Related ArticlesUrodynamic outcomes after pelvic nerve-sparing radical hysterectomy with or without neoadjuvant chemotherapy. Oncotarget. 2019 Aug 27;10(50):5207-5216 Authors: Tsunetoh S, Terai Y, Takai M, Fujiwara S, Tanaka Y, Tanaka T, Sasaki H, Ibuki N, Ubai T, Yamamoto K, Azuma H, Ohmichi M Abstract OBJECTIVE: Our purposes of this study were to characterize a group of bulky cervical cancer patients who underwent a nerve sparing radical hysterectomy...
Tue Sep 10, 2019 15:51
Inefficient induction of circulating TAA-specific CD8+ T-cell responses in hepatocellular carcinoma.
Related ArticlesInefficient induction of circulating TAA-specific CD8+ T-cell responses in hepatocellular carcinoma. Oncotarget. 2019 Aug 27;10(50):5194-5206 Authors: Tauber C, Schultheiss M, Luca R, Buettner N, Llewellyn-Lacey S, Emmerich F, Zehe S, Price DA, Neumann-Haefelin C, Schmitt-Graeff A, Hofmann M, Thimme R Abstract Background & Aims: In hepatocellular carcinoma (HCC), CD8+ T-cell responses targeting tumor-associated antigens (TAA) are...
Tue Sep 10, 2019 15:51
Related ArticlesDevelopment and analytical validation of a next-generation sequencing based microsatellite instability (MSI) assay. Oncotarget. 2019 Aug 27;10(50):5181-5193 Authors: Pabla S, Andreas J, Lenzo FL, Burgher B, Hagen J, Giamo V, Nesline MK, Wang Y, Gardner M, Conroy JM, Papanicolau-Sengos A, Morrison C, Glenn ST Abstract Background: We have developed and analytically validated a next-generation sequencing (NGS) assay to classify microsatellite...
Tue Sep 10, 2019 15:51
Detection of tyrosine kinase inhibitors-induced COX-2 expression in bladder cancer by fluorocoxib A.
Related ArticlesDetection of tyrosine kinase inhibitors-induced COX-2 expression in bladder cancer by fluorocoxib A. Oncotarget. 2019 Aug 27;10(50):5168-5180 Authors: Bourn J, Pandey S, Uddin J, Marnett L, Cekanova M Abstract Among challenges of targeted therapies is the activation of alternative pro-survival signaling pathways in cancer cells, resulting in an acquired drug resistance. Cyclooxygenase-2 (COX-2) is overexpressed in bladder cancer cells,...
Tue Sep 10, 2019 15:51
Related ArticlesDS-1205b, a novel selective inhibitor of AXL kinase, blocks resistance to EGFR-tyrosine kinase inhibitors in a non-small cell lung cancer xenograft model. Oncotarget. 2019 Aug 27;10(50):5152-5167 Authors: Jimbo T, Hatanaka M, Komatsu T, Taira T, Kumazawa K, Maeda N, Suzuki T, Ota M, Haginoya N, Isoyama T, Fujiwara K Abstract The AXL receptor tyrosine kinase is involved in signal transduction in malignant cells. Recent studies have shown...
Tue Sep 10, 2019 15:51
Related ArticlesProliferative, pro-inflammatory, and angiogenesis regulator gene expression profile defines prognosis in different histopathological subtypes of nodal peripheral T-cell lymphoma. Oncotarget. 2019 Aug 27;10(50):5136-5151 Authors: de Pádua Covas Lage LA, Levy D, Xavier FD, Reis DC, de Oliveira Costa R, Gonçalves MC, Rocha V, Zerbini MCN, Pereira J Abstract Nodal peripheral T-cell lymphoma (PTCL) is an aggressive and heterogeneous malignancy...
Tue Sep 10, 2019 15:51
Related ArticlesRas functional proximity proteomics establishes mTORC2 as new direct ras effector. Oncotarget. 2019 Aug 27;10(50):5126-5135 Authors: Kovalski JR, Shanderson RL, Khavari PA Abstract Although oncogenic mutations in the three major Ras isoforms, KRAS, HRAS and NRAS, are present in nearly a third of human cancers, therapeutic targeting of Ras remains a challenge due to its structure and complex regulation. However, an in-depth examination...
Tue Sep 10, 2019 15:51
Related ArticlesWalking the tightrope: UCH-L1 as an mTOR inhibitor and B-cell oncogene. Oncotarget. 2019 Aug 27;10(50):5124-5125 Authors: Bedekovics T, Hussain S, Galardy PJ PMID: 31497243 [PubMed]
Tue Sep 10, 2019 15:51
Publication date: 15 January 2020Source: Talanta, Volume 207Author(s): Iwona Gęca, Mateusz Ochab, Mieczyslaw KorolczukAbstractFor the first time solid lead microelectrode was utilized for analytical purposes: the article reports on its application for adsorptive stripping voltammetric determination of U(VI) ions. The proposed solid metal microelectrode of a diameter of 25 μm contains about 30 μg of metallic lead that significantly restricts amount of toxic lead introduced into the environment in...
Tue Sep 10, 2019 13:44
Related ArticlesDiscovery of a new pyrimidine synthesis inhibitor eradicating glioblastoma-initiating cells. Neuro Oncol. 2019 Sep 10;: Authors: Echizenya S, Ishii Y, Kitazawa S, Tanaka T, Matsuda S, Watanabe E, Umekawa M, Terasaka S, Houkin K, Hatta T, Natsume T, Maeda Y, Watanabe SI, Hagiwara S, Kondo T Abstract BACKGROUND: Glioblastoma-initiating cells (GICs) comprise a tumorigenic subpopulation of cells that are resistant to radio- and chemo-therapies...
Tue Sep 10, 2019 14:43
Related ArticlesDesign, synthesis, and biological evaluation of novel benzodiazepine derivatives as anticancer agents through inhibition of tubulin polymerization in vitro and in vivo. Eur J Med Chem. 2019 Sep 02;182:111670 Authors: Pang Y, Lin H, Ou C, Cao Y, An B, Yan J, Li X Abstract A series of novel structurally-related tubulin polymerization inhibitors based on benzodiazepine were designed, synthesized, and evaluated for anticancer activity. Extensive...
Tue Sep 10, 2019 14:43
Related ArticlesSmad7 Regulates Dental Epithelial Proliferation during Tooth Development. J Dent Res. 2019 Sep 09;:22034519872487 Authors: Liu Z, Chen T, Bai D, Tian W, Chen Y Abstract Tooth morphogenesis involves dynamic changes in shape and size as it proceeds through the bud, cap, and bell stages. This process requires exact regulation of cell proliferation and differentiation. Smad7, a general antagonist against transforming growth factor-β (TGF-β)...
Tue Sep 10, 2019 14:43
Related ArticlesmiR-215-5p is an anticancer gene in multiple myeloma by targeting RUNX1 and deactivating the PI3K/AKT/mTOR pathway. J Cell Biochem. 2019 Sep 09;: Authors: Liu S, Zhang Y, Huang C, Lin S Abstract This study examined the underlying mechanism of miR-215-5p in multiple myeloma (MM) at the molecular level. miR-215-5p was upregulated in bone marrow specimens of patients with MM and MM cell lines through real-time polymerase chain reaction,...
Tue Sep 10, 2019 14:43
Related ArticlesIL-34 modulates rheumatoid synovial fibroblasts proliferation and migration via ERK/AKT signalling pathway. Clin Exp Rheumatol. 2019 Aug 27; Authors: Elkhider A, Wei J, Al-Azab M, Tang Y, Walana W, Li W, Yuan B, Ye Y, Zhang Y, Li X Abstract OBJECTIVES: The interface between pro-inflammatory cytokines and rheumatoid synovial fibroblast (sFLS) has central effects on rheumatoid arthritis (RA). The present study aimed to explore the role...
Tue Sep 10, 2019 14:43
Related ArticlesProfiling the epigenetic interplay of lncRNA RUNXOR and oncogenic RUNX1 in breast cancer cells by gene in situ cis-activation. Am J Cancer Res. 2019;9(8):1635-1649 Authors: Nie Y, Zhou L, Wang H, Chen N, Jia L, Wang C, Wang Y, Chen J, Wen X, Niu C, Li H, Guo R, Zhang S, Cui J, Hoffman AR, Hu JF, Li W Abstract RUNX1 is frequently mutated as chromosomal translocations in a variety of hematological malignancies. Recent studies show that...
Tue Sep 10, 2019 14:43
Related ArticlesMicroRNA-940 inhibits glioma cells proliferation and cell cycle progression by targeting CKS1. Am J Transl Res. 2019;11(8):4851-4865 Authors: Luo H, Xu R, Chen B, Dong S, Zhou F, Yu T, Xu G, Zhang J, Wang Y, You Y Abstract Glioblastoma (GBM) is the most frequently occurred malignant human tumor that arise in brain with a poor prognosis. microRNAs (miRNAs) are vital small molecules during GBM initiation and progression. However, the expression...
Tue Sep 10, 2019 14:43
Related ArticlesDownregulation of microRNA-16-5p accelerates fracture healing by promoting proliferation and inhibiting apoptosis of osteoblasts in patients with traumatic brain injury. Am J Transl Res. 2019;11(8):4746-4760 Authors: Sun Y, Xiong Y, Yan C, Chen L, Chen D, Mi B, Liu G Abstract Patients who suffered a traumatic brain injury (TBI) show a faster fracture healing than patients with isolated fractures. Prior studies have suggested that this...
Tue Sep 10, 2019 14:43
Related ArticlesCombination of Cannabinoids, Δ9- Tetrahydrocannabinol and Cannabidiol, Ameliorates Experimental Multiple Sclerosis by Suppressing Neuroinflammation Through Regulation of miRNA-Mediated Signaling Pathways. Front Immunol. 2019;10:1921 Authors: Al-Ghezi ZZ, Miranda K, Nagarkatti M, Nagarkatti PS Abstract Multiple sclerosis (MS) is a chronic and disabling disorder of the central nervous system (CNS) characterized by neuroinflammation leading...
Tue Sep 10, 2019 14:43
Related ArticlesPaip1 overexpression is involved in the progression of gastric cancer and predicts shorter survival of diagnosed patients. Onco Targets Ther. 2019;12:6565-6576 Authors: Wang Q, Han A, Chen L, Sun J, Lin Z, Zhang X, Ren X Abstract Background: Gastric cancer (GC) is a major leading cause of cancer mortality worldwide. Polyadenylate (poly(A))-binding protein (PABP)-interacting protein 1 (Paip1) is a key regulator in the initiation of translation;...
Tue Sep 10, 2019 14:43
Related ArticlesCircLMNB1 promotes colorectal cancer by regulating cell proliferation, apoptosis and epithelial-mesenchymal transition. Onco Targets Ther. 2019;12:6349-6359 Authors: He C, Huang C, Zhou R, Yu H Abstract Objective: The aberrant expression of circular RNAs (circRNAs) is a frequent occurrence in various cancers. However, the functions and roles played by most circRNAs in colorectal cancer (CRC) remain largely unknown. Materials...
Tue Sep 10, 2019 14:43
Related ArticlesInhibition of proliferation and migration of tumor cells through phenylboronic acid-functionalized polyamidoamine-mediated delivery of a therapeutic DNAzyme Dz13. Int J Nanomedicine. 2019;14:6371-6385 Authors: Yang J, Zhang J, Xing J, Shi Z, Han H, Li Q Abstract Background: The phenylboronic acid-functionalized polyamidoamine (PP) was employed as a gene carrier for Dz13 delivery, inducing an obvious anticancer response. Materials...
Tue Sep 10, 2019 14:43
Related ArticlesMicroRNA-194 inactivates hepatic stellate cells and alleviates liver fibrosis by inhibiting AKT2. World J Gastroenterol. 2019 Aug 21;25(31):4468-4480 Authors: Wu JC, Chen R, Luo X, Li ZH, Luo SZ, Xu MY Abstract BACKGROUND: Activation of hepatic stellate cells (HSCs) is a pivotal event in the onset and progression of liver fibrosis. Loss of microRNA-194 (miR-194) has been reported in activated HSCs, but the actual role of miR-194 in liver...
Tue Sep 10, 2019 14:43
Related ArticlesEffect of Imipramine on radiosensitivity of Prostate Cancer: An In Vitro Study. Cancer Invest. 2019 Sep 09;:1-12 Authors: Barlaz Us S, Sogut F, Yildirim M, Yetkin D, Yalin S, Yilmaz SN, Comelekoglu U Abstract Prostate cancer is the most common cancer and leading cause of cancer death for males. Imipramine (IMI), which is a tricyclic antidepressant, has also been shown to has antineoplastic effect. This study was performed to investigate...
Tue Sep 10, 2019 14:43
Related ArticlesISYNA1 is overexpressed in bladder carcinoma and regulates cell proliferation and apoptosis. Biochem Biophys Res Commun. 2019 Sep 05;: Authors: Guo X, Li HH, Hu J, Duan YX, Ren WG, Guo Q, Liu PH, Cui Y, Liu LF, Chen MF, Chen JB, Zu XB Abstract BACKGROUND: Bladder cancer (BCa) is one of the most common urological malignancies. While Inositol-3-phosphate synthase 1 (ISYNA1) expression and function were largely unknown in BCa. We aimed to...
Tue Sep 10, 2019 13:42
Related ArticlesState of the art about influenza vaccination for advanced cancer patients receiving immune checkpoint inhibitors: When common sense is not enough. Crit Rev Oncol Hematol. 2019 Jul;139:87-90 Authors: Bersanelli M, Buti S, De Giorgi U, Di Maio M, Giannarelli D, Pignata S, Banna GL Abstract Influenza vaccination is recommended for advanced cancer patients, since impaired immunity is presumed to be due not only to the tumor itself but also...
Tue Sep 10, 2019 13:42
Related ArticlesMps1 regulates spindle morphology through MCRS1 to promote chromosome alignment. Mol Biol Cell. 2019 04 15;30(9):1060-1068 Authors: Yang H, Zhang F, Huang CJ, Liao J, Han Y, Hao P, Chu Y, Lu X, Li W, Yu H, Kang J Abstract Accurate partitioning of chromosomes during mitosis is essential for genetic stability and requires the assembly of the dynamic mitotic spindle and proper kinetochore-microtubule attachment. The spindle assembly checkpoint...
Tue Sep 10, 2019 13:42
Related ArticlesFBLN3 inhibited the invasion and metastasis of colorectal cancer through the AKT/mTOR pathway. Neoplasma. 2019 May 23;66(3):336-342 Authors: Mao HY, Liu SP, Kong GM, Xu Y, Xu YC, Sun GZ, Wang Z, Han F, Tong JD, Bo P Abstract Fibulin-3(FBLN3) levels are different in different types of cancers. We found that fibulin-3 was downregulated in colorectal (CRC) cells, particularly in the SW480 cell line. By comparison, transfecting SW480 cells...
Tue Sep 10, 2019 13:42
Related ArticlesDecrease in phosphorylated ERK indicates the therapeutic efficacy of a clinical PI3Kα-selective inhibitor CYH33 in breast cancer. Cancer Lett. 2018 10 01;433:273-282 Authors: Liu XL, Xu YC, Wang YX, Chen Y, Wang BB, Wang Y, Chen YH, Tan C, Hu LD, Ma QY, Zhang YC, Sun YM, Gao YL, Yang CH, Ding J, Meng LH Abstract PI3Ks are frequently hyper-activated in breast cancer and targeting PI3Kα has exhibited promising but variable response in...
Tue Sep 10, 2019 13:42
Related ArticlesSuppression of ribosomal protein RPS6KB1 by Nexrutine increases sensitivity of prostate tumors to radiation. Cancer Lett. 2018 10 01;433:232-241 Authors: Hussain SS, Huang SB, Bedolla RG, Rivas P, Basler JW, Swanson GP, Hui-Ming Huang T, Narayanasamy G, Papanikolaou N, Miyamoto H, Yeh IT, Reddick RL, Pollock BH, Ghosh R, Kumar AP Abstract Radiation therapy (XRT) is a standard treatment for prostate cancer (PCa). Although dose escalation...
Tue Sep 10, 2019 13:42
Related ArticlesComprehensive pharmacogenomic profiling of human papillomavirus-positive and -negative squamous cell carcinoma identifies sensitivity to aurora kinase inhibition in KMT2D mutants. Cancer Lett. 2018 09 01;431:64-72 Authors: Kalu NN, Mazumdar T, Peng S, Tong P, Shen L, Wang J, Banerjee U, Myers JN, Pickering CR, Brunell D, Stephan CC, Johnson FM Abstract To address the unmet need for effective biomarker-driven targeted therapy for human...
Tue Sep 10, 2019 13:42
Related Articlesβ-Trcp ubiquitin ligase and RSK2 kinase-mediated degradation of FOXN2 promotes tumorigenesis and radioresistance in lung cancer. Cell Death Differ. 2018 08;25(8):1473-1485 Authors: Ma J, Lu Y, Zhang S, Li Y, Huang J, Yin Z, Ren J, Huang K, Liu L, Yang K, Wu G, Xu S Abstract Aberrant expression of FOXN2, a member of the Forkhead box transcription factors, has been found in several types of cancer. However, the underlying mechanisms of...
Tue Sep 10, 2019 13:42
Related ArticlesSingle agent and synergistic combinatorial efficacy of first-in-class small molecule imipridone ONC201 in hematological malignancies. Cell Cycle. 2018;17(4):468-478 Authors: Prabhu VV, Talekar MK, Lulla AR, Kline CLB, Zhou L, Hall J, Van den Heuvel APJ, Dicker DT, Babar J, Grupp SA, Garnett MJ, McDermott U, Benes CH, Pu JJ, Claxton DF, Khan N, Oster W, Allen JE, El-Deiry WS Abstract ONC201, founding member of the imipridone class of...
Tue Sep 10, 2019 13:42
Epidermal growth factor receptor tyrosine kinase inhibitors therapy, such as gefitinib, have proven to be effective for lung adenocarcinoma with epidermal growth factor receptor-sensitive mutations. However, drug resistance remains inevitable and the underlying mechanisms are still elusive and poorly understood. In order to explore the mechanisms underlying tyrosine kinase inhibitors resistance, we used long non-coding RNA microarray analysis and found that long non-coding RNA H19 was highly expressed...
Mon Sep 09, 2019 03:00
Fibroblast growth factor-2 (FGF2) is a protein ligand, which exerts essential roles in development, angiogenesis, and tumor progression via activation of the downstream signaling cascades. Accumulating evidence has demonstrated that FGF2 is involved in the progression of ovarian cancer, providing a novel potential target for ovarian cancer therapy. In this study, we showed that FGF2 is significantly increased in ovarian tumors, and is negatively associated with the overall survival of ovarian cancer...
Mon Sep 09, 2019 03:00
Inflammation is essential for our innate and adaptive immunity, but chronic inflammation can also be detrimental, playing a role in tumor development and subversion of host immunity. A multitude of proteins and cytokines are involved in chronic inflammation; interleukin-1β, in particular, has been recognized as a critical pro-inflammatory cytokine that can trigger a cascade of inflammatory mediators, promoting angiogenesis, tumor invasiveness, and metastasis. The inhibition of interleukin-1β with...
Mon Sep 09, 2019 03:00
Abstract Purpose To identify the predictors of malignancy on CT for the evaluation of gastrointestinal stromal tumors (GIST) by correlating CT findings with the mitotic index in order to propose a “CT-based predictive model of Miettinen index.” Methods One radiologist and one resident in radiology with 14- and 4-year experience in oncological field reviewed...
Tue Sep 10, 2019 03:00
Related Articles[Transmastoidslotted labyrinthotomy approach cochlear implantation with customized electrode for patients with common cavity deformity]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Jul 07;54(7):489-494 Authors: Shi Y, Chen B, Chen JY, Gong Y, Cui DM, Wei XM, Li YX Abstract Objective: To discuss the benefit of using transmastoid slotted labyrinthotomy approach (TSLA) and customized electrode for common cavity deformity (CCD) patients,...
Tue Sep 10, 2019 13:40
Related ArticlesIntensity modulated radiation therapy and oral mucosa sparing in Head and neck cancer patients: A systematic review on behalf of Italian Association of Radiation Oncology - Head and neck working group. Crit Rev Oncol Hematol. 2019 Jul;139:24-30 Authors: De Sanctis V, Merlotti A, De Felice F, Trignani M, Dell'Oca I, Lastrucci L, Molteni M, Frakulli R, Bunkheila F, Bacigalupo A, Paiar F Abstract Oral mucositis is a common dose-limiting...
Tue Sep 10, 2019 13:40
Related ArticlesEndoscopic transvestibular anatomy of the infratemporal fossa and upper parapharyngeal spaces for clinical surgery: a cadaver study. Eur Arch Otorhinolaryngol. 2019 Jun;276(6):1799-1807 Authors: Fang Y, Wu H, Zhao W, Cheng L Abstract AIMS: To investigate the anatomy of the infratemporal fossa (ITF) and to discuss the practicality of endoscopic transvestibular surgery for an ITF tumor. METHODS: Five fresh cadaveric specimens...
Tue Sep 10, 2019 13:40
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