Neuropilin‐2 (NRP2) is a member of the neuropilin receptor family and known to regulate autophagy and mTORC2 signaling in prostate cancer (PCa). This study investigated the association of immunohistochemical NRP2 expression with clinicopathological data in PCa patients. For this purpose, we generated a tissue microarray with prostate tissue specimens from 400 PCa patients treated by radical prostatectomy. We focused on patients with high‐risk factors such as extraprostatic extension (pT ≥ 3), Gleason...
Wed Sep 11, 2019 19:03
The N 6‐Methyladenosine (m6A) modification plays an important role in many biological processes, especially tumor development. However, little is still known about how it affects colorectal cancer (CRC) carcinogenesis. Here we first systematically investigate the association of variants related to m6A modification with the CRC risk in 1,062 CRC cases and 2,184 controls by using our exome‐wide association data and followed by two replication sets including 7,341 CRC cases and 7,902 controls. The...
Wed Sep 11, 2019 19:03
Serum calretinin as an independent predictor for platinum resistance and prognosis in ovarian cancer
Calretinin (CRT) is a calcium‐binding protein that controls intracellular calcium signaling. Besides its prominent expression in neurons, serum CRT (sCRT) has recently been suggested as blood‐based biomarker for pre‐diagnostic mesothelioma detection. CRT is expressed in ovarian cancer tissues in up to 40% of cases; however, its clinical relevance as blood based‐biomarker for ovarian cancer is unknown. sCRT was determined by calretinin enzyme‐linked immunoabsorbent assay (Calretinin‐ELISA, DLD Diagnostika...
Wed Sep 11, 2019 19:03
Due to the increasing incidence and prevalence of neuroendocrine tumors (NETs), there is a need to assess any gaps in awareness and care. A survey was undertaken in 2017 to identify perceived unmet needs from the perspectives of patients/families, patient advocates, and healthcare professionals (HCPs). The survey consisted of 33‐37 questions (depending on type of respondent) across four areas: information, care, treatments, and research. In total, 443 participants from 26 countries responded: 338...
Wed Sep 11, 2019 19:04
CRISPR–Cas9 (clustered regularly interspaced short palindromic repeats [CRISPR]–CRISPR-associated protein 9 [Cas9]) technology has been widely applied to edit the genome of mammalian cells in vitro. Although this approach shows potential clinical usefulness and clinical trials have been initiated…
Wed Sep 11, 2019 03:00
Abstract Objective To investigate the prognostic and biologic significance of immune-related gene expression in high grade serous ovarian cancer (HGSOC). Methods Gene expression dependent survival analyses for a panel of immune related genes were evaluated in HGSOC utilizing The Cancer Genome Atlas (TCGA). Prognostic value of LCK was validated using IHC in...
Thu Sep 12, 2019 03:00
Abstract Patients with non-small cell lung cancer (NSCLC) and renal cell carcinoma (RCC) have shown benefit from anti-PD-1 therapies. However, not all patients experience tumor shrinkage, durable responses or prolonged survival, demonstrating the need to find response markers. In blood samples from NSCLC and RCC patients obtained before and after anti-PD-1 treatment, we studied leukocytes by complete blood cell count, lymphocyte subsets using flow cytometry and plasma concentration...
Thu Sep 12, 2019 03:00
Background Previous studies have shown an increased risk of secondary primary malignancies (SPMs) after diffuse large B‐cell lymphoma (DLBCL) treatment. Whether stage of DLBCL at diagnosis affects the subtypes of SPMs that occur has not been previously described. Methods The Surveillance, Epidemiology, and End Results database was queried for patients aged >18 years diagnosed with primary DLBCL from 1973 to 2010 and categorized by early stage (ES) (stage I‐II) or advanced stage (AS) (stage...
Wed Sep 11, 2019 15:58
Background This single‐arm, multicenter, phase 2 study evaluated the safety and antitumor activity of pazopanib in patients with unresectable or metastatic conventional chondrosarcoma. Methods Eligible patients had conventional chondrosarcoma of any grade with measurable tumors that were unresectable or metastatic. Patients with mesenchymal, dedifferentiated, and extraskeletal myxoid chondrosarcoma subtypes and patients who received prior tyrosine kinase inhibitor therapy were excluded. Pazopanib...
Wed Sep 11, 2019 16:01
Abstract Rationale Psychiatric disorders such as anxiety and depression are frequently observed in neuropathic pain patients, and negatively impact their quality of life. Mirogabalin is a novel ligand for the α2δ subunit of voltage-gated calcium channels and has unique binding characteristics to α2δ subunits and potent and long-lasting analgesic effects in neuropathic pain models. ...
Thu Sep 12, 2019 03:00
Background and Objectives In Holmium laser lithotripsy, usually, the surgeon is guided by a visible beam superimposing the infrared (IR) treatment radiation. It has been shown that a green aiming beam excites stone autofluorescence. This fluorescence signal can be used for calculi detection to check the correct fiber position before triggering the IR laser, thus preventing damage to soft tissue and application devices. However, also the directly reflected green light from the fiber tip gives valuable...
Wed Sep 11, 2019 19:28
Abstract The radial forearm flap is one of the most used micro‐anastomotic flaps in cervicofacial reconstruction in a carcinological context. This flap is an ideal in terms of reliability and fineness; it has, however, some disadvantages in terms of the functional and aesthetic complications of its donor site. In alternative to a radial forearm free flap, we report the use of the free super thin external pudendal artery flap (STEPA flap) for an oropharyngeal reconstruction. The aim was to decrease...
Wed Sep 11, 2019 15:36
Abstract Brevinin-1BYa is a 24-amino acid residue host-defense peptide, first isolated from skin secretions of the foothill yellow-legged frog Rana boylii. The peptide is of interest, as it shows broad-spectrum antimicrobial activity, and is particularly effective against opportunistic yeast pathogens. Its potential for clinical use, however, is hindered by its latent haemolytic activity. The structures of two analogues, the less haemolytic [C18S,C24S]brevinin-1BYa and the more...
Thu Sep 12, 2019 03:00
Abstract Immune checkpoint inhibitors have improved the prognosis of advanced melanoma. Although PD‐L1 is a well‐studied biomarker for response to anti‐PD‐1 therapy in melanoma, its clinical relevance remains unclear. It has been established that the high expression of indoleamine 2,3‐dioxygenase (IDO) is correlated to a response to anti‐CTLA‐4 treatment in melanoma. However, it is still unknown whether the IDO expression is associated with response to anti‐PD‐1 therapy in advanced melanoma. In...
Wed Sep 11, 2019 17:48
Abstract Coxsackievirus and adenovirus receptor (CAR) is a single‐pass transmembrane protein that is associated with adenoviral infection. CAR is involved in the formation of epithelial tight junctions and promotes tumor growth in some cancers. Previously, we developed mouse monoclonal antibodies against human CAR and found that one, mu6G10A, significantly inhibited tumor growth in xenografts of human cancer cells. Here, we generated and characterized a mouse‐human chimeric anti‐CAR antibody (ch6G10A)...
Wed Sep 11, 2019 20:32
Publication date: Available online 11 September 2019Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Anita Kallepalli, Prashant Verma
Thu Sep 12, 2019 12:18
Publication date: Available online 11 September 2019Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Bryce C. Hoffman, Shannon Garcia, Douglas C. Everett, Donald Y.M. Leung, Christine B. Cho
Thu Sep 12, 2019 12:18
Publication date: Available online 11 September 2019Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Warit Jithpratuck, David Kays, Panida Sriaroon
Thu Sep 12, 2019 12:18
Publication date: Available online 11 September 2019Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Di Sun, Joseph Cafone, Marcus Shaker, Matthew GreenhawtAbstractBackgroundAeroallergen immunotherapy is a safe and effective disease-modifying treatment associated with rare therapy-associated fatality. Significant practice variation surrounds universal or contextual prescription of self-injectable epinephrine (SIE) for patients receiving AIT.Objective: To characterize the cost-effectiveness...
Thu Sep 12, 2019 12:18
Publication date: Available online 12 September 2019Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Theodore Kelbel, Andrew Kampfschulte, Nicholas Hartog
Thu Sep 12, 2019 12:18
Abstract Objective The majority of cancers are diagnosed following a decision to access medical help for symptoms. People from ethnic minority backgrounds have longer patient intervals following identification of cancer symptoms. This study quantified ethnic differences in barriers to symptomatic presentation including culturally‐specific barriers. Correlates of barriers (e.g. migration status, health literacy and fatalism) were also explored. Methods A cross‐sectional survey of 720 White...
Wed Sep 11, 2019 14:18
Wed Sep 11, 2019 17:43
Abstract Objective Women with metastatic breast cancer (MBC) report high levels of disease‐related symptoms including pain, fatigue, psychological distress, and sleep disturbance. Mindfulness may be particularly relevant to women with MBC given the high symptom burden and psychological toll of this disease; however, the topic is understudied among this patient population. Therefore, we aimed to test the associations between mindfulness and patient‐reported symptoms among a sample of women with...
Wed Sep 11, 2019 19:23
Background The cultivation of Bt maize (maize genetically modified with Bacillus thuringiensis) continues to expand globally. Arbuscular mycorrhizal fungi (AMF), an important kind of microorganism closely related to soil fertility and plant nutrition, may influence the ecological risk of target lepidopteran pests in Bt crops. Methods In this study, transgenic Bt maize (Line IE09S034 with Cry1Ie vs. its parental line...
Thu Sep 12, 2019 03:00
Background Enzymatic hydrolysis of N-acyl homoserine lactones (AHLs), which are signaling molecules responsible for the development of antibiotic resistance in gram-negative bacteria, is a potential solution to overcoming antibiotic resistance problem. It has been established that hexahistidine-tagged organophosphorus hydrolase (His6-OPH) exhibits lactonase activity against a number of AHLs and that the combined application of His6-OPH with β-lactam antibiotics leads to an increase...
Thu Sep 12, 2019 03:00
It has been reported that fermented products (FPs) prepared from sweet potato-shochu distillery by-product suppressed weight gain and decreased serum cholesterol levels in mice under normal dietary conditions. Furthermore, from the information gained from the above data regarding health benefits of the FPs, the aim of this study was evaluating the effects of dietary FPs on lipid accumulation and gut microbiota in mice with or without cholesterol-load in the diet. C57BL/6N mice were fed normal (CO)...
Thu Sep 12, 2019 03:00
Compositionality refers to a structural property of human language, according to which the meaning of a complex expression is a function of the meaning of its parts and the way they are combined. Compositionality is a defining characteristic of all human language, spoken and signed. Comparative research into the emergence of human language aims at identifying precursors to such key features of human language in the communication of other primates. While it is known that chimpanzees, our closest relatives,...
Thu Sep 12, 2019 03:00
Acute farmland expansion and rapid urbanization in Central Asia have accelerated land use/land cover changes, which have substantial effects on ecosystem services. However, the spatiotemporal variations in ecosystem service values (ESVs) in Central Asia are not well understood. Here, based on land use products with 300-m resolution for the years 1995, 2005 and 2015 and transfer methodology, we predicted land use and land cover (LULC) for 2025 and 2035 using CA-Markov, assessed changes in ESVs in...
Thu Sep 12, 2019 03:00
Objective The main objective of this trial was to assess whether action observation (AO) training and motor imagery (MI) produced changes in the cervical joint position sense (CJPS) both at the end of the intervention and 10 min postintervention compared with a placebo intervention in patients with nonspecific chronic neck pain (NSCNP). Methods A single-blind placebo clinical trial was designed. A total of 30 patients...
Thu Sep 12, 2019 03:00
Aquaporins (AQPs) serve as water channel proteins and belong to major intrinsic proteins (MIPs) family, functioning in rapidly and selectively transporting water and other small solutes across biological membranes. Importantly, AQPs have been shown to play a critical role in abiotic stress response pathways of plants. As a species closely related to Arabidopsis thaliana, Eutrema salsugineum has been proposed as a model for studying salt resistance in plants. Here we surveyed 35 full-length AQP genes...
Thu Sep 12, 2019 03:00
Background Although biomimetic material has become increasingly popular in dental cosmetology nowadays, it remains unclear how it would affect the restored teeth during chewing. It is necessary to study the influence of biomimetic material on stress distribution in the restored teeth. Methods Eight three-dimensional finite element (FE) models were constructed and divided into two groups. Group 1 included the FE model of intact molar, and the FE models of inlay-restored molars fabricated...
Thu Sep 12, 2019 03:00
Growth-regulating factor (GRF), a small plant-specific transcription factor (TF) family, is extensively involved in the regulation of growth and developmental processes. However, the GRF family has not been comprehensively studied in moso bamboo (Phyllostachys edulis), a typical non-timber forest member. Here, 18 GRF genes were identified and characterized from the moso bamboo genome, and they clustered into three subfamilies (A, B and C). PeGRF genes were analyzed to determine their gene structures,...
Thu Sep 12, 2019 03:00
Although most plant species are photosynthetic, several hundred species have lost the ability to photosynthesize and instead obtain nutrients via various types of heterotrophic feeding. Their plastid genomes markedly differ from the plastid genomes of photosynthetic plants. In this work, we describe the sequenced plastid genome of the heterotrophic plant Rhopalocnemis phalloides, which belongs to the family Balanophoraceae and feeds by parasitizing other plants. The genome is highly reduced (18,622...
Thu Sep 12, 2019 03:00
Background Rise in the number of healthcare associated or hospital acquired infections is a major problem affecting the global healthcare sector. We evaluated superior antibacterial and antibiofilm photodynamic therapy (aPDT) using malachite green encapsulated mesoporous silica nanoparticles (MG-MSN) against Staphylococcus aureus and Escherichia coli, which are known to be major causative agents of nosocomial infections. Methods ...
Thu Sep 12, 2019 03:00
Background and Aims Global climate change is a major threat to biodiversity worldwide. Several arid areas might expand in the future, but it is not clear if this change would be positive or negative for arid-adapted lineages. Here, we explore whether climatic niche properties are involved in the configuration of climate refugia and thus in future species trends. Methods To estimate putative climate refugia and potential expansion areas, we used maximum entropy models and four climate-change...
Thu Sep 12, 2019 03:00
Introduction: Initial research has been conducted to determine the diagnostic accuracy of the pitch glide during the clinical swallow evaluation to identify aspiration in adults after stroke. Findings suggest that reduced pitch glide can predict aspiration in patients with dysphagia after stroke. This study aimed to identify the diagnostic accuracy of the pitch glide in detecting aspiration, pharyngeal residue and hyolaryngeal excursion during swallowing in adults with respiratory diseases. Material...
Thu Sep 12, 2019 11:42
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου