Related ArticlesMulti-institutional evaluation of knowledge-based planning performance of volumetric modulated arc therapy (VMAT) for head and neck cancer. Phys Med. 2019 Aug;64:174-181 Authors: Kamima T, Ueda Y, Fukunaga JI, Shimizu Y, Tamura M, Ishikawa K, Monzen H Abstract PURPOSE: The aim of this study was to investigate whether additional manual objectives are necessary for the RapidPlan (RP) with a single optimization. We conducted multi-institutional...
Sat Sep 14, 2019 13:47
Related ArticlesNext-generation ARIA care pathways for rhinitis and asthma: a model for multimorbid chronic diseases. Clin Transl Allergy. 2019;9:44 Authors: Bousquet JJ, Schünemann HJ, Togias A, Erhola M, Hellings PW, Zuberbier T, Agache I, Ansotegui IJ, Anto JM, Bachert C, Becker S, Bedolla-Barajas M, Bewick M, Bosnic-Anticevich S, Bosse I, Boulet LP, Bourrez JM, Brusselle G, Chavannes N, Costa E, Cruz AA, Czarlewski W, Fokkens WJ, Fonseca JA, Gaga M, Haahtela T, Illario...
Sat Sep 14, 2019 15:42
Related ArticlesParanasal sinus invasion suggested T4 classification of patients of nasopharyngeal carcinoma: A two-center retrospective investigation. Head Neck. 2019 Sep 13;: Authors: Wu L, Zhuo S, Zeng W, Liang S, Wang S, Cui C, Zhou J, Ruan G, Xu S, Wang L, Huang L, Liu L, Li H Abstract BACKGROUND: To investigate the prognostic significance of paranasal sinus invasion in nasopharyngeal carcinoma (NPC) patients. METHODS: Patients with NPC...
Sat Sep 14, 2019 15:42
Related ArticlesUnderstanding the industrial contribution to pollution offers opportunities to further improve air quality in the United States. Proc Natl Acad Sci U S A. 2019 Sep 11;: Authors: Moreno-Cruz J PMID: 31511418 [PubMed - as supplied by publisher]
Fri Sep 13, 2019 13:01
Related ArticlesMechanism of activation of the human cysteine desulfurase complex by frataxin. Proc Natl Acad Sci U S A. 2019 Sep 11;: Authors: Patra S, Barondeau DP Abstract The function of frataxin (FXN) has garnered great scientific interest since its depletion was linked to the incurable neurodegenerative disease Friedreich's ataxia (FRDA). FXN has been shown to be necessary for iron-sulfur (Fe-S) cluster biosynthesis and proper mitochondrial function....
Fri Sep 13, 2019 13:01
Related ArticlesThe nucleosome core particle remembers its position through DNA replication and RNA transcription. Proc Natl Acad Sci U S A. 2019 Sep 11;: Authors: Schlissel G, Rine J Abstract Nucleosomes are the fundamental structural unit of chromatin. In addition to stabilizing the DNA polymer, nucleosomes are modified in ways that reflect and affect gene expression in their vicinity. It has long been assumed that nucleosomes can transmit memory of...
Fri Sep 13, 2019 13:01
Related ArticlesRevisiting the protomotive vectorial motion of F0-ATPase. Proc Natl Acad Sci U S A. 2019 Sep 11;: Authors: Bai C, Warshel A Abstract The elucidation of the detailed mechanism used by F0 to convert proton gradient to torque and rotational motion presents a major puzzle despite significant biophysical and structural progress. Although the conceptual model has advanced our understanding of the working principles of such systems, it is crucial...
Fri Sep 13, 2019 13:01
Related ArticlesWhat network motifs tell us about resilience and reliability of complex networks. Proc Natl Acad Sci U S A. 2019 Sep 11;: Authors: Dey AK, Gel YR, Poor HV Abstract Network motifs are often called the building blocks of networks. Analysis of motifs has been found to be an indispensable tool for understanding local network structure, in contrast to measures based on node degree distribution and its functions that primarily address a global...
Fri Sep 13, 2019 13:01
Related ArticlesNucleosomes remember where they were. Proc Natl Acad Sci U S A. 2019 Sep 11;: Authors: Henikoff S, Ahmad K PMID: 31511423 [PubMed - as supplied by publisher]
Fri Sep 13, 2019 13:01
Related ArticlesFast-diffusing p75NTR monomers support apoptosis and growth cone collapse by neurotrophin ligands. Proc Natl Acad Sci U S A. 2019 Sep 12;: Authors: Marchetti L, Bonsignore F, Gobbo F, Amodeo R, Calvello M, Jacob A, Signore G, Schirripa Spagnolo C, Porciani D, Mainardi M, Beltram F, Luin S, Cattaneo A Abstract The p75 neurotrophin (NT) receptor (p75NTR) plays a crucial role in balancing survival-versus-death decisions in the nervous system....
Sat Sep 14, 2019 13:50
Related ArticlesPhysiological signaling in the absence of amidated peptides. Proc Natl Acad Sci U S A. 2019 Sep 12;: Authors: Lindberg I, Glembotski CC PMID: 31515450 [PubMed - as supplied by publisher]
Sat Sep 14, 2019 13:50
Related ArticlesA network of phosphatidylinositol 4,5-bisphosphate binding sites regulates gating of the Ca2+-activated Cl- channel ANO1 (TMEM16A). Proc Natl Acad Sci U S A. 2019 Sep 12;: Authors: Yu K, Jiang T, Cui Y, Tajkhorshid E, Hartzell HC Abstract ANO1 (TMEM16A) is a Ca2+-activated Cl- channel that regulates diverse cellular functions including fluid secretion, neuronal excitability, and smooth muscle contraction. ANO1 is activated by elevation...
Sat Sep 14, 2019 13:50
Related ArticlesThermalization and possible signatures of quantum chaos in complex crystalline materials. Proc Natl Acad Sci U S A. 2019 Sep 12;: Authors: Zhang J, Kountz ED, Behnia K, Kapitulnik A Abstract Analyses of thermal diffusivity data on complex insulators and on strongly correlated electron systems hosted in similar complex crystal structures suggest that quantum chaos is a good description for thermalization processes in these systems, particularly...
Sat Sep 14, 2019 13:50
Publication date: 15 November 2019Source: NeuroImage, Volume 202Author(s): Xiangbin Teng, Gregory B. Cogan, David PoeppelAbstractSegmenting the continuous speech stream into units for further perceptual and linguistic analyses is fundamental to speech recognition. The speech amplitude envelope (SE) has long been considered a fundamental temporal cue for segmenting speech. Does the temporal fine structure (TFS), a significant part of speech signals often considered to contain primarily spectral information,...
Fri Sep 13, 2019 13:03
Publication date: 15 November 2019Source: NeuroImage, Volume 202Author(s): Joshua O. Eayrs, Nilli LavieAbstractCapacity limits in perception can lead to failures of awareness in situations that overload capacity, resulting in various phenomena of ‘inattentional blindness’. In contrast, capacity limits in cognitive control over attention by working memory lead to increased processing of irrelevant distractors (reduced inattentional blindness). Here, using Voxel-Based Morphometry combined with Principal...
Fri Sep 13, 2019 13:03
Publication date: 15 November 2019Source: NeuroImage, Volume 202Author(s): Michalis Kassinopoulos, Georgios D. MitsisAbstractFunctional magnetic resonance imaging (fMRI) is widely viewed as the gold standard for studying brain function due to its high spatial resolution and non-invasive nature. However, it is well established that changes in breathing patterns and heart rate strongly influence the blood oxygen-level dependent (BOLD) fMRI signal and this, in turn, can have considerable effects on...
Sat Sep 14, 2019 14:00
Publication date: 15 November 2019Source: NeuroImage, Volume 202Author(s): Emma Christiaen, Marie-Gabrielle Goossens, Robrecht Raedt, Benedicte Descamps, Lars Emil Larsen, Erine Craey, Evelien Carrette, Kristl Vonck, Paul Boon, Christian VanhoveAbstractEpilepsy is a neurological disorder characterized by recurrent epileptic seizures. Electrophysiological and neuroimaging studies in patients with epilepsy suggest that abnormal functional brain networks play a role in the development of epilepsy, i.e....
Sat Sep 14, 2019 14:00
Publication date: 15 November 2019Source: NeuroImage, Volume 202Author(s): Ariane Saliani, Aldo Zaimi, Harris Nami, Tanguy Duval, Nikola Stikov, Julien Cohen-AdadAbstractAtlases of the central nervous system are essential for understanding the pathophysiology of neurological diseases, which remains one of the greatest challenges in neuroscience research today. These atlases provide insight into the underlying white matter microstructure and have been created from a variety of animal models, including...
Sat Sep 14, 2019 14:00
Publication date: 15 November 2019Source: NeuroImage, Volume 202Author(s): Yikang Liu, Nanyin ZhangAbstractSlow propagations of spontaneous brain activity have been reported in multiple species. However, systematical investigation of the organization of such brain activity is still lacking. In this study, we analyzed propagations of spontaneous brain activity using a reference library of characteristic resting-state functional connectivity (RSFC) patterns in awake rodents. We found that transitions...
Sat Sep 14, 2019 14:00
Related ArticlesX-ray pumping of the 229Th nuclear clock isomer. Nature. 2019 Sep;573(7773):238-242 Authors: Masuda T, Yoshimi A, Fujieda A, Fujimoto H, Haba H, Hara H, Hiraki T, Kaino H, Kasamatsu Y, Kitao S, Konashi K, Miyamoto Y, Okai K, Okubo S, Sasao N, Seto M, Schumm T, Shigekawa Y, Suzuki K, Stellmer S, Tamasaku K, Uetake S, Watanabe M, Watanabe T, Yasuda Y, Yamaguchi A, Yoda Y, Yokokita T, Yoshimura M, Yoshimura K Abstract The metastable first...
Fri Sep 13, 2019 14:28
Related ArticlesIntensifying ozonation treatment of municipal secondary effluent using a combination of microbubbles and ultraviolet irradiation. Environ Sci Pollut Res Int. 2019 Jul;26(21):21915-21924 Authors: Gao Y, Duan Y, Fan W, Guo T, Huo M, Yang W, Zhu S, An W Abstract Ozonation treatment of municipal secondary effluent is complicated by the low solubility of ozone and inefficient production of hydroxyl free radicals from ozone decomposition....
Sat Sep 14, 2019 14:02
Related ArticlesCooler temperatures slow the repair of DNA damage in tadpoles exposed to ultraviolet radiation: implications for amphibian declines at high altitude. Glob Chang Biol. 2019 Sep 13;: Authors: Morison SA, Cramp RL, Alton LA, Franklin CE Abstract Ultraviolet B radiation (UVBR) damages the DNA of exposed cells, causing dimers to form between adjacent pyrimidine nucleotides. These dimers block DNA replication, causing mutations and apoptosis....
Sat Sep 14, 2019 17:57
Publication date: Available online 12 September 2019Source: Medical HypothesesAuthor(s): E. Acaroglu, M. Doany, E. Cetin, R. CasteleinAbstractAdolescent Idiopathic Scoliosis (AIS) is a complex three dimensional deformity the treatment of which remains to be surgical correction of the deformity as it had progressed over certain thresholds. The main focus in surgical treatment had, for decades, been the amount of correction in the coronal plane whereas corrections in sagittal and rotational (axial)...
Fri Sep 13, 2019 16:00
Publication date: Available online 14 September 2019Source: Medical HypothesesAuthor(s): Leslie C. NorinsAbstractThe estimated 5.8 million Alzheimer’s disease patients in the U.S. require an enormous share of national healthcare expenditures. Other nations face similar economic burdens. There have been great efforts, thus far unsuccessful, to discover an effective therapeutic, with 1,081 Alzheimer’s disease drug trials completed as of May 2019. The pessimism thus engendered has forestalled contingency...
Sat Sep 14, 2019 14:07
Publication date: Available online 14 September 2019Source: Medical HypothesesAuthor(s): Eliseu da Cruz Moreira-JuniorAbstractDespite decades of research on Parkinson’s disease (PD), the etiology of this disease remains unclear. The present manuscript introduces a new hypothesis proposing a hyper-serotonergic state as the main mechanism leading to axonal impairment both in dopaminergic and serotonergic neurons in PD. The strong serotonergic connection between the raphe nuclei and the dorsal raphe...
Sat Sep 14, 2019 14:07
Publication date: Available online 14 September 2019Source: Medical HypothesesAuthor(s): Charles G. CoffeyAbstractIn this paper are discussed reasons to suspect that measurements of serum endothelin levels in women with preeclampsia may not provide accurate estimations of the degree of systemic endothelin receptor activation and reasons to suspect that systemic endothelin receptor saturation studies should provide such estimations more accurately.
Sat Sep 14, 2019 14:07
Related ArticlesCilostazol ameliorates high free fatty acid (FFA)-induced activation of NLRP3 inflammasome in human vascular endothelial cells. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):3704-3710 Authors: Wang X, Huang H, Su C, Zhong Q, Wu G Abstract Cardiovascular disease is recognized as a leading cause of death worldwide, but the risk of death is 2-3 times higher for individuals with diabetes. NLRP3 inflammasome activation is a leading pathway...
Sat Sep 14, 2019 14:11
Publication date: Available online 12 September 2019Source: Gene Expression PatternsAuthor(s): Yumi Sato, Akira Sato, Shota Mizuno, Jun-na Hirota, Shuhei Fujima, Chiaki Ishii, Yoshitake Sano, Teiichi FuruichiAbstractEngulfment and cell motility (ELMO) proteins bind to Dock180, a guanine nucleotide exchange factor (GEF) of the Rac family, and regulate GEF activity. The resultant ELMO/Dock180/Rac module regulates cytoskeletal reorganization responsible for the engulfment of apoptotic cells, cell migration,...
Fri Sep 13, 2019 13:40
Publication date: Available online 14 September 2019Source: Gene Expression PatternsAuthor(s): P. Arya, P.K. Pradhan, Anutosh Paria, R. Sharma, Dev K. Verma, Ravindra, G. Rathore, N. SoodAbstractIndia is the second largest fish producing country in the world with production of 12.6 million tonnes (mt) in 2017–18, and Indian major carps (IMCs) share bulk of this fish production. Catla, Catla catla is the fastest growing species among IMCs. However, the survival rate of catla during larval rearing...
Sat Sep 14, 2019 14:12
The prevalence of hearing loss among mining and oil and gas extraction noise-exposed workers is high, according to a new study (Am J Ind Med. 2019 Oct;62(10):826-837). Researchers examined the audiograms of 1.9 million workers across all industries, including 9,389 in mining and 1,076 in oil and gas extraction (OGE), from 2006 to 2015, and estimated the hearing loss prevalence and adjusted risk as compared to the reference industry of couriers and messengers for all industries combined and the mining...
Fri Sep 13, 2019 15:51
The prevalence of hearing loss among mining and oil and gas extraction noise-exposed workers is high, according to a new study (Am J Ind Med. 2019 Oct;62(10):826-837). Researchers examined the audiograms of 1.9 million workers across all industries, including 9,389 in mining and 1,076 in oil and gas extraction (OGE), from 2006 to 2015, and estimated the hearing loss prevalence and adjusted risk as compared to the reference industry of couriers and messengers for all industries combined and the mining...
Fri Sep 13, 2019 15:51
Related ArticlesBrain iron and metabolic abnormalities in C19orf12 mutation carriers: A 7.0 tesla MRI study in mitochondrial membrane protein-associated neurodegeneration. Mov Disord. 2019 Sep 13;: Authors: Dusek P, Mekle R, Skowronska M, Acosta-Cabronero J, Huelnhagen T, Robinson SD, Schubert F, Deschauer M, Els A, Ittermann B, Schottmann G, Madai VI, Paul F, Klopstock T, Kmiec T, Niendorf T, Wuerfel J, Schneider SA Abstract BACKGROUND: Mitochondrial...
Sat Sep 14, 2019 14:29
Related ArticlesInteraction of cigarette smoke condensate and some of its components with chlorpromazine toxicity on Saccharomyces cerevisiae. Drug Chem Toxicol. 2019 Sep 13;:1-11 Authors: Sayyed K, Aljebeai AK, Al-Nachar M, Chamieh H, Taha S, Abdel-Razzak Z Abstract Chlorpromazine (CPZ) is an antipsychotic phenothiazine which is still commonly prescribed though it causes idiosyncratic toxicity such as cholestasis. CPZ toxicity mechanisms involve oxidative...
Sat Sep 14, 2019 14:30
Related ArticlesAgomelatine protects heart and aorta against lipopolysaccharide-induced cardiovascular toxicity via inhibition of NF-kβ phosphorylation. Drug Chem Toxicol. 2019 Sep 13;:1-10 Authors: Asci H, Ozmen O, Erzurumlu Y, Sofu A, Icten P, Kaynak M Abstract The aim of this study was to investigate the possible ameliorating effects of agomelatine (AGO) on lipopolysaccharide (LPS)-induced endothelial and cardiac damage. Twenty-four female Wistar...
Sat Sep 14, 2019 14:30
Related ArticlesLetter to the Editor. External shunt valve after shunt removal for infection as a cost-saving measure. J Neurosurg Pediatr. 2019 Sep 13;:1-2 Authors: Kessler BA, Elton S, Quinsey C PMID: 31518972 [PubMed - as supplied by publisher]
Sat Sep 14, 2019 14:35
Related ArticlesSurgical outcomes for pediatric moyamoya: a systematic review and meta-analysis. J Neurosurg Pediatr. 2019 Sep 13;:1-10 Authors: Ravindran K, Wellons JC, Dewan MC Abstract OBJECTIVE: The optimal revascularization for pediatric moyamoya for reducing the incidence of future stroke events remains to be determined. METHODS: The authors conducted a search of PubMed, MEDLINE, Embase, and Web of Science electronic databases from inception...
Sat Sep 14, 2019 14:35
Related ArticlesEvidence of orofacial myofunctional therapy patients with asthma and rhinitis: a systematic review. Codas. 2019 Sep 02;31(4):e20190009 Authors: Araújo BCL, Simões SM, Moreira MGS, Mendes ALF, Martins-Filho PRS Abstract PURPOSE: to evaluate the efficacy of orofacial myofunctional therapy in improving orofacial function and nasal breathing in patients with asthma and rhinitis and, consequently, achieve clinical control of these conditions....
Sat Sep 14, 2019 14:42
Related ArticlesClinical illness and outcomes in Nigerian children with persistent early-appearing anaemia following initiation of artemisinin-based combination treatments of uncomplicated falciparum malaria. Parasite. 2019;26:56 Authors: Akano K, Fatunmbi B, Ntadom G, Ayede AI, Aderoyeje T, Bakre A, Alebiosu OT, Akpoborie O, Okafor C, Gbotosho GO, Folarin OA, Ebenebe JC, Ambe J, Wammanda R, Jiya N, Finomo F, Emechebe G, Mokuolu O, Agomo C, Oguche S, Happi C, Sowunmi...
Sat Sep 14, 2019 14:45
Cancers, Vol. 11, Pages 1363: HSF1 Regulates Mevalonate and Cholesterol Biosynthesis Pathways Cancers doi: 10.3390/cancers11091363 Authors: Hyeji Kang Taerim Oh Young Yil Bahk Geon-Hee Kim Sang-Yeon Kan Dong Hoon Shin Ji Hyung Kim Ji-Hong Lim Heat shock factor 1 (HSF1) is an essential transcription factor in cellular adaptation to various stresses such as heat, proteotoxic stress, metabolic stress, reactive oxygen species, and heavy metals. HSF1 promotes cancer development...
Fri Sep 13, 2019 03:00
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