Related ArticlesRELATIONSHIP BETWEEN SOIL-SOIL-SOLUTION DISTRIBUTION COEFFICIENTS OF 125I AND 127I IN PASTURE SOIL. Radiat Prot Dosimetry. 2019 Oct 01;184(3-4):380-384 Authors: Unno Y, Takeda A, Takaku Y, Hisamatsu S Abstract We measured the depth profiles of soil-soil-solution distribution coefficients (Kd) of native 127I (127I-Kd) and exogenous 125I- (125I-Kd) in soils from a pasture near the spent nuclear fuel reprocessing plant in Rokkasho, Japan,...
Fri Apr 03, 2020 14:39
Related ArticlesA SIMULATION STUDY OF DEPOSITION PARAMETERS FOR 129I DISCHARGED FROM THE ROKKASHO REPROCESSING PLANT. Radiat Prot Dosimetry. 2019 Oct 01;184(3-4):376-379 Authors: Abe K, Hasegawa H, Akata N, Kakiuchi H, Chiang JH, Suwa H, Hisamatsu S Abstract The first commercial spent nuclear fuel reprocessing plant at Rokkasho in Japan discharged 129I from actual spent nuclear fuel into the atmosphere during its test operation from 2006 to 2008. Previously,...
Fri Apr 03, 2020 14:39
Related ArticlesSPECIATION OF IODINE IN SOIL SOLUTION IN FOREST AND GRASSLAND SOILS IN ROKKASHO, JAPAN. Radiat Prot Dosimetry. 2019 Oct 01;184(3-4):368-371 Authors: Takeda A, Unno Y, Tsukada H, Takaku Y, Hisamatsu S Abstract The behaviour of I in soil depends on its chemical form in soil solution. Stable I (127I) in the soil solution under actual soil conditions was investigated as a natural analogue of long-lived radioiodine (129I). Soil samples were...
Fri Apr 03, 2020 14:39
Related ArticlesAnd Now for Something Completely Different: Immunotherapy Beyond Checkpoints in Melanoma. Am Soc Clin Oncol Educ Book. 2020 Mar;40:1-12 Authors: Glitza IC, Goff SL, Ross M, Margolin K Abstract Advances in the understanding of biology and therapy of melanoma have occurred at an astonishing pace over the past approximately 15 years, and successful melanoma therapy has led the way for similar advances in many other solid tumors that are...
Sat Apr 04, 2020 14:30
Related ArticlesOn the Shoulders of Giants: The Evolution of Renal Cell Carcinoma Treatment-Cytokines, Targeted Therapy, and Immunotherapy. Am Soc Clin Oncol Educ Book. 2020 Mar;40:1-18 Authors: Dutcher JP, Flippot R, Fallah J, Escudier B Abstract The treatment of advanced renal cell carcinoma (RCC) has evolved dramatically over the past 30 years, as has a better understanding of the biology of the disease, knowledge of multiple subtypes with distinct...
Sat Apr 04, 2020 14:30
Related ArticlesToward Modernization of Geriatric Oncology by Digital Health Technologies. Am Soc Clin Oncol Educ Book. 2020 Mar;40:1-7 Authors: Shahrokni A, Loh KP, Wood WA Abstract The number of older adults with cancer is increasing. Over the past 3 decades, geriatric oncology research has focused on improving the assessment of frailty and fitness of older adults with cancer as well as methods of improving their outcomes. At the same time, advances...
Sat Apr 04, 2020 14:30
Related ArticlesCancer Prevention in Low-Resource Countries: An Overview of the Opportunity. Am Soc Clin Oncol Educ Book. 2020 Mar;40:1-12 Authors: Kamaraju S, Drope J, Sankaranarayanan R, Shastri S Abstract Rising trends in the incidence of cancer in low- and middle-income countries (LMICs) add to the existing challenges with communicable and noncommunicable diseases. While breast and colorectal cancer incidence rates are increasing in LMICs, the incidence...
Fri Apr 03, 2020 14:33
Related ArticlesCurrent Approaches to the Treatment of Advanced or Metastatic Renal Cell Carcinoma. Am Soc Clin Oncol Educ Book. 2020 Mar;40:1-10 Authors: Tenold M, Ravi P, Kumar M, Bowman A, Hammers H, Choueiri TK, Lara PN Abstract The optimal management approach to advanced or metastatic renal cell cancer of the clear cell type continues to rapidly evolve. Risk stratification of patients into favorable-, intermediate-, and poor-risk categories is now...
Fri Apr 03, 2020 14:33
Related ArticlesEscalating and De-escalating Therapy for Early-Stage HER2-Positive Breast Cancer. Am Soc Clin Oncol Educ Book. 2020 Mar;40:1-11 Authors: File D, Curigliano G, Carey LA Abstract Untreated, HER2+ disease is the most aggressive breast cancer phenotype; however, the development of multiple highly effective HER2-targeting drugs has transformed treatment and survival. These drugs include the anti-HER2 monoclonal antibodies trastuzumab and pertuzumab;...
Fri Apr 03, 2020 14:33
Related ArticlesSuccessful Strategies to Address Disparities: Insurer and Employer Perspectives. Am Soc Clin Oncol Educ Book. 2020 Mar;40:1-9 Authors: Patel MI, Snyder R, Brawley O Abstract Disparities in cancer have been documented for decades and continue to persist despite clinical advancements in cancer prevention, detection, and treatment. Disparate cancer outcomes continue to affect many populations in the United States and globally, including...
Fri Apr 03, 2020 14:33
Related ArticlesCurrent Perspectives on Therapy for Chronic Lymphocytic Leukemia. Am Soc Clin Oncol Educ Book. 2020 Mar;40:1-10 Authors: Awan FT, Al-Sawaf O, Fischer K, Woyach JA Abstract Therapy for chronic lymphocytic leukemia has improved dramatically over the past decade with the introduction of new targeted therapies and a paradigm shift toward targeted therapies for the majority of patients. Better understanding of prognostic factors has helped...
Fri Apr 03, 2020 14:33
Related ArticlesControversies in Rectal Cancer Treatment and Management. Am Soc Clin Oncol Educ Book. 2020 Mar;40:1-11 Authors: Sun W, Al-Rajabi R, Perez RO, Abbasi S, Ash R, Habr-Gama A Abstract Incorporation of new treatment modalities has significantly increased the complexity of the treatment and management of rectal cancer, including perioperative therapy for local advanced disease and organ preservation for those with response to the preoperative...
Fri Apr 03, 2020 14:33
Related ArticlesTherapeutic Targets and Opportunities in Endometrial Cancer: Update on Endocrine Therapy and Nonimmunotherapy Targeted Options. Am Soc Clin Oncol Educ Book. 2020 Mar;40:1-11 Authors: MacKay HJ, Freixinos VR, Fleming GF Abstract Worldwide, the incidence of endometrial cancer is increasing. Although the prognosis remains good for patients diagnosed with early-stage disease, for those diagnosed with recurrent or metastatic disease, options...
Fri Apr 03, 2020 14:33
Related ArticlesHow Do We Align Health Services Research and Quality Improvement? Am Soc Clin Oncol Educ Book. 2020 Mar;40:1-10 Authors: Das D, Wilfong L, Enright K, Rocque G Abstract Quality improvement (QI) initiatives and health services research (HSR) are commonly used to target health care quality. These disciplines are increasingly important because of the movement toward value-based health care as alternative payment and care delivery models drive...
Fri Apr 03, 2020 14:33
Related ArticlesThe Changing Landscape of Treatment in Acute Myeloid Leukemia. Am Soc Clin Oncol Educ Book. 2020 Mar;40:1-12 Authors: Koenig K, Mims A, Levis MJ, Horowitz MM Abstract The treatment of acute myeloid leukemia is evolving, with increased understanding of molecular pathogenesis allowing better risk stratification and development of new therapies. Tests to identify and drugs to target specific molecular abnormalities are improving remission...
Fri Apr 03, 2020 14:33
Abstract Event‐related potential studies of emotional processing have focused on the late positive potential (LPP), a sustained positive deflection in the ERP that is increased for emotionally arousing stimuli. A prominent theory suggests that modulation of the LPP is a response to stimulus significance, defined in terms of the activation of appetitive and aversive motivational systems. The current review incorporates experimental studies showing that manipulations that alter the significance of...
Fri Apr 03, 2020 19:18
Abstract Purpose Although men with spinal cord injury (SCI) exhibit a prostate volume significantly smaller compared to age-matched able-bodied men, the independent association of lower prostate volume with its putative determinants has never been analyzed in this population. This study was designed to identify variables independently associated with prostate volume in men with chronic SCI. ...
Sat Apr 04, 2020 03:00
Abstract Objectives Given that current literature largely dissociates dental malocclusion and bruxism, the objective of this study was to gather, through a systematic review, scientific evidence to support their relationship. Methodology This study was performed according to the PECO strategy (where P = general population, E = dental malocclusion, C = no dental malocclusion, and O = bruxism). Literature searches were conducted without language or date restrictions in the following...
Sat Apr 04, 2020 12:19
Abstract Objective To evaluate the changes in occlusal surface area (OSA) and occlusal force distribution (OFD) following the wear of Vacuum‐Formed (VFR), Hawley (HR) and Bonded (BR) retainers, using T‐Scan III. Materials and Methods A total of 60 subjects using three different maxillary and mandibular orthodontic retainers, VFR (n:20), HR (n:20), and BR (n:20) were included in this study. The changes in OSA and OFD were evaluated using the T‐Scan III. The evaluations were made two...
Fri Apr 03, 2020 18:31
Abstract Background Occlusal analysis is a substantial tool for the functional improvement evaluation after using implant‐retained overdenture comparing to complete denture without dental implant retaining. Objectives To evaluate occlusal pattern, chewing force distribution in mini dental implant‐retained mandibular overdentures by computerized occlusal analysis system and to compare patient satisfaction after one‐year function. Methods Thirty‐one patients wearing complete...
Fri Apr 03, 2020 18:30
Abstract Epigenetics refers to changes in gene function, not resulting from the primary DNA sequence, influenced by the environment. It provides a link between the molecular regulation of the genome and the environmental signals exposed during the life of individuals (including lifestyle, social behavior, development, and nutrition). Notably, early development (intrauterine or postnatal) is highly influenced by the adverse socioeconomic status that leads to malnutrition or obesity; these...
Sat Apr 04, 2020 11:11
Our results confirm the presence of ancestral structures in snakes, which is here shown by the lacrimal primordium. The ancestral lacrimal bone primordium is observed as a ventral element at the early stages of prefrontal development Abstract Ontogenetic studies are crucial for understanding functional morphology, origin and adaptation of skulls in vertebrates. However, very few studies have so far released complete embryonic series focusing on skull embryonic development in species showing diverse...
Fri Apr 03, 2020 18:55
A complete review collating the currently available data on mitral valve morphometry, which specifies correlations between dimensions, mathematical models used to represent the valve, and how these can define changes in shape occurring with disease. Abstract The mitral valve is a complex anatomical structure whose physiological functioning relies on the biomechanical properties and structural integrity of its components. Their compromise can lead to mitral valve dysfunction, associated with morbidity...
Fri Apr 03, 2020 18:54
Serial block‐face scanning electron microscopy to create a 3D reconstruction of endothelial cells. Interendothelial protrusions were observed originating from a donor endothelial cell and tunnelling inside a recipient endothelial cell. These structures constitute a novel intercellular connection. Abstract The placental microvasculature is a conduit for fetal blood allowing solute exchange between the mother and the fetus. Serial block‐face scanning electron microscopy (SBF SEM) allows ultrastructure...
Fri Apr 03, 2020 18:52
New England Journal of Medicine, Ahead of Print.
Fri Apr 03, 2020 07:00
New England Journal of Medicine, Ahead of Print.
Thu Apr 02, 2020 12:01
New England Journal of Medicine, Ahead of Print.
Thu Apr 02, 2020 12:01
New England Journal of Medicine, Ahead of Print.
Thu Apr 02, 2020 12:00
New England Journal of Medicine, Ahead of Print.
Thu Apr 02, 2020 12:00
Abstract Including sex is of paramount importance in preclinical and clinical stroke research, and molecular studies dealing in depth with sex differences in stroke pathophysiology are needed. To gain insight into the molecular sex dimorphism of ischemic stroke in rat cerebral cortex, male and female adult rats were subjected to transient middle cerebral artery occlusion. The expression of neuroglobin (Ngb) and other functionally related molecules involved in sex steroid signalling (oestrogen and...
Fri Apr 03, 2020 18:27
Abstract Background Allergen extracts are the primary tool for diagnosis and treatment of allergic diseases. In the United States, most allergen extracts are non‐standardized. More sophisticated analytical approaches are needed to characterize these products and enable manufacturers and regulators to better determine potency. Objective To expand the multiple reaction monitoring (MRM) assay for an in‐depth characterization of German cockroach (GCr; Blattella germanica) allergen extracts....
Fri Apr 03, 2020 18:53
Objective. To investigate the role of CXXC5 and the CD40/CD40L pathway in lung fibrosis. Methods. (1) We constructed mouse models of bleomycin-induced pulmonary fibrosis and transfected them with a CXXC5 overexpression vector to evaluate the severity of pulmonary fibrosis. (2) Mouse lung fibroblast (MLF) models stably overexpressed or knockout of CXXC5 vector were constructed. After transforming growth factor-β1 (TGF-β1) stimulation, we examined the proliferation and apoptosis of the MLF model and...
Sat Apr 04, 2020 09:50
Sat Apr 04, 2020 09:50
Objective. The study assesses the changes in electroencephalography (EEG) power spectral density of individuals in hypoxia when wearing a different type of safety shoes under different lifting frequencies. It also assesses the EEG response behavior induced via the process of lifting loads related to these variables. Methods. The study was conducted in two consecutive phases: training and acclimatization phase and experimental lifting phase. Ten male college students participated in this study. A...
Sat Apr 04, 2020 09:35
Cadmium (Cd) is a harmful pollutant which mainly affects the liver and kidney. In this work, we investigated the hepatoprotective effects of olive leaf extract based on oleuropein against hepatic cadmium toxicity in mice. Three groups of animals were used: the first one served as the control (C); the second one received intraperitoneal injection of cadmium 2 mg/kg b.w. (CD), administered five times during two weeks; and the third group received the same doses of Cd and simultaneously 16 mg/kg b.w....
Sat Apr 04, 2020 09:05
Ensete ventricosum (Welw.) cheeseman which belongs to the family of Musaceae is one of the main sources of starch in Ethiopia. This study aimed at evaluating epichlorohydrin cross-linked enset starch as a drug release sustaining excipient in microsphere formulations of theophylline. Extracted enset starch was cross-linked using epichlorohydrin as a cross-linking agent. The effect of cross-linker concentration, cross-linking duration, and cross-linking temperature on the degree of cross-linking and...
Sat Apr 04, 2020 09:05
This study investigates the impact of reduced transmural conduction velocity (TCV) on output parameters of the human heart. In a healthy heart, the TCV contributes to synchronization of the onset of contraction in individual layers of the left ventricle (LV). However, it is unclear whether the clinically observed decrease of TCV contributes significantly to a reduction of LV contractility. The applied three-dimensional finite element model of isovolumic contraction of the human LV incorporates transmural...
Sat Apr 04, 2020 08:50
This randomized controlled study is aimed at investigating the effects of long-term use of insoles with a toe-grip bar on the balance, walking, and running of preschool children. Fifty-two preschool children were randomly assigned to an intervention group or control group. Children included in the intervention group wore shoes with insoles that had a toe-grip bar, and those in the control group wore shoes with regular insoles without a toe-grip bar for 4 weeks while they were at school. The center...
Fri Apr 03, 2020 12:50
Protein phosphorylation is a posttranslational modification that is essential for normal cellular processes; however, abnormal phosphorylation is one of the prime causes for alteration of many structural, functional, and regulatory proteins in disease conditions. In cancer, changes in the states of protein phosphorylation in tyrosine residues have been more studied than phosphorylation in threonine or serine residues, which also undergo alterations with greater predominance. In general, serine phosphorylation...
Fri Apr 03, 2020 11:05
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου