External Quality Assurance of Current Technology for the Testing of Cancer-Associated Circulating Free DNA Variants

Abstract Liquid biopsy testing is rapidly emerging as a diagnostic means of identifying circulating free DNA (cfDNA) disease-associated variants. However, the reporting of cfDNA variants remains inconsistent due in part to the application of multiple testing pipelines which raise uncertainty about current cfDNA detection efficiency. External quality assurance (EQA) programs are required to monitor, evaluate and help improve laboratory performance for cfDNA variant detection and...

Pathology & Oncology Research

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Issue Information

Pathology International

Thu Aug 29, 2019 21:37

Core needle biopsy of benign, borderline and in-situ problematic lesions of the breast: Diagnosis, differential diagnosis and immunohistochemistry

Publication date: Available online 3 September 2019Source: Annals of Diagnostic PathologyAuthor(s): Marilin Rosa, Emmanuel Agosto-ArroyoAbstractCore needle biopsy (CNB) is the most common sampling technique for the histologic evaluation of breast abnormalities. Diagnosing benign proliferative, borderline and some in-situ lesions in CNB is challenging and subject to a significant degree of interobserver variability. In addition, due to the inherent limitations of CNB, “upgrading” to a more significant...

Annals of Diagnostic Pathology

Wed Sep 04, 2019 20:24

Pulmonary metastasis of cribriform‐morular variant of thyroid carcinoma mimicking primary adenocarcinoma of the lung: A potential pitfall

Abstract Cribriform‐morular variant of papillary thyroid carcinoma (CMV‐TC) shows a peculiar mixture of follicular, cribriform, papillary, trabecular, and solid patterns with squamoid morules. Ocassionally, lung metastasis may be interpreted incorrectly as primary lung adenocarcinoma. We illustrate a case of pulmonary meastasis of CMV‐TC mimicking a primary adenocarcinoma, 7 years after diagnosis of CMV‐TC. The lung metastases may be easily missed if the pathologist is unaware of the patient's prior...

Diagnostic Cytopathology

Wed Sep 04, 2019 17:45

Distribution of neuronal nitric oxide synthase immunoreactivity in adult male Sprague-Dawley rat brain

Publication date: Available online 4 September 2019Source: Acta HistochemicaAuthor(s): Pit Shan Chong, Chi Him Poon, Man Lung Fung, Li Guan, Harry W.M. Steinbusch, Ying-Shing Chan, Wei Ling Lim, Lee Wei LimAbstractNeuronal NOS (nNOS) accounts for most of the NO production in the nervous system that modulates synaptic transmission and neuroplasticity. Although previous studies have selectively described the localisation of nNOS in specific brain regions, a comprehensive distribution profile of nNOS...

Acta Histochemica

Wed Sep 04, 2019 14:47

Shp2 expression is upregulated in cervical cancer, and Shp2 contributes to cell growth and migration and reduces sensitivity to cisplatin in cervical cancer cells

Publication date: Available online 3 September 2019Source: Pathology - Research and PracticeAuthor(s): Meng Cao, Dan Gao, Nana Zhang, Yixin Duan, Ying Wang, Hasan Mujtaba, Yili WangAbstractSrc homology phosphotyrosine phosphatase 2 (Shp2) has been found to be overexpressed in cervical cancer tissues. However, the influence of Shp2 on the biological behavior and sensitivity to cisplatin of cervical cancer cells remains unclear. We aimed to assess Shp2 expression in cervical tissues and cell lines...

ScienceDirect Publication: Pathology - Research and Practice

Wed Sep 04, 2019 13:08

Knockdown of long non-coding RNA TINCR decreases radioresistance in colorectal cancer cells

Publication date: Available online 3 September 2019Source: Pathology - Research and PracticeAuthor(s): Zhengchun Kang, E Jifu, Kai Guo, Xiuzhu Ma, Yingyi Zhang, Enda YuAbstractAn increasing number of studies have revealed the role of long non-coding RNAs in cancer. However, the mechanisms of action and functional utility in colorectal cancer (CRC) have not been fully elucidated. Here we describe the functional role and potential mechanism of TINCR (terminal differentiation-induced non-coding RNA)...

ScienceDirect Publication: Pathology - Research and Practice

Wed Sep 04, 2019 13:08