Antibiotics, Vol. 8, Pages 149: Characterization of a Carbapenem-Resistant Kluyvera Cryocrescens Isolate Carrying Blandm-1 from Hospital Sewage Antibiotics doi: 10.3390/antibiotics8030149 Authors: Ying Li Li Luo Zhijiao Xiao Guangxi Wang Chengwen Li Zhikun Zhang Yingshun Zhou Luhua Zhang Carbapenem-resistant Enterobacteriaceae have been a global public health issue in recent years. Here, a carbapenem-resistant Kluyvera cryocrescens strain SCW13 was isolated from...
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Antioxidants, Vol. 8, Pages 398: 2-Methoxy-7-Acetonyljuglone Isolated from Reynoutria japonica Increases the Activity of Nuclear Factor Erythroid 2-Related Factor-2 through Inhibition of Ubiquitin Degradation in HeLa Cells Antioxidants doi: 10.3390/antiox8090398 Authors: Jung-Hwan Kim Atif Ali Khan Khalil Hye-Jin Kim Sung-Eun Kim Mi-Jeong Ahn The nuclear factor erythroid-derived 2-related factor 2 (NRF2) is a key transcription factor for the activation of genes responsible...
Sat Sep 14, 2019 03:00
Antioxidants, Vol. 8, Pages 397: Anti-Microbiological, Anti-Hyperglycemic and Anti-Obesity Potency of Natural Antioxidants in Fruit Fractions of Saskatoon Berry Antioxidants doi: 10.3390/antiox8090397 Authors: Sabina Lachowicz Rafał Wiśniewski Ireneusz Ochmian Katarzyna Drzymała Stanisław Pluta The aim of the present work was to evaluate for content of phytochemicals (monophosphate nucleotides, free amino acids, polyphenols), and for anti-microbiological, anti-diabetic (ability...
Fri Sep 13, 2019 03:00
Antioxidants, Vol. 8, Pages 396: Traditional and Unconventional Dried Fruit Snacks as a Source of Health-Promoting Compounds Antioxidants doi: 10.3390/antiox8090396 Authors: Dario Donno Maria Gabriella Mellano Isidoro Riondato Marta De Biaggi Harilala Andriamaniraka Giovanni Gamba Gabriele Loris Beccaro Dried fruits are important, healthy and popular snacks, despite the limited information on their nutritional profiles and phytochemical composition. The present work...
Fri Sep 13, 2019 03:00
Arts, Vol. 8, Pages 118: Circling Round Vitruvius, Linear Perspective, and the Design of Roman Wall Painting Arts doi: 10.3390/arts8030118 Authors: Small Many scholars believe that linear perspective existed in classical antiquity, but a fresh examination of two key texts in Vitruvius shows that 1.2.2 is about modularity and symmetria, while 7.Pr.11 describes shading (skiagraphia). Moreover, these new interpretations are firmly based on the classical understanding of optics and the...
Sat Sep 14, 2019 03:00
Atmosphere, Vol. 10, Pages 548: Validation and Accuracy Assessment of MODIS C6.1 Aerosol Products over the Heavy Aerosol Loading Area Atmosphere doi: 10.3390/atmos10090548 Authors: Xinpeng Tian Zhiqiang Gao The aim of this study is to evaluate the accuracy of MODerate resolution Imaging Spectroradiometer (MODIS) aerosol optical depth (AOD) products over heavy aerosol loading areas. For this analysis, the Terra-MODIS Collection 6.1 (C6.1) Dark Target (DT), Deep Blue (DB) and the combined...
Sat Sep 14, 2019 03:00
Atmosphere, Vol. 10, Pages 547: Frontal Wind Field Retrieval Based on UHF Wind Profiler Radars and an S-band Radar Network Atmosphere doi: 10.3390/atmos10090547 Authors: Kim Campistron Kwon The three-dimensional wind field (WPR3D) and the multiple WPR3D (M-WPR3D) associated with the passage of a stationary front was derived from observations made by a network of eight wind profiler radars (WPR) being operated by the Korea Meteorological Administration during the summer “Jangma”...
Sat Sep 14, 2019 03:00
Atmosphere, Vol. 10, Pages 546: Method for Determining Neutral Wind Velocity Vectors Using Measurements of Internal Gravity Wave Group and Phase Velocities Atmosphere doi: 10.3390/atmos10090546 Authors: Andrey V. Medvedev Konstantin G. Ratovsky Maxim V. Tolstikov Roman V. Vasilyev Maxim F. Artamonov This study presents a new method for determining a neutral wind velocity vector. The basis of the method is measurement of the group velocities of internal gravity waves. Using...
Fri Sep 13, 2019 03:00
Atmosphere, Vol. 10, Pages 545: Precipitation Diurnal Cycle in Germany Linked to Large-Scale Weather Circulations Atmosphere doi: 10.3390/atmos10090545 Authors: Wael Ghada Ye Yuan Clemens Wastl Nicole Estrella Annette Menzel The precipitation diurnal cycle (PDC) varies with the season and location. Its link to large-scale weather circulations has been studied in different regions. However, comparable information is lacking for Central Europe. Two decades of hourly precipitation...
Fri Sep 13, 2019 03:00
Behavioral Sciences, Vol. 9, Pages 100: Turkish Adaptation of the Positive–Negative Relationship Quality (PN-RQ) Scale: A Reliability and Validity Study Behavioral Sciences doi: 10.3390/bs9090100 Authors: Arzu Araz Duygu Güngör Eda Aşçı Background: The present study investigates the reliability and validity of the Positive–Negative Relationship Quality (PN-RQ) scale in Turkey. This study aims to test different factorial models including orthogonal factors model, correlated...
Sun Sep 15, 2019 03:00
Biology, Vol. 8, Pages 67: The Interacting Head Motif Structure Does Not Explain the X-Ray Diffraction Patterns in Relaxed Vertebrate (Bony Fish) Skeletal Muscle and Insect (Lethocerus) Flight Muscle Biology doi: 10.3390/biology8030067 Authors: Knupp Morris Squire Unlike electron microscopy, which can achieve very high resolution but to date can only be used to study static structures, time-resolved X-ray diffraction from contracting muscles can, in principle, be used to follow...
Sat Sep 14, 2019 03:00
Biology, Vol. 8, Pages 66: Parasitism of the Invasive Brown Marmorated Stink Bug, Halyomorpha halys (Hemiptera: Pentatomidae), by the Native Parasitoid, Trichopoda pennipes (Diptera: Tachinidae) Biology doi: 10.3390/biology8030066 Authors: Neelendra K. Joshi Timothy W. Leslie David J. Biddinger The invasive brown marmorated stink bug, Halyomorpha halys (Hemiptera: Pentatomidae), has been an important agricultural pest in the Mid-Atlantic United States since its introduction in...
Sat Sep 14, 2019 03:00
Biomedicines, Vol. 7, Pages 71: Zebrafish: A Powerful Model for Understanding the Functional Relevance of Noncoding Region Mutations in Human Genetic Diseases Biomedicines doi: 10.3390/biomedicines7030071 Authors: Anita Mann Shipra Bhatia Determining aetiology of genetic disorders caused by damaging mutations in protein-coding genes is well established. However, understanding how mutations in the vast stretches of the noncoding genome contribute to genetic abnormalities remains a...
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Biomolecules, Vol. 9, Pages 489: Detection and identification of allergens from Canadian mustard varieties of Sinapis alba and Brassica juncea Biomolecules doi: 10.3390/biom9090489 Authors: L’Hocine Pitre Achouri Currently, information on the allergens profiles of different mustard varieties is rather scarce. Therefore, the objective of this study was to assess protein profiles and immunoglobulin E (IgE)-binding patterns of selected Canadian mustard varieties. Optimization of...
Sat Sep 14, 2019 03:00
Biomolecules, Vol. 9, Pages 488: HDX and Native Mass Spectrometry Reveals the Different Structural Basis for Interaction of the Staphylococcal Pathogenicity Island Repressor Stl with Dimeric and Trimeric Phage dUTPases Biomolecules doi: 10.3390/biom9090488 Authors: Kinga Nyíri Matthew J. Harris Judit Matejka Olivér Ozohanics Károly Vékey Antoni J. Borysik Beáta G. Vértessy The dUTPase enzyme family plays an essential role in maintaining the genome integrity and are...
Sat Sep 14, 2019 03:00
Biomolecules, Vol. 9, Pages 487: Origin of Carbon and Essential Fatty Acids in Higher Trophic Level Fish in Headwater Stream Food Webs Biomolecules doi: 10.3390/biom9090487 Authors: Megumu Fujibayashi Yoshie Miura Reina Suganuma Shinji Takahashi Takashi Sakamaki Naoyuki Miyata So Kazama Dietary carbon sources in headwater stream food webs are divided into allochthonous and autochthonous organic matters. We hypothesized that: 1) the dietary allochthonous contribution...
Fri Sep 13, 2019 03:00
Biomolecules, Vol. 9, Pages 486: Succinate Modulates Intestinal Barrier Function and Inflammation Response in Pigs Biomolecules doi: 10.3390/biom9090486 Authors: Li Mao Zhang Yu Zhu Succinate is a metabolic intermediate of the tricarboxylic acid (TCA) cycle in all aerobic organisms, and is also a vital microbial metabolite in the gut. Although succinate is known to regulate intestinal metabolism and immune function, its role in the protection of the intestinal epithelial...
Fri Sep 13, 2019 03:00
Brain Sciences, Vol. 9, Pages 235: Use of Prescribed Psychotropics during Pregnancy: A Systematic Review of Pregnancy, Neonatal, and Childhood Outcomes Brain Sciences doi: 10.3390/brainsci9090235 Authors: Creeley Denton This paper reviews the findings from preclinical animal and human clinical research investigating maternal/fetal, neonatal, and child neurodevelopmental outcomes following prenatal exposure to psychotropic drugs. Evidence for the risks associated with prenatal exposure...
Sat Sep 14, 2019 03:00
Brain Sciences, Vol. 9, Pages 236: Timing-Dependent Protection of Swimming Exercise against d-Galactose-Induced Aging-Like Impairments in Spatial Learning/Memory in Rats Brain Sciences doi: 10.3390/brainsci9090236 Authors: Xue Li Lu Wang Shuling Zhang Xiang Hu Huijun Yang Lei Xi This study was designed to investigate beneficial effects of swimming exercise training on learning/memory, synaptic plasticity and CREB (cAMP response element binding protein) expression in hippocampus...
Sat Sep 14, 2019 03:00
Brain Sciences, Vol. 9, Pages 234: Diet in Brain Health and Neurological Disorders: Risk Factors and Treatments Brain Sciences doi: 10.3390/brainsci9090234 Authors: Jason Brandt The role of nutrition in health and disease has been appreciated from time immemorial [...]
Fri Sep 13, 2019 03:00
Cancers, Vol. 11, Pages 1371: Bispecific GRPR-Antagonistic Anti-PSMA/GRPR Heterodimer for PET and SPECT Diagnostic Imaging of Prostate Cancer Cancers doi: 10.3390/cancers11091371 Authors: Bogdan Mitran Zohreh Varasteh Ayman Abouzayed Sara S. Rinne Emmi Puuvuori Maria De Rosa Mats Larhed Vladimir Tolmachev Anna Orlova Ulrika Rosenström Simultaneous targeting of the prostate-specific membrane antigen (PSMA) and gastrin-releasing peptide receptor (GRPR) could...
Sat Sep 14, 2019 03:00
Cancers, Vol. 11, Pages 1368: Cell Heterogeneity and Phenotypic Plasticity in Metastasis Formation: The Case of Colon Cancer Cancers doi: 10.3390/cancers11091368 Authors: Miriam Teeuwssen Riccardo Fodde The adenoma-to-carcinoma progression in colon cancer is driven by a sequential accumulation of genetic alterations at specific tumor suppressors and oncogenes. In contrast, the multistage route from the primary site to metastasis formation is underlined by phenotypic plasticity, i.e.,...
Sat Sep 14, 2019 03:00
Cancers, Vol. 11, Pages 1369: MicroRNA Regulation of the Autotaxin-Lysophosphatidic Acid Signaling Axis Cancers doi: 10.3390/cancers11091369 Authors: Mandi M. Murph The revelation that microRNAs (miRNAs) exist within the human genome uncovered an underappreciated mechanism of gene expression. For cells to regulate expression of their genes, miRNA molecules and argonaute proteins bind to mRNAs and interfere with efficient translation of the RNA transcript. Although miRNAs have important...
Sat Sep 14, 2019 03:00
Cancers, Vol. 11, Pages 1370: Direct Intercellular Communications and Cancer: A Snapshot of the Biological Roles of Connexins in Prostate Cancer Cancers doi: 10.3390/cancers11091370 Authors: Catalina Asencio-Barría Norah Defamie Juan C. Sáez Marc Mesnil Alejandro S. Godoy Tissue homeostasis is the result of a complex intercellular network controlling the behavior of every cell for the survival of the whole organism. In mammalian tissues, cells do communicate via diverse long-...
Sat Sep 14, 2019 03:00
Cancers, Vol. 11, Pages 1367: Hyperspectral Imaging of Head and Neck Squamous Cell Carcinoma for Cancer Margin Detection in Surgical Specimens from 102 Patients Using Deep Learning Cancers doi: 10.3390/cancers11091367 Authors: Martin Halicek James D. Dormer James V. Little Amy Y. Chen Larry Myers Baran D. Sumer Baowei Fei Surgical resection of head and neck (H and N) squamous cell carcinoma (SCC) may yield inadequate surgical cancer margins in 10 to 20% of cases. This...
Sat Sep 14, 2019 03:00
Cancers, Vol. 11, Pages 1366: Matryoshka-Type Liposomes Offer the Improved Delivery of Temoporfin to Tumor Spheroids Cancers doi: 10.3390/cancers11091366 Authors: Yakavets Millard Lamy Francois Scheglmann Wiehe Lassalle Zorin Bezdetnaya The balance between the amount of drug delivered to tumor tissue and the homogeneity of its distribution is a challenge in the efficient delivery of photosensitizers (PSs) in photodynamic therapy (PDT) of cancer. To date,...
Fri Sep 13, 2019 03:00
Cancers, Vol. 11, Pages 1362: CRISPR Loss-of-Function Screen Identifies the Hippo Signaling Pathway as the Mediator of Regorafenib Efficacy in Hepatocellular Carcinoma Cancers doi: 10.3390/cancers11091362 Authors: Shigeki Suemura Takahiro Kodama Yuta Myojin Ryoko Yamada Minoru Shigekawa Hayato Hikita Ryotaro Sakamori Tomohide Tatsumi Tetsuo Takehara Regorafenib is used for hepatocellular carcinoma (HCC), but its response does not last long, partly due to chemoresistance...
Fri Sep 13, 2019 03:00
Cancers, Vol. 11, Pages 1364: Next-Generation Sequencing Improves Diagnosis, Prognosis and Clinical Management of Myeloid Neoplasms Cancers doi: 10.3390/cancers11091364 Authors: Diego Carbonell Julia Suárez-González María Chicano Cristina Andrés-Zayas Juan Carlos Triviño Gabriela Rodríguez-Macías Mariana Bastos-Oreiro Patricia Font Mónica Ballesteros Paula Muñiz Pascual Balsalobre Mi Kwon Javier Anguita José Luis Díez-Martín Ismael Buño Carolina...
Fri Sep 13, 2019 03:00
Cancers, Vol. 11, Pages 1363: HSF1 Regulates Mevalonate and Cholesterol Biosynthesis Pathways Cancers doi: 10.3390/cancers11091363 Authors: Hyeji Kang Taerim Oh Young Yil Bahk Geon-Hee Kim Sang-Yeon Kan Dong Hoon Shin Ji Hyung Kim Ji-Hong Lim Heat shock factor 1 (HSF1) is an essential transcription factor in cellular adaptation to various stresses such as heat, proteotoxic stress, metabolic stress, reactive oxygen species, and heavy metals. HSF1 promotes cancer development...
Fri Sep 13, 2019 03:00
Cancers, Vol. 11, Pages 1365: Role of Circulating Tumor Cells (CTC), Androgen Receptor Full Length (AR-FL) and Androgen Receptor Splice Variant 7 (AR-V7) in a Prospective Cohort of Castration-Resistant Metastatic Prostate Cancer Patients Cancers doi: 10.3390/cancers11091365 Authors: Carlo Cattrini Alessandra Rubagotti Linda Zinoli Luigi Cerbone Elisa Zanardi Matteo Capaia Paola Barboro Francesco Boccardo Background: Circulating tumor cells (CTC), androgen receptor...
Fri Sep 13, 2019 03:00
Cancers, Vol. 11, Pages 1359: Allosteric AKT Inhibitors Target Synthetic Lethal Vulnerabilities in E-Cadherin-Deficient Cells Cancers doi: 10.3390/cancers11091359 Authors: Nicola Bougen-Zhukov Yasmin Nouri Tanis Godwin Megan Taylor Christopher Hakkaart Andrew Single Tom Brew Elizabeth Permina Augustine Chen Michael A. Black Parry Guilford The CDH1 gene, encoding the cell adhesion protein E-cadherin, is one of the most frequently mutated genes in gastric...
Fri Sep 13, 2019 03:00
Cancers, Vol. 11, Pages 1360: Diffuse Lung Metastases in EGFR-Mutant Non-Small Cell Lung Cancer Cancers doi: 10.3390/cancers11091360 Authors: Subba R. Digumarthy Dexter P. Mendoza Atul Padole Tianqi Chen P. Gabriel Peterson Zofia Piotrowska Lecia V. Sequist Diffuse lung metastases have been reported in non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations. The purpose of our study was to compare the incidence of diffuse lung...
Fri Sep 13, 2019 03:00
Cancers, Vol. 11, Pages 1361: In Silico Drug Prescription for Targeting Cancer Patient Heterogeneity and Prediction of Clinical Outcome Cancers doi: 10.3390/cancers11091361 Authors: Elena Piñeiro-Yáñez María José Jiménez-Santos Gonzalo Gómez-López Fátima Al-Shahrour In silico drug prescription tools for precision cancer medicine can match molecular alterations with tailored candidate treatments. These methodologies require large and well-annotated datasets to systematically...
Fri Sep 13, 2019 03:00
Cells, Vol. 8, Pages 1088: ER-Mitochondria Communication in Cells of the Innate Immune System Cells doi: 10.3390/cells8091088 Authors: Dmitry Namgaladze Vera Khodzhaeva Bernhard Brüne In cells the interorganelle communication comprises vesicular and non-vesicular mechanisms. Non-vesicular material transfer predominantly takes place at regions of close organelle apposition termed membrane contact sites and is facilitated by a growing number of specialized proteins. Contacts of the...
Sun Sep 15, 2019 03:00
Cells, Vol. 8, Pages 1089: Fisetin, a 3,7,3′,4′-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models Cells doi: 10.3390/cells8091089 Authors: Jean Christopher Chamcheu Stephane Esnault Vaqar M. Adhami Andrea L. Noll Sergette Banang-Mbeumi Tithi Roy Sitanshu S. Singh Shile Huang Konstantin G. Kousoulas Hasan Mukhtar Psoriasis is a chronic immune-mediated skin...
Sun Sep 15, 2019 03:00
Cells, Vol. 8, Pages 1086: Regulation and Function of C-Type Natriuretic Peptide (CNP) in Gonadotrope-Derived Cell Lines Cells doi: 10.3390/cells8091086 Authors: Mirczuk Lessey Catterick Perrett Scudder Read Lipscomb Niessen Childs McArdle McGonnell Fowkes C-type natriuretic peptide (CNP) is the most conserved member of the mammalian natriuretic peptide family, and is implicated in the endocrine regulation of growth, metabolism and reproduction....
Sat Sep 14, 2019 03:00
Cells, Vol. 8, Pages 1087: The Anti-Apoptotic Effect of ASC-Exosomes in an In Vitro ALS Model and Their Proteomic Analysis Cells doi: 10.3390/cells8091087 Authors: Bonafede Brandi Manfredi Scambi Schiaffino Merigo Turano Bonetti Marengo Cecconi Mariotti Stem cell therapy represents a promising approach in the treatment of several neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). The beneficial effect of stem cells is...
Sat Sep 14, 2019 03:00
Cells, Vol. 8, Pages 1085: Empagliflozin Protects HK-2 Cells from High Glucose-Mediated Injuries via a Mitochondrial Mechanism Cells doi: 10.3390/cells8091085 Authors: Wen-Chin Lee You-Ying Chau Hwee-Yeong Ng Chiu-Hua Chen Pei-Wen Wang Chia-Wei Liou Tsu-Kung Lin Jin-Bor Chen Empagliflozin is known to retard the progression of kidney disease in diabetic patients. However, the underlying mechanism is incompletely understood. High glucose induces oxidative stress in...
Sat Sep 14, 2019 03:00
Cells, Vol. 8, Pages 1084: Effect of Adenomatous Polyposis Coli Loss on Tumorigenic Potential in Pancreatic Ductal Adenocarcinoma Cells doi: 10.3390/cells8091084 Authors: Jennifer M. Cole Kaitlyn Simmons Jenifer R. Prosperi Loss of the Adenomatous Polyposis Coli (APC) tumor suppressor in colorectal cancer elicits rapid signaling through the Wnt/β-catenin signaling pathway. In contrast to this well-established role of APC, recent studies from our laboratory demonstrated...
Sat Sep 14, 2019 03:00
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