Publication date: Available online 13 September 2019Source: Sleep MedicineAuthor(s): Oscar H. Del Brutto, Robertino M. Mera, Pablo R. Castillo
Fri Sep 13, 2019 15:02
Publication date: Available online 13 September 2019Source: Sleep MedicineAuthor(s): Sirimon Reutrakul, Apichart So-ngern, Naricha Chirakalwasan, Sunee Saetung, Suwannee Chanprasertyothin, Ammarin Thakkinstian, George E. ChlipalaSummaryBackgroundGut microbiota has been linked to obesity and glucose metabolism. Insufficient sleep is also known to be associated with insulin resistance, and sleep extension was reported to improve glucose metabolism in short sleepers. This study aimed to explore whether...
Sat Sep 14, 2019 17:43
Publication date: Available online 14 September 2019Source: Sleep MedicineAuthor(s): Shermyn Neo, Zheyu Xu
Sun Sep 15, 2019 15:38
Publication date: Available online 14 September 2019Source: Journal of Neuroscience MethodsAuthor(s): Benjamin Shafer, Cristin Welle, Srikanth VasudevanAbstractBackgroundHigh-resolution peripheral nerve interfaces (PNIs) can provide amputees with intuitive motor control and sensory feedback. Current PNIs are limited by early device failure and suboptimal long-term stability. The present study aims to incorporate functional assessment into an in vivo test platform to assess the long-term safety and...
Sun Sep 15, 2019 15:43
Publication date: Available online 14 September 2019Source: Journal of Neuroscience MethodsAuthor(s): Bikei Ryu, Hidekazu Sekine, Takakazu Kawamata, Tatsuya ShimizuAbstractBackgroundIn basic research, especially animal experiments, tissue histology with preserved organ morphology is essential, and the reliability of experiments depends on the quality of tissue sections. Frozen sections adequately maintain the antigenicity of tissues and are suitable for immunohistochemistry. However, thin frozen...
Sun Sep 15, 2019 15:43
Publication date: Available online 13 September 2019Source: Dental MaterialsAuthor(s): Alexander Lunt, Enrico Salvati, Nikolaos Baimpas, Igor Dolbnya, Tee Khin Neo, Alexander M. KorsunskyAbstractObjectivesYttria Partially Stabilised Zirconia (YPSZ) is a high strength ceramic which has become widely used in porcelain veneered dental copings due to its exceptional toughness. Within these components the residual stress and crystallographic phase of YPSZ close to the interface are highly influential...
Fri Sep 13, 2019 13:07
Publication date: Available online 14 September 2019Source: Dental MaterialsAuthor(s): E. Dianne RekowAbstractObjectiveSummarizing the new state of the art of digital dentistry, opens exploration of the type and extent of innovations and technological advances that have impacted – and improved – dentistry. The objective is to describe advances and innovations, the breadth of their impact, disruptions and advantages they produce, and opportunities created for material scientists.MethodsOn-line data...
Sat Sep 14, 2019 14:27
Publication date: Available online 14 September 2019Source: Dental MaterialsAuthor(s): Konstantinos Ioannidis, Sadia Niazi, Petros Mylonas, Francesco Mannocci, Sanjukta DebAbstractObjectiveThe deleterious caustic effects of sodium hypochlorite (NaOCl) as a root canal irrigant makes it imperative that alternative methods are developed for root canal disinfection. The purpose of this study was to examine the antimicrobial efficacy of silver nanoparticles (AgNPs) synthesized on an aqueous graphene oxide...
Sun Sep 15, 2019 15:58
Publication date: October 2019Source: Dental Materials, Volume 35, Issue 10Author(s):
Sun Sep 15, 2019 15:58
Publication date: November 2019Source: Biomedicine & Pharmacotherapy, Volume 119Author(s): Zhenxing Wei, Kunpeng Chang, Chongsheng FanAbstractCircular RNAs (circRNAs) have been reported to play critical roles in tumorigenesis. However, the roles of circRNAs in laryngeal squamous cell carcinoma (LSCC) are still largely unknown. In our present study, we identified a novel circRNA hsa_circ_0042666, which was poorly expressed in LSCC. Low hsa_circ_0042666 expression was closely associated with advanced...
Fri Sep 13, 2019 16:19
Publication date: November 2019Source: Biomedicine & Pharmacotherapy, Volume 119Author(s): Zhen Wang, Huan-Huan Sha, Hai-Jun LiAbstractMicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the post-transcriptional level. Mounting evidence suggests the involvement of miRNAs in carcinogenesis and the development of human cancer. Among the miRNAs, miR-186 has been extensively studied in various cancers. The expression of miR-186 in tissues varies depending on the type of cancer...
Fri Sep 13, 2019 16:19
Publication date: November 2019Source: Biomedicine & Pharmacotherapy, Volume 119Author(s): Dongfang Guo, Airong Zhang, Jing Huang, Meifang Suo, Yaping Zhong, Yile LiangAbstractAcute lymphoblastic leukemia (ALL), usually treated with chemotherapy, has limited therapeutic effects and high toxicity. Upregulation of HSP70 induces tumor development, however, the molecular mechanism of HSP70 in ALL remains unclear. In our research, we aimed to investigate the role of HSP70 in ALL, specifically the...
Fri Sep 13, 2019 16:19
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Xinyu Ji, Shuai Shi, Bin Liu, Mingxu Shan, Danli Tang, Wantong Zhang, Yin Zhang, Lulu Zhang, Huamin Zhang, Cheng Lu, Yongyan WangAbstractDyslipidemia is a key risk factor for cardiovascular diseases, which are a major cause of morbidity and mortality worldwide. However, despite the advancement of the treatment and prevention of dyslipidemia, medications used to treat dyslipidemia are limited to chemical...
Sat Sep 14, 2019 19:54
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Zhiwen Cao, Wen Li, Rui Liu, Xiang Li, Hui Li, Linlin Liu, Youwen Chen, Cheng Lv, Yuanyan LiuAbstractIt is necessary to design a reasonable drug delivery system(DDS) for targeted release to overcome the potential toxicity and poor selectivity of anti-tumor drug. How a drug is released from a DDS is a critical issue that determines whether the DDS is designed successfully. We all know that the microenvironment...
Sat Sep 14, 2019 19:54
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Xuedong An, Qi Bao, Sha Di, Yiru Zhao, Shenghui Zhao, Haiyu Zhang, Fengmei Lian, Xiaolin TongAbstractAs technologies used to study the gut microbiota have improved, the relationship between the gut microbiota and health has become increasingly obvious. Herbal medicines have been used for thousands of years, and are known to be “simple, convenient, cheap, and effective”. However, due to many factors, such...
Sat Sep 14, 2019 19:54
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Zhong-Yan Zhou, Wai-Rong Zhao, Jing Zhang, Xin-Lin Chen, Jing-Yi TangAbstractSodium tanshinone IIA sulfonate (STS) is a water-soluble derivate of tanshinone IIA (Tan IIA) which is an active lipophilic constitute of Chinese Materia Medica Salvia miltiorrhiza Bge. (Danshen). STS presents multiple pharmacological activities, including anti-oxidant, anti-inflammation and anti-apoptosis, and has been approved...
Sat Sep 14, 2019 19:54
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Xiaojiao Yin, Siyu Yang, Mingyue Zhang, Ying YueAbstractCurrently, stem cells are reported to be involved in tumor formation, drug resistance and recurrence. Inhibiting the proliferation of tumor cells, promoting their senescence and apoptosis has been the most important anti-tumor therapy. Epigenetics is involved in the regulation of gene expression and is closely related to cancer and stem cells. It mainly...
Sat Sep 14, 2019 19:54
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Xu Jian, Yuntao Liu, Zhen Zhao, Liyun Zhao, Dawei Wang, Qing LiuAbstractAtherosclerosis (AS) is the main cause of ischemic cardiovascular, cerebrovascular and peripheral vascular diseases. Macrophage activity has been proven to play a critical role during the AS pathological process, which involves the adhesion, aggregation of mononuclear-macrophages, cell differentiation of M1/M2 macrophages as part of...
Sat Sep 14, 2019 19:54
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): YuZhen Li, XiuHua LiuAbstractApoptosis is an evolutionarily conserved suicide process. It plays critical roles in the development and homeostasis of cardiac tissues. However, excessively stimulated apoptotic activity induced by a myriad of deleterious stimuli can result in too much cardiomyocyte death. The regenerative potential of the adult cardiomyocytes is limited. The cardiomyocyte loss cannot be compensated...
Sat Sep 14, 2019 19:54
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Chun-ze Zhou, Rui-feng Wang, De-lei Cheng, Yi-jiang Zhu, Qi Cao, Wei-fu LvAbstractBackgroundThis study was conducted to investigate the protective effect of Fms-like tyrosine kinase 3 (FLT3)/FLT3 ligand (FLT3L)-dependent CD103+ dendritic cells (DCs) on hepatic ischemia-reperfusion injury (IRI).MethodsA mouse model of hepatic IRI and cellular model following hypoxia-reperfusion (H/R) treatment were established....
Sat Sep 14, 2019 19:54
Publication date: November 2019Source: Biomedicine & Pharmacotherapy, Volume 119Author(s): Wenjing Yu, Feng Qiao, Xiaoyu Su, Dan Zhang, Hui Wang, Jinhui Jiang, Huiqin XuAbstractObjectiveThe aim of this study was to evaluate the application of 18F-flortanidazole (18F-HX4)/18F-fluoromisonidazole (18F-FMISO) - based micro positron emission tomography/computed tomography (PET/CT) for imaging of tumor hypoxia and radiotherapy-associated changes in mice.Materials and methodsRadiotracer-based cellular...
Sun Sep 15, 2019 16:03
Publication date: November 2019Source: Biomedicine & Pharmacotherapy, Volume 119Author(s): Jinxiang Pan, Selvakani Prabakaran, Mariappan RajanAbstractCurrently, bio-mimetic material synthetic processes are involved in bone implant design which is closely related to natural bone. In this work, Zinc, Cerium and Selenium substituted hydroxyapatite/ Poly (sorbitol sebacate glutamate) (Zn, Ce, Se-HAP/PSSG, M-HAP/PSSG) composite was prepared by sol-gel method as a bio-mimetic materials for bone implantation....
Sun Sep 15, 2019 16:03
Publication date: October 2019Source: European Journal of Cancer, Volume 120Author(s): Robin L. Jones, Mark J. Ratain, Peter J. O'Dwyer, Lillian L. Siu, Jacek Jassem, Jacques Medioni, Maja DeJonge, Charles Rudin, Michael Sawyer, David Khayat, Ahmad Awada, Judith M.P.G.M. de Vos-Geelen, T.R. Jeffry Evans, Jennifer Obel, Bruce Brockstein, Jacques DeGreve, Jean-Francois Baurain, Robert Maki, David D'Adamo, Mark DicksonAbstractBackgroundBrivanib is a selective inhibitor of vascular endothelial growth...
Fri Sep 13, 2019 14:59
Publication date: November 2019Source: European Journal of Cancer, Volume 121Author(s): EHJ (Erwin) Tonk, TJ (Tom) Snijders, JJ (José) Koldenhof, ASR (Anne) van Lindert, KPM (Karijn) Suijkerbuijk
Fri Sep 13, 2019 14:59
Publication date: November 2019Source: European Journal of Cancer, Volume 121Author(s): Peng Song, Li Zhang
Fri Sep 13, 2019 14:59
Publication date: November 2019Source: European Journal of Cancer, Volume 121Author(s): Vincenza Conteduca, Clara Oromendia, Kenneth W. Eng, Rohan Bareja, Michael Sigouros, Ana Molina, Bishoy M. Faltas, Andrea Sboner, Juan Miguel Mosquera, Olivier Elemento, David M. Nanus, Scott T. Tagawa, Karla V. Ballman, Himisha BeltranAbstractBackgroundNeuroendocrine prostate cancer (NEPC) is an aggressive variant of prostate cancer that may arise de novo or in patients previously treated with hormonal therapies...
Sat Sep 14, 2019 14:54
Publication date: November 2019Source: European Journal of Cancer, Volume 121Author(s): Fei Liang, Zhenyu Wu, Miao Mo, Changming Zhou, Jie Shen, Zezhou Wang, Ying ZhengAbstractPurposeWe aimed to determine whether treatment effect size differed between randomised controlled phase II trials and subsequent phase III trials and examine potential predictor of positive phase III trials.MethodsWe searched MEDLINE for randomised controlled phase II studies published from January 2006 to December 2015. Matched...
Sun Sep 15, 2019 16:05
Publication date: Available online 12 September 2019Source: Computer Speech & LanguageAuthor(s): Asad Abdi, Shafaatunnur Hasan, Mohammad Arshi, Siti Mariyam Shamsuddin, Norisma IdrisAbstractQuestion answering system aims at retrieving precise information from a large collection of documents. This work presents a question answering method to apply on Hadith in order to provide an informative answer corresponding to the user's query. Hadith englobes stories and qualification of the prophet Muhammad (PBSL)....
Fri Sep 13, 2019 13:58
Publication date: Available online 14 September 2019Source: Computer Speech & LanguageAuthor(s): Jonggu Kim, Yewon Jeong, Jong-Hyeok LeeAbstractTo mitigate the ambiguity of spoken language understanding (SLU) of an utterance, we propose contextual models that can consider the relevant context by using temporal and content-related information effectively. We first propose two axes: ‘Awareness’ and ‘Attention Level’. Awareness includes three methods that consider the timing or content-similarity...
Sun Sep 15, 2019 16:09
Publication date: Available online 14 September 2019Source: Journal of ProteomicsAuthor(s): Maria Pieri, Angela Silvestre, Maristella De Cicco, Gianfranco Mamone, Emanuele Capasso, Francesco Addeo, Gianluca PicarielloAbstractProteomics was exploited to assess the nature of possible traces of vomit found on the scene of an alleged sexual assault. In the case in point, a woman reported to the police to be raped five days before by a cousin of hers in his car. The woman declared she had vomited in the...
Sat Sep 14, 2019 14:26
Publication date: Available online 14 September 2019Source: Journal of ProteomicsAuthor(s): Douglas O.C. Mariano, José Pedro Prezotto-Neto, Patrick J. Spencer, Juliana Mozer Sciani, Daniel C. PimentaAbstractAmphibians display a toxic secretion that works as chemical defenses against predators and/or microorganisms that is stored in specialized glands located in the tegument. For some animals, such glands have accumulated in specific regions of the body and formed prominent structures known as macroglands....
Sun Sep 15, 2019 16:10
Fri Sep 13, 2019 14:58
Fri Sep 13, 2019 16:08
Key points Functional disorders (i.e., interstitial cystitis/painful bladder syndrome and irritable bowel syndrome) are associated with hyperexcitability of afferent nerves innervating the urinary tract and the bowel respectively. Various non‐5‐HT3 receptor mRNA transcripts are expressed in mouse urothelium and exert functional responses to 5‐HT. Whilst 5‐HT3 receptors were not detected in mouse urothelium, 5‐HT3 receptors expressed on bladder sensory neurons plays a role in bladder afferent...
Sat Sep 14, 2019 15:54
Publication date: Available online 12 September 2019Source: European Journal of Surgical OncologyAuthor(s): Yester F. Janssen, Willemijn Y. van der Plas, Stan Benjamens, Schelto Kruijff
Fri Sep 13, 2019 15:16
Publication date: Available online 12 September 2019Source: European Journal of Surgical OncologyAuthor(s): Yves Patrice Le Treut, Emilie Grégoire, Régis Fara, Jules A. Giuly, Sophie Chopinet, Jean-Robert Delpero, Jean HardwigsenAbstractBackgroundCentral hepatectomy (CH) is technically challenging and seldom-used to treat centrally located tumors. However, CH is a parenchyma-sparing resection that may decrease the risk of postoperative liver failure. This retrospective study presents our technique...
Fri Sep 13, 2019 15:16
Publication date: Available online 12 September 2019Source: European Journal of Surgical OncologyAuthor(s): Taibi Abdelkader, Lo Dico Rea, Kaci Rachid, Naneix Anne Laure, Malgras Brice, Mathonnet Muriel, Pocard MarcAbstractThis experimental study evaluated the histological response of peritoneal metastases (PM) from colorectal cancer (CRC) after preoperative systemic chemotherapy (pCT). The results demonstrated that the Peritoneal Regression Grade Score could be used in medical practice.AimThe aim...
Fri Sep 13, 2019 15:16
Publication date: Available online 12 September 2019Source: European Journal of Surgical OncologyAuthor(s): Han Wu, Hao Xing, Lei Liang, Bin Huang, Chao Li, Wan Yee Lau, Ya-Hao Zhou, Wei-Min Gu, Hong Wang, Ting-Hao Chen, Yao-Ming Zhang, Yong-Yi Zeng, Timothy M. Pawlik, Ming-Da Wang, Meng-Chao Wu, Feng Shen, Tian YangAbstractBackgroundThe Barcelona Clinic Liver Cancer (BCLC) categorizes a patient with performance status (PS)-1 as advanced stage of hepatocellular carcinoma (HCC) and surgical resection...
Fri Sep 13, 2019 15:16
Publication date: Available online 13 September 2019Source: European Journal of Surgical OncologyAuthor(s): Xu Hu, San-Chao Xiong, Wei-Chao Dou, Yan-Xiang Shao, Wei-Xiao Yang, Jian-Bang Liu, Xiang LiAbstractObjectiveMinimally invasive surgical (MIS) approaches to radical cystectomy (RC) develop well in the past decades. We performed the present study to compare the perioperative outcomes, pathological outcomes, and oncologic outcomes between MIS approaches and open radical cystectomy (ORC) for bladder...
Fri Sep 13, 2019 15:16
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