IJMS, Vol. 20, Pages 4471: Distal Electroacupuncture at the LI4 Acupoint Reduces CFA-Induced Inflammatory Pain via the Brain TRPV1 Signaling Pathway International Journal of Molecular Sciences doi: 10.3390/ijms20184471 Authors: Chia-Ming Yen Tong-Chien Wu Ching-Liang Hsieh Yu-Wei Huang Yi-Wen Lin There is accumulating evidence supporting electroacupuncture’s (EA) therapeutic effects. In mice, local EA reliably attenuates inflammatory pain and increases the transient...
Tue Sep 10, 2019 03:00
IJMS, Vol. 20, Pages 4468: Molecular Dynamics Simulation Framework to Probe the Binding Hypothesis of CYP3A4 Inhibitors International Journal of Molecular Sciences doi: 10.3390/ijms20184468 Authors: Kiani Ranaghan Jabeen Mulholland The Cytochrome P450 family of heme-containing proteins plays a major role in catalyzing phase I metabolic reactions, and the CYP3A4 subtype is responsible for the metabolism of many currently marketed drugs. Additionally, CYP3A4 has an inherent...
Tue Sep 10, 2019 03:00
IJMS, Vol. 20, Pages 4469: Jasmonic Acid Methyl Ester Induces Xylogenesis and Modulates Auxin-Induced Xylary Cell Identity with NO Involvement International Journal of Molecular Sciences doi: 10.3390/ijms20184469 Authors: Federica Della Rovere Laura Fattorini Marilena Ronzan Giuseppina Falasca Maria Maddalena Altamura Camilla Betti In Arabidopsis basal hypocotyls of dark-grown seedlings, xylary cells may form from the pericycle as an alternative to adventitious roots....
Tue Sep 10, 2019 03:00
IJMS, Vol. 20, Pages 4467: Microglial Pro-Inflammatory and Anti-Inflammatory Phenotypes Are Modulated by Translocator Protein Activation International Journal of Molecular Sciences doi: 10.3390/ijms20184467 Authors: Pozzo Tremolanti Costa Giacomelli Milenkovic Bader Wetzel Rupprecht Taliani Settimo Martini A key role of the mitochondrial Translocator Protein 18 KDa (TSPO) in neuroinflammation has been recently proposed. However, little is known...
Tue Sep 10, 2019 03:00
IJMS, Vol. 20, Pages 4466: Chromosome Translocations as a Driver of Diversification in Mole Voles Ellobius (Rodentia, Mammalia) International Journal of Molecular Sciences doi: 10.3390/ijms20184466 Authors: Svetlana A. Romanenko Elena A. Lyapunova Abdusattor S. Saidov Patricia C.M. O’Brien Natalia A. Serdyukova Malcolm A. Ferguson-Smith Alexander S. Graphodatsky Irina Bakloushinskaya The involvement of chromosome changes in the initial steps of speciation is controversial....
Tue Sep 10, 2019 03:00
IJMS, Vol. 20, Pages 4465: High Concentration of C5a-Induced Mitochondria-Dependent Apoptosis in Murine Kidney Endothelial Cells International Journal of Molecular Sciences doi: 10.3390/ijms20184465 Authors: I-Jung Tsai Wei-Chou Lin Yao-Hsu Yang Yu-Lin Tseng Yen-Hung Lin Chia-Hung Chou Yong-Kwei Tsau Patients with a relapse of idiopathic nephrotic syndrome have significantly increased levels of serum complement component 5a (C5a), and proteinuria has been noted in mice...
Tue Sep 10, 2019 03:00
IJMS, Vol. 20, Pages 4464: Migration of Small Ribosomal Subunits on the 5′ Untranslated Regions of Capped Messenger RNA International Journal of Molecular Sciences doi: 10.3390/ijms20184464 Authors: Nikolay E. Shirokikh Yulia S. Dutikova Maria A. Staroverova Ross D. Hannan Thomas Preiss Several control mechanisms of eukaryotic gene expression target the initiation step of mRNA translation. The canonical translation initiation pathway begins with cap-dependent attachment of...
Tue Sep 10, 2019 03:00
IJMS, Vol. 20, Pages 4463: Noninvasive Urinary Monitoring of Progression in IgA Nephropathy International Journal of Molecular Sciences doi: 10.3390/ijms20184463 Authors: Joshua Y. C. Yang Reuben D. Sarwal Fernando C. Fervenza Minnie M. Sarwal Richard A. Lafayette Standard methods for detecting and monitoring of IgA nephropathy (IgAN) have conventionally required kidney biopsies or suffer from poor sensitivity and specificity. The Kidney Injury Test (KIT) Assay of urinary...
Tue Sep 10, 2019 03:00
IJMS, Vol. 20, Pages 4462: An Integrated Transcriptome and Proteome Analysis Reveals New Insights into Russeting of Bagging and Non-Bagging “Golden Delicious” Apple International Journal of Molecular Sciences doi: 10.3390/ijms20184462 Authors: Gaopeng Yuan Shuxun Bian Xiaolei Han Shanshan He Kai Liu Caixia Zhang Peihua Cong Apple skin russeting naturally occurs in many varieties, particularly in “Golden Delicious” and its pedigree, and is regarded...
Tue Sep 10, 2019 03:00
IJMS, Vol. 20, Pages 4461: Somatostatin as an Active Substance in the Mammalian Enteric Nervous System International Journal of Molecular Sciences doi: 10.3390/ijms20184461 Authors: Slawomir Gonkowski Liliana Rytel Somatostatin (SOM) is an active substance which most commonly occurs in endocrine cells, as well as in the central and peripheral nervous system. One of the parts of the nervous system where the presence of SOM has been confirmed is the enteric nervous system (ENS), located...
Tue Sep 10, 2019 03:00
IJMS, Vol. 20, Pages 4457: Promising Cytomegalovirus-Based Vaccine Vector Induces Robust CD8+ T-Cell Response International Journal of Molecular Sciences doi: 10.3390/ijms20184457 Authors: Jian Liu Dabbu Kumar Jaijyan Qiyi Tang Hua Zhu Vaccination has had great success in combating diseases, especially infectious diseases. However, traditional vaccination strategies are ineffective for several life-threatening diseases, including acquired immunodeficiency syndrome (AIDS), tuberculosis,...
Tue Sep 10, 2019 03:00
IJMS, Vol. 20, Pages 4458: LDAPred: A Method Based on Information Flow Propagation and a Convolutional Neural Network for the Prediction of Disease-Associated lncRNAs International Journal of Molecular Sciences doi: 10.3390/ijms20184458 Authors: Ping Xuan Lan Jia Tiangang Zhang Nan Sheng Xiaokun Li Jinbao Li Long non-coding RNAs (lncRNAs) play a crucial role in the pathogenesis and development of complex diseases. Predicting potential lncRNA–disease associations...
Tue Sep 10, 2019 03:00
IJMS, Vol. 20, Pages 4459: A Novel Tanshinone Analog Exerts Anti-Cancer Effects in Prostate Cancer by Inducing Cell Apoptosis, Arresting Cell Cycle at G2 Phase and Blocking Metastatic Ability International Journal of Molecular Sciences doi: 10.3390/ijms20184459 Authors: Mengling Wang Xueyi Zeng Shengyou Li Zekun Sun Jia Yu Chao Chen Xiangchun Shen Weidong Pan Heng Luo Prostate cancer (PCa), an epithelial malignant tumor, is the second common cause of cancer death...
Tue Sep 10, 2019 03:00
IJMS, Vol. 20, Pages 4460: MicroRNA Biogenesis Pathway Genes Are Deregulated in Colorectal Cancer International Journal of Molecular Sciences doi: 10.3390/ijms20184460 Authors: Petra Vychytilova-Faltejskova Alena Svobodova Kovarikova Tomas Grolich Vladimir Prochazka Katerina Slaba Tana Machackova Jana Halamkova Marek Svoboda Zdenek Kala Igor Kiss Ondrej Slaby MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression....
Tue Sep 10, 2019 03:00
JCM, Vol. 8, Pages 1434: Cardiac and Vascular Sympathetic Baroreflex Control during Orthostatic Pre-Syncope Journal of Clinical Medicine doi: 10.3390/jcm8091434 Authors: Furlan Heusser Minonzio Shiffer Cairo Tank Jordan Diedrich Gauger Zamuner Dipaola Porta Barbic We hypothesized that sympathetic baroreflex mediated uncoupling between neural sympathetic discharge pattern and arterial pressure (AP) fluctuations at 0.1 Hz during baroreceptor...
Tue Sep 10, 2019 03:00
JCM, Vol. 8, Pages 1432: Correlation between Choriocapillaris Density and Retinal Sensitivity in Stargardt Disease Journal of Clinical Medicine doi: 10.3390/jcm8091432 Authors: Mastropasqua Senatore Di Antonio Di Nicola Marchioni Perna Amore Borrelli De Nicola Carpineto Toto The aim of this work was to characterize the choriocapillaris (CC) in patients with Stargardt disease (STGD) using the swept source widefield optical coherence tomography...
Tue Sep 10, 2019 03:00
JCM, Vol. 8, Pages 1433: Characterization of Bacteria and Inducible Phages in an Intensive Care Unit
JCM, Vol. 8, Pages 1433: Characterization of Bacteria and Inducible Phages in an Intensive Care Unit Journal of Clinical Medicine doi: 10.3390/jcm8091433 Authors: Pacífico Hilbert Sofka Dinhopl Pap Aspöck Hilbert Intensive care units (ICUs) are critical locations for the transmission of pathogenic and opportunistic microorganisms. Bacteria may develop a synergistic relationship with bacteriophages and more effectively resist various stresses, enabling them to...
Tue Sep 10, 2019 03:00
JCM, Vol. 8, Pages 1431: The Risk for Glucose Intolerance after Gestational Diabetes Mellitus since the Introduction of the IADPSG Criteria: A Systematic Review and Meta-Analysis Journal of Clinical Medicine doi: 10.3390/jcm8091431 Authors: Benhalima Lens Bosteels Chantal The aim of the study was to assess the postpartum risk for glucose intolerance since the introduction of the ‘International Association of Diabetes and Pregnancy Study Groups’ (IADPSG)...
Tue Sep 10, 2019 03:00
JCM, Vol. 8, Pages 1429: Effect of Low-Dose Aspirin on Soluble FMS-Like Tyrosine Kinase 1/Placental Growth Factor (sFlt-1/PlGF Ratio) in Pregnancies at High Risk for the Development of Preeclampsia Journal of Clinical Medicine doi: 10.3390/jcm8091429 Authors: Karoline Mayer-Pickel Vassiliki Kolovetsiou-Kreiner Christina Stern Julia Münzker Katharina Eberhard Slave Trajanoski Ioana-Claudia Lakovschek Daniela Ulrich Bence Csapo Uwe Lang Barbara Obermayer-Pietsch...
Tue Sep 10, 2019 03:00
JCM, Vol. 8, Pages 1428: Decreased Blood Asprosin in Hyperglycemic Menopausal Women as a Result of Whole-Body Cryotherapy Regardless of Metabolic Syndrome Journal of Clinical Medicine doi: 10.3390/jcm8091428 Authors: Magdalena Wiecek Jadwiga Szymura Justyna Sproull Zbigniew Szygula Endocrine dysfunction often occurs in metabolic syndrome (MetS), resulting in hyperglycemia and atherogenic blood lipid profile disorders. Asprosin is a newly discovered glucose-regulating hormone....
Tue Sep 10, 2019 03:00
JCM, Vol. 8, Pages 1430: The Effects of Using Pancreases Obtained from Brain-Dead Donors for Clinical Islet Transplantation in Japan Journal of Clinical Medicine doi: 10.3390/jcm8091430 Authors: Taihei Ito Takashi Kenmochi Kei Kurihara Akihiro Kawai Naohiro Aida Yumi Akashi Sakurako Kato Background: The pool of brain-dead donors (BDDs) was increased with the revision to the relevant law in 2010, and islet transplantation from BDDs was started in 2013. The present study...
Tue Sep 10, 2019 03:00
JCM, Vol. 8, Pages 1424: Nutritional Therapy Modulates Intestinal Microbiota and Reduces Serum Levels of Total and Free Indoxyl Sulfate and P-Cresyl Sulfate in Chronic Kidney Disease (Medika Study) Journal of Clinical Medicine doi: 10.3390/jcm8091424 Authors: Biagio Raffaele Di Iorio Maria Teresa Rocchetti Maria De Angelis Carmela Cosola Stefania Marzocco Lucia Di Micco Ighli di Bari Matteo Accetturo Mirco Vacca Marco Gobbetti Mattia Di Iorio Antonio Bellasi...
Tue Sep 10, 2019 03:00
JCM, Vol. 8, Pages 1426: The Effect of Perioperative Pregabalin on Pain after Arthroscopic Anterior Cruciate Ligament Reconstruction: A Randomized Controlled Trial Journal of Clinical Medicine doi: 10.3390/jcm8091426 Authors: Eun-Ah Cho Namo Kim Bora Lee Jeehyun Song Yong Seon Choi Pain after anterior cruciate ligament (ACL) reconstruction is usually intense in the early postoperative period, but the efficacy of a multimodal analgesia approach remains controversial. This...
Tue Sep 10, 2019 03:00
JCM, Vol. 8, Pages 1425: Vascular Patterns in Retinitis Pigmentosa on Swept-Source Optical Coherence Tomography Angiography Journal of Clinical Medicine doi: 10.3390/jcm8091425 Authors: Alessandro Arrigo Francesco Romano Giorgia Albertini Emanuela Aragona Francesco Bandello Maurizio Battaglia Parodi Background: Retinitis Pigmentosa (RP) represents a retinal dystrophy with an extremely complex pathogenesis further worsened by the impairment of the retinal vascular supply....
Tue Sep 10, 2019 03:00
JCM, Vol. 8, Pages 1427: Environmental Risk Factors of Pancreatic Cancer Journal of Clinical Medicine doi: 10.3390/jcm8091427 Authors: Hui-Jen Tsai Jeffrey S. Chang Despite the advancement in medical knowledge that has improved the survival rate of many cancers, the survival rate of pancreatic cancer has remained dismal with a five-year survival rate of only 9%. The poor survival of pancreatic cancer emphasizes the urgent need to identify the causes or the risk factors of pancreatic...
Tue Sep 10, 2019 03:00
Medical Sciences, Vol. 7, Pages 95: A Review of First Line Infertility Treatments and Supporting Evidence in Women with Polycystic Ovary Syndrome Medical Sciences doi: 10.3390/medsci7090095 Authors: Michael Costello Rhonda Garad Roger Hart Hayden Homer Louise Johnson Cailin Jordan Edgar Mocanu Jie Qiao Luk Rombauts Helena Teede Eszter Vanky Christos Venetis William Ledger Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility...
Tue Sep 10, 2019 03:00
Medicina, Vol. 55, Pages 581: Prevalence of Periodontitis and its Association with Reduced Pulmonary Function: Results from the Korean National Health and Nutrition Examination Survey Medicina doi: 10.3390/medicina55090581 Authors: Lee Lee Background and Objectives: The current study was performed to evaluate the prevalence of periodontitis and to examine the association between reduced pulmonary function and periodontitis using Sixth Korea National Health and Nutrition Examination...
Tue Sep 10, 2019 03:00
Metabolites, Vol. 9, Pages 181: An Isotopic Ratio Outlier Analysis Approach for Global Metabolomics of Biosynthetically Talented Actinomycetes Metabolites doi: 10.3390/metabo9090181 Authors: Jordan Carey Thanh Nguyen Jennifer Korchak Christopher Beecher Felice de Jong Amy L. Lane Actinomycetes are powerhouses of natural product biosynthesis. Full realization of this biosynthetic potential requires approaches for recognizing novel metabolites and determining mediators of...
Tue Sep 10, 2019 03:00
Metabolites, Vol. 9, Pages 180: Nicotinamide and NAFLD: Is There Nothing New Under the Sun? Metabolites doi: 10.3390/metabo9090180 Authors: Maria Guarino Jean-François Dufour Nicotinamide adenine dinucleotide (NAD) has a critical role in cellular metabolism and energy homeostasis. Its importance has been established early with the discovery of NAD’s therapeutic role for pellagra. This review addresses some of the recent findings on NAD physiopathology and their effects on...
Tue Sep 10, 2019 03:00
Microorganisms, Vol. 7, Pages 339: Antibody Response to Toscana Virus and Sandfly Fever Sicilian Virus in Cats Naturally Exposed to Phlebotomine Sand Fly Bites in Portugal Microorganisms doi: 10.3390/microorganisms7090339 Authors: André Pereira Nazli Ayhan José Manuel Cristóvão Hugo Vilhena Ângela Martins Patrícia Cachola Joaquim Henriques Mónica Coimbra Ana Catarino Tereza Lestinova Tatiana Spitzova Petr Volf Lenea Campino Remi Charrel Carla Maia...
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Microorganisms, Vol. 7, Pages 338: Microbiota, Microbial Metabolites, and Barrier Function in A Patient with Anorexia Nervosa after Fecal Microbiota Transplantation Microorganisms doi: 10.3390/microorganisms7090338 Authors: Prochazkova Roubalova Dvorak Tlaskalova-Hogenova Cermakova Tomasova Sediva Kuzma Bulant Bilej Hrabak Meisnerova Lambertova Papezova The change in the gut microbiome and microbial metabolites in a patient suffering...
Tue Sep 10, 2019 03:00
Microorganisms, Vol. 7, Pages 337: Genetic Screening and Expression Analysis of Psychrophilic Bacillus spp. Reveal Their Potential to Alleviate Cold Stress and Modulate Phytohormones in Wheat Microorganisms doi: 10.3390/microorganisms7090337 Authors: Zubair Hanif Farzand Sheikh Khan Suleman Ayaz Gao Abiotic stress in plants pose a major threat to cereal crop production worldwide and cold stress is also notorious for causing a decrease in plant growth and...
Tue Sep 10, 2019 03:00
Molecules, Vol. 24, Pages 3300: Permeable Water-Resistant Heat Insulation Panel Based on Recycled Materials and Its Physical and Mechanical Properties Molecules doi: 10.3390/molecules24183300 Authors: Štěpán Hýsek Miroslav Frydrych Miroslav Herclík Ludmila Fridrichová Petr Louda Roman Knížek Su Le Van Hiep Le Chi This paper deals with the development and characteristics of the properties of a permeable water-resistant heat insulation panel based on recycled materials....
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Molecules, Vol. 24, Pages 3297: Characterizing Tyrosinase Modulators from the Roots of Angelica keiskei Using Tyrosinase Inhibition Assay and UPLC-MS/MS as the Combinatorial Novel Approach Molecules doi: 10.3390/molecules24183297 Authors: Jia-Hao Lee Hui-Ching Mei I-Chih Kuo Tzong-Huei Lee Yu-Hsin Chen Ching-Kuo Lee In this study, an in vitro tyrosinase inhibition assay in combination with ultra performance liquid chromatography-orbitrap mass spectrometry (UPLC-orbitrap-MS)...
Tue Sep 10, 2019 03:00
Molecules, Vol. 24, Pages 3299: Antioxidant Activity of an Aqueous Leaf Extract from Uncaria tomentosa and Its Major Alkaloids Mitraphylline and Isomitraphylline in Caenorhabditis elegans Molecules doi: 10.3390/molecules24183299 Authors: Bruna C. Azevedo Mariana Roxo Marcos C. Borges Herbenya Peixoto Eduardo J. Crevelin Bianca W. Bertoni Silvia H. T. Contini Adriana A. Lopes Suzelei C. França Ana M. S. Pereira Michael Wink Uncaria tomentosa (Rubiaceae) has...
Tue Sep 10, 2019 03:00
Molecules, Vol. 24, Pages 3296: Phenolic Acids in Jerusalem Artichoke (Helianthus tuberosus L.): Plant Organ Dependent Antioxidant Activity and Optimized Extraction from Leaves Molecules doi: 10.3390/molecules24183296 Authors: Muhammad Mir Showkat Anne Bergljot Falck-Ytter Knut Olav Strætkvern Phenolic acids including chlorogenic acids are major polyphenolic compounds found in Jerusalem artichoke (Helianthus tuberosus L.). The plant itself is an emerging biorefinery crop due to...
Tue Sep 10, 2019 03:00
Molecules, Vol. 24, Pages 3298: Effects of Seasonal Variability on the Physicochemical, Biochemical, and Nutritional Composition of Western Peninsular Malaysia Gracilaria manilaensis Molecules doi: 10.3390/molecules24183298 Authors: Abdul Qudus Aroyehun Kishneth Palaniveloo Farid Ghazali Mohammed Rizman-Idid Shariza Abdul Razak This study evaluated the effect of seasonal variation on the physicochemical, biochemical, and nutritional composition of Gracilaria manilaensis....
Tue Sep 10, 2019 03:00
Molecules, Vol. 24, Pages 3294: Understanding the Effects of Lactose Hydrolysis Modeling on the Main Oligosaccharides in Goat Milk Whey Permeate Molecules doi: 10.3390/molecules24183294 Authors: Caroline Thum Valerie Weinborn Daniela Barile Warren C McNabb Nicole C Roy Juliana Maria Leite Nobrega de Moura Bell Enzymatic hydrolysis of lactose is a crucial step to improve the efficiency and selectivity of membrane-based separations toward the recovery of milk oligosaccharides...
Tue Sep 10, 2019 03:00
Molecules, Vol. 24, Pages 3295: Antiproliferative S-Trityl-l-Cysteine -Derived Compounds as SIRT2 Inhibitors: Repurposing and Solubility Enhancement Molecules doi: 10.3390/molecules24183295 Authors: Mohamed O. Radwan Halil I. Ciftci Taha F. S. Ali Doha E. Ellakwa Ryoko Koga Hiroshi Tateishi Akiko Nakata Akihiro Ito Minoru Yoshida Yoshinari Okamoto Mikako Fujita Masami Otsuka S-trityl-l-cysteine (STLC) is a well-recognized lead compound known for its anticancer...
Tue Sep 10, 2019 03:00
Molecules, Vol. 24, Pages 3293: Normal Mode Analysis as a Routine Part of a Structural Investigation
Molecules, Vol. 24, Pages 3293: Normal Mode Analysis as a Routine Part of a Structural Investigation Molecules doi: 10.3390/molecules24183293 Authors: Jacob A. Bauer Jelena Pavlović Vladena Bauerová-Hlinková Normal mode analysis (NMA) is a technique that can be used to describe the flexible states accessible to a protein about an equilibrium position. These states have been shown repeatedly to have functional significance. NMA is probably the least computationally expensive method...
Tue Sep 10, 2019 03:00
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