Dtsch med Wochenschr 2020; 145: 474-479DOI: 10.1055/a-0963-9202 Übergeordnete Prinzipien Das Prinzip des Treat-to-Target (Remission als Ziel) wie auch die Notwendigkeit, Glukokortikoide (GC) auszuschleichen, werden betont. Remission als Ziel des Treat-to-Target Das Therapieziel ist die Remission nach den EULAR-Kriterien (z. B. SDAI < 3,3); wenn dies nicht möglich ist, dann ist die niedrige Krankheitsaktivität (DAS28 < 3,2) eine Alternative. Konventionell synthetische...
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Dtsch med Wochenschr 2020; 145: 448-452DOI: 10.1055/a-0968-0844 Vergleich von Endokarditis-Risikokonstellationen Aus der Hochrisikogruppe der Endokarditis-prädisponierenden Erkrankungen sticht die durchgemachte Endokarditis (Risiko 266-fach) hervor – Präventionsmaßnahmen wie gute Oral-/Zahnhygiene, Antibiotikaprophylaxe bei orodentalen Eingriffen und Aufklärung sind essenziell. Neues zur Enterococcus-faecalis-Endokarditis Bei Patienten mit ambulant erworbener E. faecalis-Bakteriämie...
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Dtsch med Wochenschr 2020; 145: 484-487DOI: 10.1055/a-1118-9372 Anamnese und klinischer Befund Ein 33-jähriger Koch stellte sich notfallmäßig mit Angina pectoris und Schüttelfrost sowie signifikant erhöhten Troponin-, CK- und CRP-Werten vor. Untersuchungen Eine koronare Herzerkrankung wurde koronarangiografisch ausgeschlossen. Der Verdacht auf eine akute Myokarditis erhärtete sich später MR-morphologisch. Diagnostik Aufgrund von Fieberschüben und Berufsanamnese vermuteten...
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Dtsch med Wochenschr 2020; 145: 453-457DOI: 10.1055/a-0986-3637 Definition der Sepsis Eine Sepsis ist eine akut lebensbedrohliche Organdysfunktion, hervorgerufen durch eine inadäquate Wirtsantwort auf eine Infektion. Für die Diagnose einer Sepsis-assoziierten Organdysfunktion ist eine Veränderung des Sequential Organ Failure Assessment (SOFA) Scores um ≥ 2 Punkte zu verwenden. Therapie Zur hämodynamischen Stabilisierung von Patienten sollte eine intravenöse kristalloide Lösung...
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Dtsch med Wochenschr 2020; 145: 491-491DOI: 10.1055/a-1130-6753© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
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Dtsch med Wochenschr 2020; 145: 458-463DOI: 10.1055/a-0976-8813 NP-Grenzwert zur Diagnostik einer Herzinsuffizienz Von den klinisch verfügbaren Biomarkern sind die natriuretischen Peptide (NP) die robustesten Prädiktoren für die Diagnose und Prognose bei Herzinsuffizienz (HI). Der prognostische Wert ist insbesondere bei serieller Bestimmung der NP hoch, sodass der klinische Einsatz in internationalen HI-Leitlinien mit höchster Evidenz und Empfehlung weiter in den Vordergrund gerückt ist....
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Dtsch med Wochenschr 2020; 145: 492-492DOI: 10.1055/a-1130-6823© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
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Dtsch med Wochenschr 2020; 145: 464-469DOI: 10.1055/a-0887-0595 Medikamentöse Therapie Die aktualisierte Dyslipidämie-Leitlinie der European Society of Cardiology senkt nochmals die LDL-Cholesterinzielwerte. Zur Erreichung dieser Zielwerte werden hochpotente Statine und vermehrt Kombinationspartner wie Ezetimib und PCSK9-Hemmer nötig werden. Lipidapherese Die Bestimmung von Lipoprotein(a) zur kardiovaskulären Risikostratifizierung ist nun eine Klasse-II(a)-Empfehlung. Momentan...
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Dtsch med Wochenschr 2020; 145: 495-495DOI: 10.1055/a-1130-6853© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
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Dtsch med Wochenschr 2020; 145: 470-473DOI: 10.1055/a-0985-5793 Glukokortikosteroide und Immunsuppressiva In der Therapie der Lungengerüstveränderungen bei Patienten mit Kollagenose (connective tissue disease-associated interstitial lung disease, CTD-ILD) werden Kortikosteroide, Immunsuppressiva und auch Biologika angewendet. Im Vergleich zur Scleroderma-Lung-Study (SLS) I und II, die die Effektivität der Immunsuppressiva Cyclophosphamid (CYC) und Mycophenolat-Mofetil (MMF) bei pulmonaler...
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Dtsch med Wochenschr 2020; 145: 413-413DOI: 10.1055/a-1091-2592© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
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Dtsch med Wochenschr 2020; 145: 499-501DOI: 10.1055/a-1130-6943© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
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Dtsch med WochenschrDOI: 10.1055/a-1146-1160The COVID-19 pandemic poses unprecedented challenges for the German health care system. What is already the case in some other countries, may occur in Germany in the near future also: Faced with limited ICU resources, doctors will be forced to decide which patients to treat and which to let die. This paper examines the legal implications of such decisions. It takes up arguments from the general discussion on prioritization in medicine. A constitutional...
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Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related death with a median survival time of 6-12 months. Most patients present with disseminated disease and the majority are offered palliative chemotherapy. With no approved treatment modalities for patients who progress on chemotherapy, we explored the effects of long-term Gemcitabine on the tumor microenvironment in order to identify potential therapeutic options for chemo-refractory PDAC. Using a combination of mouse models,...
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British Journal of Cancer, Published online: 02 April 2020; doi:10.1038/s41416-020-0815-9Ki-67 response-guided preoperative chemotherapy for HER2-positive breast cancer: results of a randomised Phase 2 study
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British Journal of Cancer, Published online: 02 April 2020; doi:10.1038/s41416-020-0820-zDiagnostic value of 18F-FDG-PET to predict the tumour immune status defined by tumoural PD-L1 and CD8+tumour-infiltrating lymphocytes in oral squamous cell carcinoma
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British Journal of Cancer, Published online: 02 April 2020; doi:10.1038/s41416-020-0802-1Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours
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Abstract HOX genes encode a family of evolutionarily conserved homeodomain transcription factors that are crucial both during development and adult life. In humans, 39 HOX genes are arranged in four clusters (HOXA, B, C, and D) in chromosomes 7, 17, 12, and 2, respectively. During embryonic development, particular epigenetic states accompany their expression along the anterior–posterior body axis. This tightly regulated temporal–spatial expression pattern reflects their relative...
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Abstract In rheumatoid arthritis (RA), synovial tissue abundantly expresses CCL21, a chemokine strongly associated with RA susceptibility. In this study, we aimed to characterize the functional significance of CCL21/CCR7 signaling in different phases of RA pathogenesis. We determined that CCR7 is a hallmark of RA M1 synovial fluid (SF) macrophages, and its expression in RA monocytes and in vitro differentiated macrophages is closely associated with disease activity score (DAS28)....
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Abstract FA-SAT is a highly conserved satellite DNA sequence transcribed in many Bilateria species. To disclose the cellular and functional profile of FA-SAT non-coding RNAs, a comprehensive experimental approach, including the transcripts location in the cell and in the cell cycle, the identification of its putative protein interactors, and silencing/ectopic expression phenotype analysis, was performed. FA-SAT non-coding RNAs play a nuclear function at the G1 phase of the cell...
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Atkins, Paleo or Zone – whichever diet you follow, you’ll probably only lose a bit of weight, and improvements to your cholesterol may disappear within a year
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Plant-eating cave bears vanished when ice spread across Europe – maybe because their large sinuses prevented them chewing meat to adapt to the new conditions
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The latest coronavirus news updated every day including coronavirus cases, the latest news, features and interviews from New Scientist and essential information about the covid-19 pandemic
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The factors that cause flu to decline in spring might apply to covid-19 too. But we don’t know yet if warm weather can curb the spread of the coronavirus
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A prehistoric human species that lived in Europe 1.2 million to 800,000 years ago is emerging as a contender to be our last common ancestor with Neanderthals
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Growing evidence suggests the covid-19 outbreak may not have started at Wuhan’s Huanan Seafood Market in December after all. Finding its origins may help us stop it happening again
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A 99-million-year-old skull recently discovered in amber might actually belong to a lizard, rather than a tiny bird-like dinosaur as first thought
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Pollen has a natural tendency to adsorb mercury and forms the basis of a new class of tiny robots that speed through toxic water to purify it
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Forget the simple out-of-Africa idea of how humans evolved. A huge array of fossils and genome studies has completely rewritten the story of how we came into being.
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Plastic surgeon and breast specialist Dr. Constance Chen discussed the potential complications of implant-based breast reconstruction, and how it compares to natural tissue reconstruction. (Source: CancerNetwork)
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In a podcast, published by The New England Journal of Medicine (NEJM), physicians discuss practical measures that could help prevent the coronavirus disease 2019 (COVID-19). (Source: CancerNetwork)
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Immutep reported positive data from the randomized phase IIb AIPAC clinical trial of eftilagimod alpha and paclitaxel in HER2-negative, HR-positive metastatic breast cancer (MBC). (Source: CancerNetwork)
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The deputy director at NYU Langone ’s Perlmutter Cancer Center explained the importance of these agents and the development of clinical trials in this setting. (Source: CancerNetwork)
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The American College of Surgeons released guidelines for triaging surgeries of patients with cancer during the COVID-19 pandemic. (Source: CancerNetwork)
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ASCO released new guidelines for treating patients with late-stage colorectal cancer based on previously existing guidelines using an expert panel. (Source: CancerNetwork)
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This (fig 1) is a funduscopic image of Candida albicans endogenous endophthalmitis (CAEE) in the left eye. The patient was a man in his 30s who presented in hospital with a one month history of...
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