A new research has published the Victorian Childhood Hearing Impairment Longitudinal Databank (VicCHILD), which promises to help researchers across the globe in understanding why some children with hearing loss adapt and thrive better than others. The databank containing profiles children with hearing loss shows that language development and speech in hearing-impaired children are slower compared with the development of children with normal hearing, despite advancements in earlier detection...
Tue Sep 03, 2019 17:02
Purpose: Catastrophization refers to the cognitive distortion that is experienced by patients with several diseases who suffer from pain. There is some evidence that catastrophization may be found in patients with voice disorders. The Voice Catastrophization Index (VCI) was developed in English to measure catastrophization in patients with dysphonia. The goal of this research was to translate and validate the Persian version of the VCI (P-VCI) for use with Persian-speaking people in Iran and elsewhere....
Wed Sep 04, 2019 11:31
Publication date: Available online 3 September 2019Source: Journal of VoiceAuthor(s): Nicholas A. Barone, Christy L. Ludlow, Cari M. TellisSummaryCharacteristics of true vocal fold vibration such as the proportion of closed phase of vibration to open phase, longitudinal tension, and the amount of medial compression are used to define four conditions during Estill Voice Training. However, it is unknown whether trainees achieve these phonatory differences after training. Acoustic and aerodynamic measures...
Wed Sep 04, 2019 12:46
Related ArticlesThe very large electrode array for retinal stimulation (VLARS) - a concept study. J Neural Eng. 2019 Sep 03;: Authors: Lohmann TK, Haiss F, Schaffrath K, Schnitzler AC, Waschkowski F, Barz C, van der Meer AM, Werner C, Johnen S, Laube T, Bornfeld N, Mazinani B, Roessler G, Mokwa W, Walter P Abstract BACKGROUND: The restoration of vision in blind patients suffering from degenerative retinal diseases like retinitis pigmentosa (RP) may be...
Wed Sep 04, 2019 15:01
Related ArticlesSpinal cord neural interfacing in common marmosets (Callithrix jacchus). J Neural Eng. 2019 Sep 03;: Authors: Prins NW, Mylavarapu R, Shoup AM, Debnath S, Prasad A Abstract OBJECTIVE: Spinal cord injury (SCI) remains an ailment with no comprehensive cure, and affected patients suffer from a greatly diminished quality of life. This large population could significantly benefit from prosthetic technologies to replace missing limbs, reanimate...
Wed Sep 04, 2019 15:01
Related ArticlesMechanical considerations for design and implementation of peripheral intraneural devices. J Neural Eng. 2019 Sep 03;: Authors: Stiller AM, González-González MA, Boothby JM, Sherman SE, Benavides J, Romero-Ortega M, Pancrazio JJ, Black BJ Abstract OBJECTIVE: Neural interfaces designed to stimulate or record electrical activity from peripheral nerves have applications ranging from the electrical modulation of nerve activity as a therapeutic...
Wed Sep 04, 2019 15:01
Related ArticlesDiagnosis and Outcome of Biopsies of Indeterminate Lesions of the Cavernous Sinus and Meckel's Cave: A Retrospective Case Series in 85 Patients. Neurosurgery. 2018 09 01;83(3):529-539 Authors: Hughes JD, Kapurch J, Van Gompel JJ, Meyer FB, Pollock BE, Atkinson J, Link MJ Abstract BACKGROUND: When clinical presentation, laboratory studies, or imaging cannot diagnose cavernous sinus (CS) and/or Meckel's cave (MC) lesions, biopsy may be...
Wed Sep 04, 2019 13:01
Related ArticlesPaediatric Bonebridge: bilateral simultaneous asymmetrical implantation. J Laryngol Otol. 2019 Aug;133(8):719-722 Authors: Dusu K, Walsh M, Eze N Abstract BACKGROUND: The Bonebridge is an active transcutaneous bone conduction implant recommended as a surgical option for adults and children (aged 5-18 years). Successful implantation of the Bonebridge is often restricted by an insufficient amount of temporal bone to house the transducer...
Wed Sep 04, 2019 13:01
Related ArticlesIntracranial actinomycosis of odontogenic origin masquerading as auto-immune orbital myositis: a fatal case and review of the literature. BMC Infect Dis. 2019 Sep 02;19(1):763 Authors: Hötte GJ, Koudstaal MJ, Verdijk RM, Titulaer MJ, Claes JFHM, Strabbing EM, van der Lugt A, Paridaens D Abstract BACKGROUND: Actinomycetes can rarely cause intracranial infection and may cause a variety of complications. We describe a fatal case of intracranial...
Wed Sep 04, 2019 13:01
Related ArticlesDevelopment and Validation of Novel Three-Dimensional Craniofacial Landmarks on Cone-Beam Computed Tomography Scans. J Craniofac Surg. 2019 Jun 27;: Authors: Liberton DK, Verma P, Contratto A, Lee JS Abstract As cone-beam computed tomography (CBCT) scans become increasingly common, it is vital to have reliable 3-dimensional (3D) landmarks for quantitative analysis of craniofacial skeletal morphology. While some studies have developed...
Wed Sep 04, 2019 14:56
Related ArticlesSupracerebellar Approach to a Radiation-Induced Giant Capillary Telangiectasia within a Juvenile Pilocytic Astrocytoma of the Upper Brainstem. World Neurosurg. 2019 Aug 31;: Authors: Rubio RR, Chae R, Khare A, Dubnicoff T, Winkler E, Sloan E, Bollen AW, Berger MS, Abla AA PMID: 31479784 [PubMed - as supplied by publisher]
Wed Sep 04, 2019 14:56
Related ArticlesConsensus guidance of nebulizer therapy for acute rhinosinusitis. Auris Nasus Larynx. 2019 Aug 31;: Authors: Ohki M, Hyo Y, Yoshiyama Y, Takano H, Takahata J, Suzuki M, Takeno S, Ogoshi T, Suzuki K, Takeuchi K, Naito K, Haruna S, Fujisawa T, Yamaguchi S, Hotomi M, Kawauchi H, Kurono Y, working group of the Japan Society for Infection and Aerosol in Otorhinolaryngology Abstract The guidance deals with the recommended applications, procedures,...
Wed Sep 04, 2019 13:05
Related ArticlesConcomitant use of rapamycin and rosiglitazone delays the progression of polycystic kidney disease in Han:SPRD rats: a study of the mechanism of action. Am J Physiol Renal Physiol. 2018 05 01;314(5):F844-F854 Authors: Liu C, Li H, Gao X, Yang M, Yuan L, Fu L, Wang X, Mei C Abstract Attributing to their antiproliferative effect, both rapamycin and peroxisome proliferator-activated receptor-γ (PPARγ) can halt the progression of autosomal...
Wed Sep 04, 2019 13:11
Related ArticlesEBV-associated gastric cancer evades T-cell immunity by PD-1/PD-L1 interactions. Gastric Cancer. 2019 05;22(3):486-496 Authors: Sasaki S, Nishikawa J, Sakai K, Iizasa H, Yoshiyama H, Yanagihara M, Shuto T, Shimokuri K, Kanda T, Suehiro Y, Yamasaki T, Sakaida I Abstract BACKGROUND: Epstein-Barr virus (EBV) is an oncogenic human herpesvirus involved in the development of around 10% of gastric cancers. The overexpression of PD-L1 is one...
Wed Sep 04, 2019 13:11
Related ArticlesProgression of Meiosis Is Coordinated by the Level and Location of MAPK Activation Via OGR-2 in Caenorhabditis elegans. Genetics. 2019 05;212(1):213-229 Authors: Achache H, Laurent L, Hecker-Mimoun Y, Ishtayeh H, Rappaport Y, Kroizer E, Colaiácovo MP, Tzur YB Abstract During meiosis, a series of evolutionarily conserved events allow for reductional chromosome division, which is required for sexual reproduction. Although individual meiotic...
Wed Sep 04, 2019 13:11
Related ArticlesCelastrol induce apoptosis of human multiple myeloma cells involving inhibition of proteasome activity. Eur J Pharmacol. 2019 Jun 15;853:184-192 Authors: Zhong YL, Xu GJ, Huang S, Zhao L, Zeng Y, Xiao XF, An JL, Liu J, Yang T Abstract Celastrol exhibits anticancer activity and has a number of potential molecular targets. Among them, the proteasome has attracted particular attention. Although celastrol inhibits multiple myeloma (MM) cell...
Wed Sep 04, 2019 13:11
Related ArticlesCcr4-Not maintains genomic integrity by controlling the ubiquitylation and degradation of arrested RNAPII. Genes Dev. 2019 06 01;33(11-12):705-717 Authors: Jiang H, Wolgast M, Beebe LM, Reese JC Abstract The Ccr4-Not complex regulates essentially every aspect of gene expression, from mRNA synthesis to protein destruction. The Not4 subunit of the complex contains an E3 RING domain and targets proteins for ubiquitin-dependent proteolysis....
Wed Sep 04, 2019 13:11
Related ArticlesDiscovery of Natural Dimeric Naphthopyrones as Potential Cytotoxic Agents Through ROS-Mediated Apoptotic Pathway. Mar Drugs. 2019 Apr 02;17(4): Authors: Xu K, Guo C, Shi D, Meng J, Tian H, Guo S Abstract A study on the secondary metabolites of Aspergillus sp. XNM-4, which was derived from marine algae Leathesia nana (Chordariaceae), led to the identification of one previously undescribed (1) and seventeen known compounds (2-18). Their...
Wed Sep 04, 2019 13:11
Related ArticlesA nuclear permeable Ru(ii)-based photoactivated chemotherapeutic agent towards a series of cancer cells: in vitro and in vivo studies. Dalton Trans. 2019 May 15;48(19):6492-6500 Authors: Tian N, Feng Y, Sun W, Lu J, Lu S, Yao Y, Li C, Wang X, Zhou Q Abstract Ru(ii) polypyridyl complexes which can undergo photo-induced ligand dissociation and DNA covalent binding are considered as potential photoactivated chemotherapeutic (PACT) agents....
Wed Sep 04, 2019 13:11
Related ArticlesImmune check-point in endometrial cancer. Int J Clin Oncol. 2019 Aug;24(8):910-916 Authors: De Felice F, Marchetti C, Tombolini V, Panici PB Abstract BACKGROUND: Endometrial cancer (EC) is one of the most frequent tumors in women. Despite recent advances in treatment approaches, the prognosis in advanced, recurrent, or metastatic disease remains poor. The aim was to provide the clinician with an update, the current status, and the new...
Wed Sep 04, 2019 13:11
Related ArticlesTrichostatin A‑induced miR‑30a‑5p regulates apoptosis and proliferation of keloid fibroblasts via targeting BCL2. Mol Med Rep. 2019 Jun;19(6):5251-5262 Authors: Jian X, Qu L, Wang Y, Zou Q, Zhao Q, Chen S, Gao X, Chen H, He C Abstract Keloids are benign fibrous overgrowths that occur as a result of abnormal wound healing following cutaneous injury. MicroRNAs (miRNAs/miRs) are short non‑coding RNAs that serve critical roles in numerous...
Wed Sep 04, 2019 13:11
Related ArticlesPristimerin Induces Autophagy-Mediated Cell Death in K562 Cells through the ROS/JNK Signaling Pathway. Chem Biodivers. 2019 Aug;16(8):e1900325 Authors: Liu Y, Ren Z, Li X, Zhong J, Bi Y, Li R, Zhao Q, Yu X Abstract Chronic myeloid leukemia (CML) is a lethal malignancy, and the progress toward long-term survival has stagnated in recent decades. Pristimerin, a quinone methide triterpenoid isolated from the Celastraceae and Hippocrateaceae...
Wed Sep 04, 2019 13:11
Related ArticlesThe promise of combining cancer vaccine and checkpoint blockade for treating HPV-related cancer. Cancer Treat Rev. 2019 Aug;78:8-16 Authors: Shibata T, Lieblong BJ, Sasagawa T, Nakagawa M Abstract Human papillomavirus (HPV)-associated intraepithelial neoplasia or cancers are ideal candidates for cancer immunotherapy since HPV oncoproteins, such as E6 and E7 proteins of high-risk HPVs, could be utilized as foreign antigens. In HPV-associated...
Wed Sep 04, 2019 13:11
Related ArticlesCheckpoint inhibitors in pancreatic cancer. Cancer Treat Rev. 2019 Aug;78:17-30 Authors: Henriksen A, Dyhl-Polk A, Chen I, Nielsen D Abstract INTRODUCTION: Immune checkpoint inhibitors, targeting cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and the programmed cell death protein-1 (PD-1)/programmed cell death ligand-1 (PD-L1) pathways have shown remarkable potential in several types of cancer. In this review we summarize published...
Wed Sep 04, 2019 13:11
Related ArticlesA New Histone Deacetylase Inhibitor, MHY4381, Induces Apoptosis via Generation of Reactive Oxygen Species in Human Prostate Cancer Cells. Biomol Ther (Seoul). 2019 Sep 03;: Authors: Richa S, Dey P, Park C, Yang J, Son JY, Park JH, Lee SH, Ahn MY, Kim IS, Moon HR, Kim HS Abstract Histone deacetylase (HDAC) inhibitors represent a novel class of anticancer agents, which can be used to inhibit cell proliferation and induce apoptosis in several...
Wed Sep 04, 2019 13:11
Related ArticlesMalarone® induced pancreatitis and alopecia in a dog: a case report. BMC Vet Res. 2019 Sep 02;15(1):314 Authors: Choi HI, Ko HY, Shin IS, Kim HJ Abstract BACKGROUND: Malarone® is a drug used for the treatment of malaria in humans. This drug is also particularly effective in the treatment of canine Babesia gibsoni infections. Malarone® is rarely used in dogs, and its adverse effects have not been widely reported. Its mechanism of action...
Wed Sep 04, 2019 13:11
Related ArticlesCyclin dependent kinase (CDK) inhibitors as anticancer drugs: Recent advances (2015-2019). Bioorg Med Chem Lett. 2019 Aug 26;:126637 Authors: Sánchez-Martínez C, Lallena MJ, Sanfeliciano SG, de Dios A Abstract Sustained proliferative capacity and gene dysregulation are hallmarks of cancer. In mammalian cells, cyclin-dependent kinases (CDKs) control critical cell cycle checkpoints and key transcriptional events in response to extracellular...
Wed Sep 04, 2019 13:11
Related ArticlesA potential prognostic marker and therapeutic target: SPOCK1 promotes the proliferation, metastasis, and apoptosis of pancreatic ductal adenocarcinoma cells. J Cell Biochem. 2019 Sep 03;: Authors: Li J, Ke J, Fang J, Chen JP Abstract Pancreatic ductal adenocarcinoma (PDAC), a common malignancy originated from the digestive system worldwide, has a poor clinical outcome. SPOCK1 is a widely investigated member of the Ca2+ -binding proteoglycan...
Wed Sep 04, 2019 13:11
Related ArticlesLoss of CENPF leads to developmental failure in mouse embryos. Cell Cycle. 2019 Sep 03;:1-16 Authors: Zhou CJ, Wang XY, Han Z, Wang DH, Ma YZ, Liang CG Abstract Aneuploidy caused by abnormal chromosome segregation during early embryo development leads to embryonic death or congenital malformation. Centromere protein F (CENPF) is a member of centromere protein family that regulates chromosome segregation during mitosis. However, its necessity...
Wed Sep 04, 2019 15:09
Related ArticlesWogonoside Inhibits Prostate Cancer Cell Growth and Metastasis via Regulating Wnt/β-Catenin Pathway and Epithelial-Mesenchymal Transition. Pharmacology. 2019 Sep 03;:1-8 Authors: Wei C, Jing J, Zhang Y, Fang L Abstract BACKGROUND: Wogonoside, an effective component of Scutellaria baicalensis extract, has recently become a hot topic for its newly discovered anticancer efficacy, but the underlying pharmacological mechanism is still unclear....
Wed Sep 04, 2019 15:09
Related ArticlesChanges in craniofacial and airway morphology as well as quality of life after passive myofunctional therapy in children with obstructive sleep apnea: a comparative cohort study. Sleep Breath. 2019 Sep 03;: Authors: Chuang LC, Hwang YJ, Lian YC, Hervy-Auboiron M, Pirelli P, Huang YS, Guilleminault C Abstract PURPOSE: To examine the craniofacial and airway morphology as well as the quality of life before and after passive myofunctional...
Wed Sep 04, 2019 13:19
In patients with ST-segment elevation myocardial infarction (STEMI), the preferred method of reperfusion is primary percutaneous coronary intervention (PCI) with stent implantation. In these patients, dual antiplatelet therapy, consisting of aspirin and a P2Y12 inhibitor, is essential to prevent…
Tue Sep 03, 2019 03:00
Related Articles[Influence of single-sided deafness on the auditory capacity of the better ear. German version]. HNO. 2019 Sep 02;: Authors: Arndt S, Wesarg T, Stelzig Y, Jacob R, Illg A, Lesinski-Schiedat A, Ketterer MC, Aschendorff A, Speck I Abstract BACKGROUND: Patients with single-sided deafness (SSD) are limited by their asymmetric hearing in various areas of everyday life. OBJECTIVE: The aim of this investigation was to perform an age-correlated...
Wed Sep 04, 2019 13:35
Related ArticlesImprovement in tinnitus distress, health-related quality of life and psychological comorbidities by cochlear implantation in single-sided deaf patients. HNO. 2019 Sep 02;: Authors: Häußler SM, Knopke S, Dudka S, Gräbel S, Ketterer MC, Battmer RD, Ernst A, Olze H Abstract BACKGROUND: Patients with single-sided deafness (SSD) lack the ability localize sound sources and have difficulty with speech-in-noise hearing. In addition, there is...
Wed Sep 04, 2019 13:35
Related ArticlesEtiology and therapy indication for cochlear implantation in children with single-sided deafness : Retrospective analysis. HNO. 2019 Sep 02;: Authors: Cushing SL, Gordon KA, Sokolov M, Papaioannou V, Polonenko M, Papsin BC Abstract OBJECTIVE: The characteristics of children with single-sided deafness (SSD) who become candidates for unilateral cochlear implantation (uCI) were identified. STUDY DESIGN: In all, 118 children with...
Wed Sep 04, 2019 13:35
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