Future Oncology, Ahead of Print.
Wed Sep 04, 2019 04:22
Cancers, Vol. 11, Pages 1307: Comment on “Osteopontin, Macrophage Migration Inhibitory Factor and Anti-Interleukin-8 Autoantibodies Complement CA125 for Detection of Early Stage Ovarian Cancer” Cancers 2019, 11, 596: Markers for Early Detection of Ovarian Cancer Cancers doi: 10.3390/cancers11091307 Authors: Gil Mor Thomas Rutherford Ayesha Alvero We read with interest the recent publication by Guo et al [...]
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Purpose: Vα24-invariant natural killer T cells (NKTs) are attractive carriers for chimeric antigen receptors (CARs) due to their inherent antitumor properties and preferential localization to tumor sites. However, limited persistence of CAR-NKTs in tumor-bearing mice is associated with tumor recurrence. Here, we evaluated whether co-expression of the NKT homeostatic cytokine IL-15 with a CAR enhances the in vivo persistence and therapeutic efficacy of CAR-NKTs. Experimental Design: Human primary...
Wed Sep 04, 2019 16:26
Recurrent high-risk neuroblastoma is a childhood cancer that often fails to respond to therapy. Fenretinide (4-HPR) is a cyototoxic retinoid with cliical activity in recurrent neuroblastoma and venetoclax (ABT-199) is a selective inhibitor of the anti-apoptotic protein BCL-2. We evaluated activity of 4-HPR + ABT-199 in preclinical models of neuroblastoma. Patient-derived cell lines and xenografts from progresssive neuroblastoma were tested. Cytotoxicity was evaluated by DIMSCAN, apoptosis by...
Wed Sep 04, 2019 19:00
Hyaluronic acid (HA), a constituent of the extracellular matrix, promotes colorectal cancer (CRC) growth. CD44 is a relevant HA receptor in this context. However, HA is also a ligand for TLR4, a receptor of significance in CRC. In this study we examine the relative contribution of HA interactions with CD44 and TLR4 in colon tumorigenesis. CRC models included ApcMin/+ mice, azoxymethane/dextran sodium sulfate (AOM-DSS) and CT26 tumor isografts. We used knockout mice and CT26 CRC cells with CRISPR...
Wed Sep 04, 2019 19:00
Despite the clinical benefit of trastuzumab, eventually all HER2-amplified gastric cancer tumors develop drug resistance. We aimed to identify molecular mechanisms of acquired resistance to trastuzumab in gastric cancer by using well-established cell-line based preclinical models, as well as samples from HER2-positive gastric cancer patients treated with trastuzumab. We studied trastuzumab resistance in NCI-N87 and OE19, two gastric cancer cell lines that overexpress HER2 receptor and are trastuzumab...
Wed Sep 04, 2019 19:00
British Journal of Cancer, Published online: 05 September 2019; doi:10.1038/s41416-019-0568-5Reply to Comment on: “Night shift work and risk of breast cancer in women: the Generations Study cohort”
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British Journal of Cancer, Published online: 05 September 2019; doi:10.1038/s41416-019-0567-6Comment on: “Night shift work and risk of breast cancer in women: the Generations Study cohort”
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Abstract Objective To develop and evaluate the usability of iConquerFear, an online self‐management adaptation of an efficacious face‐to‐face therapist‐delivered treatment for fear of cancer recurrence (FCR). Methods iConquerFear development was theory‐ and person‐based. Development was guided by Ritterband et al's behaviour change model for Internet interventions. iConquerFear end users (cancer survivors) provided iterative feedback in accordance with Yardley et al's person‐based approach,...
Wed Sep 04, 2019 19:15
Summary Bone morphogenetic protein (BMP) signaling plays important roles in glioblastoma multiforme (GBM), a lethal form of brain tumor. BMPs reduce GBM tumorigenicity through its differentiation‐ and apoptosis‐inducing effects on glioma‐initiating cells (GICs). However, some GICs do not respond to the tumor suppressive effects of BMPs. Using a phospho‐receptor tyrosine kinase array, we found that EPHA6 (erythropoietin‐producing hepatocellular carcinoma receptor A6) phosphorylation was regulated...
Wed Sep 04, 2019 21:19
The prognosis of N categories for patients with non-surgical esophageal carcinoma based on the number of metastatic lymph nodes is controversial. The present study analyzes prognostic implications of the numbe...
Tue Sep 03, 2019 03:00
The treatment of lung lesions with stereotactic body radiation therapy calls for highly conformal dose, which is evaluated by a number of metrics. Lung stereotactic body radiation therapy clinical trials const...
Tue Sep 03, 2019 03:00
We critically examined existing approaches for the estimation of the excess familial risk of cancer which can be attributed to identified common genetic risk variants and propose an alternative, more straightforward approach for calculating this proportion using well‐established epidemiological methodology. We applied the underlying equations of the traditional approaches and the new epidemiological approach for colorectal cancer (CRC) in a large population‐based case–control study in Germany with...
Wed Sep 04, 2019 19:35
Abstract Purpose Prostaglandin-mediated inflammatory reactions play a major role in different cancers. Recently, it has been observed that prostaglandin E2-receptor 3 (EP3) might be an independent prognostic factor for overall survival in cervical and endometrial cancer. The role of EP3 expression in ovarian cancer is currently unknown. Methods EP3 expression...
Wed Sep 04, 2019 03:00
Abstract Introduction Single-fraction stereotactic radiosurgery (SRS) is delivered predominantly via two modalities: Gamma Knife, and linear accelerator (LINAC). Implementation of the American Tax Payer Relief Act (ATRA) in 2013 represented the first time limitations specifically targeting SRS reimbursement were introduced into federal law. The subsequent impact of the ATRA on SRS utilization in the United States (US) has yet to be examined....
Wed Sep 04, 2019 03:00
Abstract Purpose This study aimed to determine the potential of positron emission tomography/computed tomography (PET/CT) in replacing routine bone-marrow biopsies (BMB) in newly diagnosed extranodal natural killer/T-cell lymphoma (ENKTCL). Methods Newly diagnosed patients underwent PET/CT imaging and routine BMB to assess bone/bone marrow involvement (BMI)....
Wed Sep 04, 2019 03:00
Background The large registry, PROVENGE Registry for the Observation, Collection, and Evaluation of Experience Data (PROCEED)(NCT01306890), evaluated sipuleucel‐T immunotherapy for asymptomatic/minimally symptomatic metastatic castration‐resistant prostate cancer (mCRPC). Methods PROCEED enrolled patients with mCRPC receiving 3 biweekly sipuleucel‐T infusions. Assessments included overall survival (OS), serious adverse events (SAEs), cerebrovascular events (CVEs), and anticancer interventions...
Wed Sep 04, 2019 18:51
Background The majority of patients with acute myeloid leukemia (AML) are aged >65 years at the time of diagnosis and are not actively treated. The objective of the current study was to determine the prevalence, temporal trends, and factors associated with no active treatment (NAT) among older patients with AML in the United States. Methods A retrospective analysis was performed of Surveillance, Epidemiology, and End Results (SEER)–Medicare data from 14,089 patients with AML residing in...
Wed Sep 04, 2019 18:51
Fri Aug 30, 2019 16:37
Publication date: Available online 3 September 2019Source: European Journal of Surgical OncologyAuthor(s): Tomoyuki Kawada
Wed Sep 04, 2019 19:30
Cancers, Vol. 11, Pages 1304: The Relationship between Imaging-Based Body Composition Analysis and the Systemic Inflammatory Response in Patients with Cancer: A Systematic Review Cancers doi: 10.3390/cancers11091304 Authors: Abbass Dolan Laird McMillan Background and aim: Cancer is the second leading cause of death globally. Nutritional status (cachexia) and systemic inflammation play a significant role in predicting cancer outcome. The aim of the present review was to examine...
Wed Sep 04, 2019 03:00
Cancers, Vol. 11, Pages 1305: The Autocrine FGF/FGFR System in both Skin and Uveal Melanoma: FGF Trapping as a Possible Therapeutic Approach Cancers doi: 10.3390/cancers11091305 Authors: Rezzola Ronca Loda Nawaz Tobia Paganini Maccarinelli Giacomini Semeraro Mor Presta Fibroblast growth factors (FGFs) play non-redundant autocrine/paracrine functions in various human cancers. The Cancer Genome Atlas (TCGA) data mining indicates that high levels...
Wed Sep 04, 2019 03:00
Cancers, Vol. 11, Pages 1306: Clinical Significance of SERPINA1 Gene and Its Encoded Alpha1-antitrypsin Protein in NSCLC Cancers doi: 10.3390/cancers11091306 Authors: Ercetin Richtmann Delgado Gomez-Mariano Wrenger Korenbaum Liu DeLuca Kühnel Jonigk Yuskaeva Warth Muley Winter Meister Welte Janciauskiene Schneider Abstract: High expression of SERPINA1 gene encoding acute phase protein, alpha1-antitrypsin (AAT), is associated...
Wed Sep 04, 2019 03:00
Abstract Purpose The clinical importance of cancer stem cells (CSCs) in head and neck squamous cell carcinoma (HNSCC) is well recognized. However, a reliable method for the detection of functioning CSC has not yet been established. We hypothesized that YAP1, a transcriptional coactivator, and SOX2, a master transcription factor of SCC, may cooperatively induce stemness through transcriptional reprogramming. ...
Wed Sep 04, 2019 03:00
Publication date: October 2019Source: European Journal of Cancer, Volume 120Author(s): Ana Lluch, Ana M. González-Angulo, David Casadevall, Agda K. Eterovic, Eduardo Martínez de Dueñas, Xiaofeng Zheng, Ángel Guerrero-Zotano, Shuying Liu, Ramón Pérez, Ken Chen, Jose Ignacio Chacón, Gordon B. Mills, Silvia Antolín, Isabel Blancas, Paula López-Serra, Eva Carrasco, Rosalía Caballero, Aleix Prat, Federico Rojo, Abel Gonzalez-PerezAbstractBackgroundChanges in the clinical subtype (CS) and intrinsic subtype...
Wed Sep 04, 2019 17:55
Abstract Objective Supra-total glioblastoma resection has gained growing attention with regard to superior long-term disease control. However, aggressive onco-surgical approaches—geared beyond conventional gross total resections (GTR)—are limited by the impairment of adjacent eloquent areas at risk that may entail severe postoperative functional morbidity. Against this backdrop we analyzed our institutional database with regard to potential...
Wed Sep 04, 2019 03:00
Cancers, Vol. 11, Pages 1301: Immunotherapy with Monoclonal Antibodies in Lung Cancer of Mice: Oxidative Stress and Other Biological Events Cancers doi: 10.3390/cancers11091301 Authors: Jun Tang Daniel Ramis-Cabrer Xuejie Wang Esther Barreiro Background: Lung cancer (LC) is a major leading cause of death worldwide. Immunomodulators that target several immune mechanisms have proven to reduce tumor burden in experimental models through induction of the immune microenvironment....
Wed Sep 04, 2019 03:00
Cancers, Vol. 11, Pages 1302: Emerging Role of USP8, HMGA, and Non-Coding RNAs in Pituitary Tumorigenesis Cancers doi: 10.3390/cancers11091302 Authors: Daniela D’Angelo Marco De Martino Claudio Arra Alfredo Fusco Two novel molecular mechanisms with a driver role in pituitary tumorigenesis have been recently identified. They are (a) mutations in the Ubiquitin-Specific Protease 8 (USP8) gene in corticotroph tumors and (b) overexpression of the HMGA1 and HMGA2 genes in most of...
Wed Sep 04, 2019 03:00
Cancers, Vol. 11, Pages 1303: Manoalide Preferentially Provides Antiproliferation of Oral Cancer Cells by Oxidative Stress-Mediated Apoptosis and DNA Damage Cancers doi: 10.3390/cancers11091303 Authors: Hui-Ru Wang Jen-Yang Tang Yen-Yun Wang Ammad Ahmad Farooqi Ching-Yu Yen Shyng-Shiou F. Yuan Hurng-Wern Huang Hsueh-Wei Chang Marine sponge-derived manoalide has a potent anti-inflammatory effect, but its potential application as an anti-cancer drug has not yet been...
Wed Sep 04, 2019 03:00
Publication date: Available online 3 September 2019Source: Cancer/RadiothérapieAuthor(s): V. Bourbonné, O. Pradier, U. Schick, S. Servagi-VernatAbstractDespite representing a 1% of diagnosed cancer cases in the USA and up to 5% in eastern Asia and Africa, oesophageal cancer still holds numerous questions concerning the best therapeutic management. For squamous cell carcinoma, while radiochemotherapy has proven itself to be the gold standard as part of the trimodality or alone as a definitive treatment,...
Wed Sep 04, 2019 14:52
Abstract Red meat and processed meat have been suggested to increase risk of colorectal cancer (CRC), especially colon cancer. However, it remains unclear whether these associations differ according to meat subtypes or colon subsites. The present study addressed this issue by conducting a pooled analysis of large population‐based cohort studies in Japan: 5 studies comprising 232,403 participants (5,694 CRC cases) for analysis based on frequency of meat intake and 2 studies comprising 123,635 participants...
Wed Sep 04, 2019 14:42
Abstract Background Autophagy plays an important role in regulating cisplatin (CDDP) resistance in gastric cancer cells. However, the underlying mechanism of methioninase (METase) in the regulation of autophagy and CDDP resistance of gastric cancer cells is still not clear. Materials and methods Western blot was used to detect the levels of autophagy-related...
Wed Sep 04, 2019 03:00
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