IJMS, Vol. 20, Pages 4548: Calcium Mechanisms in Limb-Girdle Muscular Dystrophy with CAPN3 Mutations
IJMS, Vol. 20, Pages 4548: Calcium Mechanisms in Limb-Girdle Muscular Dystrophy with CAPN3 Mutations International Journal of Molecular Sciences doi: 10.3390/ijms20184548 Authors: Jaione Lasa-Elgarresta Laura Mosqueira-Martín Neia Naldaiz-Gastesi Amets Sáenz Adolfo López de Munain Ainara Vallejo-Illarramendi Limb-girdle muscular dystrophy recessive 1 (LGMDR1), previously known as LGMD2A, is a rare disease caused by mutations in the CAPN3 gene. It is characterized by progressive...
Fri Sep 13, 2019 03:00
IJMS, Vol. 20, Pages 4537: ProTAME Arrest in Mammalian Oocytes and Embryos Does Not Require Spindle Assembly Checkpoint Activity International Journal of Molecular Sciences doi: 10.3390/ijms20184537 Authors: Lenka Radonova Tereza Svobodova Michal Skultety Ondrej Mrkva Lenka Libichova Paula Stein Martin Anger In both mitosis and meiosis, metaphase to anaphase transition requires the activity of a ubiquitin ligase known as anaphase promoting complex/cyclosome (APC/C)....
Fri Sep 13, 2019 03:00
IJMS, Vol. 20, Pages 4543: Current Clinical Strategies of Pancreatic Cancer Treatment and Open Molecular Questions International Journal of Molecular Sciences doi: 10.3390/ijms20184543 Authors: Maximilian Brunner Zhiyuan Wu Christian Krautz Christian Pilarsky Robert Grützmann Georg F. Weber Pancreatic cancer is one of the most lethal malignancies and is associated with a poor prognosis. Surgery is considered the only potential curative treatment for pancreatic cancer,...
Fri Sep 13, 2019 03:00
IJMS, Vol. 20, Pages 4542: Comparative Analysis of Proteomics and Transcriptomics during Fertility Transition in a Two-Line Hybrid Rice Line Wuxiang S International Journal of Molecular Sciences doi: 10.3390/ijms20184542 Authors: Hao Chen Jing Jin Hongyuan Zhang Ying Wang Qian Li Yu Zou Xingguo Huang Baojin Zhou Ruo Zhou Yi Ding The two-line hybrid rice is an important factor of a global crop, but its fertility transition mechanism is unclear. Here, a comparative...
Fri Sep 13, 2019 03:00
IJMS, Vol. 20, Pages 4541: Linkage of Periodontitis and Rheumatoid Arthritis: Current Evidence and Potential Biological Interactions International Journal of Molecular Sciences doi: 10.3390/ijms20184541 Authors: Rafael Scaf de Molon Carlos Rossa Jr. Rogier M. Thurlings Joni Augusto Cirelli Marije I. Koenders The association between rheumatoid arthritis (RA) and periodontal disease (PD) has been the focus of numerous investigations driven by their common pathological features....
Fri Sep 13, 2019 03:00
IJMS, Vol. 20, Pages 4545: Melatonin Enhances Mitophagy by Upregulating Expression of Heat Shock 70 kDa Protein 1L in Human Mesenchymal Stem Cells under Oxidative Stress International Journal of Molecular Sciences doi: 10.3390/ijms20184545 Authors: Yeo Min Yoon Hyung Joo Kim Jun Hee Lee Sang Hun Lee Human mesenchymal stem cells (hMSCs) are a potent source of cell-based regenerative therapeutics used to treat patients with ischemic disease. However, disease-induced oxidative...
Fri Sep 13, 2019 03:00
IJMS, Vol. 20, Pages 4538: A Model for the Homotypic Interaction between Na+,K+-ATPase β1 Subunits Reveals the Role of Extracellular Residues 221–229 in Its Ig-Like Domain International Journal of Molecular Sciences doi: 10.3390/ijms20184538 Authors: Omar Páez Marlet Martínez-Archundia Nicolás Villegas-Sepúlveda María Luisa Roldan José Correa-Basurto Liora Shoshani The Na+, K+-ATPase transports Na+ and K+ across the membrane of all animal cells. In addition to its ion...
Fri Sep 13, 2019 03:00
IJMS, Vol. 20, Pages 4539: Comparative Transcriptomic and Lipidomic Analyses of Human Male and Female Meibomian Glands Reveal Common Signature Genes of Meibogenesis International Journal of Molecular Sciences doi: 10.3390/ijms20184539 Authors: Igor A. Butovich Nita Bhat Jadwiga C. Wojtowicz Meibum is a lipid secretion that is produced by holocrine Meibomian glands (MGs). MGs are a specialized type of sebaceous glands that are embedded in the human eyelids. Chemically, meibum and...
Fri Sep 13, 2019 03:00
IJMS, Vol. 20, Pages 4540: More than just Stem Cells: Functional Roles of the Transcription Factor Sox2 in Differentiated Glia and Neurons International Journal of Molecular Sciences doi: 10.3390/ijms20184540 Authors: Sara Mercurio Linda Serra Silvia K. Nicolis The Sox2 transcription factor, encoded by a gene conserved in animal evolution, has become widely known because of its functional relevance for stem cells. In the developing nervous system, Sox2 is active in neural stem...
Fri Sep 13, 2019 03:00
IJMS, Vol. 20, Pages 4536: Overview of the Anticancer Profile of Avenanthramides from Oat International Journal of Molecular Sciences doi: 10.3390/ijms20184536 Authors: Eleonora Turrini Francesca Maffei Andrea Milelli Cinzia Calcabrini Carmela Fimognari Cancer represents one of the leading causes of death worldwide. Progresses in treatment of cancer have continued at a rapid pace. However, undesirable side effects and drug resistance remain major challenges for therapeutic...
Fri Sep 13, 2019 03:00
IJMS, Vol. 20, Pages 4535: The Epigenetics of Aging in Invertebrates International Journal of Molecular Sciences doi: 10.3390/ijms20184535 Authors: Guixiang Yu Qi Wu Yue Gao Meiling Chen Mingyao Yang Aging is an unstoppable process coupled to the loss of physiological function and increased susceptibility to diseases. Epigenetic alteration is one of the hallmarks of aging, which involves changes in DNA methylation patterns, post-translational modification of histones, chromatin...
Fri Sep 13, 2019 03:00
IJMS, Vol. 20, Pages 4534: Chloroplast Genomes and Comparative Analyses among Thirteen Taxa within Myrsinaceae s.str. Clade (Myrsinoideae, Primulaceae) International Journal of Molecular Sciences doi: 10.3390/ijms20184534 Authors: Xiaokai Yan Tongjian Liu Xun Yuan Yuan Xu Haifei Yan Gang Hao The Myrsinaceae s.str. clade is a tropical woody representative in Myrsinoideae of Primulaceae and has ca. 1300 species. The generic limits and alignments of this clade are unclear...
Fri Sep 13, 2019 03:00
IJMS, Vol. 20, Pages 4532: Reaction-Based, Fluorescent Film Deposition from Dopamine and a Diamine-Tethered, Bis–Resorcinol Coupler International Journal of Molecular Sciences doi: 10.3390/ijms20184532 Authors: Maria Laura Alfieri Mariagrazia Iacomino Alessandra Napolitano Marco d’Ischia The reaction-based deposition on various surfaces of an all-organic fluorescent coating is reported here, involving autoxidation of 2 mM dopamine in carbonate buffer at pH 9.0, in the presence...
Fri Sep 13, 2019 03:00
IJMS, Vol. 20, Pages 4533: Circulating miRNA Profiling in Plasma Samples of Ovarian Cancer Patients International Journal of Molecular Sciences doi: 10.3390/ijms20184533 Authors: András Penyige Éva Márton Beáta Soltész Melinda Szilágyi-Bónizs Róbert Póka János Lukács Lajos Széles Bálint Nagy Ovarian cancer is one of the most common cancer types in women characterized by a high mortality rate due to lack of early diagnosis. Circulating miRNAs besides being important...
Fri Sep 13, 2019 03:00
IJMS, Vol. 20, Pages 4531: Blockade of the Adenosine A3 Receptor Attenuates Caspase 1 Activation in Renal Tubule Epithelial Cells and Decreases Interleukins IL-1β and IL-18 in Diabetic Rats International Journal of Molecular Sciences doi: 10.3390/ijms20184531 Authors: Wallys Garrido Claudia Jara Angelo Torres Raibel Suarez Claudio Cappelli Carlos Oyarzún Claudia Quezada Rody San Martín Diabetic nephropathy (DN) is the main cause of end-stage renal disease, which...
Fri Sep 13, 2019 03:00
IJMS, Vol. 20, Pages 4530: Immunohistochemical Examination of Trophoblast Syncytialization during Early Placentation in Sheep International Journal of Molecular Sciences doi: 10.3390/ijms20184530 Authors: Heewon Seo Fuller W. Bazer Robert C. Burghardt Greg A. Johnson During the peri-implantation period, multinucleated syncytia are formed in the sheep placenta. For over 20 years the scientific consensus has been that during trophoblast syncytialization in sheep, binucleate trophoblast...
Fri Sep 13, 2019 03:00
JCM, Vol. 8, Pages 1471: Common Variants in 22 Genes Regulate Response to Metformin Intervention in Children with Obesity: A Pharmacogenetic Study of a Randomized Controlled Trial Journal of Clinical Medicine doi: 10.3390/jcm8091471 Authors: Augusto Anguita-Ruiz Belén Pastor-Villaescusa Rosaura Leis Gloria Bueno Raúl Hoyos Rocío Vázquez-Cobela Miriam Latorre-Millán M. Dolores Cañete Javier Caballero-Villarraso Ángel Gil Ramón Cañete Concepción M. Aguilera ...
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JCM, Vol. 8, Pages 1470: New Horizons in Early Dementia Diagnosis: Can Cerebellar Stimulation Untangle the Knot? Journal of Clinical Medicine doi: 10.3390/jcm8091470 Authors: Antonino Naro Angela Marra Luana Billeri Simona Portaro Rosaria De Luca Giuseppa Maresca Gianluca La Rosa Paola Lauria Placido Bramanti Rocco Salvatore Calabrò Differentiating Mild Cognitive Impairment (MCI) from dementia and estimating the risk of MCI-to-dementia conversion (MDC) are...
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JCM, Vol. 8, Pages 1469: High-Resolution CT Change over Time in Patients with Idiopathic Pulmonary Fibrosis on Antifibrotic Treatment Journal of Clinical Medicine doi: 10.3390/jcm8091469 Authors: Elisabetta Balestro Elisabetta Cocconcelli Chiara Giraudo Roberta Polverosi Davide Biondini Donato Lacedonia Erica Bazzan Linda Mazzai Giulia Rizzon Sara Lococo Graziella Turato Mariaenrica Tinè Manuel G. Cosio Marina Saetta Paolo Spagnolo Antifibrotic...
Sun Sep 15, 2019 03:00
JCM, Vol. 8, Pages 1467: Ophthalmological Findings in Mucopolysaccharidoses Journal of Clinical Medicine doi: 10.3390/jcm8091467 Authors: Shizuka Tomatsu Susanne Pitz Ulrike Hampel The mucopolysaccharidoses (MPS) are a heterogenous group of lysosomal storage disorders caused by the accumulation of glycosaminoglycans (GAGs). The accrual of these compounds results in phenotypically varied syndromes that produce multi-organ impairment with widespread systemic effects. The low incidence...
Sat Sep 14, 2019 03:00
JCM, Vol. 8, Pages 1468: NK Cells as Potential Targets for Immunotherapy in Endometriosis Journal of Clinical Medicine doi: 10.3390/jcm8091468 Authors: Ścieżyńska Komorowski Soszyńska Malejczyk Endometriosis is a common gynecological disease defined by the presence of endometrial-like tissue outside the uterus, most frequently on the pelvic viscera and ovaries, which is associated with pelvic pains and infertility. It is an inflammatory disorder with some features of autoimmunity....
Sat Sep 14, 2019 03:00
JCM, Vol. 8, Pages 1466: Maternal Obesity and Offspring Long-Term Infectious Morbidity Journal of Clinical Medicine doi: 10.3390/jcm8091466 Authors: Gil Gutvirtz Tamar Wainstock Daniella Landau Eyal Sheiner Obesity is a leading cause of morbidity world-wide. Maternal obesity is associated with adverse perinatal outcomes. Furthermore, Obesity has been associated with increased susceptibility to infections. The purpose of this study was to evaluate long-term pediatric infectious...
Sat Sep 14, 2019 03:00
JCM, Vol. 8, Pages 1464: Solid Lipid Nanoparticles Loaded with Glucocorticoids Protect Auditory Cells from Cisplatin-Induced Ototoxicity Journal of Clinical Medicine doi: 10.3390/jcm8091464 Authors: Blanca Cervantes Lide Arana Silvia Murillo-Cuesta Marina Bruno Itziar Alkorta Isabel Varela-Nieto Cisplatin is a chemotherapeutic agent that causes the irreversible death of auditory sensory cells, leading to hearing loss. Local administration of cytoprotective drugs is a potentially...
Sat Sep 14, 2019 03:00
JCM, Vol. 8, Pages 1465: Impact of Quantitative Feedback via High-Fidelity Airway Management Training on Success Rate in Endotracheal Intubation in Undergraduate Medical Students—A Prospective Single-Center Study Journal of Clinical Medicine doi: 10.3390/jcm8091465 Authors: Gunther Hempel Wolfgang Heinke Manuel F. Struck Tobias Piegeler Daisy Rotzoll Endotracheal intubation is still the gold standard in airway management. For medical students and young professionals, it is...
Sat Sep 14, 2019 03:00
JCM, Vol. 8, Pages 1463: Altered Metabolomic Profile in Patients with Peripheral Artery Disease Journal of Clinical Medicine doi: 10.3390/jcm8091463 Authors: Ahmed Ismaeel Marco E. Franco Ramon Lavado Evlampia Papoutsi George P. Casale Matthew Fuglestad Constance J. Mietus Gleb R. Haynatzki Robert S. Smith William T. Bohannon Ian Sawicki Iraklis I. Pipinos Panagiotis Koutakis Peripheral artery disease (PAD) is a common atherosclerotic disease characterized...
Sat Sep 14, 2019 03:00
JCM, Vol. 8, Pages 1461: Effect of Corticosteroids on C-Reactive Protein in Patients with Severe Community-Acquired Pneumonia and High Inflammatory Response: The Effect of Lymphopenia Journal of Clinical Medicine doi: 10.3390/jcm8091461 Authors: Torres Ceccato Ferrer Gabarrus Sibila Cilloniz Mendez Menendez Bermejo-Martin Niederman Background: Lymphopenic patients with community-acquired pneumonia (CAP) have shown high mortality rates. Corticosteroids...
Fri Sep 13, 2019 03:00
JCM, Vol. 8, Pages 1462: A Systematic Review and Meta-Analysis of the Accuracy of in VivoReflectance Confocal Microscopy for the Diagnosis of Primary Basal Cell Carcinoma Journal of Clinical Medicine doi: 10.3390/jcm8091462 Authors: Lupu Popa Voiculescu Caruntu Caruntu Basal cell carcinoma (BCC) is the most common cancer worldwide and its incidence is constantly rising. Early diagnosis and treatment can significantly reduce patient morbidity and healthcare costs. The...
Fri Sep 13, 2019 03:00
JCM, Vol. 8, Pages 1460: Impact of Disease-Specific Fears on Pulmonary Rehabilitation Trajectories in Patients with COPD Journal of Clinical Medicine doi: 10.3390/jcm8091460 Authors: Thomas Janssens Zora Van de Moortel Wolfgang Geidl Johannes Carl Klaus Pfeifer Nicola Lehbert Michael Wittmann Konrad Schultz Andreas von Leupoldt Disease-specific fears predict health status in chronic obstructive pulmonary disease (COPD), but their role in pulmonary rehabilitation...
Fri Sep 13, 2019 03:00
JCM, Vol. 8, Pages 1459: Do Younger Patients with Muscle-Invasive Bladder Cancer have Better Outcomes? Journal of Clinical Medicine doi: 10.3390/jcm8091459 Authors: Florian Janisch Hang Yu Malte W. Vetterlein Roland Dahlem Oliver Engel Margit Fisch Shahrokh F. Shariat Armin Soave Michael Rink Urothelial cancer of the bladder (UCB) is usually a disease of the elderly. The influence of age on oncological outcomes remains controversial. This study aims to investigate...
Fri Sep 13, 2019 03:00
JCM, Vol. 8, Pages 1458: Exercise Training in Patients with Chronic Respiratory Diseases: Are Cardiovascular Comorbidities and Outcomes Taken into Account?—A Systematic Review Journal of Clinical Medicine doi: 10.3390/jcm8091458 Authors: Ana Machado Kirsten Quadflieg Ana Oliveira Charly Keytsman Alda Marques Dominique Hansen Chris Burtin Patients with chronic obstructive pulmonary disease (COPD), asthma and interstitial lung diseases (ILD) frequently suffer from cardiovascular...
Fri Sep 13, 2019 03:00
JCM, Vol. 8, Pages 1457: Baseline D-Dimer Levels as a Risk Assessment Biomarker for Recurrent Stroke in Patients with Combined Atrial Fibrillation and Atherosclerosis Journal of Clinical Medicine doi: 10.3390/jcm8091457 Authors: Kang-Ho Choi Woo-Keun Seo Man-Seok Park Joon-Tae Kim Jong-Won Chung Oh Young Bang Geong-Moon Kim Tae-Jin Song Bum Joon Kim Sung Hyuk Heo Jin-Man Jung Kyungmi Oh Chi Kyung Kim Sungwook Yu Kwang Yeol Park Jeong-Min Kim Jong-Ho...
Fri Sep 13, 2019 03:00
JFB, Vol. 10, Pages 41: Silk-Based Therapeutics Targeting Pseudomonas aeruginosa Journal of Functional Biomaterials doi: 10.3390/jfb10030041 Authors: Tina B. McKay Rachael N. Parker Morgan J. Hawker Meghan McGill David L. Kaplan Pseudomonas aeruginosa (P. aeruginosa) infections may lead to severe damage of the cornea, mucosa, and skin. The highly aggressive nature of P. aeruginosa and the rise in multi-drug resistance, particularly in nosocomial settings, lead to an increased...
Fri Sep 13, 2019 03:00
JFMK, Vol. 4, Pages 66: Improvement in Muscular Strength in HIV-Infected Individuals Receiving Antiretroviral Therapy Journal of Functional Morphology and Kinesiology doi: 10.3390/jfmk4030066 Authors: Sookan Motala Ormsbee Antonio Magula Lalloo McKune Purpose: This study investigated (1) the effect of a progressive resistance training (PRT) program and whey protein intake on maximal muscle strength in human immunodeficiency virus (HIV)-infected individuals receiving...
Sat Sep 14, 2019 03:00
Life, Vol. 9, Pages 74: Computing the Parameter Values for the Emergence of Homochirality in Complex Networks Life doi: 10.3390/life9030074 Authors: Andrés Montoya Elkin Cruz Jesús Ágreda The goal of our research is the development of algorithmic tools for the analysis of chemical reaction networks proposed as models of biological homochirality. We focus on two algorithmic problems: detecting whether or not a chemical mechanism admits mirror symmetry-breaking; and, given one of...
Sun Sep 15, 2019 03:00
Medicina, Vol. 55, Pages 594: Acute Effects of Transdermal Administration of Jojoba Oil on Lipid Metabolism in Mice Medicina doi: 10.3390/medicina55090594 Authors: Yutaka Matsumoto Sihui Ma Takaki Tominaga Keiko Yokoyama Kanae Kitatani Kazumasa Horikawa Katsuhiko Suzuki Background and objectives: Aroma therapy is a complementary therapy using essential oils diluted with carrier oils. Jojoba oils have been widely used as carrier oils. However, limited information is...
Sun Sep 15, 2019 03:00
Medicina, Vol. 55, Pages 593: Translation, Cultural Adaptation, and Evaluation of a Brazilian Portuguese Questionnaire to Estimate the Self-Reported Prevalence of Gluten-Related Disorders and Adherence to Gluten-Free Diet Medicina doi: 10.3390/medicina55090593 Authors: Jesús Gilberto Arámburo-Gálvez Itallo Carvalho Gomes Tatiane Geralda André Carlos Eduardo Beltrán-Cárdenas María Auxiliadora Macêdo-Callou Élida Mara Braga Rocha Elaine Aparecida Mye-Takamatu-Watanabe Vivian...
Sun Sep 15, 2019 03:00
Medicina, Vol. 55, Pages 592: Association of Antihyperglycemic Therapy with Risk of Atrial Fibrillation and Stroke in Diabetic Patients Medicina doi: 10.3390/medicina55090592 Authors: Cristina-Mihaela Lăcătușu Elena-Daniela Grigorescu Cristian Stătescu Radu Andy Sascău Alina Onofriescu Bogdan-Mircea Mihai Type 2 diabetes mellitus (DM) is associated with an increased risk of cardiovascular disease (CVD). Atrial fibrillation (AF) and stroke are both forms of CVD that have...
Sun Sep 15, 2019 03:00
Medicina, Vol. 55, Pages 590: Pharmacotherapy Literacy of Parents in the Rural and Urban Areas of Serbia—Are There Any Differences? Medicina doi: 10.3390/medicina55090590 Authors: Krajnović Ubavić Bogavac-Stanojević Background and objectives: Pharmacotherapy literacy (PHTL) is an individual’s capacity to obtain, evaluate, calculate, and comprehend basic information about pharmacotherapy and pharmacy-related services necessary to make appropriate medication-related...
Fri Sep 13, 2019 03:00
Medicina, Vol. 55, Pages 589: Deduction of Novel Genes Potentially Involved in the Effects of Very Low Dose Atropine (0.003%) Treatment on Corneal Epithelial Cells Using Next-Generation Sequencing and Bioinformatics Approaches Medicina doi: 10.3390/medicina55090589 Authors: Chang Hsiao Lin Jian Chen Kuo Background and Objectives: Atropine is a nonselective muscarinic antagonist which has been used to prevent worsening of myopia in children. Different concentrations...
Fri Sep 13, 2019 03:00
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