory gating waveform recorded by an external, device based respiratory gating system. In each examination, two of the bed positions...
Sat Apr 04, 2020 01:14
Background: Patients with NHL who are treated with rituximab may develop resistant disease, often associated with changes in expression of CD20. The next generation β-particle emitting radioimmunoconjugate 177Lu-lilotomab-satetraxetan (Betalutin®) was shown to up-regulate CD20 expression in different rituximab-sensitive NHL cell lines and to act synergistically with rituximab in a rituximab-sensitive NHL animal model. We hypothesized that 177Lu-lilotomab-satetraxetan may be used to reverse rituximab-resistance...
Sat Apr 04, 2020 01:14
Metastatic colonisation, whereby a disseminated tumour cell is able to survive and proliferate at a secondary site, involves both tumour cell-intrinsic and -extrinsic factors. To identify tumour cell-extrinsic (microenvironmental) factors that regulate the ability of metastatic tumour cells to effectively colonise a tissue, we performed a genome-wide screen utilising the experimental metastasis assay on mutant mice. Mutant and wildtype (control) mice were tail vein-dosed with murine metastatic melanoma...
Sat Apr 04, 2020 00:46
Purpose. We performed a first-in-human clinical trial. The aim of this study was to determine safety and feasibility of PET imaging with 18F-PARPi in patients with head and neck cancer. Patients and Methods. Eleven patients with newly diagnosed or recurrent oral and oropharyngeal cancer were injected with 18F-PARPi (331 ± 42 MBq) and dynamic PET/CT imaging was performed between 0 min and 25 min post-injection. Static PET/CT scans were obtained at 30 min, 60 min and 120 min post injection. Blood samples...
Fri Apr 03, 2020 16:22
Purpose: Although cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors significantly extend tumor response in patients with metastatic ER-positive (ER+) breast cancer, relapse is almost inevitable. This may in part reflect the failure of CDK4/6 inhibitors to induce apoptotic cell death. We therefore evaluated combination therapy with ABT-199 (venetoclax), a potent and selective BCL2 inhibitor. Experimental Design: BCL2 family member expression was assessed following treatment with endocrine therapy...
Fri Apr 03, 2020 16:22
Related Articles[ENT-expect no teaching …?! : What is the importance of education, continuing education, and training in German ENT medicine?] HNO. 2020 Apr;68(4):229-230 Authors: Offergeld C, Praetorius M, Neudert M PMID: 32239251 [PubMed - in process]
Sat Apr 04, 2020 04:10
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b12868
Fri Apr 03, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c00836
Fri Apr 03, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c00587
Fri Apr 03, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c00134
Fri Apr 03, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c00646
Fri Apr 03, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c01649
Fri Apr 03, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c02665
Fri Apr 03, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c02406
Fri Apr 03, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c01314
Fri Apr 03, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05121
Fri Apr 03, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00252
Fri Apr 03, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00719
Fri Apr 03, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00537
Fri Apr 03, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05709
Fri Apr 03, 2020 07:00
Impulse Dynamics, based in Mt. Laurel, New Jersey, has developed the Optimizer system, a device designed to improve myocardial contractility in patients with heart failure. The system is intended to improve the quality of life of heart failure patients by reducing the severity of their symptoms. At present, many heart failure patients have few options in terms of effective treatments to reduce and control their symptoms. Medication can help certain patients, but some still experience...
Sat Apr 04, 2020 00:54
The University of Oxford and King’s College London have teamed up to develop and are now testing a new emergency ventilator that consists of devices that commonly exist in clinical spaces and scientific laboratories, and a few simple parts that can be created through 3D printing. Bringing together these devices allows the team to create so-called OxVent ventilators that don’t look like conventional ventilators, but which are sufficient to help with the current COVID-19 emergency. The UK government...
Fri Apr 03, 2020 19:09
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