Related ArticlesCytotoxicity of 1-deoxysphingolipid unraveled by genome-wide genetic screens and lipidomics in Saccharomyces cerevisiae. Mol Biol Cell. 2019 Sep 11;:mbcE19070364 Authors: Haribowo AG, Hannich JT, Michel AH, Megyeri M, Schuldiner M, Kornmann B, Riezman H Abstract Hereditary Sensory and Autonomic Neuropathy (HSAN) type IA and IC are caused by elevated levels of an atypical class of lipid named 1-deoxysphingolipid (DoxSL). How elevated levels...
Thu Sep 12, 2019 14:37
Related ArticlesThe intrinsically disordered region of the cytokinetic F-BAR protein Cdc15 provides a unique essential function in maintenance of cytokinetic ring integrity. Mol Biol Cell. 2019 Sep 11;:mbcE19060314 Authors: Mangione MC, Snider CE, Gould KL Abstract Successful separation of two daughter cells (i.e. cytokinesis) is essential for life. Many eukaryotic cells divide using a contractile apparatus called the cytokinetic ring (CR) that associates...
Thu Sep 12, 2019 14:37
Related ArticlesInhibition of Spindle Extension through the Yeast S Phase Checkpoint is Coupled to Replication Fork Stability and the Integrity of Centromeric DNA. Mol Biol Cell. 2019 Sep 11;:mbcE19030156 Authors: Julius J, Peng J, McCulley A, Caridi C, Arnak R, See C, Nugent C, Feng W, Bachant J Abstract Budding yeast treated with hydroxyurea activate the S phase checkpoint kinase Rad53, which prevents DNA replication forks from undergoing aberrant...
Thu Sep 12, 2019 14:37
Imaging endogenous synaptic proteins in primary neurons at single-cell resolution using CRISPR/Cas9.
Related ArticlesImaging endogenous synaptic proteins in primary neurons at single-cell resolution using CRISPR/Cas9. Mol Biol Cell. 2019 Sep 11;:mbcE19040223 Authors: Matsuda T, Oinuma I Abstract Fluorescence imaging at single-cell resolution is a crucial approach to analyze the spatiotemporal regulation of proteins within individual cells of complex neural networks. Here we present a non-viral strategy that enables the tagging of endogenous loci by...
Thu Sep 12, 2019 14:37
Related ArticlesShortened nuclear matrix attachment regions are sufficient for replication and maintenance of episomes in mammalian cells. Mol Biol Cell. 2019 Sep 11;:mbcE19020108 Authors: Wang XY, Zhang X, Wang TY, Jia YL, Xu DH, Yi DD Abstract Matrix attachment regions (MARs) can mediate the replication of vector episomes in mammalian cells; however, the molecular mode of action remains unclear. Here, we assessed the characteristics of MARs and the...
Thu Sep 12, 2019 14:37
Related ArticlesEffects of handwriting exercise on functional outcome in Parkinson disease: A randomized controlled trial. J Clin Neurosci. 2019 Sep 07;: Authors: Vorasoot N, Termsarasab P, Thadanipon K, Pulkes T Abstract Parkinson disease (PD) patients frequently experience micrographia and difficulty writing, which could potentially impact their quality of life. This study aimed to determine whether handwriting exercise could improve fine manual motor...
Thu Sep 12, 2019 14:42
Related ArticlesPrevalence of Laryngeal Cleft in Pediatric Patients With Esophageal Atresia. JAMA Otolaryngol Head Neck Surg. 2018 02 01;144(2):164-168 Authors: Londahl M, Irace AL, Kawai K, Dombrowski ND, Jennings R, Rahbar R Abstract Importance: Esophageal atresia (EA), with or without tracheoesophageal fistula (TEF), and laryngeal cleft are rare congenital anomalies that often occur together. Previous reports have established a link between EA/TEF...
Thu Sep 12, 2019 14:45
Related ArticlesExcess Mucin Impairs Subglottic Epithelial Host Defense in Mechanically Ventilated Patients. Am J Respir Crit Care Med. 2018 08 01;198(3):340-349 Authors: Powell J, Garnett JP, Mather MW, Cooles FAH, Nelson A, Verdon B, Scott J, Jiwa K, Ruchaud-Sparagano MH, Cummings SP, Perry JD, Wright SE, Wilson JA, Pearson J, Ward C, Simpson AJ Abstract RATIONALE: Aspiration of infective subglottic secretions causes ventilator-associated pneumonia...
Thu Sep 12, 2019 14:45
Related ArticlesInterpreting heterogeneity in intestinal tuft cell structure and function. J Clin Invest. 2018 05 01;128(5):1711-1719 Authors: Banerjee A, McKinley ET, von Moltke J, Coffey RJ, Lau KS Abstract Intestinal tuft cells are a morphologically unique cell type, best characterized by striking microvilli that form an apical tuft. These cells represent approximately 0.5% of gut epithelial cells depending on location. While they are known to express...
Thu Sep 12, 2019 14:45
Related ArticlesA Hoarse Warning: Ortner Syndrome. Am J Med. 2018 12;131(12):1460-1462 Authors: Sim MY, Lim YC, So SC, Zhang J, Teo DB PMID: 30102911 [PubMed - indexed for MEDLINE]
Thu Sep 12, 2019 14:45
Related Articles[Evaluación funcional de deglución-aspiración en pacientes sometidos a laringectomía subtotal supracricoidea con cricohioidoepiglotopexia]. Gac Med Mex. 2018;154(6):645-648 Authors: Gallegos-Hernández JF, Díaz-Guzmán ME, Pichardo-Romero PA, Mateos-Aguilar OO, Abrego JA, Ortiz-Maldonado AL Abstract Introduction: Cardiovascular disease is the main cause of mortality worldwide. In women, its incidence increases at the sixth decade of life,...
Thu Sep 12, 2019 14:45
Related ArticlesVagus Nerve Stimulation-Induced Laryngeal Motor Evoked Potentials: A Possible Biomarker of Effective Nerve Activation. Front Neurosci. 2019;13:880 Authors: Vespa S, Stumpp L, Bouckaert C, Delbeke J, Smets H, Cury J, Ferrao Santos S, Rooijakkers H, Nonclercq A, Raedt R, Vonck K, El Tahry R Abstract Vagus nerve stimulation (VNS) therapy is associated with laryngeal muscle activation and induces voice modifications, well-known side effects...
Thu Sep 12, 2019 14:45
Related ArticlesCan the Zuckerkandl tubercle assist in the location of the inferior laryngeal nerve during thyroidectomies? Rev Col Bras Cir. 2019 Sep 09;46(4):e2249 Authors: Freitas CAF, Paroni AF, Santos AN, Silva RJSD, Souza RO, Silva TFD, Levenhagen MMMD Abstract OBJECTIVE: to evaluate whether the lateral projection of the thyroid gland, called Zuckerkandl's tubercle (ZT), can assist the surgeon in identifying the inferior laryngeal nerve during...
Thu Sep 12, 2019 14:45
Related ArticlesTherapeutic Vaccines Against Human Papilloma Viruses: Achievements and Prospects. Biochemistry (Mosc). 2019 Jul;84(7):800-816 Authors: Vonsky MS, Runov AL, Gordeychuk IV, Isaguliants MG Abstract Human papillomaviruses of high carcinogenic risk (HR HPVs) are major etiological agents of malignant diseases of the cervix, vulva, penis, anal canal, larynx, head, and neck. Prophylactic vaccination against HPV, which mainly covers girls and...
Thu Sep 12, 2019 14:45
Related ArticlesEvaluating the implications of Brexit for research collaboration and policy: a network analysis and simulation study. BMJ Open. 2019 Sep 10;9(9):e025025 Authors: Garas G, Cingolani I, Patel VM, Panzarasa P, Darzi A, Athanasiou T Abstract OBJECTIVE: To evaluate the role of the European Union (EU) as a research collaborator in the UK's success as a global leader in healthcare research and innovation and quantify the impact that Brexit may...
Thu Sep 12, 2019 14:45
Related ArticlesTwo cases of multidrug-resistant Neisseria gonorrhoeae related to travel in south-eastern Asia, France, June 2019. Euro Surveill. 2019 Sep;24(36): Authors: Poncin T, Merimeche M, Braille A, Mainardis M, Bebear C, Jacquier H, Berçot B Abstract We report two cases of multidrug-resistant Neisseria gonorrhoeae urogenital infection with ceftriaxone resistance in a heterosexual couple in south-western France who were successfully treated with...
Thu Sep 12, 2019 14:47
Related ArticlesPromoting vaccination in maternity wards ─ motivational interview technique reduces hesitancy and enhances intention to vaccinate, results from a multicentre non-controlled pre- and post-intervention RCT-nested study, Quebec, March 2014 to February 2015. Euro Surveill. 2019 Sep;24(36): Authors: Gagneur A, Battista MC, Boucher FD, Tapiero B, Quach C, De Wals P, Lemaitre T, Farrands A, Boulianne N, Sauvageau C, Ouakki M, Gosselin V, Petit G, Jacques MC,...
Thu Sep 12, 2019 14:47
Related ArticlesSalmonellosis outbreak with novel Salmonella enterica subspecies enterica serotype (11:z41:e,n,z15) attributable to sesame products in five European countries, 2016 to 2017. Euro Surveill. 2019 Sep;24(36): Authors: Meinen A, Simon S, Banerji S, Szabo I, Malorny B, Borowiak M, Hadziabdic S, Becker N, Luber P, Lohr D, Harms C, Plenge-Bönig A, Mellou K, Mandilara G, Mossong J, Ragimbeau C, Weicherding P, Hau P, Dědičová D, Šafaříková L, Nair S, Dallman TJ,...
Thu Sep 12, 2019 14:47
Related ArticlesThe United Kingdom Field Epidemiology Training Programme: meeting programme objectives. Euro Surveill. 2019 Sep;24(36): Authors: Dey P, Brown J, Sandars J, Young Y, Ruggles R, Bracebridge S Abstract IntroductionMost evaluations of field epidemiology training programmes (FETP) are limited to process measures, but stakeholders may need evidence of impact.ObjectiveTo ascertain if the United Kingdom (UK) FETP met its objectives to: (i) strengthen...
Thu Sep 12, 2019 14:47
Related Articles[Prevalence of peripheral vestibular diseases in children in Germany]. HNO. 2019 Sep 10;: Authors: Hülse R, Warken C, Biesdorf A, Erhart M, Rotter N, Hörmann K, Wenzel A Abstract INTRODUCTION: Dizziness is a common complaint among patients; however, a lack of valid data concerning age and gender distribution of dizziness disorders among children under the age of 15 years can preclude effective diagnosis and treatment. The goal of this...
Thu Sep 12, 2019 14:47
Publication date: November 2019Source: International Immunopharmacology, Volume 76Author(s): Xueshibojie Liu, Xintian Jin, Duo Yu, Gang LiuAbstractα-Cyperone is the volatile oil component in Cyperus rotundus L. The previous reports had shown the inhibition of α-Cyperone on NF-κB signaling in LPS-stimulated RAW264.7 cells. However, it is still unclear whether α-Cyperone could suppress inflammatory response in acute lung injury (ALI) induced by LPS. The aim of this study is to investigate the suppression...
Thu Sep 12, 2019 14:49
Publication date: November 2019Source: International Immunopharmacology, Volume 76Author(s): Hua-Wei Zhang, Qian Wang, Hong-Xia Mei, Sheng-Xing Zheng, Abdullahi Mohamed Ali, Qi-Xing Wu, Yang Ye, Hao-Ran Xu, Shu-Yang Xiang, Sheng-Wei JinAbstractAcute lung injury (ALI) and/or acute respiratory distress syndrome (ARDS) are life-threatening critical syndromes characterized by the infiltration of a large number of inflammatory cells that lead to an excessive inflammatory response. Resolvin D1 (RvD1),...
Thu Sep 12, 2019 14:49
Publication date: November 2019Source: International Immunopharmacology, Volume 76Author(s): Laleh Sharifi, Mohammad Reza Nowroozi, Erfan Amini, Masoumeh Kourosh Arami, Mohsen Ayati, Monireh MohsenzadeganAbstractTumor-associated macrophages (TAMs) which are often referred to as immunosuppressive cells (M2 macrophage), constitute a subset of tumor microenvironment cells and affect tumor progression in solid tumors. Recently, these cells have gained remarkable importance as therapeutic candidates for...
Thu Sep 12, 2019 14:49
Publication date: November 2019Source: International Immunopharmacology, Volume 76Author(s): Huining Fan, Wei Chen, Jinshui Zhu, Jing Zhang, Shiqiao PengAbstractToosendanin (TSN), a triterpenoid extracted from the bark of fruit of Melia toosendan Sieb et Zucc, has been proven to have various biological activities including anti-inflammatory activity. But its effects on experimental colitis remain unreported. Herein, we investigated the role and potential mechanisms of TSN in dextran sulfate sodium...
Thu Sep 12, 2019 14:49
Related ArticlesClinical development of CT-P6 in HER2 positive breast cancer. Expert Opin Biol Ther. 2019 Sep 11;:1-6 Authors: Fu C, Stebbing J, Esteva FJ Abstract Introduction: CT-P6 (trastuzumab-pkrb, Herzuma) is a trastuzumab biosimilar approved for use in HER2 positive breast cancer and HER2 positive gastric cancer. CT-P6 has been shown to exhibit similar safety and efficacy profiles to its reference product, trastuzumab. Preclinical and clinical...
Thu Sep 12, 2019 14:50
Related ArticlesPredictors of Long-Term Disease Control and Survival for HER2-Positive Advanced Breast Cancer Patients Treated With Pertuzumab, Trastuzumab, and Docetaxel. Front Oncol. 2019;9:789 Authors: Hopkins AM, Rowland A, McKinnon RA, Sorich MJ Abstract Background: HER2-positive advanced breast cancer (ABC) is associated with significant heterogeneity in long-term disease control and survival. Prognostic models for HER2-positive ABC patients considering...
Thu Sep 12, 2019 14:50
Risk of seizures induced by intracranial research stimulation: analysis of 770 stimulation sessions.
Related ArticlesRisk of seizures induced by intracranial research stimulation: analysis of 770 stimulation sessions. J Neural Eng. 2019 Sep 11;: Authors: Goldstein HE, Smith E, Gross RE, Jobst BC, Lega B, Sperling M, Worrell GA, Zaghloul K, Wanda P, Kahana M, Rizzuto D, Schevon C, McKhann GM, Sheth S Abstract Objective Patients with medically refractory epilepsy often undergo intracranial electroencephalography (iEEG) monitoring to identify...
Thu Sep 12, 2019 14:51
Related ArticlesFascicle specific targeting for selective peripheral nerve stimulation. J Neural Eng. 2019 Sep 11;: Authors: Overstreet CK, Cheng J, Keefer E Abstract Objective Electrical stimulation is a blunt tool for evoking neural activity. Neurons are naturally activated asynchronously and non-uniformly, whereas stimulation drives simultaneous activity within a population of cells. These differences in activation pattern can result in unintended...
Thu Sep 12, 2019 14:51
Abstract Kallikrein-related peptidases (KLKs) are a group of 15 serine proteases implicated in a variety of biological processes. Aberrant expression of KLKs has been associated with the development of certain cancers. However, the role of KLKs in salivary tumors has not been extensively studied. This study evaluated the expression of KLKs in both adenoid cystic carcinoma (ACC) and normal salivary gland tissue. We isolated total RNA from 39 formalin-fixed, paraffin-embedded samples,...
Thu Sep 12, 2019 03:00
Related ArticlesTargeting the receptor-based interactome of the dopamine D1 receptor: looking for heteromer-selective drugs. Expert Opin Drug Discov. 2019 Sep 11;:1-16 Authors: Casadó-Anguera V, Cortés A, Casadó V, Moreno E Abstract Introduction: G protein-coupled receptors (GPCRs) are a superfamily of membrane proteins highly expressed in the brain that are involved in almost all functions of the CNS. During the last twenty years, a large number of...
Thu Sep 12, 2019 14:57
Related ArticlesResponsibility/Threat Overestimation Moderates the Relationship Between Contamination-Based Disgust and Obsessive-Compulsive Concerns About Sexual Orientation. Arch Sex Behav. 2018 05;47(4):1109-1117 Authors: Ching THW, Williams MT, Siev J, Olatunji BO Abstract Disgust has been shown to perform a "disease-avoidance" function in contamination fears. However, no studies have examined the relevance of disgust to obsessive-compulsive (OC)...
Thu Sep 12, 2019 15:03
Related ArticlesHypersexuality, Gender, and Sexual Orientation: A Large-Scale Psychometric Survey Study. Arch Sex Behav. 2018 11;47(8):2265-2276 Authors: Bőthe B, Bartók R, Tóth-Király I, Reid RC, Griffiths MD, Demetrovics Z, Orosz G Abstract Criteria for hypersexual disorder (HD) were proposed for consideration in the DSM-5 but ultimately excluded for a variety of reasons. Regardless, research continues to investigate hypersexual behavior (HB). The...
Thu Sep 12, 2019 15:03
Related ArticlesTaxometric Analysis of the Latent Structure of Pedophilic Interest. Arch Sex Behav. 2018 11;47(8):2223-2240 Authors: McPhail IV, Olver ME, Brouillette-Alarie S, Looman J Abstract The present study examined the latent structure of pedophilic interest. Using data from phallometric tests for pedophilic interest across four samples of offenders (ns = 805, 632, 531, 261), taxometric analyses were conducted to identify whether pedophilic interest...
Thu Sep 12, 2019 15:03
Related ArticlesUnderstanding the Latent Structure of Hypersexuality: A Taxometric Investigation. Arch Sex Behav. 2018 11;47(8):2207-2221 Authors: Kingston DA, Walters GD, Olver ME, Levaque E, Sawatsky M, Lalumière ML Abstract We examined the latent structure and taxonicity of hypersexuality in large university and community samples of male and female respondents. Participants completed the Hypersexual Behavior Inventory (HBI) and Sexual Compulsivity...
Thu Sep 12, 2019 15:03
115 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human physiology These pubmed results were generated on 2019/09/12PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Thu Sep 12, 2019 13:08
115 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human physiology These pubmed results were generated on 2019/09/12PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Thu Sep 12, 2019 15:04
Publication date: Available online 11 September 2019Source: World NeurosurgeryAuthor(s): Johan Pallud, Alexandre Roux, Charles Mellerio
Thu Sep 12, 2019 15:08
Publication date: Available online 12 September 2019Source: World NeurosurgeryAuthor(s): John P. Sheppard, Courtney Duong, Prasanth Romiyo, Daniel Azzam, Yasmine Alkhalid, Thien Nguyen, Diana Babayan, Carlito Lagman, Matthew Z. Sun, Giyarpuram N. Prashant, Joel S. Beckett, Isaac YangABSTRACTObjectiveWe performed a retrospective analysis in a cohort of 1,185 patients at our institution who were identified as undergoing one or more head CT exams during their inpatient stay on the neurosurgery service....
Thu Sep 12, 2019 15:08
Publication date: Available online 12 September 2019Source: World NeurosurgeryAuthor(s): Iraj Lotfinia, Ata MahdkhahAbstractSpinal masses can be diagnosed by clinical and radiographic examinations. Infrequently, pseudotumors may be due to retained masses after surgical interventions. In fact, these spinal or paraspinal expansions are caused by iatrogenic foreign bodies. Pseudotumors are mentioned as textilomas.We present a case of a patient with a history of lumbar diskectomy in the L2-L3 segments...
Thu Sep 12, 2019 15:08
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