IJMS, Vol. 20, Pages 4704: Microbiome Influence in the Pathogenesis of Prion and Alzheimer’s Diseases International Journal of Molecular Sciences doi: 10.3390/ijms20194704 Authors: Valeria D’Argenio Daniela Sarnataro Misfolded and abnormal β-sheets forms of wild-type proteins, such as cellular prion protein (PrPC) and amyloid beta (Aβ), are believed to be the vectors of neurodegenerative diseases, prion and Alzheimer’s disease (AD), respectively. Increasing...
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IJMS, Vol. 20, Pages 4705: Current Possibilities of Gynecologic Cancer Treatment with the Use of Immune Checkpoint Inhibitors International Journal of Molecular Sciences doi: 10.3390/ijms20194705 Authors: Ewelina Grywalska Małgorzata Sobstyl Lechosław Putowski Jacek Roliński Despite the ongoing progress in cancer research, the global cancer burden has increased to 18.1 million new cases and 9.6 million deaths in 2018. Gynecological cancers, such as ovarian, endometrial, and...
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IJMS, Vol. 20, Pages 4703: Genome-Wide Analysis and Identification of the Aux/IAA Gene Family in Peach International Journal of Molecular Sciences doi: 10.3390/ijms20194703 Authors: Dan Guan Xiao Hu Donghui Diao Fang Wang Yueping Liu The Auxin/indole-3-acetic acid (Aux/IAA) repressor genes down-regulate the auxin response pathway during many stages of plant and fruit development. In order to determine if and how Aux/IAAs participate in governing texture and hardness in stone...
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IJMS, Vol. 20, Pages 4701: Directed Evolution of Clostridium thermocellum β-Glucosidase A Towards Enhanced Thermostability International Journal of Molecular Sciences doi: 10.3390/ijms20194701 Authors: Shahar Yoav Johanna Stern Orly Salama-Alber Felix Frolow Michael Anbar Alon Karpol Yitzhak Hadar Ely Morag Edward A. Bayer β-Glucosidases are key enzymes in the process of cellulose utilization. It is the last enzyme in the cellulose hydrolysis chain, which...
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IJMS, Vol. 20, Pages 4702: CRISPR/Cas9-Based Mutagenesis of Starch Biosynthetic Genes in Sweet Potato (Ipomoea Batatas) for the Improvement of Starch Quality International Journal of Molecular Sciences doi: 10.3390/ijms20194702 Authors: Hongxia Wang Yinliang Wu Yandi Zhang Jun Yang Weijuan Fan Hui Zhang Shanshan Zhao Ling Yuan Peng Zhang CRISPR/Cas9-mediated genome editing is a powerful technology that has been used for the genetic modification of a number of...
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IJMS, Vol. 20, Pages 4699: Urinary Human Epididymis Secretory Protein 4 as a Useful Biomarker for Subclinical Acute Rejection Three Months after Kidney Transplantation International Journal of Molecular Sciences doi: 10.3390/ijms20194699 Authors: Soichiro Tajima Rao Fu Tomohiro Shigematsu Hiroshi Noguchi Keizo Kaku Akihiro Tsuchimoto Yasuhiro Okabe Satohiro Masuda Kidney transplantation is the treatment of choice for patients with advanced chronic kidney disease...
Sun Sep 22, 2019 03:00
IJMS, Vol. 20, Pages 4700: Efficient Epidermal Growth Factor Receptor Targeting Oligonucleotide as a Potential Molecule for Targeted Cancer Therapy International Journal of Molecular Sciences doi: 10.3390/ijms20194700 Authors: Tao Wang Svetlana Philippovich Jun Mao Rakesh N. Veedu Epidermal growth factor receptor (EGFR) is associated with the progression of a wide range of cancers including breast, glioma, lung, and liver cancer. The observation that EGFR inhibition can limit...
Sun Sep 22, 2019 03:00
IJMS, Vol. 20, Pages 4697: Knockdown of RhoE Expression Enhances TGF-β-Induced EMT (epithelial-to-mesenchymal transition) in Cervical Cancer HeLa Cells International Journal of Molecular Sciences doi: 10.3390/ijms20194697 Authors: Makoto Nishizuka Rina Komada Masayoshi Imagawa Cervical cancer with early metastasis of the primary tumor is associated with poor prognosis and poor therapeutic outcomes. Since epithelial-to-mesenchymal transition (EMT) plays a role in acquisition of...
Sun Sep 22, 2019 03:00
IJMS, Vol. 20, Pages 4698: Development of Teleost Intermuscular Bones Undergoing Intramembranous Ossification Based on Histological-Transcriptomic-Proteomic Data International Journal of Molecular Sciences doi: 10.3390/ijms20194698 Authors: Chun-Hong Nie Shi-Ming Wan Yu-Long Liu Han Liu Wei-Min Wang Ze-Xia Gao Intermuscular bones (IBs) specially exist in lower teleost fish and the molecular mechanism for its development remains to be clarified. In this study, different...
Sun Sep 22, 2019 03:00
IJMS, Vol. 20, Pages 4696: Rapid Microfluidic Preparation of Niosomes for Targeted Drug Delivery International Journal of Molecular Sciences doi: 10.3390/ijms20194696 Authors: Didem Ag Seleci Viktor Maurer Frank Stahl Thomas Scheper Georg Garnweitner Niosomes are non-ionic surfactant-based vesicles with high promise for drug delivery applications. They can be rapidly prepared via microfluidics, allowing their reproducible production without the need of a subsequent size reduction...
Sun Sep 22, 2019 03:00
IJMS, Vol. 20, Pages 4694: Beneficial and Deleterious Effects of Female Sex Hormones, Oral Contraceptives, and Phytoestrogens by Immunomodulation on the Liver International Journal of Molecular Sciences doi: 10.3390/ijms20194694 Authors: Luis E. Soria-Jasso Raquel Cariño-Cortés Víctor Manuel Muñoz-Pérez Elizabeth Pérez-Hernández Nury Pérez-Hernández Eduardo Fernández-Martínez The liver is considered the laboratory of the human body because of its many metabolic processes....
Sun Sep 22, 2019 03:00
IJMS, Vol. 20, Pages 4695: Sphingosine 1-Phosphate Receptor Blockade Affects Pro-Inflammatory Bone Marrow-Derived Macrophages and Relieves Mouse Fatty Liver Injury International Journal of Molecular Sciences doi: 10.3390/ijms20194695 Authors: Jingjing Yang Na Chang Le Yang Xiaofang Ji Xuan Zhou Lei Tian Yuehan Ma Yuanru Yang Yuran Liu Lin Yang Liying Li Fatty liver injury is characterized by liver fat accumulation and results in serious health problems worldwide....
Sun Sep 22, 2019 03:00
IJMS, Vol. 20, Pages 4693: EGFR-Specific Tyrosine Kinase Inhibitor Modifies NK Cell-Mediated Antitumoral Activity against Ovarian Cancer Cells International Journal of Molecular Sciences doi: 10.3390/ijms20194693 Authors: Nina Mallmann-Gottschalk Yvonne Sax Rainer Kimmig Stephan Lang Sven Brandau The adverse prognosis of most patients with ovarian cancer is related to recurrent disease caused by resistance to chemotherapeutic and targeted therapeutics. Besides their direct...
Sun Sep 22, 2019 03:00
IJMS, Vol. 20, Pages 4687: The Role of Exo-miRNAs in Cancer: A Focus on Therapeutic and Diagnostic Applications International Journal of Molecular Sciences doi: 10.3390/ijms20194687 Authors: Francesco Ingenito Giuseppina Roscigno Alessandra Affinito Silvia Nuzzo Iolanda Scognamiglio Cristina Quintavalle Gerolama Condorelli Exosomes are extracellular vesicles released into biological fluids where they act as carriers of various molecules, including proteins, lipids,...
Sat Sep 21, 2019 03:00
IJMS, Vol. 20, Pages 4692: Fibroblast Growth Factor 21 and the Adaptive Response to Nutritional Challenges International Journal of Molecular Sciences doi: 10.3390/ijms20194692 Authors: Úrsula Martínez-Garza Daniel Torres-Oteros Alex Yarritu-Gallego Pedro F. Marrero Diego Haro Joana Relat The Fibroblast Growth Factor 21 (FGF21) is considered an attractive therapeutic target for obesity and obesity-related disorders due to its beneficial effects in lipid and carbohydrate...
Sat Sep 21, 2019 03:00
IJMS, Vol. 20, Pages 4690: Nickel Carcinogenesis Mechanism: DNA Damage International Journal of Molecular Sciences doi: 10.3390/ijms20194690 Authors: Hongrui Guo Huan Liu Hongbin Wu Hengmin Cui Jing Fang Zhicai Zuo Junliang Deng Yinglun Li Xun Wang Ling Zhao Nickel (Ni) is known to be a major carcinogenic heavy metal. Occupational and environmental exposure to Ni has been implicated in human lung and nasal cancers. Currently, the molecular mechanisms of Ni...
Sat Sep 21, 2019 03:00
IJMS, Vol. 20, Pages 4691: Silver Nanoparticles Addition in Poly(Methyl Methacrylate) Dental Matrix: Topographic and Antimycotic Studies International Journal of Molecular Sciences doi: 10.3390/ijms20194691 Authors: Valeria De Matteis Mariafrancesca Cascione Chiara Cristina Toma Giovanni Albanese Maria Luisa De Giorgi Massimo Corsalini Rosaria Rinaldi The widespread use of nanoparticles (NPs) in medical devices has opened a new scenario in the treatment and prevention...
Sat Sep 21, 2019 03:00
IJMS, Vol. 20, Pages 4686: Chloride as a Beneficial Macronutrient in Higher Plants: New Roles and Regulation International Journal of Molecular Sciences doi: 10.3390/ijms20194686 Authors: José M. Colmenero-Flores Juan D. Franco-Navarro Paloma Cubero-Font Procopio Peinado-Torrubia Miguel A. Rosales Chloride (Cl−) has traditionally been considered a micronutrient largely excluded by plants due to its ubiquity and abundance in nature, its antagonism with nitrate (NO3−),...
Sat Sep 21, 2019 03:00
IJMS, Vol. 20, Pages 4689: Osteoclast-Like Cells in Aneurysmal Disease Exhibit an Enhanced Proteolytic Phenotype International Journal of Molecular Sciences doi: 10.3390/ijms20194689 Authors: Matthew J. Kelly Kimihiro Igari Dai Yamanouchi Abdominal aortic aneurysm (AAA) is among the top 20 causes of death in the United States. Surgical repair is the gold standard for AAA treatment, therefore, there is a need for non-invasive therapeutic interventions. Aneurysms are more closely...
Sat Sep 21, 2019 03:00
IJMS, Vol. 20, Pages 4685: Short-Time Ocular Ischemia Induces Vascular Endothelial Dysfunction and Ganglion Cell Loss in the Pig Retina International Journal of Molecular Sciences doi: 10.3390/ijms20194685 Authors: Jenia Kouchek Zadeh Andreas Garcia-Bardon Erik Kristoffer Hartmann Norbert Pfeiffer Wael Omran Marion Ludwig Andreas Patzak Ning Xia Huige Li Adrian Gericke Visual impairment and blindness are often caused by retinal ischemia-reperfusion (I/R) injury....
Sat Sep 21, 2019 03:00
IJMS, Vol. 20, Pages 4688: SNPs rs11240569, rs708727, and rs823156 in SLC41A1 Do Not Discriminate Between Slovak Patients with Idiopathic Parkinson’s Disease and Healthy Controls: Statistics and Machine-Learning Evidence International Journal of Molecular Sciences doi: 10.3390/ijms20194688 Authors: Michal Cibulka Maria Brodnanova Marian Grendar Milan Grofik Egon Kurca Ivana Pilchova Oto Osina Zuzana Tatarkova Dusan Dobrota Martin Kolisek Gene SLC41A1 (A1) is...
Sat Sep 21, 2019 03:00
IJMS, Vol. 20, Pages 4681: Robust Sampling of Defective Pathways in Multiple Myeloma International Journal of Molecular Sciences doi: 10.3390/ijms20194681 Authors: Juan Luis Fernández-Martínez Enrique J. de Andrés-Galiana Francisco Javier Fernández-Ovies Ana Cernea Andrzej Kloczkowski We present the analysis of defective pathways in multiple myeloma (MM) using two recently developed sampling algorithms of the biological pathways: The Fisher’s ratio sampler, and...
Sat Sep 21, 2019 03:00
IJMS, Vol. 20, Pages 4684: Challenges in Exosome Isolation and Analysis in Health and Disease International Journal of Molecular Sciences doi: 10.3390/ijms20194684 Authors: Nils Ludwig Theresa L. Whiteside Torsten E. Reichert A growing body of evidence emphasizes the important role exosomes in different physiological and pathological conditions. Exosomes, virus-size extracellular vesicles (EVs), carry a complex molecular cargo, which is actively processed in the endocytic compartment...
Sat Sep 21, 2019 03:00
IJMS, Vol. 20, Pages 4680: Xanthine Oxidase Inhibitor Febuxostat Exerts an Anti-Inflammatory Action and Protects against Diabetic Nephropathy Development in KK-Ay Obese Diabetic Mice International Journal of Molecular Sciences doi: 10.3390/ijms20194680 Authors: Yu Mizuno Takeshi Yamamotoya Yusuke Nakatsu Koji Ueda Yasuka Matsunaga Masa-Ki Inoue Hideyuki Sakoda Midori Fujishiro Hiraku Ono Takako Kikuchi Masahiro Takahashi Kenichi Morii Kensuke Sasaki Takao...
Sat Sep 21, 2019 03:00
IJMS, Vol. 20, Pages 4682: Smad7 Binds Differently to Individual and Tandem WW3 and WW4 Domains of WWP2 Ubiquitin Ligase Isoforms International Journal of Molecular Sciences doi: 10.3390/ijms20194682 Authors: Lloyd C. Wahl Jessica E. Watt Hiu T. T. Yim Danielle De Bourcier James Tolchard Surinder M. Soond Tharin M. A. Blumenschein Andrew Chantry WWP2 is an E3 ubiquitin ligase that differentially regulates the contextual tumour suppressor/progressor TGFβ...
Sat Sep 21, 2019 03:00
IJMS, Vol. 20, Pages 4683: Active DNA Demethylation in Plants International Journal of Molecular Sciences doi: 10.3390/ijms20194683 Authors: Jara Teresa Parrilla-Doblas Teresa Roldán-Arjona Rafael R. Ariza Dolores Córdoba-Cañero Methylation of cytosine (5-meC) is a critical epigenetic modification in many eukaryotes, and genomic DNA methylation landscapes are dynamically regulated by opposed methylation and demethylation processes. Plants are unique in possessing a mechanism...
Sat Sep 21, 2019 03:00
IJMS, Vol. 20, Pages 4679: Unique Features of Entamoeba Sulfur Metabolism; Compartmentalization, Physiological Roles of Terminal Products, Evolution and Pharmaceutical Exploitation International Journal of Molecular Sciences doi: 10.3390/ijms20194679 Authors: Fumika Mi-ichi Hiroki Yoshida Sulfur metabolism is essential for all living organisms. Recently, unique features of the Entamoeba metabolic pathway for sulfated biomolecules have been described. Entamoeba is a genus in the phylum...
Sat Sep 21, 2019 03:00
IJMS, Vol. 20, Pages 4677: Phosphorus Localization and Its Involvement in the Formation of Concentrated Uranium in the Renal Proximal Tubules of Rats Exposed to Uranyl Acetate International Journal of Molecular Sciences doi: 10.3390/ijms20194677 Authors: Homma-Takeda Numako Kitahara Yoshida Oikawa Terada Kokubo Shimada Although the kidneys comprise a critical target of uranium exposure, the dynamics of renal uranium distribution have remained obscure. Uranium...
Fri Sep 20, 2019 03:00
IJMS, Vol. 20, Pages 4678: Comparison of Whole Plastome Sequences between Thermogenic Skunk Cabbage Symplocarpus renifolius and Nonthermogenic S. nipponicus (Orontioideae; Araceae) in East Asia International Journal of Molecular Sciences doi: 10.3390/ijms20194678 Authors: Seon-Hee Kim JiYoung Yang Jongsun Park Takayuki Yamada Masayuki Maki Seung-Chul Kim Symplocarpus, a skunk cabbage genus, includes two sister groups, which are drastically different in life history traits...
Fri Sep 20, 2019 03:00
IJMS, Vol. 20, Pages 4673: Postbiotics and Their Potential Applications in Early Life Nutrition and Beyond International Journal of Molecular Sciences doi: 10.3390/ijms20194673 Authors: Carrie A. M. Wegh Sharon Y. Geerlings Jan Knol Guus Roeselers Clara Belzer Postbiotics are functional bioactive compounds, generated in a matrix during fermentation, which may be used to promote health. The term postbiotics can be regarded as an umbrella term for all synonyms and related terms...
Fri Sep 20, 2019 03:00
IJMS, Vol. 20, Pages 4676: Lead, Cadmium and Zinc Phytotoxicity Alter DNA Methylation Levels to Confer Heavy Metal Tolerance in Wheat International Journal of Molecular Sciences doi: 10.3390/ijms20194676 Authors: Sarfraz Shafiq Qudsia Zeb Asim Ali Yasar Sajjad Rashid Nazir Emilie Widemann Liangyu Liu Being a staple food, wheat (Triticum aestivum) nutritionally fulfills all requirements of human health and also serves as a significant link in the food chain for the ingestion...
Fri Sep 20, 2019 03:00
IJMS, Vol. 20, Pages 4675: Hyperbaric Oxygen Treatment Ameliorates Hearing Loss and Auditory Cortex Injury in Noise Exposed Mice by Repressing Local Ceramide Accumulation International Journal of Molecular Sciences doi: 10.3390/ijms20194675 Authors: Yu-Ting Su Yi-Bin Guo Yao-Ping Cheng Xi Zhang Xiao-Ping Xie Yao-Ming Chang Jun-Xiang Bao Noise-induced hearing loss (NIHL) relates closely to auditory cortex (AC) injury, so countermeasures aiming at the AC recovery would...
Fri Sep 20, 2019 03:00
IJMS, Vol. 20, Pages 4672: A Novel Prognostic DNA Methylation Panel for Colorectal Cancer International Journal of Molecular Sciences doi: 10.3390/ijms20194672 Authors: Hsin-Hua Chung Chih-Chi Kuo Cheng-Wen Hsiao Chao-Yang Chen Je-Ming Hu Chih-Hsiung Hsu Yu-Ching Chou Ya-Wen Lin Yu-Lueng Shih Colorectal cancer (CRC) is one of the most common cancers and the second leading cause of cancer-related deaths. Discrepancies in clinical outcomes are observed even among...
Fri Sep 20, 2019 03:00
IJMS, Vol. 20, Pages 4674: VGF Peptides in Cerebrospinal Fluid of Patients with Dementia with Lewy Bodies International Journal of Molecular Sciences doi: 10.3390/ijms20194674 Authors: Inger van Steenoven Barbara Noli Cristina Cocco Gian-Luca Ferri Patrick Oeckl Markus Otto Marleen J. A. Koel-Simmelink Claire Bridel Wiesje M. van der Flier Afina W. Lemstra Charlotte E. Teunissen In a previous proteomic study, we identified the neurosecretory protein VGF...
Fri Sep 20, 2019 03:00
IJMS, Vol. 20, Pages 4671: Hydrogel-Mediated DOX⋅HCl/PTX Delivery System for Breast Cancer Therapy International Journal of Molecular Sciences doi: 10.3390/ijms20194671 Authors: Hoon Hyun Young Bum Yoo So Yeon Kim Hyun Sun Ko Heung Jae Chun Dae Hyeok Yang We used a hydrogel-mediated dual drug delivery approach, based on an injectable glycol chitosan (GC) hydrogel, doxorubicin hydrochloride (DOX⋅HCl), and a complex of beta-cyclodextrin (β-CD) and paclitaxel...
Fri Sep 20, 2019 03:00
IJMS, Vol. 20, Pages 4669: Diagnostic Performance and Prognostic Value of PET/CT with Different Tracers for Brain Tumors: A Systematic Review of Published Meta-Analyses International Journal of Molecular Sciences doi: 10.3390/ijms20194669 Authors: Giorgio Treglia Barbara Muoio Gianluca Trevisi Maria Vittoria Mattoli Domenico Albano Francesco Bertagna Luca Giovanella Background: Several meta-analyses reporting data on the diagnostic performance or prognostic value of...
Fri Sep 20, 2019 03:00
IJMS, Vol. 20, Pages 4668: Suppressing Antibacterial Resistance: Chemical Binding of Monolayer Quaternary Ammonium Salts to Polymethyl Methacrylate in an Aqueous Solution and Its Clinical Efficacy International Journal of Molecular Sciences doi: 10.3390/ijms20194668 Authors: Chung-Yuan Lee Yi-Ting Chen Bor-Shiunn Lee Che-Chen Chang Antibacterial resistance (ABR) poses an enormous threat to human health. ABR mainly develops due to bacteria being constantly exposed to diluted...
Fri Sep 20, 2019 03:00
IJMS, Vol. 20, Pages 4667: Increased ROS Scavenging and Antioxidant Efficiency of Chlorogenic Acid Compound Delivered via a Chitosan Nanoparticulate System for Efficient In Vitro Visualization and Accumulation in Human Renal Adenocarcinoma Cells International Journal of Molecular Sciences doi: 10.3390/ijms20194667 Authors: Revathi Kavi Rajan Mohd Zobir Hussein Sharida Fakurazi Khatijah Yusoff Mas Jaffri Masarudin Naturally existing Chlorogenic acid (CGA) is an antioxidant-rich...
Fri Sep 20, 2019 03:00
IJMS, Vol. 20, Pages 4670: Activation of the Sphingosine 1 Phosphate–Rho Pathway in Pterygium and in Ultraviolet-Irradiated Normal Conjunctiva International Journal of Molecular Sciences doi: 10.3390/ijms20194670 Authors: Nozomi Igarashi Megumi Honjo Takashi Fujishiro Tetsuya Toyono Takashi Ono Yosai Mori Kazunori Miyata Hideru Obinata Makoto Aihara Sphingosine 1 phosphate (S1P) is a bioactive lipid that regulates cellular activity, including proliferation, cytoskeletal...
Fri Sep 20, 2019 03:00
IJMS, Vol. 20, Pages 4666: Natural Products as Modulators of the Proteostasis Machinery: Implications in Neurodegenerative Diseases International Journal of Molecular Sciences doi: 10.3390/ijms20194666 Authors: Karina Cuanalo-Contreras Ines Moreno-Gonzalez Proteins play crucial and diverse roles within the cell. To exert their biological function they must fold to acquire an appropriate three-dimensional conformation. Once their function is fulfilled, they need to be properly degraded...
Fri Sep 20, 2019 03:00
IJMS, Vol. 20, Pages 4663: Platelet-Derived Growth Factor Receptor and Ionizing Radiation in High Grade Glioma Cell Lines International Journal of Molecular Sciences doi: 10.3390/ijms20194663 Authors: Oana Alexandru Ani-Simona Sevastre Juan Castro Stefan-Alexandru Artene Daniela Elise Tache Oana Stefana Purcaru Veronica Sfredel Ligia Gabriela Tataranu Anica Dricu Treatment of high grade gliomas (HGGs) has remained elusive due to their high heterogeneity and aggressiveness....
Fri Sep 20, 2019 03:00
IJMS, Vol. 20, Pages 4664: A New Approach for the Fabrication of Cytocompatible PLLA-Magnetite Nanoparticle Composite Scaffolds International Journal of Molecular Sciences doi: 10.3390/ijms20194664 Authors: Esperanza Díaz María Blanca Valle Sylvie Ribeiro Senentxu Lanceros‑Mendez José Manuel Barandiarán Magnetic biomimetic scaffolds of poly(L-lactide) (PLLA) and nanoparticles of magnetite (nFe3O4) are prepared in a wide ratio of compositions by lyophilization for bone regeneration....
Fri Sep 20, 2019 03:00
IJMS, Vol. 20, Pages 4662: Royal Jelly and Its Components Promote Healthy Aging and Longevity: From Animal Models to Humans International Journal of Molecular Sciences doi: 10.3390/ijms20194662 Authors: Hiroshi Kunugi Amira Mohammed Ali Aging is a natural phenomenon that occurs in all living organisms. In humans, aging is associated with lowered overall functioning and increased mortality out of the risk for various age-related diseases. Hence, researchers are pushed to find effective...
Fri Sep 20, 2019 03:00
IJMS, Vol. 20, Pages 4665: Unravelling the Metabolic and Hormonal Machinery During Key Steps of Somatic Embryogenesis: A Case Study in Coffee International Journal of Molecular Sciences doi: 10.3390/ijms20194665 Authors: Rayan Awada Claudine Campa Estelle Gibault Eveline Déchamp Frédéric Georget Maud Lepelley Cécile Abdallah Alexander Erban Federico Martinez-Seidel Joachim Kopka Laurent Legendre Sophie Léran Geneviève Conéjéro Jean-Luc Verdeil Dominique...
Fri Sep 20, 2019 03:00
IJMS, Vol. 20, Pages 4661: The Role of Protein Misfolding and Tau Oligomers (TauOs) in Alzheimer′s Disease (AD) International Journal of Molecular Sciences doi: 10.3390/ijms20194661 Authors: Mroczko Groblewska Litman-Zawadzka Although the causative role of the accumulation of amyloid β 1–42 (Aβ42) deposits in the pathogenesis of Alzheimer′s disease (AD) has been under debate for many years, it is supposed that the toxicity soluble oligomers...
Fri Sep 20, 2019 03:00
IJMS, Vol. 20, Pages 4660: The Roles of Sex Hormones in the Course of Atopic Dermatitis International Journal of Molecular Sciences doi: 10.3390/ijms20194660 Authors: Naoko Kanda Toshihiko Hoashi Hidehisa Saeki Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by T helper 2 cell (Th2)-shifted abnormal immunity, skin barrier impairment, and pruritus. The prevalence of AD in childhood is slightly higher in boys than in girls; after puberty, the sexual difference...
Fri Sep 20, 2019 03:00
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